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Items: 37


Conduction through a narrow inward-rectifier K+ channel pore.

Bernsteiner H, Zangerl-Plessl EM, Chen X, Stary-Weinzinger A.

J Gen Physiol. 2019 Sep 11. pii: jgp.201912359. doi: 10.1085/jgp.201912359. [Epub ahead of print]


LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.

Br J Pharmacol. 2019 Jul 24. doi: 10.1111/bph.14798. [Epub ahead of print]


A structural model of the human serotonin transporter in an outward-occluded state.

Hellsberg E, Ecker GF, Stary-Weinzinger A, Forrest LR.

PLoS One. 2019 Jun 28;14(6):e0217377. doi: 10.1371/journal.pone.0217377. eCollection 2019.


Computational Identification of Novel Kir6 Channel Inhibitors.

Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM, Langer T, van der Heyden MAG, Stary-Weinzinger A.

Front Pharmacol. 2019 May 24;10:549. doi: 10.3389/fphar.2019.00549. eCollection 2019.


Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.

Houtman MJC, Chen X, Qile M, Duran K, van Haaften G, Stary-Weinzinger A, van der Heyden MAG.

J Cell Mol Med. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329. Epub 2019 May 22.


Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go channel superfamily member Kv 12.1.

Dierich M, van Ham WB, Stary-Weinzinger A, Leitner MG.

Br J Pharmacol. 2019 Aug;176(15):2708-2723. doi: 10.1111/bph.14693. Epub 2019 Jun 17.


Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.

Cell Physiol Biochem. 2018;45(6):2233-2245. doi: 10.1159/000488169. Epub 2018 Mar 10.


Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.

Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S.

Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15.


Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.


Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG.

J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.


PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.

Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K, van Haaften G, Zangerl-Plessl EM, Takanari H, Stary-Weinzinger A, van der Heyden MAG.

J Biomed Sci. 2017 Jul 15;24(1):44. doi: 10.1186/s12929-017-0352-x.


Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2017 Oct;92(4):437-450. doi: 10.1124/mol.117.108886. Epub 2017 Jul 13.


Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations.

Bernsteiner H, Bründl M, Stary-Weinzinger A.

Biochem Biophys Res Commun. 2017 Feb 26;484(1):107-112. doi: 10.1016/j.bbrc.2017.01.064. Epub 2017 Jan 19.


Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.

Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG.

J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15.


New potential binding determinant for hERG channel inhibitors.

Saxena P, Zangerl-Plessl EM, Linder T, Windisch A, Hohaus A, Timin E, Hering S, Stary-Weinzinger A.

Sci Rep. 2016 Apr 12;6:24182. doi: 10.1038/srep24182.


Drug trapping in hERG K+ channels: (not) a matter of drug size?

Linder T, Bernsteiner H, Saxena P, Bauer F, Erker T, Timin E, Hering S, Stary-Weinzinger A.

Medchemcomm. 2016 Mar 1;7(3):512-518. doi: 10.1039/c5md00443h. Epub 2015 Dec 22.


Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.

Linder T, Wang S, Zangerl-Plessl EM, Nichols CG, Stary-Weinzinger A.

J Chem Inf Model. 2015 Apr 27;55(4):814-22. doi: 10.1021/acs.jcim.5b00010. Epub 2015 Apr 3.


Structural insights into trapping and dissociation of small molecules in K⁺ channels.

Linder T, Saxena P, Timin E, Hering S, Stary-Weinzinger A.

J Chem Inf Model. 2014 Nov 24;54(11):3218-28. doi: 10.1021/ci500353r. Epub 2014 Oct 21.


Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

Houtman MJ, Korte SM, Ji Y, Kok B, Vos MA, Stary-Weinzinger A, van der Heyden MA.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):992-7. doi: 10.1016/j.bbrc.2014.09.031. Epub 2014 Sep 16.


Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations.

Ke S, Timin EN, Stary-Weinzinger A.

PLoS Comput Biol. 2014 Jul 31;10(7):e1003746. doi: 10.1371/journal.pcbi.1003746. eCollection 2014 Jul.


Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.

Lukacs P, Gawali VS, Cervenka R, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Stary-Weinzinger A, Todt H.

J Biol Chem. 2014 Aug 1;289(31):21770-81. doi: 10.1074/jbc.M113.541763. Epub 2014 Jun 19.


Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.

Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J, Hilber K, Boehm S, Sandtner W, Koenig X.

J Pharmacol Exp Ther. 2014 Feb;348(2):346-58. doi: 10.1124/jpet.113.209643. Epub 2013 Dec 4.


Probing the energy landscape of activation gating of the bacterial potassium channel KcsA.

Linder T, de Groot BL, Stary-Weinzinger A.

PLoS Comput Biol. 2013;9(5):e1003058. doi: 10.1371/journal.pcbi.1003058. Epub 2013 May 2.


Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

Takanari H, Nalos L, Stary-Weinzinger A, de Git KC, Varkevisser R, Linder T, Houtman MJ, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MA.

Cardiovasc Res. 2013 Jul 1;99(1):203-14. doi: 10.1093/cvr/cvt103. Epub 2013 Apr 25.


Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.

Varkevisser R, Houtman MJ, Linder T, de Git KC, Beekman HD, Tidwell RR, Ijzerman AP, Stary-Weinzinger A, Vos MA, van der Heyden MA.

Br J Pharmacol. 2013 Jul;169(6):1322-34. doi: 10.1111/bph.12208.


Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

van der Heyden MA, Stary-Weinzinger A, Sanchez-Chapula JA.

Curr Mol Med. 2013 Sep;13(8):1284-98. Review.


ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.

Garg V, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2013 Apr;83(4):805-13. doi: 10.1124/mol.112.084384. Epub 2013 Jan 14.


Distinct interactions of Na+ and Ca2+ ions with the selectivity filter of the bacterial sodium channel Na(V)Ab.

Ke S, Zangerl EM, Stary-Weinzinger A.

Biochem Biophys Res Commun. 2013 Jan 25;430(4):1272-6. doi: 10.1016/j.bbrc.2012.12.055. Epub 2012 Dec 19.


Surprises from an unusual CLC homolog.

Phillips S, Brammer AE, Rodriguez L, Lim HH, Stary-Weinzinger A, Matulef K.

Biophys J. 2012 Nov 7;103(9):L44-6. doi: 10.1016/j.bpj.2012.08.063.


Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model.

Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Linder T, Timin E, Hering S.

Pflugers Arch. 2012 Oct;464(4):391-401. Epub 2012 Sep 2.


Grayanotoxin poisoning: 'mad honey disease' and beyond.

Jansen SA, Kleerekooper I, Hofman ZL, Kappen IF, Stary-Weinzinger A, van der Heyden MA.

Cardiovasc Toxicol. 2012 Sep;12(3):208-15. doi: 10.1007/s12012-012-9162-2. Review.


In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel.

Knape K, Linder T, Wolschann P, Beyer A, Stary-Weinzinger A.

PLoS One. 2011;6(12):e28778. doi: 10.1371/journal.pone.0028778. Epub 2011 Dec 15.


Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC.

Mol Pharmacol. 2011 Oct;80(4):630-7. doi: 10.1124/mol.111.073809. Epub 2011 Jul 8.


Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.

Depil K, Beyl S, Stary-Weinzinger A, Hohaus A, Timin E, Hering S.

J Biol Chem. 2011 Sep 9;286(36):31557-64. doi: 10.1074/jbc.M111.255273. Epub 2011 Jun 17.


Computer simulations of structure-activity relationships for HERG channel blockers.

Boukharta L, Keränen H, Stary-Weinzinger A, Wallin G, de Groot BL, Aqvist J.

Biochemistry. 2011 Jul 12;50(27):6146-56. doi: 10.1021/bi200173n. Epub 2011 Jun 16.


Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysis.

Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Timin E, Shabbir W, Kudrnac M, Hering S.

Pflugers Arch. 2011 Jan;461(1):53-63. doi: 10.1007/s00424-010-0885-2. Epub 2010 Oct 7.


Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating.

Karmazinova M, Beyl S, Stary-Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S, Lacinova L.

Pflugers Arch. 2010 Nov;460(6):1015-28. doi: 10.1007/s00424-010-0874-5. Epub 2010 Sep 9.


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