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Items: 1 to 50 of 84

1.

Are ENT1/ENT1, NOTCH3, and miR-21 Reliable Prognostic Biomarkers in Patients with Resected Pancreatic Adenocarcinoma Treated with Adjuvant Gemcitabine Monotherapy?

Jiraskova L, Ryska A, Duintjer Tebbens EJ, Hornychova H, Cecka F, Staud F, Cerveny L.

Cancers (Basel). 2019 Oct 23;11(11). pii: E1621. doi: 10.3390/cancers11111621.

2.

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.

Hofman J, Sorf A, Vagiannis D, Sucha S, Kammerer S, Küpper JH, Chen S, Guo L, Ceckova M, Staud F.

Mol Pharm. 2019 Nov 4;16(11):4436-4450. doi: 10.1021/acs.molpharmaceut.9b00361. Epub 2019 Oct 21.

PMID:
31633365
3.

Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices.

Martinec O, Huliciak M, Staud F, Cecka F, Vokral I, Cerveny L.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e00910-19. doi: 10.1128/AAC.00910-19. Print 2019 Nov.

PMID:
31481446
4.

Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics.

Tupova L, Ceckova M, Ambrus C, Sorf A, Ptackova Z, Gaborik Z, Staud F.

Drug Metab Dispos. 2019 Sep;47(9):954-960. doi: 10.1124/dmd.119.087684. Epub 2019 Jul 2.

PMID:
31266750
5.

Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance.

Hofman J, Sorf A, Vagiannis D, Sucha S, Novotna E, Kammerer S, Küpper JH, Ceckova M, Staud F.

Drug Metab Dispos. 2019 Jul;47(7):699-709. doi: 10.1124/dmd.119.086975. Epub 2019 May 8.

PMID:
31068367
6.

Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters.

Sorf A, Novotna E, Hofman J, Morell A, Staud F, Wsol V, Ceckova M.

Biochem Pharmacol. 2019 May;163:290-298. doi: 10.1016/j.bcp.2019.02.035. Epub 2019 Feb 28.

PMID:
30826329
7.

The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta.

Karahoda R, Ceckova M, Staud F.

Toxicol Appl Pharmacol. 2019 Apr 1;368:18-25. doi: 10.1016/j.taap.2019.02.002. Epub 2019 Feb 5.

PMID:
30735677
8.

Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters.

Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F.

Biochem Pharmacol. 2019 May;163:60-70. doi: 10.1016/j.bcp.2019.01.024. Epub 2019 Feb 2.

PMID:
30716294
9.

Trophoblast: The central unit of fetal growth, protection and programming.

Staud F, Karahoda R.

Int J Biochem Cell Biol. 2018 Dec;105:35-40. doi: 10.1016/j.biocel.2018.09.016. Epub 2018 Sep 25. Review.

PMID:
30266525
10.

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F.

PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018.

11.

Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta.

Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F.

Drug Metab Dispos. 2018 Nov;46(11):1817-1826. doi: 10.1124/dmd.118.083329. Epub 2018 Aug 10.

PMID:
30097436
12.

Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats.

Cerveny L, Ptackova Z, Durisova M, Staud F.

Reprod Toxicol. 2018 Aug;79:57-65. doi: 10.1016/j.reprotox.2018.05.008. Epub 2018 May 30.

PMID:
29859254
13.

Expression of Concentrative Nucleoside Transporters ( SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents.

Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F.

Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238. Epub 2018 May 25.

PMID:
29782174
14.

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

Široká J, Čečková M, Urbánek L, Kryštof V, Gucký T, Hofman J, Strnad M, Štaud F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:24-32. doi: 10.1016/j.jchromb.2018.04.049. Epub 2018 May 1.

PMID:
29753211
15.

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro.

Sorf A, Hofman J, Kučera R, Staud F, Ceckova M.

Biochem Pharmacol. 2018 Aug;154:10-17. doi: 10.1016/j.bcp.2018.04.013. Epub 2018 Apr 16.

PMID:
29673999
16.

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O.

Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083. Epub 2018 Mar 2.

PMID:
29533874
17.

Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine.

Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F.

Placenta. 2017 Dec;60:86-92. doi: 10.1016/j.placenta.2017.10.011. Epub 2017 Nov 10.

PMID:
29208244
18.

MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption.

Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00837-17. doi: 10.1128/AAC.00837-17. Print 2017 Sep.

19.

Etravirine inhibits ABCG2 drug transporter and affects transplacental passage of tenofovir disoproxil fumarate.

Reznicek J, Ceckova M, Tupova L, Staud F.

Placenta. 2016 Nov;47:124-129. doi: 10.1016/j.placenta.2016.09.019. Epub 2016 Sep 29.

PMID:
27780535
20.

Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5563-72. doi: 10.1128/AAC.00648-16. Print 2016 Sep.

21.

Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters.

Reznicek J, Ceckova M, Cerveny L, Müller F, Staud F.

Xenobiotica. 2017 Jan;47(1):77-85. doi: 10.3109/00498254.2016.1158886. Epub 2016 Apr 6.

PMID:
27052107
22.

Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.

Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F.

J Pharm Pharmacol. 2016 Jan;68(1):84-92. doi: 10.1111/jphp.12495. Epub 2016 Jan 4.

PMID:
26727197
23.

Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

Biopharm Drug Dispos. 2016 Jan;37(1):28-38. doi: 10.1002/bdd.1993.

PMID:
26390406
24.

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F.

Xenobiotica. 2016;46(5):416-23. doi: 10.3109/00498254.2015.1086039. Epub 2015 Sep 12.

PMID:
26364927
25.

Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro.

Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F.

Biochem Pharmacol. 2015 Dec 1;98(3):465-72. doi: 10.1016/j.bcp.2015.08.099. Epub 2015 Aug 20.

PMID:
26300056
26.

Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir.

Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F.

Reprod Toxicol. 2015 Nov;57:176-82. doi: 10.1016/j.reprotox.2015.07.070. Epub 2015 Jul 10.

PMID:
26169552
27.

Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.

Cihalova D, Staud F, Ceckova M.

Cancer Chemother Pharmacol. 2015 Jul;76(1):105-16. doi: 10.1007/s00280-015-2772-1. Epub 2015 May 19.

PMID:
25986678
28.

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms.

Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S.

Toxicol Appl Pharmacol. 2015 May 15;285(1):12-22. doi: 10.1016/j.taap.2015.03.004. Epub 2015 Mar 12.

PMID:
25771127
29.

Regulation of drug transporter expression and function in the placenta.

Staud F, Ceckova M.

Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):533-55. doi: 10.1517/17425255.2015.1005073. Epub 2015 Jan 20. Review.

PMID:
25600150
30.

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats.

Kadova Z, Dolezelova E, Cermanova J, Hroch M, Laho T, Muchova L, Staud F, Vitek L, Mokry J, Chladek J, Havlinova Z, Holecek M, Micuda S.

Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F388-99. doi: 10.1152/ajprenal.00266.2014. Epub 2014 Dec 10.

31.

Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

AIDS. 2014 Jan 2;28(1):9-17. doi: 10.1097/QAD.0000000000000112.

PMID:
24413260
32.

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro.

Cihalova D, Hofman J, Ceckova M, Staud F.

PLoS One. 2013 Dec 23;8(12):e83467. doi: 10.1371/journal.pone.0083467. eCollection 2013.

33.

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1).

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F.

PLoS One. 2013 Oct 8;8(10):e75520. doi: 10.1371/journal.pone.0075520. eCollection 2013.

34.

Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics.

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M.

Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11. doi: 10.1016/j.biocel.2013.06.022. Epub 2013 Jul 5. Review.

PMID:
23831838
35.

Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein.

Ahmadimoghaddam D, Staud F.

Reprod Toxicol. 2013 Aug;39:17-22. doi: 10.1016/j.reprotox.2013.03.001. Epub 2013 Apr 3.

PMID:
23562376
36.

Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages of gestation.

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovský M, Micuda S, Staud F.

Biol Reprod. 2013 Mar 7;88(3):55. doi: 10.1095/biolreprod.112.105064. Print 2013 Mar.

PMID:
23303678
37.

Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.

Cerveny L, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J.

Infect Immun. 2013 Mar;81(3):629-35. doi: 10.1128/IAI.01035-12. Epub 2012 Dec 21. Review.

38.

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.

Staud F, Cerveny L, Ceckova M.

J Drug Target. 2012 Nov;20(9):736-63. doi: 10.3109/1061186X.2012.716847. Epub 2012 Sep 20. Review.

PMID:
22994411
39.

Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F.

Toxicol Sci. 2012 Aug;128(2):471-81. doi: 10.1093/toxsci/kfs160. Epub 2012 Apr 26.

PMID:
22543277
40.

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F.

Pharmacol Res. 2012 Mar;65(3):312-9. doi: 10.1016/j.phrs.2011.11.017. Epub 2011 Dec 6.

PMID:
22173067
41.

Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy.

Hahnova-Cygalova L, Ceckova M, Staud F.

Drug Metab Rev. 2011 Feb;43(1):53-68. doi: 10.3109/03602532.2010.512293. Epub 2010 Sep 20. Review.

PMID:
20854129
42.

Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats.

Brcakova E, Fuksa L, Cermanova J, Kolouchova G, Hroch M, Hirsova P, Martinkova J, Staud F, Micuda S.

Biol Pharm Bull. 2009 Dec;32(12):1978-85.

43.

Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics.

Staud F, Ceckova M, Micuda S, Pavek P.

Methods Mol Biol. 2010;596:199-222. doi: 10.1007/978-1-60761-416-6_10.

PMID:
19949926
44.

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats.

Fuksa L, Brcakova E, Kolouchova G, Hirsova P, Hroch M, Cermanova J, Staud F, Micuda S.

Toxicology. 2010 Jan 12;267(1-3):165-71. doi: 10.1016/j.tox.2009.11.010. Epub 2009 Nov 14.

PMID:
19922765
45.

Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.

Cygalova LH, Hofman J, Ceckova M, Staud F.

J Pharmacol Exp Ther. 2009 Dec;331(3):1118-25. doi: 10.1124/jpet.109.160564. Epub 2009 Sep 24.

PMID:
19779128
46.

Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats.

Cermanova J, Fuksa L, Brcakova E, Hroch M, Kucera O, Kolouchova G, Hirsova P, Malakova J, Staud F, Martinkova J, Cervinkova Z, Micuda S.

Pharmacol Res. 2010 Feb;61(2):129-35. doi: 10.1016/j.phrs.2009.08.005. Epub 2009 Aug 22.

PMID:
19703566
47.

Variation of drug kinetics in pregnancy.

Pavek P, Ceckova M, Staud F.

Curr Drug Metab. 2009 Jun;10(5):520-9. Review.

PMID:
19689248
48.

Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta.

Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F.

Reprod Toxicol. 2009 Jul;28(1):46-51. doi: 10.1016/j.reprotox.2009.02.006. Epub 2009 Feb 24.

PMID:
19490994
49.

Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation.

Vagnerová K, Vacková Z, Klusonová P, Staud F, Kopecký M, Ergang P, Miksík I, Pácha J.

Reprod Sci. 2008 Nov;15(9):921-31. doi: 10.1177/1933719108319161.

PMID:
19050325
50.

Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta.

Sklenárová H, Pávek P, Satínský D, Solich P, Karlíček R, Staud F, Fendrich Z.

Talanta. 2002 Dec 6;58(6):1145-9.

PMID:
18968851

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