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Items: 1 to 50 of 72

1.

Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations.

Cassidy CK, Himes BA, Sun D, Ma J, Zhao G, Parkinson JS, Stansfeld PJ, Luthey-Schulten Z, Zhang P.

Commun Biol. 2020 Jan 10;3(1):24. doi: 10.1038/s42003-019-0748-0.

2.

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors.

Pye VE, Rosa A, Bertelli C, Struwe WB, Maslen SL, Corey R, Liko I, Hassall M, Mattiuzzo G, Ballandras-Colas A, Nans A, Takeuchi Y, Stansfeld PJ, Skehel JM, Robinson CV, Pizzato M, Cherepanov P.

Nat Struct Mol Biol. 2020 Jan;27(1):78-83. doi: 10.1038/s41594-019-0357-0. Epub 2020 Jan 6.

PMID:
31907454
3.

A mass spectrometry-based approach to distinguish annular and specific lipid binding to membrane proteins.

Bolla JR, Corey RA, Sahin C, Gault J, Hummer A, Hopper JTS, Lane DP, Drew D, Allison TM, Stansfeld PJ, Robinson CV, Landreh M.

Angew Chem Int Ed Engl. 2019 Dec 30. doi: 10.1002/anie.201914411. [Epub ahead of print]

PMID:
31886601
4.

InSitu Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface Layer.

von Kügelgen A, Tang H, Hardy GG, Kureisaite-Ciziene D, Brun YV, Stansfeld PJ, Robinson CV, Bharat TAM.

Cell. 2019 Dec 21. pii: S0092-8674(19)31332-7. doi: 10.1016/j.cell.2019.12.006. [Epub ahead of print]

5.

The energetics of protein-lipid interactions as viewed by molecular simulations.

Corey RA, Stansfeld PJ, Sansom MSP.

Biochem Soc Trans. 2019 Dec 24. pii: BST20190149. doi: 10.1042/BST20190149. [Epub ahead of print]

PMID:
31872229
6.

Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer.

Parker JL, Corey RA, Stansfeld PJ, Newstead S.

Nat Commun. 2019 Oct 11;10(1):4657. doi: 10.1038/s41467-019-12673-w.

7.

Sharing Data from Molecular Simulations.

Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin AMJJ, Chavent M, Chodera J, Čondić-Jurkić K, Delemotte L, Grubmüller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A.

J Chem Inf Model. 2019 Oct 28;59(10):4093-4099. doi: 10.1021/acs.jcim.9b00665. Epub 2019 Oct 11.

PMID:
31525920
8.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP.

Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1.

9.

Insights into Membrane Protein-Lipid Interactions from Free Energy Calculations.

Corey RA, Vickery ON, Sansom MSP, Stansfeld PJ.

J Chem Theory Comput. 2019 Oct 8;15(10):5727-5736. doi: 10.1021/acs.jctc.9b00548. Epub 2019 Sep 17.

10.

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates.

Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MSP.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13989-13995. doi: 10.1073/pnas.1902702116. Epub 2019 Jun 24.

11.

The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels.

Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N.

Elife. 2019 Feb 26;8. pii: e39476. doi: 10.7554/eLife.39476.

12.

A lipid gating mechanism for the channel-forming O antigen ABC transporter.

Caffalette CA, Corey RA, Sansom MSP, Stansfeld PJ, Zimmer J.

Nat Commun. 2019 Feb 18;10(1):824. doi: 10.1038/s41467-019-08646-8.

13.

The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions.

Newport TD, Sansom MSP, Stansfeld PJ.

Nucleic Acids Res. 2019 Jan 8;47(D1):D390-D397. doi: 10.1093/nar/gky1047.

14.

Water and hydrophobic gates in ion channels and nanopores.

Rao S, Lynch CI, Klesse G, Oakley GE, Stansfeld PJ, Tucker SJ, Sansom MSP.

Faraday Discuss. 2018 Sep 28;209(0):231-247. doi: 10.1039/c8fd00013a.

15.

Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment.

Autzen HE, Koldsø H, Stansfeld PJ, Gourdon P, Sansom MSP, Nissen P.

Biochemistry. 2018 Jul 17;57(28):4063-4073. doi: 10.1021/acs.biochem.8b00326. Epub 2018 Jun 27.

PMID:
29894640
16.

Lipid binding attenuates channel closure of the outer membrane protein OmpF.

Liko I, Degiacomi MT, Lee S, Newport TD, Gault J, Reading E, Hopper JTS, Housden NG, White P, Colledge M, Sula A, Wallace BA, Kleanthous C, Stansfeld PJ, Bayley H, Benesch JLP, Allison TM, Robinson CV.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6691-6696. doi: 10.1073/pnas.1721152115. Epub 2018 Jun 11.

17.

Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function.

Chavent M, Karia D, Kalli AC, Domański J, Duncan AL, Hedger G, Stansfeld PJ, Seiradake E, Jones EY, Sansom MSP.

Structure. 2018 Jul 3;26(7):1025-1034.e2. doi: 10.1016/j.str.2018.05.003. Epub 2018 Jun 7.

18.

Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1.

Ni T, Williams SI, Rezelj S, Anderluh G, Harlos K, Stansfeld PJ, Gilbert RJC.

Sci Adv. 2018 Mar 21;4(3):eaaq0762. doi: 10.1126/sciadv.aaq0762. eCollection 2018 Mar.

19.

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis.

El Ghachi M, Howe N, Huang CY, Olieric V, Warshamanage R, Touzé T, Weichert D, Stansfeld PJ, Wang M, Kerff F, Caffrey M.

Nat Commun. 2018 Mar 14;9(1):1078. doi: 10.1038/s41467-018-03477-5.

20.

Balancing Force Field Protein-Lipid Interactions To Capture Transmembrane Helix-Helix Association.

Domański J, Sansom MSP, Stansfeld PJ, Best RB.

J Chem Theory Comput. 2018 Mar 13;14(3):1706-1715. doi: 10.1021/acs.jctc.7b00983. Epub 2018 Feb 9.

21.

Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli.

Habersetzer J, Moore K, Cherry J, Buchanan G, Stansfeld PJ, Palmer T.

Open Biol. 2017 Aug;7(8). pii: 170091. doi: 10.1098/rsob.170091.

22.

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.

Cutts EE, Laasch N, Reiter DM, Trenker R, Slater LM, Stansfeld PJ, Vakonakis I.

PLoS Pathog. 2017 Aug 14;13(8):e1006552. doi: 10.1371/journal.ppat.1006552. eCollection 2017 Aug.

23.

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Wiktor M, Weichert D, Howe N, Huang CY, Olieric V, Boland C, Bailey J, Vogeley L, Stansfeld PJ, Buddelmeijer N, Wang M, Caffrey M.

Nat Commun. 2017 Jul 4;8:15952. doi: 10.1038/ncomms15952.

24.

Computational studies of membrane proteins: from sequence to structure to simulation.

Stansfeld PJ.

Curr Opin Struct Biol. 2017 Aug;45:133-141. doi: 10.1016/j.sbi.2017.04.004. Epub 2017 May 13. Review.

PMID:
28511148
25.

A BEST example of channel structure annotation by molecular simulation.

Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MSP.

Channels (Austin). 2017 Jul 4;11(4):347-353. doi: 10.1080/19336950.2017.1306163. Epub 2017 Mar 20.

26.

The role of interfacial lipids in stabilizing membrane protein oligomers.

Gupta K, Donlan JAC, Hopper JTS, Uzdavinys P, Landreh M, Struwe WB, Drew D, Baldwin AJ, Stansfeld PJ, Robinson CV.

Nature. 2017 Jan 19;541(7637):421-424. doi: 10.1038/nature20820. Epub 2017 Jan 11.

27.

Assembling the Tat protein translocase.

Alcock F, Stansfeld PJ, Basit H, Habersetzer J, Baker MA, Palmer T, Wallace MI, Berks BC.

Elife. 2016 Dec 3;5. pii: e20718. doi: 10.7554/eLife.20718.

28.

Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association.

Domański J, Hedger G, Best RB, Stansfeld PJ, Sansom MSP.

J Phys Chem B. 2017 Apr 20;121(15):3364-3375. doi: 10.1021/acs.jpcb.6b08445. Epub 2016 Nov 17.

29.

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.

Lörinczi E, Helliwell M, Finch A, Stansfeld PJ, Davies NW, Mahaut-Smith M, Muskett FW, Mitcheson JS.

J Biol Chem. 2016 Aug 19;291(34):17907-18. doi: 10.1074/jbc.M116.733576. Epub 2016 Jun 20.

30.

Interaction of lipids with the neurotensin receptor 1.

Bolivar JH, Muñoz-García JC, Castro-Dopico T, Dijkman PM, Stansfeld PJ, Watts A.

Biochim Biophys Acta. 2016 Jun;1858(6):1278-87. doi: 10.1016/j.bbamem.2016.02.032. Epub 2016 Mar 21.

31.

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin.

Vogeley L, El Arnaout T, Bailey J, Stansfeld PJ, Boland C, Caffrey M.

Science. 2016 Feb 19;351(6275):876-80. doi: 10.1126/science.aad3747.

32.

Structural basis of outer membrane protein insertion by the BAM complex.

Gu Y, Li H, Dong H, Zeng Y, Zhang Z, Paterson NG, Stansfeld PJ, Wang Z, Zhang Y, Wang W, Dong C.

Nature. 2016 Mar 3;531(7592):64-9. doi: 10.1038/nature17199. Epub 2016 Feb 22.

PMID:
26901871
33.

Ternary structure reveals mechanism of a membrane diacylglycerol kinase.

Li D, Stansfeld PJ, Sansom MSP, Keogh A, Vogeley L, Howe N, Lyons JA, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin NA, Cherezov V, Liu W, Bandaru S, English NJ, Gati C, Barty A, Yefanov O, Chapman HN, Diederichs K, Messerschmidt M, Boutet S, Williams GJ, Marvin Seibert M, Caffrey M.

Nat Commun. 2015 Dec 17;6:10140. doi: 10.1038/ncomms10140.

34.

A Coarse Grained Model for a Lipid Membrane with Physiological Composition and Leaflet Asymmetry.

Sharma S, Kim BN, Stansfeld PJ, Sansom MS, Lindau M.

PLoS One. 2015 Dec 14;10(12):e0144814. doi: 10.1371/journal.pone.0144814. eCollection 2015.

35.

The centriolar protein CPAP G-box: an amyloid fibril in a single domain.

Cutts EE, Inglis A, Stansfeld PJ, Vakonakis I, Hatzopoulos GN.

Biochem Soc Trans. 2015 Oct;43(5):838-43. doi: 10.1042/BST20150082. Review.

36.

Structure and function of the Escherichia coli Tol-Pal stator protein TolR.

Wojdyla JA, Cutts E, Kaminska R, Papadakos G, Hopper JT, Stansfeld PJ, Staunton D, Robinson CV, Kleanthous C.

J Biol Chem. 2015 Oct 30;290(44):26675-87. doi: 10.1074/jbc.M115.671586. Epub 2015 Sep 9.

37.

The TatC component of the twin-arginine protein translocase functions as an obligate oligomer.

Cléon F, Habersetzer J, Alcock F, Kneuper H, Stansfeld PJ, Basit H, Wallace MI, Berks BC, Palmer T.

Mol Microbiol. 2015 Oct;98(1):111-29. doi: 10.1111/mmi.13106. Epub 2015 Jul 22.

38.

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

Stansfeld PJ, Goose JE, Caffrey M, Carpenter EP, Parker JL, Newstead S, Sansom MS.

Structure. 2015 Jul 7;23(7):1350-61. doi: 10.1016/j.str.2015.05.006. Epub 2015 Jun 11.

39.

Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD.

Gu Y, Stansfeld PJ, Zeng Y, Dong H, Wang W, Dong C.

Structure. 2015 Mar 3;23(3):496-504. doi: 10.1016/j.str.2015.01.001. Epub 2015 Feb 12.

40.

Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.

Chavent M, Chetwynd AP, Stansfeld PJ, Sansom MS.

Biochemistry. 2014 Oct 28;53(42):6641-52. doi: 10.1021/bi500800x. Epub 2014 Oct 17.

41.

Structural basis for outer membrane lipopolysaccharide insertion.

Dong H, Xiang Q, Gu Y, Wang Z, Paterson NG, Stansfeld PJ, He C, Zhang Y, Wang W, Dong C.

Nature. 2014 Jul 3;511(7507):52-6. doi: 10.1038/nature13464. Epub 2014 Jun 18.

PMID:
24990744
42.

Structural biology of Tat protein transport.

Berks BC, Lea SM, Stansfeld PJ.

Curr Opin Struct Biol. 2014 Aug;27:32-7. doi: 10.1016/j.sbi.2014.03.003. Epub 2014 Apr 5. Review.

43.

Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domain.

Rothwell SW, Stansfeld PJ, Bragg L, Verkhratsky A, North RA.

J Biol Chem. 2014 Jan 10;289(2):618-26. doi: 10.1074/jbc.M113.529099. Epub 2013 Nov 22.

44.

Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I.

Structure. 2013 Nov 5;21(11):2069-77. doi: 10.1016/j.str.2013.08.019. Epub 2013 Sep 26.

45.

Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.

Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2.

46.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28.

47.

Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins.

Stansfeld PJ, Jefferys EE, Sansom MS.

Structure. 2013 May 7;21(5):810-9. doi: 10.1016/j.str.2013.03.005. Epub 2013 Apr 18.

48.

The structural basis of ZMPSTE24-dependent laminopathies.

Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP.

Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513.

PMID:
23539603
49.

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.

Schmidt MR, Stansfeld PJ, Tucker SJ, Sansom MS.

Biochemistry. 2013 Jan 15;52(2):279-81. doi: 10.1021/bi301350s. Epub 2012 Dec 28.

50.

Structure of the TatC core of the twin-arginine protein transport system.

Rollauer SE, Tarry MJ, Graham JE, Jääskeläinen M, Jäger F, Johnson S, Krehenbrink M, Liu SM, Lukey MJ, Marcoux J, McDowell MA, Rodriguez F, Roversi P, Stansfeld PJ, Robinson CV, Sansom MS, Palmer T, Högbom M, Berks BC, Lea SM.

Nature. 2012 Dec 13;492(7428):210-4. doi: 10.1038/nature11683. Epub 2012 Dec 2.

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