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Items: 1 to 50 of 59

1.

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.

PMID:
31744929
2.

The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis.

Fenech MA, Carter MM, Stathopulos PB, Pin CL.

Biochim Biophys Acta Mol Cell Res. 2020 Jan;1867(1):118567. doi: 10.1016/j.bbamcr.2019.118567. Epub 2019 Oct 30.

PMID:
31676354
3.

Coordination of a single calcium ion in the EF-hand maintains the off state of the stromal interaction molecule luminal domain.

Enomoto M, Nishikawa T, Back SI, Ishiyama N, Zheng L, Stathopulos PB, Ikura M.

J Mol Biol. 2019 Oct 15. pii: S0022-2836(19)30594-7. doi: 10.1016/j.jmb.2019.10.003. [Epub ahead of print]

PMID:
31626806
4.

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.

Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M.

ACS Cent Sci. 2019 Jan 23;5(1):153-166. doi: 10.1021/acscentsci.8b00773. Epub 2019 Jan 4.

5.

Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease.

Lin QT, Stathopulos PB.

Int J Mol Sci. 2019 Jan 12;20(2). pii: E286. doi: 10.3390/ijms20020286. Review.

6.

Does stromal interaction molecule-1 have five senses?

Stathopulos PB, Ikura M.

Cell Calcium. 2019 Jan;77:79-80. doi: 10.1016/j.ceca.2018.12.001. Epub 2018 Dec 3.

PMID:
30528613
7.

The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains.

Chung S, Zhang M, Stathopulos PB.

Int J Mol Sci. 2018 Oct 25;19(11). pii: E3316. doi: 10.3390/ijms19113316.

8.

Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels.

Thompson JL, Lai-Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ.

J Biol Chem. 2018 Jul 13;293(28):11241. doi: 10.1074/jbc.AAC118.004562. No abstract available.

9.

S-Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca2+ Entry.

Gui L, Zhu J, Lu X, Sims SM, Lu WY, Stathopulos PB, Feng Q.

J Mol Biol. 2018 Jun 8;430(12):1773-1785. doi: 10.1016/j.jmb.2018.04.028. Epub 2018 Apr 27.

PMID:
29705071
10.

Structural elements of stromal interaction molecule function.

Novello MJ, Zhu J, Feng Q, Ikura M, Stathopulos PB.

Cell Calcium. 2018 Jul;73:88-94. doi: 10.1016/j.ceca.2018.04.006. Epub 2018 Apr 18. Review.

PMID:
29698850
11.

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress.

Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M.

Cell Rep. 2018 Apr 24;23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098.

12.

A charge-sensing region in the stromal interaction molecule 1 luminal domain confers stabilization-mediated inhibition of SOCE in response to S-nitrosylation.

Zhu J, Lu X, Feng Q, Stathopulos PB.

J Biol Chem. 2018 Jun 8;293(23):8900-8911. doi: 10.1074/jbc.RA117.000503. Epub 2018 Apr 16.

13.

Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels.

Thompson JL, Lai-Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ.

J Biol Chem. 2018 Mar 2;293(9):3145-3155. doi: 10.1074/jbc.M117.819078. Epub 2018 Jan 11. Erratum in: J Biol Chem. 2018 Jul 13;293(28):11241.

14.

Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces.

Alevriadou BR, Shanmughapriya S, Patel A, Stathopulos PB, Madesh M.

J R Soc Interface. 2017 Dec;14(137). pii: 20170672. doi: 10.1098/rsif.2017.0672. Epub 2017 Dec 13. Review.

15.

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins.

Choi YJ, Zhu J, Chung S, Siddiqui N, Feng Q, Stathopulos PB.

J Vis Exp. 2017 Oct 4;(128). doi: 10.3791/56302.

16.

The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex.

Zhu J, Feng Q, Stathopulos PB.

Adv Exp Med Biol. 2017;993:15-38. doi: 10.1007/978-3-319-57732-6_2. Review.

PMID:
28900907
17.

Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.

Dong Z, Shanmughapriya S, Tomar D, Siddiqui N, Lynch S, Nemani N, Breves SL, Zhang X, Tripathi A, Palaniappan P, Riitano MF, Worth AM, Seelam A, Carvalho E, Subbiah R, Jaña F, Soboloff J, Peng Y, Cheung JY, Joseph SK, Caplan J, Rajan S, Stathopulos PB, Madesh M.

Mol Cell. 2017 Mar 16;65(6):1014-1028.e7. doi: 10.1016/j.molcel.2017.01.032. Epub 2017 Mar 2.

18.

From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation.

Enomoto M, Nishikawa T, Siddiqui N, Chung S, Ikura M, Stathopulos PB.

Adv Exp Med Biol. 2017;981:215-251. doi: 10.1007/978-3-319-55858-5_10. Review.

PMID:
29594864
19.

Store operated calcium entry: From concept to structural mechanisms.

Stathopulos PB, Ikura M.

Cell Calcium. 2017 May;63:3-7. doi: 10.1016/j.ceca.2016.11.005. Epub 2016 Nov 25. Review.

PMID:
27914753
20.

Structural perturbations induced by Asn131 and Asn171 glycosylation converge within the EFSAM core and enhance stromal interaction molecule-1 mediated store operated calcium entry.

Choi YJ, Zhao Y, Bhattacharya M, Stathopulos PB.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1054-1063. doi: 10.1016/j.bbamcr.2016.11.015. Epub 2016 Nov 17.

21.

Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.

Lee SK, Shanmughapriya S, Mok MCY, Dong Z, Tomar D, Carvalho E, Rajan S, Junop MS, Madesh M, Stathopulos PB.

Cell Chem Biol. 2016 Sep 22;23(9):1157-1169. doi: 10.1016/j.chembiol.2016.07.012. Epub 2016 Aug 25.

22.

Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells.

Fenech MA, Sullivan CM, Ferreira LT, Mehmood R, MacDonald WA, Stathopulos PB, Pin CL.

J Cell Physiol. 2016 Dec;231(12):2768-78. doi: 10.1002/jcp.25391. Epub 2016 Apr 21.

PMID:
27017909
23.

Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.

24.

Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum.

Marshall CB, Nishikawa T, Osawa M, Stathopulos PB, Ikura M.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):5-21. doi: 10.1016/j.bbrc.2015.01.106. Review.

PMID:
25998729
25.

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari MT, Marshall CB, Smith MJ, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6625-30. doi: 10.1073/pnas.1419895112. Epub 2015 May 4.

26.

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.

27.

Structural insights into endoplasmic reticulum stored calcium regulation by inositol 1,4,5-trisphosphate and ryanodine receptors.

Seo MD, Enomoto M, Ishiyama N, Stathopulos PB, Ikura M.

Biochim Biophys Acta. 2015 Sep;1853(9):1980-91. doi: 10.1016/j.bbamcr.2014.11.023. Epub 2014 Nov 25. Review.

28.

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M.

Nat Commun. 2013;4:2963. doi: 10.1038/ncomms3963.

29.

Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

Fedorenko OA, Popugaeva E, Enomoto M, Stathopulos PB, Ikura M, Bezprozvanny I.

Eur J Pharmacol. 2014 Sep 15;739:39-48. doi: 10.1016/j.ejphar.2013.10.074. Epub 2013 Dec 1. Review.

30.

Structural aspects of calcium-release activated calcium channel function.

Stathopulos PB, Ikura M.

Channels (Austin). 2013 Sep-Oct;7(5):344-53. doi: 10.4161/chan.26734. Epub 2013 Nov 8. Review.

31.

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

Amador FJ, Kimlicka L, Stathopulos PB, Gasmi-Seabrook GM, Maclennan DH, Van Petegem F, Ikura M.

J Mol Biol. 2013 Nov 1;425(21):4034-46. doi: 10.1016/j.jmb.2013.08.015. Epub 2013 Aug 23.

PMID:
23978697
32.

Structure and function of endoplasmic reticulum STIM calcium sensors.

Stathopulos PB, Ikura M.

Curr Top Membr. 2013;71:59-93. doi: 10.1016/B978-0-12-407870-3.00003-2.

PMID:
23890111
33.

Initial activation of STIM1, the regulator of store-operated calcium entry.

Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Gudlur A, Stathopulos PB, Ikura M, Rao A, Hogan PG.

Nat Struct Mol Biol. 2013 Aug;20(8):973-81. doi: 10.1038/nsmb.2625. Epub 2013 Jul 14.

34.

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8507-12. doi: 10.1073/pnas.1220847110. Epub 2013 May 6.

35.

Ryanodine receptor calcium release channels: lessons from structure-function studies.

Amador FJ, Stathopulos PB, Enomoto M, Ikura M.

FEBS J. 2013 Nov;280(21):5456-70. doi: 10.1111/febs.12194. Epub 2013 Mar 18. Review.

36.

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

Mazhab-Jafari MT, Marshall CB, Stathopulos PB, Kobashigawa Y, Stambolic V, Kay LE, Inagaki F, Ikura M.

J Am Chem Soc. 2013 Mar 6;135(9):3367-70. doi: 10.1021/ja312508w. Epub 2013 Feb 20.

PMID:
23409921
37.

Energetics of oligomeric protein folding and association.

Doyle CM, Rumfeldt JA, Broom HR, Broom A, Stathopulos PB, Vassall KA, Almey JJ, Meiering EM.

Arch Biochem Biophys. 2013 Mar;531(1-2):44-64. doi: 10.1016/j.abb.2012.12.005. Epub 2012 Dec 13. Review.

PMID:
23246784
38.

Themes and variations in ER/SR calcium release channels: structure and function.

Stathopulos PB, Seo MD, Enomoto M, Amador FJ, Ishiyama N, Ikura M.

Physiology (Bethesda). 2012 Dec;27(6):331-42. doi: 10.1152/physiol.00013.2012. Review.

39.

Structural and functional conservation of key domains in InsP3 and ryanodine receptors.

Seo MD, Velamakanni S, Ishiyama N, Stathopulos PB, Rossi AM, Khan SA, Dale P, Li C, Ames JB, Ikura M, Taylor CW.

Nature. 2012 Jan 29;483(7387):108-12. doi: 10.1038/nature10751.

40.

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.

Zheng L, Stathopulos PB, Schindl R, Li GY, Romanin C, Ikura M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1337-42. doi: 10.1073/pnas.1015125108. Epub 2011 Jan 7.

41.

Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis.

Hwang YM, Stathopulos PB, Dimmick K, Yang H, Badiei HR, Tong MS, Rumfeldt JA, Chen P, Karanassios V, Meiering EM.

J Biol Chem. 2010 Dec 31;285(53):41701-11. doi: 10.1074/jbc.M110.113696. Epub 2010 Oct 25.

42.

Secretion of human superoxide dismutase in Escherichia coli using the condensed single-protein-production system.

Mao L, Stathopulos PB, Ikura M, Inouye M.

Protein Sci. 2010 Dec;19(12):2330-5. doi: 10.1002/pro.512.

43.

Partial unfolding and oligomerization of stromal interaction molecules as an initiation mechanism of store operated calcium entry.

Stathopulos PB, Ikura M.

Biochem Cell Biol. 2010 Apr;88(2):175-83. doi: 10.1139/o09-125. Review.

PMID:
20453920
44.

Structurally delineating stromal interaction molecules as the endoplasmic reticulum calcium sensors and regulators of calcium release-activated calcium entry.

Stathopulos PB, Ikura M.

Immunol Rev. 2009 Sep;231(1):113-31. doi: 10.1111/j.1600-065X.2009.00814.x. Review.

PMID:
19754893
45.

Folding and association of thermophilic dimeric and trimeric DsrEFH proteins: Tm0979 and Mth1491.

Galvagnion C, Smith MT, Broom A, Vassall KA, Meglei G, Gaspar JA, Stathopulos PB, Cheyne B, Meiering EM.

Biochemistry. 2009 Apr 7;48(13):2891-906. doi: 10.1021/bi801784d.

PMID:
19290646
46.

Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics.

Stathopulos PB, Zheng L, Ikura M.

J Biol Chem. 2009 Jan 9;284(2):728-32. doi: 10.1074/jbc.C800178200. Epub 2008 Nov 19.

47.

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.

Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M.

Cell. 2008 Oct 3;135(1):110-22. doi: 10.1016/j.cell.2008.08.006.

48.

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2.

Zheng L, Stathopulos PB, Li GY, Ikura M.

Biochem Biophys Res Commun. 2008 Apr 25;369(1):240-6. doi: 10.1016/j.bbrc.2007.12.129. Epub 2007 Dec 31.

PMID:
18166150
49.

Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry.

Stathopulos PB, Li GY, Plevin MJ, Ames JB, Ikura M.

J Biol Chem. 2006 Nov 24;281(47):35855-62. Epub 2006 Oct 3.

50.

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases.

Vassall KA, Stathopulos PB, Rumfeldt JA, Lepock JR, Meiering EM.

Biochemistry. 2006 Jun 13;45(23):7366-79.

PMID:
16752926

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