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Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme.

Carpenedo RL, Kwon SY, Tanner RM, Yockell-Lelièvre J, Choey C, Doré C, Ho M, Stewart DJ, Perkins TJ, Stanford WL.

Stem Cell Reports. 2019 Dec 10;13(6):1111-1125. doi: 10.1016/j.stemcr.2019.11.001.


Development of a novel screening platform for the identification of small molecule inhibitors of human adenovirus.

Saha B, Varette O, Stanford WL, Diallo JS, Parks RJ.

Virology. 2019 Dec;538:24-34. doi: 10.1016/j.virol.2019.09.005. Epub 2019 Sep 13.


Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression.

Shelton M, Ritso M, Liu J, O'Neil D, Kocharyan A, Rudnicki MA, Stanford WL, Skerjanc IS, Blais A.

PLoS One. 2019 Sep 27;14(9):e0222946. doi: 10.1371/journal.pone.0222946. eCollection 2019.


Evaluating dose-limiting toxicities of MDM2 inhibitors in patients with solid organ and hematologic malignancies: A systematic review of the literature.

Pi L, Rooprai J, Allan DS, Atkins H, Bredeson C, Fulcher AJ, Ito C, Ramsay T, Shorr, Stanford WL, Sabloff M, Christou G.

Leuk Res. 2019 Nov;86:106222. doi: 10.1016/j.leukres.2019.106222. Epub 2019 Sep 5.


The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier.

Hordeaux J, Yuan Y, Clark PM, Wang Q, Martino RA, Sims JJ, Bell P, Raymond A, Stanford WL, Wilson JM.

Mol Ther. 2019 May 8;27(5):912-921. doi: 10.1016/j.ymthe.2019.02.013. Epub 2019 Feb 20.


The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system.

Shrestha A, Brunette S, Stanford WL, Megeney LA.

Cell Discov. 2019 Jan 22;5:6. doi: 10.1038/s41421-018-0071-9. eCollection 2019.


Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High-Content Drug Screening.

Tam RY, Yockell-Lelièvre J, Smith LJ, Julian LM, Baker AEG, Choey C, Hasim MS, Dimitroulakos J, Stanford WL, Shoichet MS.

Adv Mater. 2019 Feb;31(7):e1806214. doi: 10.1002/adma.201806214. Epub 2018 Dec 27.


Could Immunotherapy Sink Its Teeth into Lymphangioleiomyomatosis?

Pietrobon A, Delaney SP, Stanford WL.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):663-665. doi: 10.1165/rcmb.2018-0251ED. No abstract available.


Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy.

Maganti HB, Jrade H, Cafariello C, Manias Rothberg JL, Porter CJ, Yockell-Lelièvre J, Battaion HL, Khan ST, Howard JP, Li Y, Grzybowski AT, Sabri E, Ruthenburg AJ, Dilworth FJ, Perkins TJ, Sabloff M, Ito CY, Stanford WL.

Cancer Discov. 2018 Nov;8(11):1376-1389. doi: 10.1158/2159-8290.CD-17-0841. Epub 2018 Aug 16.


Metformin Preconditioning of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells Promotes Their Engraftment and Improves Post-Stroke Regeneration and Recovery.

Ould-Brahim F, Sarma SN, Syal C, Lu KJ, Seegobin M, Carter A, Jeffers MS, Doré C, Stanford WL, Corbett D, Wang J.

Stem Cells Dev. 2018 Aug 15;27(16):1085-1096. doi: 10.1089/scd.2018.0055. Epub 2018 Jul 18.


Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.

Rothberg JLM, Maganti HB, Jrade H, Porter CJ, Palidwor GA, Cafariello C, Battaion HL, Khan ST, Perkins TJ, Paulson RF, Ito CY, Stanford WL.

Cell Discov. 2018 May 1;4:21. doi: 10.1038/s41421-018-0022-5. eCollection 2018.


Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition.

Li J, Li SH, Wu J, Weisel RD, Yao A, Stanford WL, Liu SM, Li RK.

Theranostics. 2018 Feb 12;8(7):1766-1781. doi: 10.7150/thno.22788. eCollection 2018.


Reprogramming patient-derived tumor cells generates model cell lines for tuberous sclerosis-associated lymphangioleiomyomatosis.

Julian LM, Stanford WL.

Oncoscience. 2017 Nov 2;4(11-12):170-172. doi: 10.18632/oncoscience.375. eCollection 2017 Nov. No abstract available.


Engineering PTEN-L for Cell-Mediated Delivery.

Lavictoire SJ, Gont A, Julian LM, Stanford WL, Vlasschaert C, Gray DA, Jomaa D, Lorimer IAJ.

Mol Ther Methods Clin Dev. 2017 Nov 21;9:12-22. doi: 10.1016/j.omtm.2017.11.006. eCollection 2018 Jun 15.


Human induced pluripotent stem cell-derived lung progenitor and alveolar epithelial cells attenuate hyperoxia-induced lung injury.

Shafa M, Ionescu LI, Vadivel A, Collins JJP, Xu L, Zhong S, Kang M, de Caen G, Daneshmand M, Shi J, Fu KZ, Qi A, Wang Y, Ellis J, Stanford WL, Thébaud B.

Cytotherapy. 2018 Jan;20(1):108-125. doi: 10.1016/j.jcyt.2017.09.003. Epub 2017 Oct 20.


Micro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis.

Barrera-Ramirez J, Lavoie JR, Maganti HB, Stanford WL, Ito C, Sabloff M, Brand M, Rosu-Myles M, Le Y, Allan DS.

Stem Cell Rev Rep. 2017 Dec;13(6):817-825. doi: 10.1007/s12015-017-9762-0.


Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis.

Kiernan J, Davies JE, Stanford WL.

Stem Cells Transl Med. 2017 Oct;6(10):1930-1939. doi: 10.1002/sctm.17-0054. Epub 2017 Aug 18. Review.


Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis.

Julian LM, Delaney SP, Wang Y, Goldberg AA, Doré C, Yockell-Lelièvre J, Tam RY, Giannikou K, McMurray F, Shoichet MS, Harper ME, Henske EP, Kwiatkowski DJ, Darling TN, Moss J, Kristof AS, Stanford WL.

Cancer Res. 2017 Oct 15;77(20):5491-5502. doi: 10.1158/0008-5472.CAN-17-0925. Epub 2017 Aug 22.


Sol gel-derived hydroxyapatite films over porous calcium polyphosphate substrates for improved tissue engineering of osteochondral-like constructs.

Lee WD, Gawri R, Pilliar RM, Stanford WL, Kandel RA.

Acta Biomater. 2017 Oct 15;62:352-361. doi: 10.1016/j.actbio.2017.08.016. Epub 2017 Aug 14.


Direct reprogramming with SOX factors: masters of cell fate.

Julian LM, McDonald AC, Stanford WL.

Curr Opin Genet Dev. 2017 Oct;46:24-36. doi: 10.1016/j.gde.2017.06.005. Epub 2017 Jul 4. Review.


Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.

Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Doré C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL.

Aging Cell. 2017 Aug;16(4):870-887. doi: 10.1111/acel.12621. Epub 2017 Jun 8.


Simple Silica Column-Based Method to Quantify Inorganic Polyphosphates in Cartilage and Other Tissues.

Lee WD, Gawri R, Shiba T, Ji AR, Stanford WL, Kandel RA.

Cartilage. 2018 Oct;9(4):417-427. doi: 10.1177/1947603517690856. Epub 2017 Mar 16.


PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Agnihotri S, Golbourn B, Huang X, Remke M, Younger S, Cairns RA, Chalil A, Smith CA, Krumholtz SL, Mackenzie D, Rakopoulos P, Ramaswamy V, Taccone MS, Mischel PS, Fuller GN, Hawkins C, Stanford WL, Taylor MD, Zadeh G, Rutka JT.

Cancer Res. 2016 Aug 15;76(16):4708-19. doi: 10.1158/0008-5472.CAN-15-3079. Epub 2016 Jun 20.


Human pluripotent stem cells.

Carpenedo RL, Julian LM, Stanford WL.

Methods. 2016 May 15;101:1-3. doi: 10.1016/j.ymeth.2016.04.012. Epub 2016 Apr 19. No abstract available.


Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age-Related Osteoporosis.

Kiernan J, Hu S, Grynpas MD, Davies JE, Stanford WL.

Stem Cells Transl Med. 2016 May;5(5):683-93. doi: 10.5966/sctm.2015-0231. Epub 2016 Mar 17.


Formula G1: Cell cycle in the driver's seat of stem cell fate determination.

Julian LM, Carpenedo RL, Rothberg JL, Stanford WL.

Bioessays. 2016 Apr;38(4):325-32. doi: 10.1002/bies.201500187. Epub 2016 Feb 9. Review.


MKRN1: Uncovering function by an unbiased systems approach.

Carpenedo RL, Cassar PA, Stanford WL.

Cell Cycle. 2016;15(3):303-4. doi: 10.1080/15384101.2015.1124698. Epub 2015 Dec 10. No abstract available.


Robust generation and expansion of skeletal muscle progenitors and myocytes from human pluripotent stem cells.

Shelton M, Kocharyan A, Liu J, Skerjanc IS, Stanford WL.

Methods. 2016 May 15;101:73-84. doi: 10.1016/j.ymeth.2015.09.019. Epub 2015 Sep 25.


Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

Cassar PA, Carpenedo RL, Samavarchi-Tehrani P, Olsen JB, Park CJ, Chang WY, Chen Z, Choey C, Delaney S, Guo H, Guo H, Tanner RM, Perkins TJ, Tenenbaum SA, Emili A, Wrana JL, Gibbings D, Stanford WL.

EMBO Rep. 2015 Oct;16(10):1334-57. doi: 10.15252/embr.201540974. Epub 2015 Aug 11.


Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells.

Lee WD, Hurtig MB, Pilliar RM, Stanford WL, Kandel RA.

Osteoarthritis Cartilage. 2015 Aug;23(8):1307-15. doi: 10.1016/j.joca.2015.04.010. Epub 2015 Apr 17.


The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis.

Delaney SP, Julian LM, Stanford WL.

Front Cell Dev Biol. 2014 Nov 25;2:69. doi: 10.3389/fcell.2014.00069. eCollection 2014. Review.


Sox17-mediated XEN cell conversion identifies dynamic networks controlling cell-fate decisions in embryo-derived stem cells.

McDonald AC, Biechele S, Rossant J, Stanford WL.

Cell Rep. 2014 Oct 23;9(2):780-93. doi: 10.1016/j.celrep.2014.09.026. Epub 2014 Oct 16.


Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.

Shelton M, Metz J, Liu J, Carpenedo RL, Demers SP, Stanford WL, Skerjanc IS.

Stem Cell Reports. 2014 Sep 9;3(3):516-29. doi: 10.1016/j.stemcr.2014.07.001. Epub 2014 Aug 7. Erratum in: Stem Cell Reports. 2014 Dec 9;3(6):1159.


Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS.

Dang LT, Feric NT, Laschinger C, Chang WY, Zhang B, Wood GA, Stanford WL, Radisic M.

Biomaterials. 2014 Sep;35(27):7786-99. doi: 10.1016/j.biomaterials.2014.05.018. Epub 2014 Jun 13.


Critical components of the pluripotency network are targets for the p300/CBP interacting protein (p/CIP) in embryonic stem cells.

Chitilian JM, Thillainadesan G, Manias JL, Chang WY, Walker E, Isovic M, Stanford WL, Torchia J.

Stem Cells. 2014 Jan;32(1):204-15. doi: 10.1002/stem.1564.


Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL.

PLoS One. 2013 Sep 25;8(9):e75472. doi: 10.1371/journal.pone.0075472. eCollection 2013.


Toll-like receptor 4/stem cell antigen 1 signaling promotes hematopoietic precursor cell commitment to granulocyte development during the granulopoietic response to Escherichia coli bacteremia.

Shi X, Siggins RW, Stanford WL, Melvan JN, Basson MD, Zhang P.

Infect Immun. 2013 Jun;81(6):2197-205. doi: 10.1128/IAI.01280-12. Epub 2013 Apr 1.


BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.

Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S.

J Thorac Cardiovasc Surg. 2013 Oct;146(4):949-960.e4. doi: 10.1016/j.jtcvs.2012.12.064. Epub 2013 Feb 14.


Feeder-independent derivation of induced-pluripotent stem cells from peripheral blood endothelial progenitor cells.

Chang WY, Lavoie JR, Kwon SY, Chen Z, Manias JL, Behbahani J, Ling V, Kandel RA, Stewart DJ, Stanford WL.

Stem Cell Res. 2013 Mar;10(2):195-202. doi: 10.1016/j.scr.2012.11.006. Epub 2012 Dec 3.


Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells.

Kinnear C, Chang WY, Khattak S, Hinek A, Thompson T, de Carvalho Rodrigues D, Kennedy K, Mahmut N, Pasceri P, Stanford WL, Ellis J, Mital S.

Stem Cells Transl Med. 2013 Jan;2(1):2-15. doi: 10.5966/sctm.2012-0054. Epub 2012 Dec 21.


Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.

Chaturvedi CP, Somasundaram B, Singh K, Carpenedo RL, Stanford WL, Dilworth FJ, Brand M.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18845-50. doi: 10.1073/pnas.1213951109. Epub 2012 Oct 29.


Mass spectrometry-based proteomic analysis of the matrix microenvironment in pluripotent stem cell culture.

Hughes C, Radan L, Chang WY, Stanford WL, Betts DH, Postovit LM, Lajoie GA.

Mol Cell Proteomics. 2012 Dec;11(12):1924-36. doi: 10.1074/mcp.M112.020057. Epub 2012 Sep 27.


The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.


Deciphering the complexities of human diseases and disorders by coupling induced-pluripotent stem cells and systems genetics.

Chang WY, Garcha K, Manias JL, Stanford WL.

Wiley Interdiscip Rev Syst Biol Med. 2012 Jul-Aug;4(4):339-50. doi: 10.1002/wsbm.1170. Epub 2012 Apr 10. Review.


Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.

Melvan JN, Siggins RW, Stanford WL, Porretta C, Nelson S, Bagby GJ, Zhang P.

J Immunol. 2012 Feb 15;188(4):1961-9. doi: 10.4049/jimmunol.1102395. Epub 2012 Jan 11.


BRCA1 is an essential regulator of heart function and survival following myocardial infarction.

Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S.

Nat Commun. 2011 Dec 20;2:593. doi: 10.1038/ncomms1601.


BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure.

Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S.

J Biol Chem. 2012 Feb 24;287(9):6604-14. doi: 10.1074/jbc.M111.292664. Epub 2011 Dec 8.


Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, Penninger JM.

Cell Stem Cell. 2011 Dec 2;9(6):563-74. doi: 10.1016/j.stem.2011.10.012.


Cardiac dysfunction and impaired compensatory response to pressure overload in mice deficient in stem cell antigen-1.

Rosenblatt-Velin N, Ogay S, Felley A, Stanford WL, Pedrazzini T.

FASEB J. 2012 Jan;26(1):229-39. doi: 10.1096/fj.11-189605. Epub 2011 Sep 28.


Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.

Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL.

Exp Hematol. 2012 Jan;40(1):48-60. doi: 10.1016/j.exphem.2011.09.007. Epub 2011 Sep 14.

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