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Fast breakthrough of resistant cytomegalovirus during secondary letermovir prophylaxis in a hematopoietic stem cell transplant recipient.

Jung S, Michel M, Stamminger T, Michel D.

BMC Infect Dis. 2019 May 8;19(1):388. doi: 10.1186/s12879-019-4016-1.


Emerging roles of cytomegalovirus-encoded G protein-coupled receptors during lytic and latent infection.

Frank T, Niemann I, Reichel A, Stamminger T.

Med Microbiol Immunol. 2019 Aug;208(3-4):447-456. doi: 10.1007/s00430-019-00595-9. Epub 2019 Mar 21. Review.


A Noncanonical Function of Polycomb Repressive Complexes Promotes Human Cytomegalovirus Lytic DNA Replication and Serves as a Novel Cellular Target for Antiviral Intervention.

Svrlanska A, Reichel A, Schilling EM, Scherer M, Stamminger T, Reuter N.

J Virol. 2019 Apr 17;93(9). pii: e02143-18. doi: 10.1128/JVI.02143-18. Print 2019 May 1.


Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel.

Heim C, Khan MA, von Silva-Tarouca B, Kuckhahn A, Stamminger T, Ramsperger-Gleixner M, Nicolls MR, Weyand M, Ensminger SM.

Transplantation. 2019 May;103(5):899-908. doi: 10.1097/TP.0000000000002571.


In Vivo Emergence of UL56 C325Y Cytomegalovirus Resistance to Letermovir in a Patient with Acute Myeloid Leukemia after Hematopoietic Cell Transplantation.

Frietsch JJ, Michel D, Stamminger T, Hunstig F, Birndt S, Schnetzke U, Scholl S, Hochhaus A, Hilgendorf I.

Mediterr J Hematol Infect Dis. 2019 Jan 1;11(1):e2019001. doi: 10.4084/MJHID.2019.001. eCollection 2019.


Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU.

Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12.


A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.

Poole EL, Kew VG, Lau JCH, Murray MJ, Stamminger T, Sinclair JH, Reeves MB.

Cell Rep. 2018 Jul 17;24(3):594-606. doi: 10.1016/j.celrep.2018.06.048.


Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.

Reichel A, Stilp AC, Scherer M, Reuter N, Lukassen S, Kasmapour B, Schreiner S, Cicin-Sain L, Winterpacht A, Stamminger T.

J Virol. 2018 Jun 29;92(14). pii: e00342-18. doi: 10.1128/JVI.00342-18. Print 2018 Jul 15.


In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.

Cloarec R, Bauer S, Teissier N, Schaller F, Luche H, Courtens S, Salmi M, Pauly V, Bois E, Pallesi-Pocachard E, Buhler E, Michel FJ, Gressens P, Malissen M, Stamminger T, Streblow DN, Bruneau N, Szepetowski P.

Front Cell Neurosci. 2018 Mar 6;12:55. doi: 10.3389/fncel.2018.00055. eCollection 2018.


SUMOylation of IE2p86 is required for efficient autorepression of the human cytomegalovirus major immediate-early promoter.

Reuter N, Reichel A, Stilp AC, Scherer M, Stamminger T.

J Gen Virol. 2018 Feb 8. doi: 10.1099/jgv.0.001021. [Epub ahead of print]


Artesunate-derived monomeric, dimeric and trimeric experimental drugs - Their unique mechanistic basis and pronounced antiherpesviral activity.

Hahn F, Fröhlich T, Frank T, Bertzbach LD, Kohrt S, Kaufer BB, Stamminger T, Tsogoeva SB, Marschall M.

Antiviral Res. 2018 Apr;152:104-110. doi: 10.1016/j.antiviral.2018.02.013. Epub 2018 Feb 16.


Human Cytomegalovirus Particles Treated with Specific Antibodies Induce Intrinsic and Adaptive but Not Innate Immune Responses.

Wu Z, Qin R, Wang L, Bosso M, Scherer M, Stamminger T, Hotter D, Mertens T, Frascaroli G.

J Virol. 2017 Oct 27;91(22). pii: e00678-17. doi: 10.1128/JVI.00678-17. Print 2017 Nov 15.


The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies.

Scherer M, Schilling EM, Stamminger T.

Adv Anat Embryol Cell Biol. 2017;223:77-94. doi: 10.1007/978-3-319-53168-7_4. Review.


Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.

Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, Vitt D, Steingruber M, Sonntag E, Zeitträger I, Bahsi H, Stamminger T, Rawlinson W, Strobl S, Marschall M.

Antiviral Res. 2017 Jul;143:113-121. doi: 10.1016/j.antiviral.2017.04.003. Epub 2017 Apr 9.


The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus.

Reuter N, Schilling EM, Scherer M, Müller R, Stamminger T.

J Virol. 2017 Apr 28;91(10). pii: e02335-16. doi: 10.1128/JVI.02335-16. Print 2017 May 15.


The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells.

Heilingloh CS, Grosche L, Kummer M, Mühl-Zürbes P, Kamm L, Scherer M, Latzko M, Stamminger T, Steinkasserer A.

Front Microbiol. 2017 Feb 1;8:119. doi: 10.3389/fmicb.2017.00119. eCollection 2017.


Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28.

Frank T, Reichel A, Larsen O, Stilp AC, Rosenkilde MM, Stamminger T, Ozawa T, Tschammer N.

Cell Commun Signal. 2016 Dec 12;14(1):31.


The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation.

Schilling EM, Scherer M, Reuter N, Schweininger J, Muller YA, Stamminger T.

J Virol. 2017 Jan 31;91(4). pii: e02049-16. doi: 10.1128/JVI.02049-16. Print 2017 Feb 15.


Human promyelocytic leukemia protein is targeted to distinct subnuclear domains in plant nuclei and colocalizes with nucleolar constituents in a SUMO-dependent manner.

Lamm CE, Scherer M, Reuter N, Amin B, Stamminger T, Sonnewald U.

FEBS Open Bio. 2016 Oct 19;6(11):1141-1154. eCollection 2016 Nov.


Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.

Kim YJ, Kim ET, Kim YE, Lee MK, Kwon KM, Kim KI, Stamminger T, Ahn JH.

PLoS Pathog. 2016 Aug 26;12(8):e1005850. doi: 10.1371/journal.ppat.1005850. eCollection 2016 Aug.


Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins.

Steingruber M, Kraut A, Socher E, Sticht H, Reichel A, Stamminger T, Amin B, Couté Y, Hutterer C, Marschall M.

Viruses. 2016 Aug 18;8(8). pii: E219. doi: 10.3390/v8080219.


Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation.

Cloarec R, Bauer S, Luche H, Buhler E, Pallesi-Pocachard E, Salmi M, Courtens S, Massacrier A, Grenot P, Teissier N, Watrin F, Schaller F, Adle-Biassette H, Gressens P, Malissen M, Stamminger T, Streblow DN, Bruneau N, Szepetowski P.

PLoS One. 2016 Jul 29;11(7):e0160176. doi: 10.1371/journal.pone.0160176. eCollection 2016.


Emerging Role of PML Nuclear Bodies in Innate Immune Signaling.

Scherer M, Stamminger T.

J Virol. 2016 Jun 10;90(13):5850-5854. doi: 10.1128/JVI.01979-15. Print 2016 Jul 1. Review.


E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection.

Zheng Y, Stamminger T, Hearing P.

PLoS Pathog. 2016 Jan 25;12(1):e1005415. doi: 10.1371/journal.ppat.1005415. eCollection 2016 Jan.


TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner.

Kahle T, Volkmann B, Eissmann K, Herrmann A, Schmitt S, Wittmann S, Merkel L, Reuter N, Stamminger T, Gramberg T.

Viruses. 2015 Dec 23;8(1). pii: E2. doi: 10.3390/v8010002.


Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses.

Scherer M, Otto V, Stump JD, Klingl S, Müller R, Reuter N, Muller YA, Sticht H, Stamminger T.

J Virol. 2015 Nov 11;90(3):1190-205. doi: 10.1128/JVI.01973-15. Print 2016 Feb 1.


New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97.

Graf L, Feichtinger S, Naing Z, Hutterer C, Milbradt J, Webel R, Wagner S, Scott GM, Hamilton ST, Rawlinson WD, Stamminger T, Thomas M, Marschall M.

J Gen Virol. 2016 Jan;97(1):144-51. doi: 10.1099/jgv.0.000337. Epub 2015 Nov 6.


The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.

Hutterer C, Niemann I, Milbradt J, Fröhlich T, Reiter C, Kadioglu O, Bahsi H, Zeitträger I, Wagner S, Einsiedel J, Gmeiner P, Vogel N, Wandinger S, Godl K, Stamminger T, Efferth T, Tsogoeva SB, Marschall M.

Antiviral Res. 2015 Dec;124:101-9. doi: 10.1016/j.antiviral.2015.10.003. Epub 2015 Nov 4.


pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication.

Thomas M, Sonntag E, Müller R, Schmidt S, Zielke B, Fossen T, Stamminger T.

J Virol. 2015 Sep;89(18):9601-15. doi: 10.1128/JVI.01399-15. Epub 2015 Jul 15.


Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein.

Klingl S, Scherer M, Stamminger T, Muller YA.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1493-504. doi: 10.1107/S1399004715008792. Epub 2015 Jun 30.


Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1.

Wagenknecht N, Reuter N, Scherer M, Reichel A, Müller R, Stamminger T.

Viruses. 2015 Jun 5;7(6):2884-907. doi: 10.3390/v7062751.


Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression.

Vink EI, Zheng Y, Yeasmin R, Stamminger T, Krug LT, Hearing P.

Viruses. 2015 May 13;7(5):2428-49. doi: 10.3390/v7052428.


Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

Scherer M, Klingl S, Sevvana M, Otto V, Schilling EM, Stump JD, Müller R, Reuter N, Sticht H, Muller YA, Stamminger T.

PLoS Pathog. 2014 Nov 20;10(11):e1004512. doi: 10.1371/journal.ppat.1004512. eCollection 2014 Nov.


Methods to study the nucleocytoplasmic transport of macromolecules with respect to their impact on the regulation of human cytomegalovirus gene expression.

Thomas M, Zielke B, Reuter N, Stamminger T.

Methods Mol Biol. 2014;1119:197-216. doi: 10.1007/978-1-62703-788-4_12.


Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.

Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A.

PLoS Pathog. 2014 Jan;10(1):e1003863. doi: 10.1371/journal.ppat.1003863. Epub 2014 Jan 16.


Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.

Marschall M, Niemann I, Kosulin K, Bootz A, Wagner S, Dobner T, Herz T, Kramer B, Leban J, Vitt D, Stamminger T, Hutterer C, Strobl S.

Antiviral Res. 2013 Dec;100(3):640-8. doi: 10.1016/j.antiviral.2013.10.003. Epub 2013 Oct 20.


Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK.

Hutterer C, Wandinger SK, Wagner S, Müller R, Stamminger T, Zeitträger I, Godl K, Baumgartner R, Strobl S, Marschall M.

Antiviral Res. 2013 Aug;99(2):139-48. doi: 10.1016/j.antiviral.2013.04.017. Epub 2013 May 4.


Human cytomegalovirus pp71 stimulates major histocompatibility complex class i presentation of IE1-derived peptides at immediate early times of infection.

Hesse J, Reyda S, Tenzer S, Besold K, Reuter N, Krauter S, Büscher N, Stamminger T, Plachter B.

J Virol. 2013 May;87(9):5229-38. doi: 10.1128/JVI.03484-12. Epub 2013 Feb 28.


Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments.

Scherer M, Reuter N, Wagenknecht N, Otto V, Sticht H, Stamminger T.

J Gen Virol. 2013 Jun;94(Pt 6):1373-84. doi: 10.1099/vir.0.051078-0. Epub 2013 Feb 13.


PML promotes MHC class II gene expression by stabilizing the class II transactivator.

Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P.

J Cell Biol. 2012 Oct 1;199(1):49-63. doi: 10.1083/jcb.201112015. Epub 2012 Sep 24.


Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.

Frankenberg N, Lischka P, Pepperl-Klindworth S, Stamminger T, Plachter B.

Med Microbiol Immunol. 2012 Nov;201(4):567-79. doi: 10.1007/s00430-012-0269-7. Epub 2012 Sep 11.


Procurement regimens to reduce ischemia reperfusion injury of vascular grafts.

Abele-Ohl S, Heim C, Eckl S, Weyand M, Stamminger T, Ensminger SM.

Eur Surg Res. 2012;49(2):80-7. doi: 10.1159/000341551. Epub 2012 Aug 22.


Perinuclear localization of the HIV-1 regulatory protein Vpr is important for induction of G2-arrest.

Sörgel S, Fraedrich K, Votteler J, Thomas M, Stamminger T, Schubert U.

Virology. 2012 Oct 25;432(2):444-51. doi: 10.1016/j.virol.2012.06.027. Epub 2012 Jul 24.


Human cytomegalovirus infection leads to elevated levels of transplant arteriosclerosis in a humanized mouse aortic xenograft model.

Abele-Ohl S, Leis M, Wollin M, Mahmoudian S, Hoffmann J, Müller R, Heim C, Spriewald BM, Weyand M, Stamminger T, Ensminger SM.

Am J Transplant. 2012 Jul;12(7):1720-9. doi: 10.1111/j.1600-6143.2012.04018.x. Epub 2012 Mar 19.


Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100.

Full F, Reuter N, Zielke K, Stamminger T, Ensser A.

J Virol. 2012 Apr;86(7):3541-53. doi: 10.1128/JVI.06992-11. Epub 2012 Jan 25.


In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.

Marschall M, Stamminger T, Urban A, Wildum S, Ruebsamen-Schaeff H, Zimmermann H, Lischka P.

Antimicrob Agents Chemother. 2012 Feb;56(2):1135-7. doi: 10.1128/AAC.05908-11. Epub 2011 Nov 21.


B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies.

Pötzsch S, Spindler N, Wiegers AK, Fisch T, Rücker P, Sticht H, Grieb N, Baroti T, Weisel F, Stamminger T, Martin-Parras L, Mach M, Winkler TH.

PLoS Pathog. 2011 Aug;7(8):e1002172. doi: 10.1371/journal.ppat.1002172. Epub 2011 Aug 11.


The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants.

Chou S, Marousek G, Auerochs S, Stamminger T, Milbradt J, Marschall M.

Antiviral Res. 2011 Nov;92(2):364-8. doi: 10.1016/j.antiviral.2011.07.018. Epub 2011 Aug 6.


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