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Items: 30

1.

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.

Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.

Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014.

2.

Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.

Prunetti L, Graf M, Blaby IK, Peil L, Makkay AM, Starosta AL, Papke RT, Oshima T, Wilson DN, de Crécy-Lagard V.

Archaea. 2016 Dec 8;2016:7316725. doi: 10.1155/2016/7316725. eCollection 2016.

3.

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.

Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25.

4.

Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome.

Doerfel LK, Wohlgemuth I, Kubyshkin V, Starosta AL, Wilson DN, Budisa N, Rodnina MV.

J Am Chem Soc. 2015 Oct 14;137(40):12997-3006. doi: 10.1021/jacs.5b07427. Epub 2015 Oct 5.

PMID:
26384033
5.

Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA.

Antimicrob Agents Chemother. 2015 Sep;59(9):5870. doi: 10.1128/AAC.01551-15. No abstract available.

6.

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.

7.

Corrigendum: Arginine-rhamnosylation as new strategy to activate translation elongation factor P.

Lassak J, Keilhauer EC, Fürst M, Wuichet K, Gödeke J, Starosta AL, Chen JM, Søgaard-Andersen L, Rohr J, Wilson DN, Häussler S, Mann M, Jung K.

Nat Chem Biol. 2015 Apr;11(4):299. doi: 10.1038/nchembio0415-299d. No abstract available.

PMID:
25785429
8.

Arginine-rhamnosylation as new strategy to activate translation elongation factor P.

Lassak J, Keilhauer EC, Fürst M, Wuichet K, Gödeke J, Starosta AL, Chen JM, Søgaard-Andersen L, Rohr J, Wilson DN, Häussler S, Mann M, Jung K.

Nat Chem Biol. 2015 Apr;11(4):266-70. doi: 10.1038/nchembio.1751. Epub 2015 Feb 16. Erratum in: Nat Chem Biol. 2015 Apr;11(4):299.

9.

A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P.

Starosta AL, Lassak J, Peil L, Atkinson GC, Woolstenhulme CJ, Virumäe K, Buskirk A, Tenson T, Remme J, Jung K, Wilson DN.

Cell Rep. 2014 Oct 23;9(2):476-83. doi: 10.1016/j.celrep.2014.09.008. Epub 2014 Oct 9.

10.

Drug sensing by the ribosome induces translational arrest via active site perturbation.

Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.

Mol Cell. 2014 Nov 6;56(3):446-52. doi: 10.1016/j.molcel.2014.09.014. Epub 2014 Oct 8.

11.

Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site.

Starosta AL, Lassak J, Peil L, Atkinson GC, Virumäe K, Tenson T, Remme J, Jung K, Wilson DN.

Nucleic Acids Res. 2014;42(16):10711-9. doi: 10.1093/nar/gku768. Epub 2014 Aug 20.

12.

The bacterial translation stress response.

Starosta AL, Lassak J, Jung K, Wilson DN.

FEMS Microbiol Rev. 2014 Nov;38(6):1172-201. doi: 10.1111/1574-6976.12083. Epub 2014 Sep 26. Review.

13.

Ribosome rescue, nearing the end.

Starosta AL, Wilson DN.

Cell. 2014 Feb 27;156(5):866-7. doi: 10.1016/j.cell.2014.02.028.

14.

Tetracycline antibiotics and resistance mechanisms.

Nguyen F, Starosta AL, Arenz S, Sohmen D, Dönhöfer A, Wilson DN.

Biol Chem. 2014 May;395(5):559-75. doi: 10.1515/hsz-2013-0292. Review.

PMID:
24497223
15.

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P.

Peil L, Starosta AL, Lassak J, Atkinson GC, Virumäe K, Spitzer M, Tenson T, Jung K, Remme J, Wilson DN.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15265-70. doi: 10.1073/pnas.1310642110. Epub 2013 Sep 3.

16.

On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel.

Mamos P, Krokidis MG, Papadas A, Karahalios P, Starosta AL, Wilson DN, Kalpaxis DL, Dinos GP.

Biochimie. 2013 Sep;95(9):1765-72. doi: 10.1016/j.biochi.2013.06.004. Epub 2013 Jun 14.

PMID:
23770443
17.

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.

Jenner L, Starosta AL, Terry DS, Mikolajka A, Filonava L, Yusupov M, Blanchard SC, Wilson DN, Yusupova G.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3812-6. doi: 10.1073/pnas.1216691110. Epub 2013 Feb 19.

18.

Nascent peptides that block protein synthesis in bacteria.

Woolstenhulme CJ, Parajuli S, Healey DW, Valverde DP, Petersen EN, Starosta AL, Guydosh NR, Johnson WE, Wilson DN, Buskirk AR.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E878-87. doi: 10.1073/pnas.1219536110. Epub 2013 Feb 19.

19.

Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.

Ude S, Lassak J, Starosta AL, Kraxenberger T, Wilson DN, Jung K.

Science. 2013 Jan 4;339(6115):82-5. doi: 10.1126/science.1228985. Epub 2012 Dec 13.

20.

Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.

Peil L, Starosta AL, Virumäe K, Atkinson GC, Tenson T, Remme J, Wilson DN.

Nat Chem Biol. 2012 Aug;8(8):695-7. doi: 10.1038/nchembio.1001. Epub 2012 Jun 17.

PMID:
22706199
21.

Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA.

Antimicrob Agents Chemother. 2012 May;56(5):2559-64. doi: 10.1128/AAC.06187-11. Epub 2012 Feb 21. Erratum in: Antimicrob Agents Chemother. 2015 Sep;59(9):5870.

22.

Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases.

Mikolajka A, Liu H, Chen Y, Starosta AL, Márquez V, Ivanova M, Cooperman BS, Wilson DN.

Chem Biol. 2011 May 27;18(5):589-600. doi: 10.1016/j.chembiol.2011.03.010.

23.

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM.

Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547.

24.

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.

Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R.

Mol Cell. 2010 Oct 8;40(1):138-46. doi: 10.1016/j.molcel.2010.09.009.

25.

Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition.

Starosta AL, Karpenko VV, Shishkina AV, Mikolajka A, Sumbatyan NV, Schluenzen F, Korshunova GA, Bogdanov AA, Wilson DN.

Chem Biol. 2010 May 28;17(5):504-14. doi: 10.1016/j.chembiol.2010.04.008.

26.

Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

Palaniappan N, Dhote V, Ayers S, Starosta AL, Wilson DN, Reynolds KA.

Chem Biol. 2009 Nov 25;16(11):1180-9. doi: 10.1016/j.chembiol.2009.10.013.

27.

Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays.

Starosta AL, Qin H, Mikolajka A, Leung GY, Schwinghammer K, Nicolaou KC, Chen DY, Cooperman BS, Wilson DN.

Chem Biol. 2009 Oct 30;16(10):1087-96. doi: 10.1016/j.chembiol.2009.09.016.

28.

The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux.

Dhote V, Starosta AL, Wilson DN, Reynolds KA.

Antimicrob Agents Chemother. 2009 Dec;53(12):5163-72. doi: 10.1128/AAC.01069-09. Epub 2009 Sep 21.

29.

Time-resolved binding of azithromycin to Escherichia coli ribosomes.

Petropoulos AD, Kouvela EC, Starosta AL, Wilson DN, Dinos GP, Kalpaxis DL.

J Mol Biol. 2009 Jan 30;385(4):1179-92. doi: 10.1016/j.jmb.2008.11.042. Epub 2008 Nov 27.

PMID:
19071138
30.

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

Wilson DN, Schluenzen F, Harms JM, Starosta AL, Connell SR, Fucini P.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13339-44. doi: 10.1073/pnas.0804276105. Epub 2008 Aug 29.

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