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A translational EEG-based approach to assess modulation of long-lasting NMDAR-dependent synaptic plasticity.

Burgdorf JS, Christian EP, Sørensen L, Stanton PK, Leaderbrand K, Madsen TM, Khan MA, Kroes RA, Moskal JR.

Psychopharmacology (Berl). 2019 Aug 7. doi: 10.1007/s00213-019-05341-w. [Epub ahead of print]


Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus.

Irfan M, Zurawski Z, Hamm H, Bark C, Stanton PK.

Neuroreport. 2019 Jul 3;30(10):695-699. doi: 10.1097/WNR.0000000000001258.


SNAP-25 isoforms differentially regulate synaptic transmission and long-term synaptic plasticity at central synapses.

Irfan M, Gopaul KR, Miry O, Hökfelt T, Stanton PK, Bark C.

Sci Rep. 2019 Apr 25;9(1):6403. doi: 10.1038/s41598-019-42833-3.


Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S.

Nat Neurosci. 2019 Feb;22(2):229-242. doi: 10.1038/s41593-018-0313-z. Epub 2019 Jan 21.


Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects.

Donello JE, Banerjee P, Li YX, Guo YX, Yoshitake T, Zhang XL, Miry O, Kehr J, Stanton PK, Gross AL, Burgdorf JS, Kroes RA, Moskal JR.

Int J Neuropsychopharmacol. 2019 Mar 1;22(3):247-259. doi: 10.1093/ijnp/pyy101.


Zinc enhances hippocampal long-term potentiation at CA1 synapses through NR2B containing NMDA receptors.

Sullivan JA, Zhang XL, Sullivan AP, Vose LR, Moghadam AA, Fried VA, Stanton PK.

PLoS One. 2018 Nov 28;13(11):e0205907. doi: 10.1371/journal.pone.0205907. eCollection 2018.


Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE.

Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350.


NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory.

Khan MA, Houck DR, Gross AL, Zhang XL, Cearley C, Madsen TM, Kroes RA, Stanton PK, Burgdorf J, Moskal JR.

Int J Neuropsychopharmacol. 2018 Mar 1;21(3):242-254. doi: 10.1093/ijnp/pyx096.


From the Cover: 7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release: A Novel Therapeutic Approach for Lead Intoxicated Children.

Zhang XL, McGlothan JL, Miry O, Stansfield KH, Loth MK, Stanton PK, Guilarte TR.

Toxicol Sci. 2018 Jan 1;161(1):186-195. doi: 10.1093/toxsci/kfx210.


IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity.

Burgdorf J, Colechio EM, Ghoreishi-Haack N, Gross AL, Rex CS, Zhang XL, Stanton PK, Kroes RA, Moskal JR.

Int J Neuropsychopharmacol. 2017 Jun 1;20(6):476-484. doi: 10.1093/ijnp/pyx007.


Tetramethylenedisulfotetramine: pest control gone awry.

Shakarjian MP, Laukova M, Velíšková J, Stanton PK, Heck DE, Velíšek L.

Ann N Y Acad Sci. 2016 Aug;1378(1):68-79. doi: 10.1111/nyas.13120. Epub 2016 Jul 6. Review.


The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant.

Moskal JR, Burgdorf JS, Stanton PK, Kroes RA, Disterhoft JF, Burch RM, Khan MA.

Curr Neuropharmacol. 2017;15(1):47-56. Review.


Synaptic Plasticity, Metaplasticity and Depression.

Vose LR, Stanton PK.

Curr Neuropharmacol. 2017;15(1):71-86. Review.


Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus.

Burgdorf J, Zhang XL, Colechio EM, Ghoreishi-Haack N, Gross A, Kroes RA, Stanton PK, Moskal JR.

Int J Neuropsychopharmacol. 2015 Sep 15;19(2). pii: pyv101. doi: 10.1093/ijnp/pyv101.


The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.

Burgdorf J, Zhang XL, Weiss C, Gross A, Boikess SR, Kroes RA, Khan MA, Burch RM, Rex CS, Disterhoft JF, Stanton PK, Moskal JR.

Neuroscience. 2015 Nov 12;308:202-11. doi: 10.1016/j.neuroscience.2015.09.004. Epub 2015 Sep 4.


Suppression of spreading depolarization and stabilization of dendritic spines by GLYX-13, an NMDA receptor glycine-site functional partial agonist.

Zhang XL, Shuttleworth CW, Moskal JR, Stanton PK.

Exp Neurol. 2015 Nov;273:312-21. doi: 10.1016/j.expneurol.2015.07.025. Epub 2015 Aug 2.


Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.

Burgdorf J, Kroes RA, Zhang XL, Gross AL, Schmidt M, Weiss C, Disterhoft JF, Burch RM, Stanton PK, Moskal JR.

Behav Brain Res. 2015 Nov 1;294:177-85. doi: 10.1016/j.bbr.2015.07.039. Epub 2015 Jul 22.


Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number.

Zhang XL, Guariglia SR, McGlothan JL, Stansfield KH, Stanton PK, Guilarte TR.

PLoS One. 2015 May 26;10(5):e0127461. doi: 10.1371/journal.pone.0127461. eCollection 2015.


Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice.

Shakarjian MP, Ali MS, Velíšková J, Stanton PK, Heck DE, Velíšek L.

Neurotoxicology. 2015 May;48:100-8. doi: 10.1016/j.neuro.2015.03.007. Epub 2015 Mar 14.


Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy.

Goldstein LE, McKee AC, Stanton PK.

Alzheimers Res Ther. 2014 Sep 5;6(5):64. doi: 10.1186/s13195-014-0064-3. eCollection 2014. Review.


GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.

Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, Leander JD.

Expert Opin Investig Drugs. 2014 Feb;23(2):243-54. doi: 10.1517/13543784.2014.852536. Epub 2013 Nov 20. Review.


Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus.

Zhang XL, Pöschel B, Faul C, Upreti C, Stanton PK, Mundel P.

J Neurosci. 2013 Jul 24;33(30):12510-8. doi: 10.1523/JNEUROSCI.2983-12.2013.


Two distinct modes of exocytotic fusion pore expansion in large astrocytic vesicles.

Peng H, Kang N, Xu J, Stanton PK, Kang J.

J Biol Chem. 2013 Jun 7;288(23):16872-81. doi: 10.1074/jbc.M113.468231. Epub 2013 Apr 25.


Astrocytes release D-serine by a large vesicle.

Kang N, Peng H, Yu Y, Stanton PK, Guilarte TR, Kang J.

Neuroscience. 2013 Jun 14;240:243-57. doi: 10.1016/j.neuroscience.2013.02.029. Epub 2013 Feb 26.


GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects.

Burgdorf J, Zhang XL, Nicholson KL, Balster RL, Leander JD, Stanton PK, Gross AL, Kroes RA, Moskal JR.

Neuropsychopharmacology. 2013 Apr;38(5):729-42. doi: 10.1038/npp.2012.246. Epub 2012 Dec 5.


Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors.

Shakarjian MP, Velíšková J, Stanton PK, Velíšek L.

Toxicol Appl Pharmacol. 2012 Nov 15;265(1):113-21. doi: 10.1016/j.taap.2012.08.037. Epub 2012 Sep 27.


Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants.

Vinukonda G, Hu F, Upreti C, Ungvari Z, Zia MT, Stanton PK, Ballabh P.

J Neurosci Res. 2012 Nov;90(11):2173-82. doi: 10.1002/jnr.23102. Epub 2012 Jul 17.


Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release.

Upreti C, Zhang XL, Alford S, Stanton PK.

Neuropharmacology. 2013 Mar;66:31-9. doi: 10.1016/j.neuropharm.2012.05.004. Epub 2012 May 22. Review.


Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC.

Sci Transl Med. 2012 May 16;4(134):134ra60. doi: 10.1126/scitranslmed.3003716.


β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.

Nebieridze N, Zhang XL, Chachua T, Velíšek L, Stanton PK, Velíšková J.

Psychoneuroendocrinology. 2012 Nov;37(11):1845-54. doi: 10.1016/j.psyneuen.2012.03.023. Epub 2012 Apr 27.


Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy.

Upreti C, Otero R, Partida C, Skinner F, Thakker R, Pacheco LF, Zhou ZY, Maglakelidze G, Velíšková J, Velíšek L, Romanovicz D, Jones T, Stanton PK, Garrido-Sanabria ER.

Brain. 2012 Mar;135(Pt 3):869-85. doi: 10.1093/brain/awr341. Epub 2012 Feb 16.


Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.

Zhang XL, Upreti C, Stanton PK.

PLoS One. 2011;6(5):e20500. doi: 10.1371/journal.pone.0020500. Epub 2011 May 25.


Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13.

Stanton PK, Potter PE, Aguilar J, Decandia M, Moskal JR.

Neuroreport. 2009 Aug 26;20(13):1193-7. doi: 10.1097/WNR.0b013e32832f5130.


The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.

Burgdorf J, Zhang XL, Weiss C, Matthews E, Disterhoft JF, Stanton PK, Moskal JR.

Neurobiol Aging. 2011 Apr;32(4):698-706. doi: 10.1016/j.neurobiolaging.2009.04.012. Epub 2009 May 14.


A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus.

Zhang XL, Sullivan JA, Moskal JR, Stanton PK.

Neuropharmacology. 2008 Dec;55(7):1238-50. doi: 10.1016/j.neuropharm.2008.08.018. Epub 2008 Aug 29.


Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses.

Bailey CP, Nicholls RE, Zhang XL, Zhou ZY, Müller W, Kandel ER, Stanton PK.

Learn Mem. 2008 Apr 7;15(4):261-70. doi: 10.1101/lm.810208. Print 2008 Apr.


A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing.

Sehatpour P, Molholm S, Schwartz TH, Mahoney JR, Mehta AD, Javitt DC, Stanton PK, Foxe JJ.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4399-404. doi: 10.1073/pnas.0708418105. Epub 2008 Mar 11.


Glutamate-induced exocytosis of glutamate from astrocytes.

Xu J, Peng H, Kang N, Zhao Z, Lin JH, Stanton PK, Kang J.

J Biol Chem. 2007 Aug 17;282(33):24185-97. Epub 2007 Jun 21.


BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses.

Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK, Pozzo-Miller L.

J Physiol. 2006 Aug 1;574(Pt 3):787-803. Epub 2006 May 18.


mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.

Nicholls RE, Zhang XL, Bailey CP, Conklin BR, Kandel ER, Stanton PK.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6380-5. Epub 2006 Apr 10.


Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia.

de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK, Rozental R.

Stroke. 2005 Oct;36(10):2232-7. Epub 2005 Sep 22.


Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice.

Zervas M, Opitz T, Edelmann W, Wainer B, Kucherlapati R, Stanton PK.

J Neurosci Res. 2005 Oct 1;82(1):83-92.


Alterations in metabolism and gap junction expression may determine the role of astrocytes as "good samaritans" or executioners.

Farahani R, Pina-Benabou MH, Kyrozis A, Siddiq A, Barradas PC, Chiu FC, Cavalcante LA, Lai JC, Stanton PK, Rozental R.

Glia. 2005 Jun;50(4):351-61.


Two-photon imaging of spontaneous vesicular release in acute brain slices and its modulation by presynaptic GABAA receptors.

Axmacher N, Winterer J, Stanton PK, Draguhn A, Müller W.

Neuroimage. 2004 Jun;22(2):1014-21.


Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigra.

Galanopoulou AS, Kyrozis A, Claudio OI, Stanton PK, Moshé SL.

Exp Neurol. 2003 Oct;183(2):628-37.


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