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Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers.

Fresques T, Zirbes A, Shalabi S, Samson S, Preto S, Stampfer MR, LaBarge MA.

Front Cell Dev Biol. 2019 Aug 28;7:174. doi: 10.3389/fcell.2019.00174. eCollection 2019. Review.


Superresolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes.

Potapova TA, Unruh JR, Yu Z, Rancati G, Li H, Stampfer MR, Gerton JL.

J Cell Biol. 2019 Aug 5;218(8):2492-2513. doi: 10.1083/jcb.201810166. Epub 2019 Jul 3.


Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect.

Anglada T, Repullés J, Espinal A, LaBarge MA, Stampfer MR, Genescà A, Martín M.

Aging (Albany NY). 2019 Mar 14;11(5):1510-1523. doi: 10.18632/aging.101849.


Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.

Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, Zavadil J.

Genome Res. 2019 Apr;29(4):521-531. doi: 10.1101/gr.242453.118. Epub 2019 Mar 7.


Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure.

Sridharan DM, Enerio S, Wang C, LaBarge MA, Stampfer MR, Pluth JM.

Life Sci Space Res (Amst). 2019 Feb;20:101-112. doi: 10.1016/j.lssr.2018.10.002. Epub 2018 Oct 21.


Different culture media modulate growth, heterogeneity, and senescence in human mammary epithelial cell cultures.

Lee JK, Bloom J, Zubeldia-Plazaola A, Garbe JC, Stampfer MR, LaBarge MA.

PLoS One. 2018 Oct 1;13(10):e0204645. doi: 10.1371/journal.pone.0204645. eCollection 2018.


Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance.

Jokela TA, Engelsen AST, Rybicka A, Pelissier Vatter FA, Garbe JC, Miyano M, Tiron C, Ferariu D, Akslen LA, Stampfer MR, Lorens JB, LaBarge MA.

Front Cell Dev Biol. 2018 Apr 17;6:41. doi: 10.3389/fcell.2018.00041. eCollection 2018.


High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia.

Pelissier Vatter FA, Schapiro D, Chang H, Borowsky AD, Lee JK, Parvin B, Stampfer MR, LaBarge MA, Bodenmiller B, Lorens JB.

Cell Rep. 2018 Apr 24;23(4):1205-1219. doi: 10.1016/j.celrep.2018.03.114.


Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.

Miyano M, Sayaman RW, Stoiber MH, Lin CH, Stampfer MR, Brown JB, LaBarge MA.

Aging (Albany NY). 2017 Oct 9;9(10):2026-2051. doi: 10.18632/aging.101298.


Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis.

Park JL, Lee YS, Song MJ, Hong SH, Ahn JH, Seo EH, Shin SP, Lee SJ, Johnson BH, Stampfer MR, Kim HP, Kim SY, Lee YS.

Oncogene. 2017 Dec 7;36(49):6793-6804. doi: 10.1038/onc.2017.285. Epub 2017 Aug 28.


A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers.

Vrba L, Garbe JC, Stampfer MR, Futscher BW.

Epigenetics. 2015;10(11):1074-83. doi: 10.1080/15592294.2015.1106673.


The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL.

Genome Biol. 2015 Sep 17;16:194. doi: 10.1186/s13059-015-0748-4.


Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.

Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP.

FEBS J. 2015 Sep;282(18):3455-73. doi: 10.1111/febs.13354. Epub 2015 Jul 14.


Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells.

Lee JK, Garbe JC, Vrba L, Miyano M, Futscher BW, Stampfer MR, LaBarge MA.

Front Cell Dev Biol. 2015 Mar 11;3:13. doi: 10.3389/fcell.2015.00013. eCollection 2015.


Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations.

Garbe JC, Vrba L, Sputova K, Fuchs L, Novak P, Brothman AR, Jackson M, Chin K, LaBarge MA, Watts G, Futscher BW, Stampfer MR.

Cell Cycle. 2014;13(21):3423-35. doi: 10.4161/15384101.2014.954456.


Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.

Severson PL, Vrba L, Stampfer MR, Futscher BW.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.


Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.

Pelissier FA, Garbe JC, Ananthanarayanan B, Miyano M, Lin C, Jokela T, Kumar S, Stampfer MR, Lorens JB, LaBarge MA.

Cell Rep. 2014 Jun 26;7(6):1926-39. doi: 10.1016/j.celrep.2014.05.021. Epub 2014 Jun 5.


Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties.

He X, Arslan AD, Ho TT, Yuan C, Stampfer MR, Beck WT.

Oncogenesis. 2014 Jan 13;3:e84. doi: 10.1038/oncsis.2013.47.


Cellular senescence mediated by p16INK4A-coupled miRNA pathways.

Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH, Bishop CL.

Nucleic Acids Res. 2014 Feb;42(3):1606-18. doi: 10.1093/nar/gkt1096. Epub 2013 Nov 11.


The regulation of SOX7 and its tumor suppressive role in breast cancer.

Stovall DB, Wan M, Miller LD, Cao P, Maglic D, Zhang Q, Stampfer MR, Liu W, Xu J, Sui G.

Am J Pathol. 2013 Nov;183(5):1645-1653. doi: 10.1016/j.ajpath.2013.07.025. Epub 2013 Sep 5.


Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability.

Hosseini SA, Horton S, Saldivar JC, Miuma S, Stampfer MR, Heerema NA, Huebner K.

Genes Chromosomes Cancer. 2013 Nov;52(11):1017-29. doi: 10.1002/gcc.22097. Epub 2013 Aug 9. Erratum in: Genes Chromosomes Cancer. 2019 Nov;58(11):824.


Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length.

Sputova K, Garbe JC, Pelissier FA, Chang E, Stampfer MR, LaBarge MA.

Genome Integr. 2013 May 29;4(1):4. doi: 10.1186/2041-9414-4-4.


miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer.

Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW.

PLoS One. 2013;8(1):e54398. doi: 10.1371/journal.pone.0054398. Epub 2013 Jan 16.


Processing of human reduction mammoplasty and mastectomy tissues for cell culture.

Labarge MA, Garbe JC, Stampfer MR.

J Vis Exp. 2013 Jan 3;(71). pii: 50011. doi: 10.3791/50011.


Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak P, Stampfer MR, Munoz-Rodriguez JL, Garbe JC, Ehrich M, Futscher BW, Jensen TJ.

PLoS One. 2012;7(12):e52299. doi: 10.1371/journal.pone.0052299. Epub 2012 Dec 20.


Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia.

Garbe JC, Pepin F, Pelissier FA, Sputova K, Fridriksdottir AJ, Guo DE, Villadsen R, Park M, Petersen OW, Borowsky AD, Stampfer MR, Labarge MA.

Cancer Res. 2012 Jul 15;72(14):3687-701. doi: 10.1158/0008-5472.CAN-12-0157. Epub 2012 May 2.


Epigenetic regulation of normal human mammary cell type-specific miRNAs.

Vrba L, Garbe JC, Stampfer MR, Futscher BW.

Genome Res. 2011 Dec;21(12):2026-37. doi: 10.1101/gr.123935.111. Epub 2011 Aug 26.


Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.

Chanson L, Brownfield D, Garbe JC, Kuhn I, Stampfer MR, Bissell MJ, LaBarge MA.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3264-9. doi: 10.1073/pnas.1019556108. Epub 2011 Feb 7.


Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).

Bishop CL, Bergin AM, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J, Beach DH.

Mol Cell. 2010 Nov 24;40(4):533-47. doi: 10.1016/j.molcel.2010.10.027.


Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW.

PLoS One. 2010 Jan 13;5(1):e8697. doi: 10.1371/journal.pone.0008697.


Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.

LaBarge MA, Nelson CM, Villadsen R, Fridriksdottir A, Ruth JR, Stampfer MR, Petersen OW, Bissell MJ.

Integr Biol (Camb). 2009 Jan;1(1):70-9. doi: 10.1039/b816472j. Epub 2008 Nov 12.


Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.

Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek AJ, Stampfer MR.

Cancer Res. 2009 Oct 1;69(19):7557-68. doi: 10.1158/0008-5472.CAN-09-0270. Epub 2009 Sep 22.


Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Novak P, Jensen TJ, Garbe JC, Stampfer MR, Futscher BW.

Cancer Res. 2009 Jun 15;69(12):5251-8. doi: 10.1158/0008-5472.CAN-08-4977. Epub 2009 Jun 9.


Cell type-specific DNA methylation patterns in the human breast.

Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14076-81. doi: 10.1073/pnas.0805206105. Epub 2008 Sep 9.


Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.

Sudo H, Garbe J, Stampfer MR, Barcellos-Hoff MH, Kronenberg A.

Radiat Res. 2008 Jul;170(1):23-32. doi: 10.1667/RR1317.1.


Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.

Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR.

Cell Cycle. 2007 Aug 1;6(15):1927-36. Epub 2007 May 30.


Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized.

Li Y, Pan J, Li JL, Lee JH, Tunkey C, Saraf K, Garbe JC, Whitley MZ, Jelinsky SA, Stampfer MR, Haney SA.

Mol Cancer. 2007 Jan 18;6:7.


ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.

Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF.

Mol Cancer Res. 2006 Sep;4(9):655-65.


Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models.

Goldstein JC, Rodier F, Garbe JC, Stampfer MR, Campisi J.

Aging Cell. 2005 Aug;4(4):217-22.


Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter.

Strunnikova M, Schagdarsurengin U, Kehlen A, Garbe JC, Stampfer MR, Dammann R.

Mol Cell Biol. 2005 May;25(10):3923-33.


Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.

Nijjar T, Bassett E, Garbe J, Takenaka Y, Stampfer MR, Gilley D, Yaswen P.

Oncogene. 2005 May 5;24(20):3369-76.


Culture models of human mammary epithelial cell transformation.

Stampfer MR, Yaswen P.

J Mammary Gland Biol Neoplasia. 2000 Oct;5(4):365-78. Review.


Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines.

Stampfer MR, Garbe J, Nijjar T, Wigington D, Swisshelm K, Yaswen P.

Oncogene. 2003 Aug 14;22(34):5238-51.


Human epithelial cell immortalization as a step in carcinogenesis.

Stampfer MR, Yaswen P.

Cancer Lett. 2003 May 15;194(2):199-208. Review.


Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells.

Yaswen P, Stampfer MR.

Int J Biochem Cell Biol. 2002 Nov;34(11):1382-94. Review.


Epigenetic changes accompanying human mammary epithelial cell immortalization.

Yaswen P, Stampfer MR.

J Mammary Gland Biol Neoplasia. 2001 Apr;6(2):223-34. Review.


Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells.

Stampfer MR, Garbe J, Levine G, Lichtsteiner S, Vasserot AP, Yaswen P.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4498-503. Epub 2001 Apr 3.


The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells.

Nonet GH, Stampfer MR, Chin K, Gray JW, Collins CC, Yaswen P.

Cancer Res. 2001 Feb 15;61(4):1250-4.


Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.

Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD.

Nature. 2001 Feb 1;409(6820):633-7.


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