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Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning.

Solans BP, Chiesa R, Doncheva B, Prunty H, Veys P, Trocóniz IF, Standing JF.

Br J Clin Pharmacol. 2020 Feb 19. doi: 10.1111/bcp.14260. [Epub ahead of print]


Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Pan S, Tsakok T, Dand N, Lonsdale DO, Loeff FC, Bloem K, de Vries A, Baudry D, Duckworth M, Mahil S, Pushpa-Rajah A, Russell A, Alsharqi A, Becher G, Murphy R, Wahie S, Wright A, Griffiths CEM, Reynolds NJ, Barker J, Warren RB, David Burden A, Rispens T, Standing JF, Smith CH; BADBIR Study Group, the BSTOP Study Group, the PSORT Consortium.

Clin Transl Sci. 2020 Mar;13(2):400-409. doi: 10.1111/cts.12725. Epub 2020 Jan 29.


Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view.

Folgori L, Lutsar I, Standing JF, Walker AS, Roilides E, Zaoutis TE, Jafri H, Giaquinto C, Turner MA, Sharland M.

BMJ Open. 2019 Dec 31;9(12):e032592. doi: 10.1136/bmjopen-2019-032592.


Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review.

Rashed AN, Jackson C, Gastine S, Hsia Y, Bielicki J, Standing JF, Tomlin S, Sharland M.

Expert Rev Clin Pharmacol. 2019 Dec;12(12):1099-1106. doi: 10.1080/17512433.2019.1693257. Epub 2019 Nov 25.


GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies - development and application in pediatric antibiotic studies.

Gastine S, Rashed AN, Hsia Y, Jackson C, Barker CIS, Mathur S, Tomlin S, Lutsar I, Bielicki J, Standing JF, Sharland M.

Expert Rev Clin Pharmacol. 2019 Dec;12(12):1091-1098. doi: 10.1080/17512433.2019.1695600. Epub 2019 Nov 30. Review.


Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial.

Chiesa R, Standing JF, Winter R, Nademi Z, Chu J, Pinner D, Kloprogge F, McLellen S, Amrolia PJ, Rao K, Lucchini G, Silva J, Ciocarlie O, Lazareva A, Gennery AR, Doncheva B, Cant AJ, Hambleton S, Flood T, Rogerson E, Devine K, Prunty H, Heales S, Veys P, Slatter M.

Clin Pharmacol Ther. 2019 Nov 7. doi: 10.1002/cpt.1715. [Epub ahead of print]


Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life.

Hallik M, Ilmoja ML, Standing JF, Soeorg H, Jalas T, Raidmäe M, Uibo K, Köbas K, Sõnajalg M, Takkis K, Veigure R, Kipper K, Starkopf J, Metsvaht T.

Br J Clin Pharmacol. 2020 Feb;86(2):318-328. doi: 10.1111/bcp.14146. Epub 2020 Jan 17.


Cefepime/sulbactam as an enhanced antimicrobial combination therapy for the treatment of MDR Gram-negative infections.

Wareham DW, Momin MHFA, Phee LM, Hornsey M, Standing JF.

J Antimicrob Chemother. 2020 Jan 1;75(1):135-139. doi: 10.1093/jac/dkz420.


Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis.

Tsakok T, Wilson N, Dand N, Loeff FC, Bloem K, Baudry D, Duckworth M, Pan S, Pushpa-Rajah A, Standing JF, de Vries A, Alsharqi A, Becher G, Murphy R, Wahie S, Wright A, Griffiths CEM, Reynolds NJ, Barker J, Warren RB, Burden AD, Rispens T, Stocken D, Smith C; British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR) Study Group and the Psoriasis Stratification to Optimise Relevant Therapy (PSORT) Consortium.

JAMA Dermatol. 2019 Sep 18. doi: 10.1001/jamadermatol.2019.1783. [Epub ahead of print]


Optimizing clonidine dosage for sedation in mechanically ventilated children: A pharmacokinetic simulation study.

Hayden JC, Bardol M, Doherty DR, Dawkins I, Healy M, Breatnach CV, Gallagher PJ, Cousins G, Standing JF.

Paediatr Anaesth. 2019 Oct;29(10):1002-1010. doi: 10.1111/pan.13715. Epub 2019 Aug 26.


Pharmacodynamics of rituximab on B lymphocytes in paediatric patients with autoimmune diseases.

Pan S, Yu H, Surti A, Cheng I, Marks SD, Brogan PA, Eleftheriou D, Standing JF.

Br J Clin Pharmacol. 2019 Aug;85(8):1790-1797. doi: 10.1111/bcp.13970. Epub 2019 Jun 20.


Revising Pediatric Vancomycin Dosing Accounting for Nephrotoxicity in a Pharmacokinetic-Pharmacodynamic Model.

Kloprogge F, Hill LF, Booth J, Klein N, Irwin AD, Dixon G, Standing JF.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e00067-19. doi: 10.1128/AAC.00067-19. Print 2019 May.


A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load.

Johnson SM, Standing JF, Klein N, Irwin AD, Shingadia D, Lonsdale DO, Gilmour KC, Flynn J, Manns C, Clapson M, Bamford A.

HIV Med. 2019 Apr;20(4):e8-e9. doi: 10.1111/hiv.12706. Epub 2019 Jan 28. No abstract available.


Development and external evaluation of a population pharmacokinetic model for continuous and intermittent administration of vancomycin in neonates and infants using prospectively collected data.

Germovsek E, Osborne L, Gunaratnam F, Lounis SA, Busquets FB, Standing JF, Sinha AK.

J Antimicrob Chemother. 2019 Apr 1;74(4):1003-1011. doi: 10.1093/jac/dky525.


Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants.

Hallik M, Ilmoja ML, Tasa T, Standing JF, Takkis K, Veigure R, Kipper K, Jalas T, Raidmäe M, Uibo K, Starkopf J, Metsvaht T.

Pediatr Crit Care Med. 2019 Jul;20(7):621-629. doi: 10.1097/PCC.0000000000001879.


Pharmacokinetic-pharmacodynamic modelling to investigate in vitro synergy between colistin and fusidic acid against MDR Acinetobacter baumannii.

Phee LM, Kloprogge F, Morris R, Barrett J, Wareham DW, Standing JF.

J Antimicrob Chemother. 2019 Apr 1;74(4):961-969. doi: 10.1093/jac/dky524.


What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies.

Picetti R, Shakur-Still H, Medcalf RL, Standing JF, Roberts I.

Blood Coagul Fibrinolysis. 2019 Jan;30(1):1-10. doi: 10.1097/MBC.0000000000000789.


The use of polymyxins to treat carbapenem resistant infections in neonates and children.

Thomas R, Velaphi S, Ellis S, Walker AS, Standing JF, Heath P, Sharland M, Dona' D.

Expert Opin Pharmacother. 2019 Mar;20(4):415-422. doi: 10.1080/14656566.2018.1559817. Epub 2018 Dec 21. Review.


Correction to: Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.

Boonsathorn S, Cheng I, Kloprogge F, Alonso C, Lee C, Doncheva B, Booth J, Chiesa R, Irwin A, Standing JF.

Clin Pharmacokinet. 2019 Jan;58(1):141. doi: 10.1007/s40262-018-0722-x.


Correction to: Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance.

Germovsek E, Barker CIS, Sharland M, Standing JF.

Clin Pharmacokinet. 2019 Jan;58(1):139. doi: 10.1007/s40262-018-0723-9.


Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation.

Gkazi AS, Margetts BK, Attenborough T, Mhaldien L, Standing JF, Oakes T, Heather JM, Booth J, Pasquet M, Chiesa R, Veys P, Klein N, Chain B, Callard R, Adams SP.

Front Immunol. 2018 Nov 5;9:2547. doi: 10.3389/fimmu.2018.02547. eCollection 2018.


Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media.

Mead A, Lees P, Mitchell J, Rycroft A, Standing JF, Toutain PL, Pelligand L.

J Vet Pharmacol Ther. 2019 Jan;42(1):52-59. doi: 10.1111/jvp.12719. Epub 2018 Sep 28.


Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age.

Lonsdale DO, Baker EH, Kipper K, Barker C, Philips B, Rhodes A, Sharland M, Standing JF.

Br J Clin Pharmacol. 2019 Feb;85(2):316-346. doi: 10.1111/bcp.13756. Epub 2018 Nov 26.


Corrigendum to "Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine" (Br J Anaesth 2018; 120: 960-968).

Li A, Yuen VM, Goulay-Dufaÿ S, Sheng Y, Standing JF, Kwok PCL, Leung MKM, Leung AS, Wong ICK, Irwin MG.

Br J Anaesth. 2018 Sep;121(3):687. doi: 10.1016/j.bja.2018.07.001. Epub 2018 Jul 24. No abstract available.


Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate.

Hecht M, Veigure R, Couchman L, S Barker CI, Standing JF, Takkis K, Evard H, Johnston A, Herodes K, Leito I, Kipper K.

Bioanalysis. 2018 Aug 1;10(15):1229-1248. doi: 10.4155/bio-2018-0078. Epub 2018 Jul 23.


Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".

Standing JF, Anderson BJ, Hennig S, Holford NH, Johnston TN, Knibbe CAJ, Lonsdale DO, Rostami-Hodjegan A.

Clin Pharmacokinet. 2018 Nov;57(11):1471-1472. doi: 10.1007/s40262-018-0697-7. No abstract available.


Use of Whole-Genome Sequencing of Adenovirus in Immunocompromised Pediatric Patients to Identify Nosocomial Transmission and Mixed-Genotype Infection.

Houldcroft CJ, Roy S, Morfopoulou S, Margetts BK, Depledge DP, Cudini J, Shah D, Brown JR, Romero EY, Williams R, Cloutman-Green E, Rao K, Standing JF, Hartley JC, Breuer J.

J Infect Dis. 2018 Sep 8;218(8):1261-1271. doi: 10.1093/infdis/jiy323.


External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

Ge S, Beechinor RJ, Hornik CP, Standing JF, Zimmerman K, Cohen-Wolkowiez M, Laughon MM, Clark R, Gonzalez D.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00669-18. doi: 10.1128/AAC.00669-18. Print 2018 Sep.


Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.

Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium.

J Antimicrob Chemother. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128.


Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.

Boonsathorn S, Cheng I, Kloprogge F, Alonso C, Lee C, Doncheva B, Booth J, Chiesa R, Irwin A, Standing JF.

Clin Pharmacokinet. 2019 Jan;58(1):53-61. doi: 10.1007/s40262-018-0658-1. Erratum in: Clin Pharmacokinet. 2018 Dec 17;:.


Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance.

Germovsek E, Barker CIS, Sharland M, Standing JF.

Clin Pharmacokinet. 2019 Jan;58(1):39-52. doi: 10.1007/s40262-018-0659-0. Review. Erratum in: Clin Pharmacokinet. 2018 Dec 17;:.


Pharmacokinetic studies in children: recommendations for practice and research.

Barker CIS, Standing JF, Kelly LE, Hanly Faught L, Needham AC, Rieder MJ, de Wildt SN, Offringa M.

Arch Dis Child. 2018 Jul;103(7):695-702. doi: 10.1136/archdischild-2017-314506. Epub 2018 Apr 19. Review.


Useful pharmacodynamic endpoints in children: selection, measurement, and next steps.

Kelly LE, Sinha Y, Barker CIS, Standing JF, Offringa M.

Pediatr Res. 2018 Jun;83(6):1095-1103. doi: 10.1038/pr.2018.38. Epub 2018 Apr 18. Review.


Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine.

Li A, Yuen VM, Goulay-Dufaÿ S, Sheng Y, Standing JF, Kwok PCL, Leung MKM, Leung AS, Wong ICK, Irwin MG.

Br J Anaesth. 2018 May;120(5):960-968. doi: 10.1016/j.bja.2017.11.100. Epub 2018 Feb 2. Erratum in: Br J Anaesth. 2018 Sep;121(3):687.


Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition.

Standing JF, Ongas MO, Ogwang C, Kagwanja N, Murunga S, Mwaringa S, Ali R, Mturi N, Timbwa M, Manyasi C, Mwalekwa L, Bandika VL, Ogutu B, Waichungo J, Kipper K, Berkley JA; FLACSAM-PK Study Group.

Clin Pharmacol Ther. 2018 Dec;104(6):1165-1174. doi: 10.1002/cpt.1078. Epub 2018 Apr 19.


Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages.

Voak AA, Standing JF, Sepúlveda N, Harris A, Croft SL, Seifert K.

J Antimicrob Chemother. 2018 May 1;73(5):1314-1323. doi: 10.1093/jac/dky014.


Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children.

Ongas M, Standing J, Ogutu B, Waichungo J, Berkley JA, Kipper K.

Wellcome Open Res. 2017 Jun 19;2:43. doi: 10.12688/wellcomeopenres.11728.2. eCollection 2017.


Pharmacokinetics of Penicillin G in Preterm and Term Neonates.

Padari H, Metsvaht T, Germovsek E, Barker CI, Kipper K, Herodes K, Standing JF, Oselin K, Tasa T, Soeorg H, Lutsar I.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02238-17. doi: 10.1128/AAC.02238-17. Print 2018 May.


Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design.

Kipper K, Barker CIS, Standing JF, Sharland M, Johnston A.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01540-17. doi: 10.1128/AAC.01540-17. Print 2018 Jan.


Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).

Musuamba FT, Manolis E, Holford N, Cheung S, Friberg LE, Ogungbenro K, Posch M, Yates J, Berry S, Thomas N, Corriol-Rohou S, Bornkamp B, Bretz F, Hooker AC, Van der Graaf PH, Standing JF, Hay J, Cole S, Gigante V, Karlsson K, Dumortier T, Benda N, Serone F, Das S, Brochot A, Ehmann F, Hemmings R, Rusten IS.

CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):418-429. doi: 10.1002/psp4.12196. Epub 2017 Jul 19.


Commentary on the MID3 Good Practices Paper.

Manolis E, Brogren J, Cole S, Hay JL, Nordmark A, Karlsson KE, Lentz F, Benda N, Wangorsch G, Pons G, Zhao W, Gigante V, Serone F, Standing JF, Dokoumetzidis A, Vakkilainen J, van den Heuvel M, Mangas Sanjuan V, Taminiau J, Kerwash E, Khan D, Musuamba FT, Skottheim Rusten I; EMA Modelling and Simulation Working Group.

CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):416-417. doi: 10.1002/psp4.12223. Epub 2017 Jul 22.


The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.

Neubert A, Baarslag MA, Dijk MV, Rosmalen JV, Standing JF, Sheng Y, Rascher W, Roberts D, Winslade J, Rawcliffe L, Hanning SM, Metsvaht T, Giannuzzi V, Larsson P, Pokorná P, Simonetti A, Tibboel D; CLOSED Consortium.

BMJ Open. 2017 Jun 21;7(6):e016031. doi: 10.1136/bmjopen-2017-016031. Erratum in: BMJ Open. 2017 Nov 8;7(11):e016031corr1.


The Potential Role of Fosfomycin in Neonatal Sepsis Caused by Multidrug-Resistant Bacteria.

Li G, Standing JF, Bielicki J, Hope W, van den Anker J, Heath PT, Sharland M.

Drugs. 2017 Jun;77(9):941-950. doi: 10.1007/s40265-017-0745-x. Review.


A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive.

Veigure R, Aro R, Metsvaht T, Standing JF, Lutsar I, Herodes K, Kipper K; CloSed Consortium.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:150-157. doi: 10.1016/j.jchromb.2017.03.007. Epub 2017 Mar 10.


Effect of age on the performance of bispectral and entropy indices during sevoflurane pediatric anesthesia: a pharmacometric study.

Sciusco A, Standing JF, Sheng Y, Raimondo P, Cinnella G, Dambrosio M.

Paediatr Anaesth. 2017 Apr;27(4):399-408. doi: 10.1111/pan.13086. Epub 2017 Feb 17.


Predicting CD4 T-Cell Reconstitution Following Pediatric Hematopoietic Stem Cell Transplantation.

Hoare RL, Veys P, Klein N, Callard R, Standing JF.

Clin Pharmacol Ther. 2017 Aug;102(2):349-357. doi: 10.1002/cpt.621. Epub 2017 May 26.


Scaling clearance in paediatric pharmacokinetics: All models are wrong, which are useful?

Germovsek E, Barker CI, Sharland M, Standing JF.

Br J Clin Pharmacol. 2017 Apr;83(4):777-790. doi: 10.1111/bcp.13160. Epub 2016 Dec 2.


Understanding and applying pharmacometric modelling and simulation in clinical practice and research.

Standing JF.

Br J Clin Pharmacol. 2017 Feb;83(2):247-254. doi: 10.1111/bcp.13119. Epub 2016 Sep 29. Review.


New generalized poisson mixture model for bimodal count data with drug effect: An application to rodent brief-access taste aversion experiments.

Sheng Y, Soto J, Orlu Gul M, Cortina-Borja M, Tuleu C, Standing JF.

CPT Pharmacometrics Syst Pharmacol. 2016 Aug;5(8):427-36. doi: 10.1002/psp4.12093. Epub 2016 Jul 29.


Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants.

Germovsek E, Kent A, Metsvaht T, Lutsar I, Klein N, Turner MA, Sharland M, Nielsen EI, Heath PT, Standing JF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77. doi: 10.1128/AAC.00577-16. Print 2016 Aug.

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