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Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.

Ali S, Zhang Y, Zhou M, Li H, Jin W, Zheng L, Yu X, Stark JM, Weitzel JN, Shen B.

Oncogene. 2019 Oct 15. doi: 10.1038/s41388-019-1061-6. [Epub ahead of print]


The Metabolic Requirements of Th2 Cell Differentiation.

Stark JM, Tibbitt CA, Coquet JM.

Front Immunol. 2019 Sep 27;10:2318. doi: 10.3389/fimmu.2019.02318. eCollection 2019. Review.


Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.

Kelso AA, Lopezcolorado FW, Bhargava R, Stark JM.

PLoS Genet. 2019 Aug 5;15(8):e1008319. doi: 10.1371/journal.pgen.1008319. eCollection 2019 Aug.


Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.

Tibbitt CA, Stark JM, Martens L, Ma J, Mold JE, Deswarte K, Oliynyk G, Feng X, Lambrecht BN, De Bleser P, Nylén S, Hammad H, Arsenian Henriksson M, Saeys Y, Coquet JM.

Immunity. 2019 Jul 16;51(1):169-184.e5. doi: 10.1016/j.immuni.2019.05.014. Epub 2019 Jun 20.


Comparison of pneumococcal vaccination response in children with sickle cell disease: HbSS and HbSC.

Le Ng X, Alikhan M, Stark JM, Mosquera RA, Shahrukh Hashmi S, Gonzales T, Brown DL, Nguyen TT, Yadav A.

Allergol Immunopathol (Madr). 2019 Jun 1. pii: S0301-0546(19)30051-5. doi: 10.1016/j.aller.2019.04.003. [Epub ahead of print]


Carbon control on terrestrial ecosystem function across contrasting site productivities: the carbon connection revisited.

Dove NC, Stark JM, Newman GS, Hart SC.

Ecology. 2019 Jul;100(7):e02695. doi: 10.1002/ecy.2695. Epub 2019 May 23.


An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.

Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF.

JCI Insight. 2019 Mar 21;4(6). pii: 126125. doi: 10.1172/jci.insight.126125. eCollection 2019 Mar 21.


TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS.

Khoenkhoen S, Erikson E, Ádori M, Stark JM, Scholz JL, Cancro MP, Pedersen GK, Karlsson Hedestam GB.

Immunol Cell Biol. 2019 May;97(5):485-497. doi: 10.1111/imcb.12228. Epub 2019 Jan 30.


Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells.

Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA.

J Biol Chem. 2019 Jan 11;294(2):397-404. doi: 10.1074/jbc.AC118.005899. Epub 2018 Nov 26.


The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA.

Gu L, Lingeman R, Yakushijin F, Sun E, Cui Q, Chao J, Hu W, Li H, Hickey RJ, Stark JM, Yuan YC, Chen Y, Vonderfecht SL, Synold TW, Shi Y, Reckamp KL, Horne D, Malkas LH.

Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. doi: 10.1158/1078-0432.CCR-18-0592. Epub 2018 Jul 2.


C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains.

Bhargava R, Sandhu M, Muk S, Lee G, Vaidehi N, Stark JM.

Nat Commun. 2018 Jun 27;9(1):2484. doi: 10.1038/s41467-018-04867-5.


Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbitt CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):e145-e158. doi: 10.1161/ATVBAHA.118.310802.


Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements.

Mendez-Dorantes C, Bhargava R, Stark JM.

Genes Dev. 2018 Apr 1;32(7-8):524-536. doi: 10.1101/gad.311084.117. Epub 2018 Apr 10.


Role of prophylactic azithromycin to reduce airway inflammation and mortality in a RSV mouse infection model.

Mosquera RA, De Jesus-Rojas W, Stark JM, Yadav A, Jon CK, Atkins CL, Samuels CL, Gonzales TR, McBeth KE, Hashmi SS, Garolalo R, Colasurdo GN.

Pediatr Pulmonol. 2018 May;53(5):567-574. doi: 10.1002/ppul.23956. Epub 2018 Feb 6.


Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.

Soldemo M, Àdori M, Stark JM, Feng Y, Tran K, Wilson R, Yang L, Guenaga J, Wyatt RT, Karlsson Hedestam GB.

Front Immunol. 2017 Nov 27;8:1654. doi: 10.3389/fimmu.2017.01654. eCollection 2017.


Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB.

J Immunol. 2018 Jan 15;200(2):775-787. doi: 10.4049/jimmunol.1700791. Epub 2017 Dec 8.


PRPF8 is important for BRCA1-mediated homologous recombination.

Onyango DO, Lee G, Stark JM.

Oncotarget. 2017 Oct 6;8(55):93319-93337. doi: 10.18632/oncotarget.21555. eCollection 2017 Nov 7.


Severe Hepatopulmonary Syndrome in a Child with Caroli Syndrome.

De Jesus-Rojas W, McBeth K, Yadav A, Stark JM, Mosquera RA, Jon C.

Case Rep Pediatr. 2017;2017:2171974. doi: 10.1155/2017/2171974. Epub 2017 Aug 13.


Use of Nasal Non-Invasive Ventilation with a RAM Cannula in the Outpatient Home Setting.

De Jesus Rojas W, Samuels CL, Gonzales TR, McBeth KE, Yadav A, Stark JM, Jon C, Mosquera RA.

Open Respir Med J. 2017 Jul 21;11:41-46. doi: 10.2174/1874306401711010041. eCollection 2017.


PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

Chen T, Tibbitt CA, Feng X, Stark JM, Rohrbeck L, Rausch L, Sedimbi SK, Karlsson MCI, Lambrecht BN, Karlsson Hedestam GB, Hendriks RW, Chambers BJ, Nylén S, Coquet JM.

Sci Immunol. 2017 Mar 10;2(9). pii: eaal5196. doi: 10.1126/sciimmunol.aal5196.


Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.

Bhargava R, Carson CR, Lee G, Stark JM.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):728-733. doi: 10.1073/pnas.1612204114. Epub 2017 Jan 5.


Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.

Skrdlant L, Stark JM, Lin RJ.

BMC Mol Biol. 2016 Aug 23;17(1):18. doi: 10.1186/s12867-016-0071-y.


Regulation of Single-Strand Annealing and its Role in Genome Maintenance.

Bhargava R, Onyango DO, Stark JM.

Trends Genet. 2016 Sep;32(9):566-575. doi: 10.1016/j.tig.2016.06.007. Epub 2016 Jul 19. Review.


Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.

Onyango DO, Howard SM, Neherin K, Yanez DA, Stark JM.

Nucleic Acids Res. 2016 Jul 8;44(12):5702-16. doi: 10.1093/nar/gkw275. Epub 2016 Apr 15.


Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens.

Pedersen GK, Ádori M, Stark JM, Khoenkhoen S, Arnold C, Beutler B, Karlsson Hedestam GB.

Front Immunol. 2016 Mar 1;7:65. doi: 10.3389/fimmu.2016.00065. eCollection 2016.


The invasive annual cheatgrass releases more nitrogen than crested wheatgrass through root exudation and senescence.

Morris KA, Stark JM, Bugbee B, Norton JM.

Oecologia. 2016 Aug;181(4):971-83. doi: 10.1007/s00442-015-3544-7. Epub 2016 Jan 21.


RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.

Kuo CY, Li X, Stark JM, Shih HM, Ann DK.

Cell Cycle. 2016;15(6):787-98. doi: 10.1080/15384101.2016.1138184.


Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease.

Yadav A, Corrales-Medina FF, Stark JM, Hashmi SS, Carroll MP, Smith KG, Meulmester KM, Brown DL, Jon C, Mosquera RA.

Pediatr Allergy Immunol Pulmonol. 2015 Sep 1;28(3):177-182.


EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.

Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM, Stracker TH.

Nucleic Acids Res. 2015 Sep 3;43(15):7371-87. doi: 10.1093/nar/gkv691. Epub 2015 Jul 8.


DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.

Howard SM, Yanez DA, Stark JM.

PLoS Genet. 2015 Jan 28;11(1):e1004943. doi: 10.1371/journal.pgen.1004943. eCollection 2015 Jan.


The invasive annual cheatgrass increases nitrogen availability in 24-year-old replicated field plots.

Stark JM, Norton JM.

Oecologia. 2015 Mar;177(3):799-809. doi: 10.1007/s00442-014-3093-5. Epub 2014 Oct 11.


Resolution of airflow obstruction on polysomnography after laryngotracheal reconstruction with anterior tracheal wall suspension in a patient with DiGeorge Syndrome.

Jon C, Mitchell SE, Mosquera RA, Stark JM, Yuksel S.

Int J Pediatr Otorhinolaryngol. 2014 Oct;78(10):1799-803. doi: 10.1016/j.ijporl.2014.07.035. Epub 2014 Aug 2.


TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.

Liu L, Zhou W, Cheng CT, Ren X, Somlo G, Fong MY, Chin AR, Li H, Yu Y, Xu Y, O'Connor ST, O'Connor TR, Ann DK, Stark JM, Wang SE.

Mol Cancer Res. 2014 Nov;12(11):1597-609. doi: 10.1158/1541-7786.MCR-14-0201. Epub 2014 Aug 7.


An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.

Muñoz MC, Yanez DA, Stark JM.

Nucleic Acids Res. 2014 Jul;42(12):7720-33. doi: 10.1093/nar/gku421. Epub 2014 May 14.


A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth.

Gu L, Smith S, Li C, Hickey RJ, Stark JM, Fields GB, Lang WH, Sandoval JA, Malkas LH.

PLoS One. 2014 Apr 11;9(4):e94773. doi: 10.1371/journal.pone.0094773. eCollection 2014.


Functional and immune response to respiratory syncytial virus infection in aged BALB/c mice: a search for genes determining disease severity.

Mosquera RA, Stark JM, Atkins CL, Colasurdo GN, Chevalier J, Samuels CL, Pacheco SS.

Exp Lung Res. 2014 Feb;40(1):40-9. doi: 10.3109/01902148.2013.859334. Epub 2013 Dec 19.


Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.

Cannon B, Kuhnlein J, Yang SH, Cheng A, Schindler D, Stark JM, Russell R, Paull TT.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18868-73. doi: 10.1073/pnas.1309816110. Epub 2013 Nov 4.


Sagebrush carrying out hydraulic lift enhances surface soil nitrogen cycling and nitrogen uptake into inflorescences.

Cardon ZG, Stark JM, Herron PM, Rasmussen JA.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18988-93. doi: 10.1073/pnas.1311314110. Epub 2013 Nov 4.


SFTPC gene mutation p.R167Q in a premature infant.

Jon C, Nolan PK, Ekong M, Mosquera RA, Stark JM.

Pediatr Pulmonol. 2014 Mar;49(3):E66-8. doi: 10.1002/ppul.22825. Epub 2013 Jun 17.


The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R.

J Cell Biol. 2013 May 27;201(5):693-707. doi: 10.1083/jcb.201302145.


HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response.

Lee YH, Kuo CY, Stark JM, Shih HM, Ann DK.

Nucleic Acids Res. 2013 Jun;41(11):5784-98. doi: 10.1093/nar/gkt231. Epub 2013 Apr 15.


Examining the roles of DNA2 during mammalian end resection.

Stark JM, Shen B.

Cell Cycle. 2012 Nov 15;11(22):4111. doi: 10.4161/cc.22605. Epub 2012 Oct 25. No abstract available.


RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.

J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.


I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks.

Gunn A, Stark JM.

Methods Mol Biol. 2012;920:379-91. doi: 10.1007/978-1-61779-998-3_27.


The HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanism.

Schumacher AJ, Mohni KN, Kan Y, Hendrickson EA, Stark JM, Weller SK.

PLoS Pathog. 2012;8(8):e1002862. doi: 10.1371/journal.ppat.1002862. Epub 2012 Aug 9.


Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma.

Chen X, Wong P, Radany EH, Stark JM, Laulier C, Wong JY.

Mol Cancer Res. 2012 Aug;10(8):1052-64. doi: 10.1158/1541-7786.MCR-11-0587. Epub 2012 Jun 22.


RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.

Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP.

Nucleic Acids Res. 2012 Aug;40(15):7347-57. doi: 10.1093/nar/gks353. Epub 2012 May 9.


A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C.

Dev Cell. 2012 May 15;22(5):1001-16. doi: 10.1016/j.devcel.2011.12.027. Epub 2012 Apr 26.


Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining.

Chakraborty S, Stark JM, Sun CL, Modi H, Chen W, O'Connor TR, Forman SJ, Bhatia S, Bhatia R.

Blood. 2012 Jun 28;119(26):6187-97. doi: 10.1182/blood-2011-05-352252. Epub 2012 Apr 4.


SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.

Wang Z, Yuan H, Roth M, Stark JM, Bhatia R, Chen WY.

Oncogene. 2013 Jan 31;32(5):589-98. doi: 10.1038/onc.2012.83. Epub 2012 Mar 12.

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