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Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals.

Young JL, Yan X, Xu J, Yin X, Zhang X, Arteel GE, Barnes GN, States JC, Watson WH, Kong M, Cai L, Freedman JH.

Sci Rep. 2019 Oct 11;9(1):14675. doi: 10.1038/s41598-019-50771-3.


Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.

Baldauf KJ, Salazar-González RA, Doll MA, Pierce WM Jr, States JC, Hein DW.

Environ Mol Mutagen. 2019 Sep 6. doi: 10.1002/em.22331. [Epub ahead of print]


Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes.

Wu J, Ferragut Cardoso AP, States VAR, Al-Eryani L, Doll M, Wise SS, Rai SN, States JC.

Toxicol Appl Pharmacol. 2019 Sep 1;378:114614. doi: 10.1016/j.taap.2019.114614. Epub 2019 Jun 6.


miRNA expression profiles of premalignant and malignant arsenic-induced skin lesions.

Al-Eryani L, Jenkins SF, States VA, Pan J, Malone JC, Rai SN, Galandiuk S, Giri AK, States JC.

PLoS One. 2018 Aug 16;13(8):e0202579. doi: 10.1371/journal.pone.0202579. eCollection 2018.


Impact of prenatal arsenic exposure on chronic adult diseases.

Young JL, Cai L, States JC.

Syst Biol Reprod Med. 2018 Dec;64(6):469-483. doi: 10.1080/19396368.2018.1480076. Epub 2018 Jun 6. Review.


Arsenic-Induced Carcinogenesis: The Impact of miRNA Dysregulation.

Cardoso APF, Al-Eryani L, States JC.

Toxicol Sci. 2018 Oct 1;165(2):284-290. doi: 10.1093/toxsci/kfy128. Review.


Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis.

Siefring ML, Lu D, States JC, Van Hoang M.

BMJ Case Rep. 2018 Mar 30;2018. pii: bcr-2017-222645. doi: 10.1136/bcr-2017-222645.


Differentially Expressed mRNA Targets of Differentially Expressed miRNAs Predict Changes in the TP53 Axis and Carcinogenesis-Related Pathways in Human Keratinocytes Chronically Exposed to Arsenic.

Al-Eryani L, Waigel S, Tyagi A, Peremarti J, Jenkins SF, Damodaran C, States JC.

Toxicol Sci. 2018 Apr 1;162(2):645-654. doi: 10.1093/toxsci/kfx292.


Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231.

Stepp MW, Doll MA, Carlisle SM, States JC, Hein DW.

Mol Carcinog. 2018 Apr;57(4):549-558. doi: 10.1002/mc.22779. Epub 2018 Feb 3.


Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite.

Al-Eryani L, Waigel S, Jala V, Jenkins SF, States JC.

Toxicol Appl Pharmacol. 2017 Sep 15;331:130-134. doi: 10.1016/j.taap.2017.06.002. Epub 2017 Jun 14.


Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.

Stepp MW, Doll MA, Samuelson DJ, Sanders MA, States JC, Hein DW.

BMC Cancer. 2017 Mar 31;17(1):233. doi: 10.1186/s12885-017-3221-9.


Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1.

Carlisle SM, Trainor PJ, Yin X, Doll MA, Stepp MW, States JC, Zhang X, Hein DW.

Metabolomics. 2016 Jul;12(7). pii: 111. Epub 2016 Jun 21.


Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.

Wahlang B, Prough RA, Falkner KC, Hardesty JE, Song M, Clair HB, Clark BJ, States JC, Arteel GE, Cave MC.

Toxicol Sci. 2016 Feb;149(2):396-410. doi: 10.1093/toxsci/kfv250. Epub 2015 Nov 25.


Arsenic Disruption of DNA Damage Responses-Potential Role in Carcinogenesis and Chemotherapy.

Muenyi CS, Ljungman M, States JC.

Biomolecules. 2015 Sep 24;5(4):2184-93. doi: 10.3390/biom5042184. Review.


Folate-Dependent Hydrolysis of Acetyl-Coenzyme A by Recombinant Human and Rodent Arylamine N-Acetyltransferases.

Stepp MW, Mamaliga G, Doll MA, States JC, Hein DW.

Biochem Biophys Rep. 2015 Sep;3:45-50.


Disruption of Mitotic Progression by Arsenic.

States JC.

Biol Trace Elem Res. 2015 Jul;166(1):34-40. doi: 10.1007/s12011-015-0306-7. Epub 2015 Mar 22. Review.


Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.

Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC.

Toxicol Sci. 2014 Aug 1;140(2):283-97. doi: 10.1093/toxsci/kfu083. Epub 2014 May 8.


Systems approach to identify environmental exposures contributing to organ-specific carcinogenesis.

States JC, Ouyang M, Helm CW.

Cancer Epidemiol. 2014 Jun;38(3):321-7. doi: 10.1016/j.canep.2014.03.005. Epub 2014 Apr 12.


Cisplatin plus sodium arsenite and hyperthermia induces pseudo-G1 associated apoptotic cell death in ovarian cancer cells.

Muenyi CS, Trivedi AP, Helm CW, States JC.

Toxicol Sci. 2014 May;139(1):74-82. doi: 10.1093/toxsci/kfu029. Epub 2014 Feb 11.


Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure.

Ngalame NN, Micciche AF, Feil ME, States JC.

Toxicol Sci. 2013 Jan;131(1):225-33. doi: 10.1093/toxsci/kfs264. Epub 2012 Sep 5.


Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India.

Das N, Paul S, Chatterjee D, Banerjee N, Majumder NS, Sarma N, Sau TJ, Basu S, Banerjee S, Majumder P, Bandyopadhyay AK, States JC, Giri AK.

BMC Public Health. 2012 Aug 10;12:639. doi: 10.1186/1471-2458-12-639.


Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis.

States JC, Singh AV, Knudsen TB, Rouchka EC, Ngalame NO, Arteel GE, Piao Y, Ko MS.

PLoS One. 2012;7(6):e38713. doi: 10.1371/journal.pone.0038713. Epub 2012 Jun 15.


Predicting later-life outcomes of early-life exposures.

Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM.

Environ Health Perspect. 2012 Oct;120(10):1353-61. doi: 10.1289/ehp.1204934. Epub 2012 Jun 6. Review.


Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses.

Muenyi CS, Pinhas AR, Fan TW, Brock GN, Helm CW, States JC.

Toxicol Sci. 2012 May;127(1):139-49. doi: 10.1093/toxsci/kfs085. Epub 2012 Feb 13.


Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

Millner LM, Doll MA, Stepp MW, States JC, Hein DW.

Carcinogenesis. 2012 Feb;33(2):348-55. doi: 10.1093/carcin/bgr273. Epub 2011 Nov 22. Erratum in: Carcinogenesis. 2012 Jul;33(7):1431.


Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Drug Metab Dispos. 2012 Jan;40(1):198-204. doi: 10.1124/dmd.111.041855. Epub 2011 Oct 18.


Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice.

Tan M, Schmidt RH, Beier JI, Watson WH, Zhong H, States JC, Arteel GE.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):356-64. doi: 10.1016/j.taap.2011.09.019. Epub 2011 Sep 29.


NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Mol Carcinog. 2012 Aug;51(8):636-46. doi: 10.1002/mc.20836. Epub 2011 Aug 11.


Arsenic toxicology: translating between experimental models and human pathology.

States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC.

Environ Health Perspect. 2011 Oct;119(10):1356-63. doi: 10.1289/ehp.1103441. Epub 2011 Jun 17. Review.


Polymorphisms in the TNF-α and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects.

Banerjee N, Nandy S, Kearns JK, Bandyopadhyay AK, Das JK, Majumder P, Basu S, Banerjee S, Sau TJ, States JC, Giri AK.

Toxicol Sci. 2011 May;121(1):132-9. doi: 10.1093/toxsci/kfr046. Epub 2011 Feb 25.


Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.

Zhu Y, States JC, Wang Y, Hein DW.

Birth Defects Res A Clin Mol Teratol. 2011 Feb;91(2):77-84. doi: 10.1002/bdra.20763. Epub 2011 Feb 2.


Precancerous and non-cancer disease endpoints of chronic arsenic exposure: the level of chromosomal damage and XRCC3 T241M polymorphism.

Kundu M, Ghosh P, Mitra S, Das JK, Sau TJ, Banerjee S, States JC, Giri AK.

Mutat Res. 2011 Jan 10;706(1-2):7-12. doi: 10.1016/j.mrfmmm.2010.10.004. Epub 2010 Oct 28.


Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.

Banerjee M, Banerjee N, Ghosh P, Das JK, Basu S, Sarkar AK, States JC, Giri AK.

Toxicol Appl Pharmacol. 2010 Nov 15;249(1):47-54. doi: 10.1016/j.taap.2010.08.013. Epub 2010 Aug 20.


PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division.

von Montfort C, Beier JI, Kaiser JP, Guo L, Joshi-Barve S, Pritchard MT, States JC, Arteel GE.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G657-66. doi: 10.1152/ajpgi.00107.2009. Epub 2010 Mar 4.


Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM Jr, Hein DW.

Mutat Res. 2010 Feb 3;684(1-2):66-73. doi: 10.1016/j.mrfmmm.2009.12.001. Epub 2009 Dec 11.


Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.

Salazar AM, Miller HL, McNeely SC, Sordo M, Ostrosky-Wegman P, States JC.

Chem Res Toxicol. 2010 Feb 15;23(2):357-64. doi: 10.1021/tx900353v.


No association between variant DNA repair genes and prostate cancer risk among men of African descent.

Lavender NA, Komolafe OO, Benford M, Brock G, Moore JH, Vancleave TT, States JC, Kittles RA, Kidd LC.

Prostate. 2010 Feb 1;70(2):113-9. doi: 10.1002/pros.21048.


Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice.

Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC.

Toxicol Appl Pharmacol. 2009 Nov 15;241(1):90-100. doi: 10.1016/j.taap.2009.08.004. Epub 2009 Aug 12.


Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts.

Bendaly J, Metry KJ, Doll MA, Jiang G, States JC, Smith NB, Neale JR, Holloman JL, Pierce WM, Hein DW.

Xenobiotica. 2009 May;39(5):399-406. doi: 10.1080/00498250902748953.


Enhancing the efficacy of cisplatin in ovarian cancer treatment - could arsenic have a role.

Helm CW, States JC.

J Ovarian Res. 2009 Jan 14;2:2. doi: 10.1186/1757-2215-2-2.


Arsenic and cardiovascular disease.

States JC, Srivastava S, Chen Y, Barchowsky A.

Toxicol Sci. 2009 Feb;107(2):312-23. doi: 10.1093/toxsci/kfn236. Epub 2008 Nov 17. Review.


Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.

Barker DF, Walraven JM, Ristagno EH, Doll MA, States JC, Hein DW.

Drug Metab Dispos. 2008 Dec;36(12):2445-51. doi: 10.1124/dmd.108.023564. Epub 2008 Sep 17.


Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent.

McNeely SC, Taylor BF, States JC.

Toxicol Appl Pharmacol. 2008 Aug 15;231(1):61-7. doi: 10.1016/j.taap.2008.03.020. Epub 2008 Apr 9.


Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization.

Taylor BF, McNeely SC, Miller HL, States JC.

Toxicol Appl Pharmacol. 2008 Jul 15;230(2):235-46. doi: 10.1016/j.taap.2008.02.030. Epub 2008 Mar 14.


Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest.

McNeely SC, Belshoff AC, Taylor BF, Fan TW, McCabe MJ Jr, Pinhas AR, States JC.

Toxicol Appl Pharmacol. 2008 Jun 1;229(2):252-61. doi: 10.1016/j.taap.2008.01.020. Epub 2008 Feb 5.


Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice.

Arteel GE, Guo L, Schlierf T, Beier JI, Kaiser JP, Chen TS, Liu M, Conklin DJ, Miller HL, von Montfort C, States JC.

Toxicol Appl Pharmacol. 2008 Jan 15;226(2):128-39. Epub 2007 Aug 31.


Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.

Husain A, Zhang X, Doll MA, States JC, Barker DF, Hein DW.

Drug Metab Dispos. 2007 Sep;35(9):1649-56. Epub 2007 Jun 25.

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