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Items: 33

1.

Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.

Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE.

Gastroenterology. 2019 Oct 1. pii: S0016-5085(19)41368-1. doi: 10.1053/j.gastro.2019.09.026. [Epub ahead of print]

2.

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.

Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK.

Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7. doi: 10.1016/j.stem.2019.07.008. Epub 2019 Aug 15.

3.

CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids.

Hennig A, Wolf L, Jahnke B, Polster H, Seidlitz T, Werner K, Aust DE, Hampe J, Distler M, Weitz J, Stange DE, Welsch T.

Stem Cells Int. 2019 May 2;2019:1024614. doi: 10.1155/2019/1024614. eCollection 2019.

4.

Human gastric cancer modelling using organoids.

Seidlitz T, Merker SR, Rothe A, Zakrzewski F, von Neubeck C, Grützmann K, Sommer U, Schweitzer C, Schölch S, Uhlemann H, Gaebler AM, Werner K, Krause M, Baretton GB, Welsch T, Koo BK, Aust DE, Klink B, Weitz J, Stange DE.

Gut. 2019 Feb;68(2):207-217. doi: 10.1136/gutjnl-2017-314549. Epub 2018 Apr 27.

5.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.

Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610-E619. doi: 10.1073/pnas.1715911114. Epub 2018 Jan 8.

6.

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability.

Kurlishchuk Y, Vynnytska-Myronovska B, Grosse-Gehling P, Bobak Y, Manig F, Chen O, Merker SR, Henle T, Löck S, Stange DE, Stasyk O, Kunz-Schughart LA.

Oncotarget. 2016 Nov 8;7(45):73292-73308. doi: 10.18632/oncotarget.12320.

7.

Gastrointestinal organoids: How they gut it out.

Merker SR, Weitz J, Stange DE.

Dev Biol. 2016 Dec 15;420(2):239-250. doi: 10.1016/j.ydbio.2016.08.010. Epub 2016 Aug 10. Review.

8.

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.

9.

Intestinal stem cells.

Stange DE.

Dig Dis. 2013;31(3-4):293-8. doi: 10.1159/000355231. Epub 2013 Nov 14. Review.

PMID:
24246977
10.

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H.

Cell. 2013 Oct 10;155(2):357-68. doi: 10.1016/j.cell.2013.09.008.

11.

Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors.

Stange DE, Clevers H.

Stem Cells. 2013 Nov;31(11):2287-95. doi: 10.1002/stem.1475. Review.

12.

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.

Nature. 2012 Aug 30;488(7413):665-9. doi: 10.1038/nature11308.

PMID:
22895187
13.

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.

Kim HA, Koo BK, Cho JH, Kim YY, Seong J, Chang HJ, Oh YM, Stange DE, Park JG, Hwang D, Kong YY.

J Clin Invest. 2012 Sep;122(9):3248-59. doi: 10.1172/JCI61216. Epub 2012 Aug 6.

14.

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H.

Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.

15.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H.

EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166.

16.

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB.

Nat Cell Biol. 2012 Mar 4;14(4):401-8. doi: 10.1038/ncb2464.

17.

Controlled gene expression in primary Lgr5 organoid cultures.

Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.

Nat Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802.

PMID:
22138822
18.

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H.

Gastroenterology. 2011 Nov;141(5):1762-72. doi: 10.1053/j.gastro.2011.07.050. Epub 2011 Sep 2.

PMID:
21889923
19.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.

Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.

PMID:
21727895
20.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H.

Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28.

21.

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.

Kosinski C, Stange DE, Xu C, Chan AS, Ho C, Yuen ST, Mifflin RC, Powell DW, Clevers H, Leung SY, Chen X.

Gastroenterology. 2010 Sep;139(3):893-903. doi: 10.1053/j.gastro.2010.06.014. Epub 2010 Jun 11.

22.

Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.

Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B.

Gut. 2010 Sep;59(9):1236-44. doi: 10.1136/gut.2009.195701. Epub 2010 May 17.

PMID:
20479215
23.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.

24.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.

Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013.

25.

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H.

Gastroenterology. 2009 Oct;137(4):1333-45.e1-3. doi: 10.1053/j.gastro.2009.06.044. Epub 2009 Jun 21.

PMID:
19549527
26.

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.

van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H.

Gastroenterology. 2009 Jul;137(1):15-7. doi: 10.1053/j.gastro.2009.05.035. Epub 2009 May 18. No abstract available.

PMID:
19450592
27.

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H.

Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.

PMID:
19329995
28.

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H.

Gastroenterology. 2009 Jun;136(7):2187-2194.e1. doi: 10.1053/j.gastro.2009.03.002. Epub 2009 Mar 24.

PMID:
19324043
29.

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H.

Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.

30.

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

Fellermann K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, Bevins CL, Reinisch W, Teml A, Schwab M, Lichter P, Radlwimmer B, Stange EF.

Am J Hum Genet. 2006 Sep;79(3):439-48. Epub 2006 Jul 12.

31.

High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer.

Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter P.

Clin Cancer Res. 2006 Jan 15;12(2):345-52.

32.

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.

Mendrzyk F, Radlwimmer B, Joos S, Kokocinski F, Benner A, Stange DE, Neben K, Fiegler H, Carter NP, Reifenberger G, Korshunov A, Lichter P.

J Clin Oncol. 2005 Dec 1;23(34):8853-62.

PMID:
16314645
33.

Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization.

Zielinski B, Gratias S, Toedt G, Mendrzyk F, Stange DE, Radlwimmer B, Lohmann DR, Lichter P.

Genes Chromosomes Cancer. 2005 Jul;43(3):294-301.

PMID:
15834944

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