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A dynamic switch in inactive p38γ leads to an excited state on pathway to an active kinase.

Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE.

Biochemistry. 2019 Dec 3. doi: 10.1021/acs.biochem.9b00932. [Epub ahead of print]


Structure and Dynamics of Stacking Interactions in an Antibody Binding Site.

Adhikary R, Zimmermann J, Stanfield RL, Wilson IA, Yu W, Oda M, Romesberg FE.

Biochemistry. 2019 Jul 9;58(27):2987-2995. doi: 10.1021/acs.biochem.9b00119. Epub 2019 Jun 19.


Super-Resolution Microscopy of Phloem Proteins.

Stanfield RC, Schulz A.

Methods Mol Biol. 2019;2014:83-94. doi: 10.1007/978-1-4939-9562-2_7.


Structural Insights into the Lipid A Transport Pathway in MsbA.

Padayatti PS, Lee SC, Stanfield RL, Wen PC, Tajkhorshid E, Wilson IA, Zhang Q.

Structure. 2019 Jul 2;27(7):1114-1123.e3. doi: 10.1016/j.str.2019.04.007. Epub 2019 May 23.


Stabilization of amyloidogenic immunoglobulin light chains by small molecules.

Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8360-8369. doi: 10.1073/pnas.1817567116. Epub 2019 Apr 10.


Integrating Prolonged Field Care Into Rough Terrain and Mountain Warfare Training: The Mountain Critical Care Course.

Nicholson B, Neskey J, Stanfield R, Fetterolf B, Ersando J, Cohen J, Kue R.

J Spec Oper Med. Spring 2019;19(1):66-69.


Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.

Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ.

ACS Cent Sci. 2019 Feb 27;5(2):237-249. doi: 10.1021/acscentsci.8b00588. Epub 2019 Feb 6.


Aquaporins Respond to Chilling in the Phloem by Altering Protein and mRNA Expression.

Stanfield R, Laur J.

Cells. 2019 Feb 27;8(3). pii: E202. doi: 10.3390/cells8030202.


Never too late for endothelin.

Stanfield RL.

Acta Crystallogr F Struct Biol Commun. 2019 Jan 1;75(Pt 1):45-46. doi: 10.1107/S2053230X18018101. Epub 2019 Jan 1. No abstract available.


Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.

Yang K, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10040-10045. doi: 10.1073/pnas.1810397115. Epub 2018 Sep 19.


Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.

Murin CD, Bruhn JF, Bornholdt ZA, Copps J, Stanfield R, Ward AB.

Cell Rep. 2018 Sep 4;24(10):2723-2732.e4. doi: 10.1016/j.celrep.2018.08.009.


Computational models evaluating the impact of sieve plates and radial water exchange on phloem pressure gradients.

Stanfield RC, Schulte PJ, Randolph KE, Hacke UG.

Plant Cell Environ. 2019 Feb;42(2):466-479. doi: 10.1111/pce.13414. Epub 2018 Sep 24.


Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.

Sarkar A, Bale S, Behrens AJ, Kumar S, Sharma SK, de Val N, Pallesen J, Irimia A, Diwanji DC, Stanfield RL, Ward AB, Crispin M, Wyatt RT, Wilson IA.

Nat Commun. 2018 May 16;9(1):1956. doi: 10.1038/s41467-018-04272-y.


CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso.

Nikolova EN, Stanfield RL, Dyson HJ, Wright PE.

Biochemistry. 2018 Apr 10;57(14):2109-2120. doi: 10.1021/acs.biochem.8b00065. Epub 2018 Mar 26.


The Unusual Genetics and Biochemistry of Bovine Immunoglobulins.

Stanfield RL, Haakenson J, Deiss TC, Criscitiello MF, Wilson IA, Smider VV.

Adv Immunol. 2018;137:135-164. doi: 10.1016/ Epub 2018 Feb 9.


Detect, correct, retract: How to manage incorrect structural models.

Wlodawer A, Dauter Z, Porebski PJ, Minor W, Stanfield R, Jaskolski M, Pozharski E, Weichenberger CX, Rupp B.

FEBS J. 2018 Feb;285(3):444-466. doi: 10.1111/febs.14320. Epub 2017 Nov 27. Review.


Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW.

J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28.


Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers.

Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U.

Sci Rep. 2017 Aug 21;7(1):8390. doi: 10.1038/s41598-017-08273-7.


Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.

Oyen D, Fenwick RB, Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE.

J Am Chem Soc. 2017 Aug 16;139(32):11233-11240. doi: 10.1021/jacs.7b05958. Epub 2017 Aug 3.


Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows.

Sok D, Le KM, Vadnais M, Saye-Francisco KL, Jardine JG, Torres JL, Berndsen ZT, Kong L, Stanfield R, Ruiz J, Ramos A, Liang CH, Chen PL, Criscitiello MF, Mwangi W, Wilson IA, Ward AB, Smider VV, Burton DR.

Nature. 2017 Aug 3;548(7665):108-111. doi: 10.1038/nature23301. Epub 2017 Jul 20.


Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.

Ozorowski G, Pallesen J, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB.

Nature. 2017 Jul 20;547(7663):360-363. doi: 10.1038/nature23010. Epub 2017 Jul 12.


Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.

Park S, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5335-E5342. doi: 10.1073/pnas.1703105114. Epub 2017 Jun 19.


The National Physician Associate Expansion Programme.

Akabogu U, Jenkins N, Stanfield R, Baker-Lacey D.

Future Healthc J. 2017 Jun;4(Suppl 2):s9. doi: 10.7861/futurehosp.4-2s-s9. No abstract available.


Are phloem sieve tubes leaky conduits supported by numerous aquaporins?

Stanfield RC, Hacke UG, Laur J.

Am J Bot. 2017 May;104(5):719-732. doi: 10.3732/ajb.1600422. Epub 2017 May 19.


Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.

Guenaga J, Garces F, de Val N, Stanfield RL, Dubrovskaya V, Higgins B, Carrette B, Ward AB, Wilson IA, Wyatt RT.

Immunity. 2017 May 16;46(5):792-803.e3. doi: 10.1016/j.immuni.2017.04.014.


Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

Irimia A, Serra AM, Sarkar A, Jacak R, Kalyuzhniy O, Sok D, Saye-Francisco KL, Schiffner T, Tingle R, Kubitz M, Adachi Y, Stanfield RL, Deller MC, Burton DR, Schief WR, Wilson IA.

PLoS Pathog. 2017 Feb 22;13(2):e1006212. doi: 10.1371/journal.ppat.1006212. eCollection 2017 Feb.


Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EM, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DA, Stanfield RL, Wilson IA, Burton DR, Schief WR.

PLoS Pathog. 2016 Sep 14;12(9):e1005905. doi: 10.1371/journal.ppat.1005905. eCollection 2016 Sep.


HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR.

Immunity. 2016 Sep 20;45(3):483-496. doi: 10.1016/j.immuni.2016.08.016. Epub 2016 Sep 8.


Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.

Stanfield RL, Wilson IA, Smider VV.

Sci Immunol. 2016 Jul;1(1). pii: aaf7962. doi: 10.1126/sciimmunol.aaf7962. Epub 2016 Jul 14.


Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DM, Stanfield RL, Wilson IA, Burton DR, Schief WR.

PLoS Pathog. 2016 Aug 25;12(8):e1005815. doi: 10.1371/journal.ppat.1005815. eCollection 2016 Aug. Erratum in: PLoS Pathog. 2016 Sep;12(9):e1005905.


Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.

Irimia A, Sarkar A, Stanfield RL, Wilson IA.

Immunity. 2016 Jan 19;44(1):21-31. doi: 10.1016/j.immuni.2015.12.001. Epub 2016 Jan 5.


Additional Comment on Three X-ray Crystal Structure Papers.

Stanfield R, Pozharski E, Rupp B.

J Immunol. 2016 Jan 15;196(2):528-30. doi: 10.4049/jimmunol.1502281. No abstract available.


Comment on Three X-ray Crystal Structure Papers.

Stanfield R, Pozharski E, Rupp B.

J Immunol. 2016 Jan 15;196(2):521-4. doi: 10.4049/jimmunol.1501343. No abstract available.


Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Garces F, Lee JH, de Val N, de la Pena AT, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA.

Immunity. 2015 Dec 15;43(6):1053-63. doi: 10.1016/j.immuni.2015.11.007.


Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

Kong L, Torrents de la Peña A, Deller MC, Garces F, Sliepen K, Hua Y, Stanfield RL, Sanders RW, Wilson IA.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2099-108. doi: 10.1107/S1399004715013917. Epub 2015 Sep 26.


Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.

Wu Y, Stauffer SR, Stanfield RL, Tapia PH, Ursu O, Fisher GW, Szent-Gyorgyi C, Evangelisti A, Waller A, Strouse JJ, Carter MB, Bologa C, Gouveia K, Poslusney M, Waggoner AS, Lindsley CW, Jarvik JW, Sklar LA.

J Biomol Screen. 2016 Jan;21(1):74-87. doi: 10.1177/1087057115609145. Epub 2015 Oct 6.


Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity.

Hu JK, Crampton JC, Cupo A, Ketas T, van Gils MJ, Sliepen K, de Taeye SW, Sok D, Ozorowski G, Deresa I, Stanfield R, Ward AB, Burton DR, Klasse PJ, Sanders RW, Moore JP, Crotty S.

J Virol. 2015 Oct;89(20):10383-98. doi: 10.1128/JVI.01653-15. Epub 2015 Aug 5.


Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.

Oyen D, Fenwick RB, Stanfield RL, Dyson HJ, Wright PE.

J Am Chem Soc. 2015 Jul 29;137(29):9459-68. doi: 10.1021/jacs.5b05707. Epub 2015 Jul 14.


Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526.

Kong L, Kadam RU, Giang E, Ruwona TB, Nieusma T, Culhane JC, Stanfield RL, Dawson PE, Wilson IA, Law M.

J Mol Biol. 2015 Aug 14;427(16):2617-28. doi: 10.1016/j.jmb.2015.06.012. Epub 2015 Jun 30.


Adaptive mutations alter antibody structure and dynamics during affinity maturation.

Adhikary R, Yu W, Oda M, Walker RC, Chen T, Stanfield RL, Wilson IA, Zimmermann J, Romesberg FE.

Biochemistry. 2015 Mar 24;54(11):2085-93. doi: 10.1021/bi501417q. Epub 2015 Mar 10.


Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose.

Stanfield RL, De Castro C, Marzaioli AM, Wilson IA, Pantophlet R.

Glycobiology. 2015 Apr;25(4):412-9. doi: 10.1093/glycob/cwu123. Epub 2014 Nov 7.


Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.

Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ.

J Biol Chem. 2014 Nov 28;289(48):33557-67. doi: 10.1074/jbc.M114.607176. Epub 2014 Oct 15.


Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy.

Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB.

J Virol. 2014 Sep 1;88(17):10177-88. doi: 10.1128/JVI.01229-14. Epub 2014 Jun 25.


Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.

Lee PS, Ohshima N, Stanfield RL, Yu W, Iba Y, Okuno Y, Kurosawa Y, Wilson IA.

Nat Commun. 2014 Apr 10;5:3614. doi: 10.1038/ncomms4614.


Antibody Structure.

Stanfield RL, Wilson IA.

Microbiol Spectr. 2014 Apr;2(2). doi: 10.1128/microbiolspec.AID-0012-2013. Review.


Antibody modeling assessment II. Structures and models.

Teplyakov A, Luo J, Obmolova G, Malia TJ, Sweet R, Stanfield RL, Kodangattil S, Almagro JC, Gilliland GL.

Proteins. 2014 Aug;82(8):1563-82. doi: 10.1002/prot.24554. Epub 2014 Mar 31.


Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign.

Tran K, Poulsen C, Guenaga J, de Val N, Wilson R, Sundling C, Li Y, Stanfield RL, Wilson IA, Ward AB, Karlsson Hedestam GB, Wyatt RT.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E738-47. doi: 10.1073/pnas.1319512111. Epub 2014 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1159. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7). doi:10.1073/pnas.1403776111. de Val Alda, Natalia [corrected to de Val, Natalia].


Determination of antibody structures.

Stanfield RL.

Methods Mol Biol. 2014;1131:395-406. doi: 10.1007/978-1-62703-992-5_23.


Crystal structure determination of anti-DNA Fab A52.

Stanfield RL, Eilat D.

Proteins. 2014 Aug;82(8):1674-8. doi: 10.1002/prot.24514. Epub 2014 Feb 18.


Effects of phyllotaxy on biomechanical properties of stems of Cercis occidentalis (Fabaceae).

Caringella MA, Bergman BA, Stanfield RC, Ewers MM, Bobich EG, Ewers FW.

Am J Bot. 2014 Jan;101(1):206-10. doi: 10.3732/ajb.1300260. Epub 2013 Dec 26.

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