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Items: 36

1.

Clinical applications of small molecule inhibitors of Pregnane X receptor.

Staudinger JL.

Mol Cell Endocrinol. 2019 Apr 5;485:61-71. doi: 10.1016/j.mce.2019.02.002. Epub 2019 Feb 3. Review.

PMID:
30726709
2.

The Molecular Interface Between the SUMO and Ubiquitin Systems.

Staudinger JL.

Adv Exp Med Biol. 2017;963:99-110. doi: 10.1007/978-3-319-50044-7_6. Review.

PMID:
28197908
3.

A SUMO-acetyl switch in PXR biology.

Cui W, Sun M, Zhang S, Shen X, Galeva N, Williams TD, Staudinger JL.

Biochim Biophys Acta. 2016 Sep;1859(9):1170-1182. doi: 10.1016/j.bbagrm.2016.02.008. Epub 2016 Feb 12.

4.

SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes.

Cui W, Sun M, Galeva N, Williams TD, Azuma Y, Staudinger JL.

Drug Metab Dispos. 2015 Sep;43(9):1316-25. doi: 10.1124/dmd.115.065201. Epub 2015 Jun 10.

5.

Pregnane X receptor modulates the inflammatory response in primary cultures of hepatocytes.

Sun M, Cui W, Woody SK, Staudinger JL.

Drug Metab Dispos. 2015 Mar;43(3):335-43. doi: 10.1124/dmd.114.062307. Epub 2014 Dec 19.

6.

Disease, drug metabolism, and transporter interactions.

Staudinger JL.

Pharm Res. 2013 Sep;30(9):2171-3. doi: 10.1007/s11095-013-1129-x. Epub 2013 Jul 19. No abstract available.

7.

Protein targets of thioacetamide metabolites in rat hepatocytes.

Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2013 Apr 15;26(4):564-74. doi: 10.1021/tx400001x. Epub 2013 Mar 20.

8.

Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.

Staudinger JL, Woody S, Sun M, Cui W.

Drug Metab Rev. 2013 Feb;45(1):48-59. doi: 10.3109/03602532.2012.748793. Review.

9.

Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.

Hajovsky H, Hu G, Koen Y, Sarma D, Cui W, Moore DS, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1955-63. doi: 10.1021/tx3002719. Epub 2012 Aug 17.

10.

Liver protein targets of hepatotoxic 4-bromophenol metabolites.

Koen YM, Hajovsky H, Liu K, Williams TD, Galeva NA, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Aug 20;25(8):1777-86. doi: 10.1021/tx3002675. Epub 2012 Aug 3.

11.

Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

Sarma D, Hajovsky H, Koen YM, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1868-77. doi: 10.1021/tx3001658. Epub 2012 Jun 15.

12.

Post-translational modification of pregnane x receptor.

Staudinger JL, Xu C, Biswas A, Mani S.

Pharmacol Res. 2011 Jul;64(1):4-10. doi: 10.1016/j.phrs.2011.02.011. Epub 2011 Mar 21. Review.

13.

Pregnane X receptor is SUMOylated to repress the inflammatory response.

Hu G, Xu C, Staudinger JL.

J Pharmacol Exp Ther. 2010 Nov;335(2):342-50. doi: 10.1124/jpet.110.171744. Epub 2010 Aug 18.

14.

Nuclear receptor-mediated regulation of carboxylesterase expression and activity.

Staudinger JL, Xu C, Cui YJ, Klaassen CD.

Expert Opin Drug Metab Toxicol. 2010 Mar;6(3):261-71. doi: 10.1517/17425250903483215. Review.

15.

A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.

Lichti-Kaiser K, Brobst D, Xu C, Staudinger JL.

J Pharmacol Exp Ther. 2009 Oct;331(1):65-76. doi: 10.1124/jpet.109.157180. Epub 2009 Jul 17.

16.

Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.

Xu C, Wang X, Staudinger JL.

Drug Metab Dispos. 2009 Jul;37(7):1539-47. doi: 10.1124/dmd.109.026989. Epub 2009 Apr 9.

17.

Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner.

Lichti-Kaiser K, Xu C, Staudinger JL.

J Biol Chem. 2009 Mar 13;284(11):6639-49. doi: 10.1074/jbc.M807426200. Epub 2009 Jan 13.

18.

Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.

Singh RK, Dai Y, Staudinger JL, Muma NA.

Int J Neuropsychopharmacol. 2009 Jun;12(5):651-65. doi: 10.1017/S1461145708009590. Epub 2008 Oct 31.

19.

The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes.

Lichti-Kaiser K, Staudinger JL.

Drug Metab Dispos. 2008 Aug;36(8):1538-45. doi: 10.1124/dmd.108.021774. Epub 2008 May 12.

20.

Liver-enriched nuclear receptors: therapeutic opportunities.

Staudinger JL.

Mol Pharm. 2008 Jan-Feb;5(1):1-2. doi: 10.1021/mp700146b. No abstract available.

PMID:
18247475
21.

Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.

Staudinger JL, Lichti K.

Mol Pharm. 2008 Jan-Feb;5(1):17-34. Epub 2007 Dec 27. Review.

22.

Pregnane X receptor and natural products: beyond drug-drug interactions.

Staudinger JL, Ding X, Lichti K.

Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):847-57. Review.

23.

Gender dictates the nuclear receptor-mediated regulation of CYP3A44.

Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW.

Drug Metab Dispos. 2007 Jan;35(1):36-42. Epub 2006 Oct 4.

PMID:
17020958
25.

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.

Ding X, Lichti K, Staudinger JL.

Toxicol Sci. 2006 Jun;91(2):448-55. Epub 2006 Mar 17.

26.
27.

Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.

Ding X, Staudinger JL.

Biochem Pharmacol. 2005 Mar 1;69(5):867-73. Epub 2005 Jan 21.

PMID:
15710363
28.

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway.

Ding X, Staudinger JL.

J Pharmacol Exp Ther. 2005 Feb;312(2):849-56. Epub 2004 Sep 30.

PMID:
15459237
29.

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.

Brobst DE, Ding X, Creech KL, Goodwin B, Kelley B, Staudinger JL.

J Pharmacol Exp Ther. 2004 Aug;310(2):528-35. Epub 2004 Apr 1.

PMID:
15075359
30.

CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.

Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, Strobel HW.

Pharmacogenomics J. 2004;4(2):91-101.

PMID:
14770174
31.

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.

Anakk S, Kalsotra A, Shen Q, Vu MT, Staudinger JL, Davies PJ, Strobel HW.

FASEB J. 2003 Sep;17(12):1736-8. Epub 2003 Jul 3.

PMID:
12958193
32.
33.

Regulation of drug transporter gene expression by nuclear receptors.

Staudinger JL, Madan A, Carol KM, Parkinson A.

Drug Metab Dispos. 2003 May;31(5):523-7.

PMID:
12695338
34.

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.

Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74.

35.

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.

Yan ZH, Karam WG, Staudinger JL, Medvedev A, Ghanayem BI, Jetten AM.

J Biol Chem. 1998 May 1;273(18):10948-57.

36.

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JM.

Cell. 1998 Jan 9;92(1):73-82.

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