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Items: 41

1.

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy.

Pomeroy EJ, Hunzeker JT, Kluesner MG, Lahr WS, Smeester BA, Crosby MR, Lonetree CL, Yamamoto K, Bendzick L, Miller JS, Geller MA, Walcheck B, Felices M, Webber BR, Starr TK, Moriarity BS.

Mol Ther. 2019 Oct 15. pii: S1525-0016(19)30463-0. doi: 10.1016/j.ymthe.2019.10.009. [Epub ahead of print]

PMID:
31704085
2.

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner.

Conboy CB, VĂ©lez-Reyes GL, Tschida BR, Hu H, Kaufmann G, Koes N, Keller B, Alsinet C, CornellĂ  H, Pinyol R, Abrahante JE, Temiz NA, Linden MA, Amin K, Kuka TP, Keng VW, Llovet JM, Starr TK, Largaespada DA.

Hepatol Commun. 2019 Sep 3;3(11):1496-1509. doi: 10.1002/hep4.1422. eCollection 2019 Nov.

3.

De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironments.

Woo J, Winterhoff BJ, Starr TK, Aliferis C, Wang J.

Life Sci Alliance. 2019 Jul 2;2(4). pii: e201900443. doi: 10.26508/lsa.201900443. Print 2019 Aug.

4.

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells.

Desir S, Wong P, Turbyville T, Chen, Shetty M, Clark C, Zhai E, Romin Y, Manova-Todorova K, Starr TK, Nissley DV, Steer CJ, Subramanian S, Lou E.

Cancers (Basel). 2019 Jun 26;11(7). pii: E892. doi: 10.3390/cancers11070892.

5.

Biological Insights into Chemotherapy Resistance in Ovarian Cancer.

Glasgow MA, Argenta P, Abrahante JE, Shetty M, Talukdar S, Croonquist PA, Khalifa MA, Starr TK.

Int J Mol Sci. 2019 Apr 30;20(9). pii: E2131. doi: 10.3390/ijms20092131.

6.

Meta-analytic framework for modeling genetic coexpression dynamics.

Kinzy TG, Starr TK, Tseng GC, Ho YY.

Stat Appl Genet Mol Biol. 2019 Feb 9;18(1). pii: /j/sagmb.2019.18.issue-1/sagmb-2017-0052/sagmb-2017-0052.xml. doi: 10.1515/sagmb-2017-0052.

PMID:
30735484
7.

Simultaneous Measurement of 92 Serum Protein Biomarkers for the Development of a Multiprotein Classifier for Ovarian Cancer Detection.

Skubitz APN, Boylan KLM, Geschwind K, Cao Q, Starr TK, Geller MA, Celestino J, Bast RC Jr, Lu KH, Koopmeiners JS.

Cancer Prev Res (Phila). 2019 Mar;12(3):171-184. doi: 10.1158/1940-6207.CAPR-18-0221. Epub 2019 Feb 1.

PMID:
30709840
8.

Cancer Gene Discovery: Past to Present.

Clark CR, DuRose W, Starr TK.

Methods Mol Biol. 2019;1907:1-15. doi: 10.1007/978-1-4939-8967-6_1.

PMID:
30542987
9.

Single-cell sequencing in ovarian cancer: a new frontier in precision medicine.

Winterhoff B, Talukdar S, Chang Z, Wang J, Starr TK.

Curr Opin Obstet Gynecol. 2019 Feb;31(1):49-55. doi: 10.1097/GCO.0000000000000516.

PMID:
30507625
10.

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.

Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.

Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.

PMID:
30355676
11.

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene.

Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, Abrahante JE, Starr TK.

Sci Rep. 2018 Oct 17;8(1):15327. doi: 10.1038/s41598-018-33527-3.

12.

Corrigendum to "Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells" [Gyncol. Oncol. 144 (2017) 598-606].

Winterhoff BJ, Maile M, Mitra AK, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK.

Gynecol Oncol. 2018 Oct;151(1):182-186. doi: 10.1016/j.ygyno.2018.07.015. Epub 2018 Aug 7. No abstract available.

13.

Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment.

Burns MB, Montassier E, Abrahante J, Priya S, Niccum DE, Khoruts A, Starr TK, Knights D, Blekhman R.

PLoS Genet. 2018 Jun 20;14(6):e1007376. doi: 10.1371/journal.pgen.1007376. eCollection 2018 Jun.

14.

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.

Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinsky AK.

Nucleic Acids Res. 2018 Jun 20;46(11):5634-5650. doi: 10.1093/nar/gky313.

15.

A multiplex platform for the identification of ovarian cancer biomarkers.

Boylan KLM, Geschwind K, Koopmeiners JS, Geller MA, Starr TK, Skubitz APN.

Clin Proteomics. 2017 Oct 10;14:34. doi: 10.1186/s12014-017-9169-6. eCollection 2017.

16.

Tumor location impacts immune response in mouse models of colon cancer.

Zhao X, Li L, Starr TK, Subramanian S.

Oncotarget. 2017 Jun 9;8(33):54775-54787. doi: 10.18632/oncotarget.18423. eCollection 2017 Aug 15.

17.

CFTR is a tumor suppressor gene in murine and human intestinal cancer.

Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, Van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT.

Oncogene. 2017 Jun 15;36(24):3504. doi: 10.1038/onc.2017.3. Epub 2017 Feb 13.

PMID:
28192405
18.

Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells.

Winterhoff BJ, Maile M, Mitra AK, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK.

Gynecol Oncol. 2017 Mar;144(3):598-606. doi: 10.1016/j.ygyno.2017.01.015. Epub 2017 Jan 19. Erratum in: Gynecol Oncol. 2018 Oct;151(1):182-186.

19.

Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.

Morris SM, Davison J, Carter KT, O'Leary RM, Trobridge P, Knoblaugh SE, Myeroff LL, Markowitz SD, Brett BT, Scheetz TE, Dupuy AJ, Starr TK, Grady WM.

Int J Cancer. 2017 Feb 15;140(4):853-863. doi: 10.1002/ijc.30491. Epub 2016 Nov 7.

20.

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.

Ho YY, Starr TK, LaRue RS, Largaespada DA.

BMC Med Genomics. 2016 Apr 1;9:16. doi: 10.1186/s12920-016-0176-7.

21.

Mouse models for the discovery of colorectal cancer driver genes.

Clark CR, Starr TK.

World J Gastroenterol. 2016 Jan 14;22(2):815-22. doi: 10.3748/wjg.v22.i2.815. Review.

22.

CFTR is a tumor suppressor gene in murine and human intestinal cancer.

Than BL, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJ, Meijer GA, Van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT.

Oncogene. 2016 Aug 11;35(32):4179-87. doi: 10.1038/onc.2015.483. Epub 2016 Jan 11. Erratum in: Oncogene. 2017 Jun 15;36(24):3504.

23.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.

Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.

24.

Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment.

Burns MB, Lynch J, Starr TK, Knights D, Blekhman R.

Genome Med. 2015 Jun 24;7(1):55. doi: 10.1186/s13073-015-0177-8. eCollection 2015.

25.

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK.

Mol Cancer Res. 2015 Aug;13(8):1238-47. doi: 10.1158/1541-7786.MCR-14-0674-T. Epub 2015 May 20.

26.

The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice.

Abbott KL, Nyre ET, Abrahante J, Ho YY, Isaksson Vogel R, Starr TK.

Nucleic Acids Res. 2015 Jan;43(Database issue):D844-8. doi: 10.1093/nar/gku770. Epub 2014 Sep 4.

27.

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.

Been RA, Linden MA, Hager CJ, DeCoursin KJ, Abrahante JE, Landman SR, Steinbach M, Sarver AL, Largaespada DA, Starr TK.

PLoS One. 2014 May 14;9(5):e97280. doi: 10.1371/journal.pone.0097280. eCollection 2014.

28.

The role of KCNQ1 in mouse and human gastrointestinal cancers.

Than BL, Goos JA, Sarver AL, O'Sullivan MG, Rod A, Starr TK, Fijneman RJ, Meijer GA, Zhao L, Zhang Y, Largaespada DA, Scott PM, Cormier RT.

Oncogene. 2014 Jul 17;33(29):3861-8. doi: 10.1038/onc.2013.350. Epub 2013 Aug 26.

29.

Identification of Sleeping Beauty transposon insertions in solid tumors using linker-mediated PCR.

Janik CL, Starr TK.

J Vis Exp. 2013 Feb 1;(72):e50156. doi: 10.3791/50156.

30.

Recurrent R-spondin fusions in colon cancer.

Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ.

Nature. 2012 Aug 30;488(7413):660-4. doi: 10.1038/nature11282.

31.

New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens.

Bergemann TL, Starr TK, Yu H, Steinbach M, Erdmann J, Chen Y, Cormier RT, Largaespada DA, Silverstein KA.

Nucleic Acids Res. 2012 May;40(9):3822-33. doi: 10.1093/nar/gkr1295. Epub 2012 Jan 12.

32.

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.

Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5765-70. doi: 10.1073/pnas.1018012108. Epub 2011 Mar 21.

33.

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG.

Cancer Res. 2009 Oct 15;69(20):8150-6. doi: 10.1158/0008-5472.CAN-09-1135. Epub 2009 Oct 6.

34.

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.

Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L, Copeland NG, Jenkins NA, Cormier RT, Largaespada DA.

Science. 2009 Mar 27;323(5922):1747-50. doi: 10.1126/science.1163040. Epub 2009 Feb 26.

35.

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG, Llovet JM, Largaespada DA.

Nat Biotechnol. 2009 Mar;27(3):264-74. doi: 10.1038/nbt.1526. Epub 2009 Feb 22.

36.

Cancer gene discovery using the Sleeping Beauty transposon.

Starr TK, Largaespada DA.

Cell Cycle. 2005 Dec;4(12):1744-8. Epub 2005 Dec 5.

PMID:
16294016
37.

A requirement for sustained ERK signaling during thymocyte positive selection in vivo.

McNeil LK, Starr TK, Hogquist KA.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13574-9. Epub 2005 Sep 8.

38.

The regulated expression of a diverse set of genes during thymocyte positive selection in vivo.

Mick VE, Starr TK, McCaughtry TM, McNeil LK, Hogquist KA.

J Immunol. 2004 Nov 1;173(9):5434-44.

39.

Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation.

Starr TK, Daniels MA, Lucido MM, Jameson SC, Hogquist KA.

J Immunol. 2003 Nov 1;171(9):4512-20.

40.

Receptor sensitivity: when T cells lose their sense of self.

Hogquist KA, Starr TK, Jameson SC.

Curr Biol. 2003 Mar 18;13(6):R239-41.

41.

Positive and negative selection of T cells.

Starr TK, Jameson SC, Hogquist KA.

Annu Rev Immunol. 2003;21:139-76. Epub 2002 Oct 16. Review.

PMID:
12414722

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