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Items: 1 to 50 of 78

1.

The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta.

Karahoda R, Ceckova M, Staud F.

Toxicol Appl Pharmacol. 2019 Feb 5. pii: S0041-008X(19)30043-2. doi: 10.1016/j.taap.2019.02.002. [Epub ahead of print]

PMID:
30735677
2.

Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters.

Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F.

Biochem Pharmacol. 2019 Feb 2;163:60-70. doi: 10.1016/j.bcp.2019.01.024. [Epub ahead of print]

PMID:
30716294
3.

Trophoblast: The central unit of fetal growth, protection and programming.

Staud F, Karahoda R.

Int J Biochem Cell Biol. 2018 Dec;105:35-40. doi: 10.1016/j.biocel.2018.09.016. Epub 2018 Sep 25.

PMID:
30266525
4.

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F.

PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018.

5.

Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta.

Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F.

Drug Metab Dispos. 2018 Nov;46(11):1817-1826. doi: 10.1124/dmd.118.083329. Epub 2018 Aug 10.

PMID:
30097436
6.

Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats.

Cerveny L, Ptackova Z, Durisova M, Staud F.

Reprod Toxicol. 2018 Aug;79:57-65. doi: 10.1016/j.reprotox.2018.05.008. Epub 2018 May 30.

PMID:
29859254
7.

Expression of Concentrative Nucleoside Transporters ( SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents.

Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F.

Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238. Epub 2018 May 25.

PMID:
29782174
8.

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

Široká J, Čečková M, Urbánek L, Kryštof V, Gucký T, Hofman J, Strnad M, Štaud F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:24-32. doi: 10.1016/j.jchromb.2018.04.049. Epub 2018 May 1.

PMID:
29753211
9.

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro.

Sorf A, Hofman J, Kučera R, Staud F, Ceckova M.

Biochem Pharmacol. 2018 Aug;154:10-17. doi: 10.1016/j.bcp.2018.04.013. Epub 2018 Apr 16.

PMID:
29673999
10.

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O.

Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083. Epub 2018 Mar 2.

PMID:
29533874
11.

Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine.

Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F.

Placenta. 2017 Dec;60:86-92. doi: 10.1016/j.placenta.2017.10.011. Epub 2017 Nov 10.

PMID:
29208244
12.

MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption.

Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00837-17. doi: 10.1128/AAC.00837-17. Print 2017 Sep.

13.

Etravirine inhibits ABCG2 drug transporter and affects transplacental passage of tenofovir disoproxil fumarate.

Reznicek J, Ceckova M, Tupova L, Staud F.

Placenta. 2016 Nov;47:124-129. doi: 10.1016/j.placenta.2016.09.019. Epub 2016 Sep 29.

PMID:
27780535
14.

Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5563-72. doi: 10.1128/AAC.00648-16. Print 2016 Sep.

15.

Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters.

Reznicek J, Ceckova M, Cerveny L, Müller F, Staud F.

Xenobiotica. 2017 Jan;47(1):77-85. doi: 10.3109/00498254.2016.1158886. Epub 2016 Apr 6.

PMID:
27052107
16.

Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.

Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F.

J Pharm Pharmacol. 2016 Jan;68(1):84-92. doi: 10.1111/jphp.12495. Epub 2016 Jan 4.

PMID:
26727197
17.

Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

Biopharm Drug Dispos. 2016 Jan;37(1):28-38. doi: 10.1002/bdd.1993.

PMID:
26390406
18.

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F.

Xenobiotica. 2016;46(5):416-23. doi: 10.3109/00498254.2015.1086039. Epub 2015 Sep 12.

PMID:
26364927
19.

Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro.

Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F.

Biochem Pharmacol. 2015 Dec 1;98(3):465-72. doi: 10.1016/j.bcp.2015.08.099. Epub 2015 Aug 20.

PMID:
26300056
20.

Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir.

Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F.

Reprod Toxicol. 2015 Nov;57:176-82. doi: 10.1016/j.reprotox.2015.07.070. Epub 2015 Jul 10.

PMID:
26169552
21.

Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.

Cihalova D, Staud F, Ceckova M.

Cancer Chemother Pharmacol. 2015 Jul;76(1):105-16. doi: 10.1007/s00280-015-2772-1. Epub 2015 May 19.

PMID:
25986678
22.

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms.

Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S.

Toxicol Appl Pharmacol. 2015 May 15;285(1):12-22. doi: 10.1016/j.taap.2015.03.004. Epub 2015 Mar 12.

PMID:
25771127
23.

Regulation of drug transporter expression and function in the placenta.

Staud F, Ceckova M.

Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):533-55. doi: 10.1517/17425255.2015.1005073. Epub 2015 Jan 20. Review.

PMID:
25600150
24.

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats.

Kadova Z, Dolezelova E, Cermanova J, Hroch M, Laho T, Muchova L, Staud F, Vitek L, Mokry J, Chladek J, Havlinova Z, Holecek M, Micuda S.

Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F388-99. doi: 10.1152/ajprenal.00266.2014. Epub 2014 Dec 10.

25.

Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

AIDS. 2014 Jan 2;28(1):9-17. doi: 10.1097/QAD.0000000000000112.

PMID:
24413260
26.

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro.

Cihalova D, Hofman J, Ceckova M, Staud F.

PLoS One. 2013 Dec 23;8(12):e83467. doi: 10.1371/journal.pone.0083467. eCollection 2013.

27.

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1).

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F.

PLoS One. 2013 Oct 8;8(10):e75520. doi: 10.1371/journal.pone.0075520. eCollection 2013.

28.

Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics.

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M.

Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11. doi: 10.1016/j.biocel.2013.06.022. Epub 2013 Jul 5. Review.

PMID:
23831838
29.

Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein.

Ahmadimoghaddam D, Staud F.

Reprod Toxicol. 2013 Aug;39:17-22. doi: 10.1016/j.reprotox.2013.03.001. Epub 2013 Apr 3.

PMID:
23562376
30.

Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages of gestation.

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovský M, Micuda S, Staud F.

Biol Reprod. 2013 Mar 7;88(3):55. doi: 10.1095/biolreprod.112.105064. Print 2013 Mar.

PMID:
23303678
31.

Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.

Cerveny L, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J.

Infect Immun. 2013 Mar;81(3):629-35. doi: 10.1128/IAI.01035-12. Epub 2012 Dec 21. Review.

32.

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.

Staud F, Cerveny L, Ceckova M.

J Drug Target. 2012 Nov;20(9):736-63. doi: 10.3109/1061186X.2012.716847. Epub 2012 Sep 20. Review.

PMID:
22994411
33.

Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F.

Toxicol Sci. 2012 Aug;128(2):471-81. doi: 10.1093/toxsci/kfs160. Epub 2012 Apr 26.

PMID:
22543277
34.

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F.

Pharmacol Res. 2012 Mar;65(3):312-9. doi: 10.1016/j.phrs.2011.11.017. Epub 2011 Dec 6.

PMID:
22173067
35.

Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy.

Hahnova-Cygalova L, Ceckova M, Staud F.

Drug Metab Rev. 2011 Feb;43(1):53-68. doi: 10.3109/03602532.2010.512293. Epub 2010 Sep 20. Review.

PMID:
20854129
36.

Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats.

Brcakova E, Fuksa L, Cermanova J, Kolouchova G, Hroch M, Hirsova P, Martinkova J, Staud F, Micuda S.

Biol Pharm Bull. 2009 Dec;32(12):1978-85.

37.

Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics.

Staud F, Ceckova M, Micuda S, Pavek P.

Methods Mol Biol. 2010;596:199-222. doi: 10.1007/978-1-60761-416-6_10.

PMID:
19949926
38.

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats.

Fuksa L, Brcakova E, Kolouchova G, Hirsova P, Hroch M, Cermanova J, Staud F, Micuda S.

Toxicology. 2010 Jan 12;267(1-3):165-71. doi: 10.1016/j.tox.2009.11.010. Epub 2009 Nov 14.

PMID:
19922765
39.

Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.

Cygalova LH, Hofman J, Ceckova M, Staud F.

J Pharmacol Exp Ther. 2009 Dec;331(3):1118-25. doi: 10.1124/jpet.109.160564. Epub 2009 Sep 24.

PMID:
19779128
40.

Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats.

Cermanova J, Fuksa L, Brcakova E, Hroch M, Kucera O, Kolouchova G, Hirsova P, Malakova J, Staud F, Martinkova J, Cervinkova Z, Micuda S.

Pharmacol Res. 2010 Feb;61(2):129-35. doi: 10.1016/j.phrs.2009.08.005. Epub 2009 Aug 22.

PMID:
19703566
41.

Variation of drug kinetics in pregnancy.

Pavek P, Ceckova M, Staud F.

Curr Drug Metab. 2009 Jun;10(5):520-9. Review.

PMID:
19689248
42.

Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta.

Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F.

Reprod Toxicol. 2009 Jul;28(1):46-51. doi: 10.1016/j.reprotox.2009.02.006. Epub 2009 Feb 24.

PMID:
19490994
43.

Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation.

Vagnerová K, Vacková Z, Klusonová P, Staud F, Kopecký M, Ergang P, Miksík I, Pácha J.

Reprod Sci. 2008 Nov;15(9):921-31. doi: 10.1177/1933719108319161.

PMID:
19050325
44.

Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta.

Sklenárová H, Pávek P, Satínský D, Solich P, Karlíček R, Staud F, Fendrich Z.

Talanta. 2002 Dec 6;58(6):1145-9.

PMID:
18968851
45.

Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F.

Toxicol In Vitro. 2008 Dec;22(8):1846-52. doi: 10.1016/j.tiv.2008.09.001. Epub 2008 Sep 9.

PMID:
18801423
46.

Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats.

Fuksa L, Brcakova E, Cermanova J, Hroch M, Chladek J, Kolouchova G, Malakova J, Martinkova J, Staud F, Micuda S.

Biopharm Drug Dispos. 2008 Jul;29(5):289-99. doi: 10.1002/bdd.614.

PMID:
18548509
47.

Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat.

Cygalova L, Ceckova M, Pavek P, Staud F.

Toxicol Lett. 2008 May 30;178(3):176-80. doi: 10.1016/j.toxlet.2008.03.007. Epub 2008 Mar 21.

PMID:
18450391
48.

P-glycoprotein function and expression during obstructive cholestasis in rats.

Micuda S, Brcakova E, Fuksa L, Cermanova J, Osterreicher J, Hroch M, Mokry J, Pejchal J, Martinkova J, Staud F.

Eur J Gastroenterol Hepatol. 2008 May;20(5):404-12. doi: 10.1097/MEG.0b013e3282f471bf.

PMID:
18403942
49.

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P.

Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12.

PMID:
17998298
50.

In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project.

Bremer S, Brittebo E, Dencker L, Knudsen LE, Mathisien L, Olovsson M, Pazos P, Pellizzer C, Paulesu LR, Schaefer W, Schwarz M, Staud F, Stavreus-Evers A, Vähänkangas K.

Altern Lab Anim. 2007 Aug;35(4):421-39. No abstract available.

PMID:
17850188

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