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Pneumococcal Conjugate Vaccine Modulates Macrophage-mediated Innate Immunity in Pneumonia Caused by Streptococcus pneumoniae Following Influenza.

Mimura K, Kimura S, Kajiwara C, Nakakubo S, Schaller MA, Ishii Y, Standiford TJ, Kunkel SL, Tateda K.

Microbes Infect. 2020 Jan 17. pii: S1286-4579(20)30008-3. doi: 10.1016/j.micinf.2019.12.005. [Epub ahead of print]


Transcriptomic Profiles of Sepsis in the Human Brain.

Bustamante AC, Opron K, Ehlenbach WJ, Larson EB, Crane PK, Keene CD, Standiford TJ, Singer BH.

Am J Respir Crit Care Med. 2020 Jan 15. doi: 10.1164/rccm.201909-1713LE. [Epub ahead of print] No abstract available.


Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation.

Agarwal S, Loder SJ, Cholok D, Li J, Bian G, Yalavarthi S, Li S, Carson WF, Hwang C, Marini S, Pagani C, Edwards N, Delano MJ, Standiford TJ, Knight JS, Kunkel SL, Mishina Y, Ward PA, Levi B.

Front Immunol. 2019 Oct 24;10:2148. doi: 10.3389/fimmu.2019.02148. eCollection 2019.


Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease.

Diao W, Labaki WW, Han MK, Yeomans L, Sun Y, Smiley Z, Kim JH, McHugh C, Xiang P, Shen N, Sun X, Guo C, Lu M, Standiford TJ, He B, Stringer KA.

Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2015-2025. doi: 10.2147/COPD.S210598. eCollection 2019.


Persistent Neuroinflammation and Brain Specific Immune Priming in A Novel Survival Model of Murine Pneumosepsis.

Denstaedt SJ, Spencer-Segal JL, Newstead M, Laborc K, Zeng X, Standiford TJ, Singer BH.

Shock. 2019 Aug 13. doi: 10.1097/SHK.0000000000001435. [Epub ahead of print]


Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.

Labaki WW, Gu T, Murray S, Curtis JL, Yeomans L, Bowler RP, Barr RG, Comellas AP, Hansel NN, Cooper CB, Barjaktarevic I, Kanner RE, Paine R 3rd, McDonald MN, Krishnan JA, Peters SP, Woodruff PG, O'Neal WK, Diao W, He B, Martinez FJ, Standiford TJ, Stringer KA, Han MK.

Sci Rep. 2019 Aug 6;9(1):11367. doi: 10.1038/s41598-019-47761-w.


Inkjet-printed micro-calibration standards for ultraquantitative Raman spectral cytometry.

LaLone V, Fawaz MV, Morales-Mercado J, Mourão MA, Snyder CS, Kim SY, Lieberman AP, Tuteja A, Mehta G, Standiford TJ, Raghavendran K, Shedden K, Schwendeman A, Stringer KA, Rosania GR.

Analyst. 2019 Jun 21;144(12):3790-3799. doi: 10.1039/c9an00500e. Epub 2019 May 22.


Sepsis and Nosocomial Infection: Patient Characteristics, Mechanisms, and Modulation.

Denstaedt SJ, Singer BH, Standiford TJ.

Front Immunol. 2018 Oct 23;9:2446. doi: 10.3389/fimmu.2018.02446. eCollection 2018. Review.


An Expandable Mechanopharmaceutical Device (3): a Versatile Raman Spectral Cytometry Approach to Study the Drug Cargo Capacity of Individual Macrophages.

LaLone V, Mourão MA, Standiford TJ, Raghavendran K, Shedden K, Stringer KA, Rosania GR.

Pharm Res. 2018 Nov 6;36(1):2. doi: 10.1007/s11095-018-2540-0.


Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia.

Nanjo Y, Newstead MW, Aoyagi T, Zeng X, Takahashi K, Yu FS, Tateda K, Standiford TJ.

Infect Immun. 2018 Dec 19;87(1). pii: e00583-18. doi: 10.1128/IAI.00583-18. Print 2019 Jan.


Macrophage Polarization in Sarcoidosis: An Unexpected Accomplice?

Standiford TJ.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):9-10. doi: 10.1165/rcmb.2018-0298ED. No abstract available.


Potential Role of Gr-1+ CD8+ T Lymphocytes as a Source of Interferon-γ and M1/M2 Polarization during the Acute Phase of Murine Legionella pneumophila Pneumonia.

Kusaka Y, Kajiwara C, Shimada S, Ishii Y, Miyazaki Y, Inase N, Standiford TJ, Tateda K.

J Innate Immun. 2018;10(4):328-338. doi: 10.1159/000490585. Epub 2018 Jul 18.


Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study.

Maile MD, Standiford TJ, Engoren MC, Stringer KA, Jewell ES, Rajendiran TM, Soni T, Burant CF.

Respir Res. 2018 Apr 10;19(1):60. doi: 10.1186/s12931-018-0758-3.


S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis.

Denstaedt SJ, Spencer-Segal JL, Newstead MW, Laborc K, Zhao AP, Hjelmaas A, Zeng X, Akil H, Standiford TJ, Singer BH.

J Immunol. 2018 May 1;200(9):3188-3200. doi: 10.4049/jimmunol.1700834. Epub 2018 Mar 21.


Epithelial-mesenchymal transition leads to NK cell-mediated metastasis-specific immunosurveillance in lung cancer.

Chockley PJ, Chen J, Chen G, Beer DG, Standiford TJ, Keshamouni VG.

J Clin Invest. 2018 Apr 2;128(4):1384-1396. doi: 10.1172/JCI97611. Epub 2018 Feb 26.


Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species.

Kajiwara C, Kusaka Y, Kimura S, Yamaguchi T, Nanjo Y, Ishii Y, Udono H, Standiford TJ, Tateda K.

J Immunol. 2018 Jan 15;200(2):623-631. doi: 10.4049/jimmunol.1700474. Epub 2017 Dec 15.


Bacterial Dissemination to the Brain in Sepsis.

Singer BH, Dickson RP, Denstaedt SJ, Newstead MW, Kim K, Falkowski NR, Erb-Downward JR, Schmidt TM, Huffnagle GB, Standiford TJ.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):747-756. doi: 10.1164/rccm.201708-1559OC.


Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2.

Aoyagi T, Newstead MW, Zeng X, Nanjo Y, Peters-Golden M, Kaku M, Standiford TJ.

PLoS Pathog. 2017 Nov 22;13(11):e1006737. doi: 10.1371/journal.ppat.1006737. eCollection 2017 Nov.


Reply: Comments on "Stressing the Brain…Acute Respiratory Distress Syndrome".

Spencer-Segal JL, Standiford TJ.

Ann Am Thorac Soc. 2018 Jan;15(1):115. doi: 10.1513/AnnalsATS.201708-697LE. No abstract available.


Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.


Metabolomics as a Driver in Advancing Precision Medicine in Sepsis.

Eckerle M, Ambroggio L, Puskarich MA, Winston B, Jones AE, Standiford TJ, Stringer KA.

Pharmacotherapy. 2017 Sep;37(9):1023-1032. doi: 10.1002/phar.1974. Epub 2017 Jul 31. Review.


Psychiatric Symptoms in Survivors of Acute Respiratory Distress Syndrome. Effects of Age, Sex, and Immune Modulation.

Spencer-Segal JL, Hyzy RC, Iwashyna TJ, Standiford TJ.

Ann Am Thorac Soc. 2017 Jun;14(6):960-967. doi: 10.1513/AnnalsATS.201606-468OC.


IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.

Ross BX, Gao N, Cui X, Standiford TJ, Xu J, Yu FX.

J Immunol. 2017 May 1;198(9):3536-3547. doi: 10.4049/jimmunol.1602087. Epub 2017 Mar 22.


IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

Kovach MA, Singer B, Martinez-Colon G, Newstead MW, Zeng X, Mancuso P, Moore TA, Kunkel SL, Peters-Golden M, Moore BB, Standiford TJ.

Mucosal Immunol. 2017 Sep;10(5):1320-1334. doi: 10.1038/mi.2016.130. Epub 2017 Feb 8.


IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.

Aoyagi T, Newstead MW, Zeng X, Kunkel SL, Kaku M, Standiford TJ.

Mucosal Immunol. 2017 Jul;10(4):1043-1055. doi: 10.1038/mi.2016.107. Epub 2016 Dec 14.


Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome.

Dickson RP, Singer BH, Newstead MW, Falkowski NR, Erb-Downward JR, Standiford TJ, Huffnagle GB.

Nat Microbiol. 2016 Jul 18;1(10):16113. doi: 10.1038/nmicrobiol.2016.113.


Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State.

Yoon GS, Keswani RK, Sud S, Rzeczycki PM, Murashov MD, Koehn TA, Standiford TJ, Stringer KA, Rosania GR.

Antimicrob Agents Chemother. 2016 May 23;60(6):3470-9. doi: 10.1128/AAC.00265-16. Print 2016 Jun.


IL-36γ is secreted in microparticles and exosomes by lung macrophages in response to bacteria and bacterial components.

Kovach MA, Singer BH, Newstead MW, Zeng X, Moore TA, White ES, Kunkel SL, Peters-Golden M, Standiford TJ.

J Leukoc Biol. 2016 Aug;100(2):413-21. doi: 10.1189/jlb.4A0315-087R. Epub 2016 Feb 10.


Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation.

Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ.

PLoS One. 2016 Feb 10;11(2):e0149136. doi: 10.1371/journal.pone.0149136. eCollection 2016.


MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway.

Podsiad A, Standiford TJ, Ballinger MN, Eakin R, Park P, Kunkel SL, Moore BB, Bhan U.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L465-75. doi: 10.1152/ajplung.00224.2015. Epub 2015 Nov 20.


A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs.

Lin S, Racz J, Tai MF, Brooks KM, Rzeczycki P, Heath LJ, Newstead MW, Standiford TJ, Rosania GR, Stringer KA.

Pharm Res. 2016 Jan;33(1):72-82. doi: 10.1007/s11095-015-1763-6. Epub 2015 Aug 1.


Regulation of complement-dependent cytotoxicity by TGF-β-induced epithelial-mesenchymal transition.

Goswami MT, Reka AK, Kurapati H, Kaza V, Chen J, Standiford TJ, Keshamouni VG.

Oncogene. 2016 Apr 14;35(15):1888-98. doi: 10.1038/onc.2015.258. Epub 2015 Jul 6.


Therapeutic targeting of acute lung injury and acute respiratory distress syndrome.

Standiford TJ, Ward PA.

Transl Res. 2016 Jan;167(1):183-91. doi: 10.1016/j.trsl.2015.04.015. Epub 2015 May 5. Review.


Epigenetic Regulation of Tolerance to Toll-Like Receptor Ligands in Alveolar Epithelial Cells.

Neagos J, Standiford TJ, Newstead MW, Zeng X, Huang SK, Ballinger MN.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):872-81. doi: 10.1165/rcmb.2015-0057OC.


Phagocytosed Clofazimine Biocrystals Can Modulate Innate Immune Signaling by Inhibiting TNFα and Boosting IL-1RA Secretion.

Yoon GS, Sud S, Keswani RK, Baik J, Standiford TJ, Stringer KA, Rosania GR.

Mol Pharm. 2015 Jul 6;12(7):2517-27. doi: 10.1021/acs.molpharmaceut.5b00035. Epub 2015 Jun 5.


Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome.

Kovach MA, Stringer KA, Bunting R, Wu X, San Mateo L, Newstead MW, Paine R, Standiford TJ.

Respir Res. 2015 Feb 21;16:29. doi: 10.1186/s12931-015-0190-x.


Linezolid has unique immunomodulatory effects in post-influenza community acquired MRSA pneumonia.

Bhan U, Podsiad AB, Kovach MA, Ballinger MN, Keshamouni V, Standiford TJ.

PLoS One. 2015 Jan 30;10(1):e0114574. doi: 10.1371/journal.pone.0114574. eCollection 2015.


IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.

Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ.

J Immunol. 2015 Feb 15;194(4):1894-904. doi: 10.4049/jimmunol.1402377. Epub 2015 Jan 16.


Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa.

Tolle L, Yu FS, Kovach MA, Ballinger MN, Newstead MW, Zeng X, Nunez G, Standiford TJ.

J Innate Immun. 2015;7(2):177-86. doi: 10.1159/000367790. Epub 2014 Nov 12.


Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection.

Liu X, Gao N, Dong C, Zhou L, Mi QS, Standiford TJ, Yu FS.

Eur J Immunol. 2014 Sep;44(9):2667-79. doi: 10.1002/eji.201444490. Epub 2014 Aug 14.


Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS.

Burnham EL, Hyzy RC, Paine R 3rd, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ.

Chest. 2014 Nov;146(5):1196-1204. doi: 10.1378/chest.13-2708.


Epithelial-mesenchymal transition-associated secretory phenotype predicts survival in lung cancer patients.

Reka AK, Chen G, Jones RC, Amunugama R, Kim S, Karnovsky A, Standiford TJ, Beer DG, Omenn GS, Keshamouni VG.

Carcinogenesis. 2014 Jun;35(6):1292-300. doi: 10.1093/carcin/bgu041. Epub 2014 Feb 7.


Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health.

Evans CR, Karnovsky A, Kovach MA, Standiford TJ, Burant CF, Stringer KA.

J Proteome Res. 2014 Feb 7;13(2):640-9. doi: 10.1021/pr4007624. Epub 2013 Dec 9.


Interferon regulatory factor-1 in flagellin-induced reprogramming: potential protective role of CXCL10 in cornea innate defense against Pseudomonas aeruginosa infection.

Yoon GS, Dong C, Gao N, Kumar A, Standiford TJ, Yu FS.

Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7510-21. doi: 10.1167/iovs.13-12453.


Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury.

Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA.

FASEB J. 2013 Dec;27(12):5010-21. doi: 10.1096/fj.13-236380. Epub 2013 Aug 27.


Immunophenotyping and protein profiling of Fontan-associated plastic bronchitis airway casts.

Racz J, Mane G, Ford M, Schmidt L, Myers J, Standiford TJ, Schumacher KR, Fifer C, Russell MW, Stringer KA.

Ann Am Thorac Soc. 2013 Apr;10(2):98-107. doi: 10.1513/AnnalsATS.201209-080OC.


Genome-wide transcriptional analysis of differentially expressed genes in flagellin-pretreated mouse corneal epithelial cells in response to Pseudomonas aeruginosa: involvement of S100A8/A9.

Gao N, Sang Yoon G, Liu X, Mi X, Chen W, Standiford TJ, Yu FS.

Mucosal Immunol. 2013 Sep;6(5):993-1005. doi: 10.1038/mi.2012.137. Epub 2013 Jan 23.


Chest CT features are associated with poorer quality of life in acute lung injury survivors.

Burnham EL, Hyzy RC, Paine R 3rd, Coley C 2nd, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ.

Crit Care Med. 2013 Feb;41(2):445-56. doi: 10.1097/CCM.0b013e31826a5062.


Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils.

Krupa A, Fudala R, Florence JM, Tucker T, Allen TC, Standiford TJ, Luchowski R, Fol M, Rahman M, Gryczynski Z, Gryczynski I, Kurdowska AK.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):240-9. doi: 10.1165/rcmb.2012-0039OC. Epub 2012 Dec 13.


TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis.

Bhan U, Newstead MJ, Zeng X, Podsaid A, Goswami M, Ballinger MN, Kunkel SL, Standiford TJ.

J Immunol. 2013 Jan 1;190(1):349-56. doi: 10.4049/jimmunol.1202225. Epub 2012 Nov 23.

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