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Items: 1 to 50 of 130

1.

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups.

Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J.

J Crohns Colitis. 2019 Mar 16. pii: jjz021. doi: 10.1093/ecco-jcc/jjz021. [Epub ahead of print]

PMID:
30877309
2.

PAI-1 augments mucosal damage in colitis.

Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirović A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaat0852. doi: 10.1126/scitranslmed.aat0852.

PMID:
30842312
3.

Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen.

Wegorzewska MM, Glowacki RWP, Hsieh SA, Donermeyer DL, Hickey CA, Horvath SC, Martens EC, Stappenbeck TS, Allen PM.

Sci Immunol. 2019 Feb 8;4(32). pii: eaau9079. doi: 10.1126/sciimmunol.aau9079.

PMID:
30737355
4.

Microbiome control of innate reactivity.

Chen F, Stappenbeck TS.

Curr Opin Immunol. 2019 Jan 21;56:107-113. doi: 10.1016/j.coi.2018.12.003. [Epub ahead of print] Review.

PMID:
30677624
5.

Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses.

White JP, Xiong S, Malvin NP, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS, Diamond MS.

Cell. 2018 Nov 15;175(5):1198-1212.e12. doi: 10.1016/j.cell.2018.08.069. Epub 2018 Oct 4.

PMID:
30293866
6.

Cellular differentiation: Potential insight into butyrate paradox?

Ryu SH, Kaiko GE, Stappenbeck TS.

Mol Cell Oncol. 2018 Feb 27;5(3):e1212685. doi: 10.1080/23723556.2016.1212685. eCollection 2018.

7.

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.

Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS.

J Clin Invest. 2018 Nov 1;128(11):5110-5122. doi: 10.1172/JCI120453. Epub 2018 Oct 15.

8.

Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration.

Jain U, Lai CW, Xiong S, Goodwin VM, Lu Q, Muegge BD, Christophi GP, VanDussen KL, Cummings BP, Young E, Hambor J, Stappenbeck TS.

Cell Host Microbe. 2018 Sep 12;24(3):353-363.e5. doi: 10.1016/j.chom.2018.07.019. Epub 2018 Aug 16.

PMID:
30122655
9.

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.

Zhao D, Kim YH, Jeong S, Greenson JK, Chaudhry MS, Hoepting M, Anderson ER, van den Brink MR, Peled JU, Gomes AL, Slingerland AE, Donovan MJ, Harris AC, Levine JE, Ozbek U, Hooper LV, Stappenbeck TS, Ver Heul A, Liu TC, Reddy P, Ferrara JL.

J Clin Invest. 2018 Nov 1;128(11):4970-4979. doi: 10.1172/JCI99261. Epub 2018 Sep 24.

10.

Deep Learning Global Glomerulosclerosis in Transplant Kidney Frozen Sections.

Marsh JN, Matlock MK, Kudose S, Liu TC, Stappenbeck TS, Gaut JP, Swamidass SJ.

IEEE Trans Med Imaging. 2018 Dec;37(12):2718-2728. doi: 10.1109/TMI.2018.2851150. Epub 2018 Jun 27.

PMID:
29994669
11.

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro.

Wilke G, Ravindran S, Funkhouser-Jones L, Barks J, Wang Q, VanDussen KL, Stappenbeck TS, Kuhlenschmidt TB, Kuhlenschmidt MS, Sibley LD.

mSphere. 2018 May 30;3(3). pii: e00124-18. doi: 10.1128/mSphere.00124-18. Print 2018 Jun 27.

12.

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease.

VanDussen KL, Stojmirović A, Li K, Liu TC, Kimes PK, Muegge BD, Simpson KF, Ciorba MA, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS.

Gastroenterology. 2018 Sep;155(3):815-828. doi: 10.1053/j.gastro.2018.05.028. Epub 2018 May 18.

PMID:
29782846
13.

Intestinal Stem Cells Live Off the Fat of the Land.

Barisas DAG, Stappenbeck TS.

Cell Stem Cell. 2018 May 3;22(5):611-612. doi: 10.1016/j.stem.2018.04.018.

PMID:
29727673
14.

A Common Mechanism Links Activities of Butyrate in the Colon.

Verma MS, Fink MJ, Salmon GL, Fornelos N, Ohara TE, Ryu SH, Vlamakis H, Xavier RJ, Stappenbeck TS, Whitesides GM.

ACS Chem Biol. 2018 May 18;13(5):1291-1298. doi: 10.1021/acschembio.8b00073. Epub 2018 Apr 10.

PMID:
29584955
15.

Assigning function to symbionts.

Stappenbeck TS.

Nat Microbiol. 2018 Jan;3(1):6-7. doi: 10.1038/s41564-017-0088-0. No abstract available.

PMID:
29255283
16.

B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.

Kim AH, Chung JJ, Akilesh S, Koziell A, Jain S, Hodgin JB, Miller MJ, Stappenbeck TS, Miner JH, Shaw AS.

JCI Insight. 2017 Nov 2;2(21). pii: 81836. doi: 10.1172/jci.insight.81836.

17.

ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.

Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S.

J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528.

18.

The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS.

Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336.

19.

Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation.

Chai JN, Peng Y, Rengarajan S, Solomon BD, Ai TL, Shen Z, Perry JSA, Knoop KA, Tanoue T, Narushima S, Honda K, Elson CO, Newberry RD, Stappenbeck TS, Kau AL, Peterson DA, Fox JG, Hsieh CS.

Sci Immunol. 2017 Jul 21;2(13). pii: eaal5068. doi: 10.1126/sciimmunol.aal5068.

20.

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.

Liu TC, Naito T, Liu Z, VanDussen KL, Haritunians T, Li D, Endo K, Kawai Y, Nagasaki M, Kinouchi Y, McGovern DP, Shimosegawa T, Kakuta Y, Stappenbeck TS.

JCI Insight. 2017 Mar 23;2(6):e91917. doi: 10.1172/jci.insight.91917.

21.

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition.

Wagner VE, Dey N, Guruge J, Hsiao A, Ahern PP, Semenkovich NP, Blanton LV, Cheng J, Griffin N, Stappenbeck TS, Ilkayeva O, Newgard CB, Petri W, Haque R, Ahmed T, Gordon JI.

Sci Transl Med. 2016 Nov 23;8(366):366ra164.

22.

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.

Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Núñez G, Martens EC.

Cell. 2016 Nov 17;167(5):1339-1353.e21. doi: 10.1016/j.cell.2016.10.043.

23.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034. No abstract available.

24.

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.

Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS.

EMBO J. 2017 Jan 4;36(1):5-24. doi: 10.15252/embj.201694660. Epub 2016 Oct 24.

25.

Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease.

Stappenbeck TS, McGovern DPB.

Gastroenterology. 2017 Feb;152(2):322-326. doi: 10.1053/j.gastro.2016.10.003. Epub 2016 Oct 8.

26.

Paneth cell defects in Crohn's disease patients promote dysbiosis.

Liu TC, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DP, Xavier RJ, Stappenbeck TS, Salzman NH.

JCI Insight. 2016 Jun 2;1(8):e86907. doi: 10.1172/jci.insight.86907.

27.

Accounting for reciprocal host-microbiome interactions in experimental science.

Stappenbeck TS, Virgin HW.

Nature. 2016 Jun 9;534(7606):191-9. doi: 10.1038/nature18285.

PMID:
27279212
28.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Jun 16;165(7):1708-1720. doi: 10.1016/j.cell.2016.05.018. Epub 2016 Jun 2. Erratum in: Cell. 2016 Nov 3;167(4):1137.

29.

Genetics and Pathogenesis of Inflammatory Bowel Disease.

Liu TC, Stappenbeck TS.

Annu Rev Pathol. 2016 May 23;11:127-48. doi: 10.1146/annurev-pathol-012615-044152. Epub 2016 Feb 22. Review.

30.

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.

Tinkum KL, Stemler KM, White LS, Loza AJ, Jeter-Jones S, Michalski BM, Kuzmicki C, Pless R, Stappenbeck TS, Piwnica-Worms D, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7148-54. doi: 10.1073/pnas.1509249112. Epub 2015 Dec 7.

31.

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

Song C, Lee JS, Gilfillan S, Robinette ML, Newberry RD, Stappenbeck TS, Mack M, Cella M, Colonna M.

J Exp Med. 2015 Oct 19;212(11):1869-82. doi: 10.1084/jem.20151403. Epub 2015 Oct 12.

32.

Runx3 specifies lineage commitment of innate lymphoid cells.

Ebihara T, Song C, Ryu SH, Plougastel-Douglas B, Yang L, Levanon D, Groner Y, Bern MD, Stappenbeck TS, Colonna M, Egawa T, Yokoyama WM.

Nat Immunol. 2015 Nov;16(11):1124-33. doi: 10.1038/ni.3272. Epub 2015 Sep 28.

33.

Gut-Pancreatic Axis AMPlified in Islets of Langerhans.

Ryu SH, Stappenbeck TS.

Immunity. 2015 Aug 18;43(2):216-8. doi: 10.1016/j.immuni.2015.08.003.

34.

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis.

Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS.

J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17.

35.

Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.

Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ.

EBioMedicine. 2014 Oct 24;1(1):46-57. doi: 10.1016/j.ebiom.2014.10.011. eCollection 2014 Nov.

36.

IL13 activates autophagy to regulate secretion in airway epithelial cells.

Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL.

Autophagy. 2016;12(2):397-409. doi: 10.1080/15548627.2015.1056967. Epub 2015 Jun 10.

37.

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH.

Development. 2015 Jun 15;142(12):2163-72. doi: 10.1242/dev.117341. Epub 2015 May 28.

38.

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.

Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M, Malvin NP, Glowacki RW, Hansson GC, Allen PM, Martens EC, Stappenbeck TS.

Cell Host Microbe. 2015 May 13;17(5):672-80. doi: 10.1016/j.chom.2015.04.002.

39.

IgG "detoxes" the intestinal mucosa.

Eckmann L, Stappenbeck TS.

Cell Host Microbe. 2015 May 13;17(5):538-9. doi: 10.1016/j.chom.2015.05.001.

40.

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy.

Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI.

Sci Transl Med. 2015 Feb 25;7(276):276ra24. doi: 10.1126/scitranslmed.aaa4877.

41.

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation.

Moon C, Baldridge MT, Wallace MA, D CA, Burnham, Virgin HW, Stappenbeck TS.

Nature. 2015 May 7;521(7550):90-93. doi: 10.1038/nature14139. Epub 2015 Feb 16.

42.

Disease-specific alterations in the enteric virome in inflammatory bowel disease.

Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW.

Cell. 2015 Jan 29;160(3):447-60. doi: 10.1016/j.cell.2015.01.002. Epub 2015 Jan 22.

43.

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.

Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.

44.

Type I interferons link viral infection to enhanced epithelial turnover and repair.

Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS.

Cell Host Microbe. 2015 Jan 14;17(1):85-97. doi: 10.1016/j.chom.2014.11.004. Epub 2014 Dec 4.

45.

IL-6 stimulates intestinal epithelial proliferation and repair after injury.

Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS.

PLoS One. 2014 Dec 5;9(12):e114195. doi: 10.1371/journal.pone.0114195. eCollection 2014.

46.

Role of viruses and bacteria-virus interactions in autoimmunity.

Steed AL, Stappenbeck TS.

Curr Opin Immunol. 2014 Dec;31:102-7. doi: 10.1016/j.coi.2014.10.006. Epub 2014 Oct 27. Review.

47.

Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.

Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ.

J Virol. 2015 Jan;89(1):337-49. doi: 10.1128/JVI.02110-14. Epub 2014 Oct 15.

48.

Host-microbe interactions shaping the gastrointestinal environment.

Kaiko GE, Stappenbeck TS.

Trends Immunol. 2014 Nov;35(11):538-48. doi: 10.1016/j.it.2014.08.002. Epub 2014 Sep 11. Review.

49.

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.

VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA, Stappenbeck TS.

Gut. 2015 Jun;64(6):911-20. doi: 10.1136/gutjnl-2013-306651. Epub 2014 Jul 9.

50.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

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