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Items: 21

1.

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G.

Nature. 2020 Jan 16. doi: 10.1038/s41586-020-1954-0. [Epub ahead of print]

PMID:
31945772
2.

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.

Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ.

J Biol Chem. 2019 Sep 6;294(36):13218-13223. doi: 10.1074/jbc.AC119.009848. Epub 2019 Jul 30.

PMID:
31362983
3.

Mechanism of β2AR regulation by an intracellular positive allosteric modulator.

Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B.

Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27.

4.

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.

Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC.

Cell. 2019 Jan 24;176(3):479-490.e12. doi: 10.1016/j.cell.2018.12.006. Epub 2019 Jan 10.

5.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ.

Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10.

6.

G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.

Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ.

Sci Signal. 2018 Aug 21;11(544). pii: eaar7084. doi: 10.1126/scisignal.aar7084.

PMID:
30131371
7.

Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.

Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, Huang LY, Franch T, Chen X, Lefkowitz RJ.

Mol Pharmacol. 2018 Aug;94(2):850-861. doi: 10.1124/mol.118.111948. Epub 2018 May 16.

8.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26.

9.

i is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.

Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA.

Nat Commun. 2017 Nov 22;8(1):1706. doi: 10.1038/s41467-017-01855-z.

10.

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling.

Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC.

Cell. 2017 Apr 6;169(2):338-349.e11. doi: 10.1016/j.cell.2017.03.028.

11.

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.

12.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.

13.

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ.

Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11.

14.

Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.

Staus DP, Weise-Cross L, Mangum KD, Medlin MD, Mangiante L, Taylor JM, Mack CP.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H379-90. doi: 10.1152/ajpheart.01002.2013. Epub 2014 Jun 6.

15.

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ.

Mol Pharmacol. 2014 Mar;85(3):472-81. doi: 10.1124/mol.113.089516. Epub 2013 Dec 6.

16.

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.

Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ.

Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.

17.

Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain.

Staus DP, Taylor JM, Mack CP.

Biochem J. 2011 Oct 1;439(1):57-65. doi: 10.1042/BJ20101700.

18.

Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype.

Staus DP, Blaker AL, Medlin MD, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):360-7. doi: 10.1161/ATVBAHA.110.212993. Epub 2010 Nov 24.

19.

Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.

Medlin MD, Staus DP, Dubash AD, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1779-86. doi: 10.1161/ATVBAHA.110.209395. Epub 2010 Aug 11.

20.

Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta.

Nikolaishvili-Feinberg N, Jenkins GS, Nevis KR, Staus DP, Scarlett CO, Unsal-Kaçmaz K, Kaufmann WK, Cordeiro-Stone M.

Biochemistry. 2008 Apr 1;47(13):4141-50. doi: 10.1021/bi702329h. Epub 2008 Mar 6.

PMID:
18321066
21.

Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.

Staus DP, Blaker AL, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):478-86. Epub 2006 Dec 14.

PMID:
17170370

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