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Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in Infection.

Helble JD, Reinhold-Larsson NV, Starnbach MN.

Infect Immun. 2019 Aug 21;87(9). pii: e00405-19. doi: 10.1128/IAI.00405-19. Print 2019 Sep.


A Chlamydia trachomatis Strain Expressing Ovalbumin Stimulates an Antigen-Specific CD4+ T Cell Response in Mice.

Helble JD, Starnbach MN.

Infect Immun. 2019 Jun 20;87(7). pii: e00837-18. doi: 10.1128/IAI.00837-18. Print 2019 Jul.


A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion.

Park JS, Helble JD, Lazarus JE, Yang G, Blondel CJ, Doench JG, Starnbach MN, Waldor MK.

iScience. 2019 Jan 25;11:71-84. doi: 10.1016/j.isci.2018.12.011. Epub 2018 Dec 14.


The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes.

Cruz-Leal Y, Grubaugh D, Nogueira CV, Lopetegui-González I, Del Valle A, Escalona F, Laborde RJ, Alvarez C, Fernández LE, Starnbach MN, Higgins DE, Lanio ME.

Front Immunol. 2018 Nov 5;9:2473. doi: 10.3389/fimmu.2018.02473. eCollection 2018.


Action Needed on Chlamydia Vaccines.

Starnbach MN.

Trends Microbiol. 2018 Aug;26(8):639-640. doi: 10.1016/j.tim.2018.05.006. Epub 2018 May 29.


LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.


Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populations.

Lijek RS, Helble JD, Olive AJ, Seiger KW, Starnbach MN.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2216-2221. doi: 10.1073/pnas.1711356115. Epub 2018 Feb 9.


TRAPPC13 modulates autophagy and the response to Golgi stress.

Ramírez-Peinado S, Ignashkova TI, van Raam BJ, Baumann J, Sennott EL, Gendarme M, Lindemann RK, Starnbach MN, Reiling JH.

J Cell Sci. 2017 Jul 15;130(14):2251-2265. doi: 10.1242/jcs.199521. Epub 2017 May 23.


Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response.

Laborde RJ, Sanchez-Ferras O, Luzardo MC, Cruz-Leal Y, Fernández A, Mesa C, Oliver L, Canet L, Abreu-Butin L, Nogueira CV, Tejuca M, Pazos F, Álvarez C, Alonso ME, Longo-Maugéri IM, Starnbach MN, Higgins DE, Fernández LE, Lanio ME.

J Immunol. 2017 Apr 1;198(7):2772-2784. doi: 10.4049/jimmunol.1600310. Epub 2017 Mar 3.


An Excess of the Proinflammatory Cytokines IFN-γ and IL-12 Impairs the Development of the Memory CD8+ T Cell Response to Chlamydia trachomatis.

Zhang X, Starnbach MN.

J Immunol. 2015 Aug 15;195(4):1665-75. doi: 10.4049/jimmunol.1500457. Epub 2015 Jul 15.


Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.

Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox JS, Starnbach MN, Derre I, Valdivia R, Krogan NJ, Engel J.

Cell Host Microbe. 2015 Jul 8;18(1):109-21. doi: 10.1016/j.chom.2015.06.004. Epub 2015 Jun 25.


VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells.

Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH.

Science. 2015 Jun 19;348(6241):aaa8205. doi: 10.1126/science.aaa8205.


Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae.

Nogueira CV, Zhang X, Giovannone N, Sennott EL, Starnbach MN.

J Immunol. 2015 Mar 1;194(5):2319-29. doi: 10.4049/jimmunol.1402675. Epub 2015 Jan 30.


Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.

Davila SJ, Olive AJ, Starnbach MN.

J Immunol. 2014 May 1;192(9):4284-93. doi: 10.4049/jimmunol.1303238. Epub 2014 Mar 21.


Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth.

Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN.

Cell Host Microbe. 2014 Jan 15;15(1):113-24. doi: 10.1016/j.chom.2013.12.009.


PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.

Fankhauser SC, Starnbach MN.

J Immunol. 2014 Feb 1;192(3):1079-90. doi: 10.4049/jimmunol.1301657. Epub 2013 Dec 18.


A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM.

Nat Cell Biol. 2013 Dec;15(12):1473-85. doi: 10.1038/ncb2865. Epub 2013 Nov 3.


Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen.

McCluskey AJ, Olive AJ, Starnbach MN, Collier RJ.

Mol Oncol. 2013 Jun;7(3):440-51. doi: 10.1016/j.molonc.2012.12.003. Epub 2012 Dec 19.


IFNγ inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I.

Jehl SP, Nogueira CV, Zhang X, Starnbach MN.

PLoS Pathog. 2012;8(8):e1002809. doi: 10.1371/journal.ppat.1002809. Epub 2012 Aug 9.


CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.

Gondek DC, Olive AJ, Stary G, Starnbach MN.

J Immunol. 2012 Sep 1;189(5):2441-9. doi: 10.4049/jimmunol.1103032. Epub 2012 Aug 1.


Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.

Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10059-64. doi: 10.1073/pnas.1120244109. Epub 2012 Jun 6.


The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free mice.

Lamousé-Smith ES, Tzeng A, Starnbach MN.

PLoS One. 2011;6(11):e27662. doi: 10.1371/journal.pone.0027662. Epub 2011 Nov 17.


Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.

Coers J, Gondek DC, Olive AJ, Rohlfing A, Taylor GA, Starnbach MN.

PLoS Pathog. 2011 Jun;7(6):e1001346. doi: 10.1371/journal.ppat.1001346. Epub 2011 Jun 23.


Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri.

Jehl SP, Doling AM, Giddings KS, Phalipon A, Sansonetti PJ, Goldberg MB, Starnbach MN.

Infect Immun. 2011 May;79(5):2021-30. doi: 10.1128/IAI.00939-10. Epub 2011 Feb 28.


CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa.

Olive AJ, Gondek DC, Starnbach MN.

Mucosal Immunol. 2011 Mar;4(2):208-16. doi: 10.1038/mi.2010.58. Epub 2010 Sep 15.


CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells.

Bergman MA, Loomis WP, Mecsas J, Starnbach MN, Isberg RR.

PLoS Pathog. 2009 Sep;5(9):e1000573. doi: 10.1371/journal.ppat.1000573. Epub 2009 Sep 4.


T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.

Gondek DC, Roan NR, Starnbach MN.

J Immunol. 2009 Jul 15;183(2):1313-9. doi: 10.4049/jimmunol.0900295. Epub 2009 Jun 26.


Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.

Coers J, Starnbach MN, Howard JC.

PLoS Pathog. 2009 May;5(5):e1000333. doi: 10.1371/journal.ppat.1000333. Epub 2009 May 29. No abstract available.


Balance of Irgm protein activities determines IFN-gamma-induced host defense.

Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA.

J Leukoc Biol. 2009 May;85(5):877-85. doi: 10.1189/jlb.1008599. Epub 2009 Jan 27.


Secreted antibody is required for immunity to Plasmodium berghei.

Nunes JK, Starnbach MN, Wirth DF.

Infect Immun. 2009 Jan;77(1):414-8. doi: 10.1128/IAI.00982-08. Epub 2008 Nov 10.


Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.

Coers J, Bernstein-Hanley I, Grotsky D, Parvanova I, Howard JC, Taylor GA, Dietrich WF, Starnbach MN.

J Immunol. 2008 May 1;180(9):6237-45.


Down-modulation of TCR expression by Salmonella enterica serovar Typhimurium.

van der Velden AW, Dougherty JT, Starnbach MN.

J Immunol. 2008 Apr 15;180(8):5569-74.


Both CD4+ and CD8+ T cells respond to antigens fused to anthrax lethal toxin.

Shaw CA, Starnbach MN.

Infect Immun. 2008 Jun;76(6):2603-11. doi: 10.1128/IAI.01718-07. Epub 2008 Mar 17.


Conquering sexually transmitted diseases.

Starnbach MN, Roan NR.

Nat Rev Immunol. 2008 Apr;8(4):313-7. doi: 10.1038/nri2272. Epub 2008 Feb 29. Review.


Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.

Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3831-6. doi: 10.1073/pnas.0711504105. Epub 2008 Feb 1.


Immune-mediated control of Chlamydia infection.

Roan NR, Starnbach MN.

Cell Microbiol. 2008 Jan;10(1):9-19. Epub 2007 Nov 2. Review.


Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.

Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, Siggers KA, Starnbach MN, Lesser CF.

PLoS Pathog. 2007 Feb;3(2):e21.


Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.

Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL.

ACS Chem Biol. 2006 Dec 20;1(11):713-23.


Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1.

Balsara ZR, Misaghi S, Lafave JN, Starnbach MN.

Infect Immun. 2006 Oct;74(10):5602-8.


The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.

Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7. Epub 2006 Sep 7.


Chlamydia trachomatis infection alters the development of memory CD8+ T cells.

Loomis WP, Starnbach MN.

J Immunol. 2006 Sep 15;177(6):4021-7.


Monitoring the T cell response to genital tract infection.

Roan NR, Gierahn TM, Higgins DE, Starnbach MN.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12069-74. Epub 2006 Jul 31.


Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.

Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN.

Mol Microbiol. 2006 Jul;61(1):142-50.


Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen.

Balsara ZR, Roan NR, Steele LN, Starnbach MN.

J Infect Dis. 2006 May 15;193(10):1459-63. Epub 2006 Apr 12.


H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes.

D'Orazio SE, Shaw CA, Starnbach MN.

J Exp Med. 2006 Feb 20;203(2):383-91. Epub 2006 Feb 6.


Genetic analysis of susceptibility to Chlamydia trachomatis in mouse.

Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF.

Genes Immun. 2006 Mar;7(2):122-9.


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