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Items: 1 to 50 of 118

1.

Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.

Nichols CE, Lamb HK, Thompson P, El Omari K, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Protein Sci. 2013 May;22(5):628-40. doi: 10.1002/pro.2247. Epub 2013 Mar 26.

2.

Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form.

El Omari K, Dhaliwal B, Ren J, Abrescia NG, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1179-83. doi: 10.1107/S1744309111029228. Epub 2011 Sep 24.

3.

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Stamp AL, Owen P, El Omari K, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Proteins. 2011 Jul;79(7):2352-7. doi: 10.1002/prot.23060. Epub 2011 May 10. No abstract available.

PMID:
21560168
4.

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Stamp AL, Owen P, El Omari K, Nichols CE, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Protein Sci. 2010 Oct;19(10):1897-905. doi: 10.1002/pro.475.

5.

Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.

Bird LE, Ren J, Nettleship JE, Folkers GE, Owens RJ, Stammers DK.

BMC Struct Biol. 2010 May 28;10:13. doi: 10.1186/1472-6807-10-13.

6.

The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.

Wienk H, Lammers I, Hotze A, Wu J, Wechselberger RW, Owens R, Stammers DK, Stuart D, Kaptein R, Folkers GE.

Biochemistry. 2009 Jun 2;48(21):4431-9. doi: 10.1021/bi9001997.

PMID:
19348505
7.

The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis.

Nichols CE, Sainsbury S, Ren J, Walter TS, Verma A, Stammers DK, Saunders NJ, Owens RJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):204-9. doi: 10.1107/S174430910900414X. Epub 2009 Feb 26.

8.

Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein.

El Omari K, Scott K, Dhaliwal B, Ren J, Abrescia NG, Budworth J, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1019-23. doi: 10.1107/S1744309108031059. Epub 2008 Oct 28.

9.

Dinucleotide-sensing proteins: linking signaling networks and regulating transcription.

Lamb HK, Stammers DK, Hawkins AR.

Sci Signal. 2008 Aug 19;1(33):pe38. doi: 10.1126/scisignal.133pe38.

PMID:
18714085
10.

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ren J, Chamberlain PP, Stamp A, Short SA, Weaver KL, Romines KR, Hazen R, Freeman A, Ferris RG, Andrews CW, Boone L, Chan JH, Stammers DK.

J Med Chem. 2008 Aug 28;51(16):5000-8. doi: 10.1021/jm8004493. Epub 2008 Jul 30.

PMID:
18665583
11.

Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.

Kotaka M, Johnson C, Lamb HK, Hawkins AR, Ren J, Stammers DK.

J Mol Biol. 2008 Aug 29;381(2):373-82. doi: 10.1016/j.jmb.2008.05.077. Epub 2008 Jun 5.

PMID:
18602114
12.

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase.

Ren J, Stammers DK.

Virus Res. 2008 Jun;134(1-2):157-70. doi: 10.1016/j.virusres.2007.12.018. Epub 2008 Mar 3. Review.

PMID:
18313784
13.

Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.

Nichols CE, Johnson C, Lamb HK, Lockyer M, Charles IG, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):922-8. Epub 2007 Oct 24.

14.

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

Lamb HK, Thompson P, Elliott C, Charles IG, Richards J, Lockyer M, Watkins N, Nichols C, Stammers DK, Bagshaw CR, Cooper A, Hawkins AR.

Protein Sci. 2007 Nov;16(11):2391-402. Epub 2007 Sep 28.

15.

The design and development of drugs acting against the smallpox virus.

El Omari K, Stammers DK.

Expert Opin Drug Discov. 2007 Sep;2(9):1263-72. doi: 10.1517/17460441.2.9.1263.

PMID:
23496133
16.

Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.

Cader MZ, Ren J, James PA, Bird LE, Talbot K, Stammers DK.

FEBS Lett. 2007 Jun 26;581(16):2959-64. Epub 2007 May 29.

17.

Evolution of a novel 5-amino-acid insertion in the beta3-beta4 loop of HIV-1 reverse transcriptase.

Huigen MC, de Graaf L, Eggink D, Schuurman R, Müller V, Stamp A, Stammers DK, Boucher CA, Nijhuis M.

Virology. 2007 Aug 1;364(2):395-406. Epub 2007 Apr 23.

18.

Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

Ren J, Nichols CE, Chamberlain PP, Weaver KL, Short SA, Chan JH, Kleim JP, Stammers DK.

J Med Chem. 2007 May 17;50(10):2301-9. Epub 2007 Apr 19.

PMID:
17441703
19.

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.

Nichols CE, Lamb HK, Lockyer M, Charles IG, Pyne S, Hawkins AR, Stammers DK.

Proteins. 2007 Jul 1;68(1):13-25.

PMID:
17393457
20.

The structure and transcriptional analysis of a global regulator from Neisseria meningitidis.

Ren J, Sainsbury S, Combs SE, Capper RG, Jordan PW, Berrow NS, Stammers DK, Saunders NJ, Owens RJ.

J Biol Chem. 2007 May 11;282(19):14655-64. Epub 2007 Mar 20.

21.

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.

Wu X, Knapp S, Stamp A, Stammers DK, Jörnvall H, Dellaporta SL, Oppermann U.

FEBS J. 2007 Mar;274(5):1172-82.

22.

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

El Omari K, Solaroli N, Karlsson A, Balzarini J, Stammers DK.

BMC Struct Biol. 2006 Oct 24;6:22.

23.

Calcium regulation of chloroplast protein translocation is mediated by calmodulin binding to Tic32.

Chigri F, Hörmann F, Stamp A, Stammers DK, Bölter B, Soll J, Vothknecht UC.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16051-6. Epub 2006 Oct 11.

24.

Structure of Staphylococcus aureus guanylate monophosphate kinase.

El Omari K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):949-53. Epub 2006 Sep 19.

25.

Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.

Ren J, Nichols CE, Stamp A, Chamberlain PP, Ferris R, Weaver KL, Short SA, Stammers DK.

FEBS J. 2006 Aug;273(16):3850-60.

26.

Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine.

Kotaka M, Ren J, Lockyer M, Hawkins AR, Stammers DK.

J Biol Chem. 2006 Oct 20;281(42):31544-52. Epub 2006 Aug 12.

27.

Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5'-monophosphate.

Dhaliwal B, Ren J, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):710-5. Epub 2006 Jul 24.

28.

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.

El Omari K, Bronckaers A, Liekens S, Pérez-Pérez MJ, Balzarini J, Stammers DK.

Biochem J. 2006 Oct 15;399(2):199-204.

29.

Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 A resolution.

Nichols CE, Sainsbury S, Berrow NS, Alderton D, Saunders NJ, Stammers DK, Owens RJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):494-7. Epub 2006 May 31.

30.

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.

Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A.

J Biol Chem. 2006 Jul 14;281(28):19273-9. Epub 2006 May 15.

31.

Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog.

Nichols CE, Johnson C, Lockyer M, Charles IG, Lamb HK, Hawkins AR, Stammers DK.

Proteins. 2006 Jul 1;64(1):111-23.

PMID:
16617437
32.

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

El Omari K, Liekens S, Bird LE, Balzarini J, Stammers DK.

Mol Pharmacol. 2006 Jun;69(6):1891-6. Epub 2006 Mar 23.

PMID:
16556772
33.

Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.

Kotaka M, Dhaliwal B, Ren J, Nichols CE, Angell R, Lockyer M, Hawkins AR, Stammers DK.

Protein Sci. 2006 Apr;15(4):774-84. Epub 2006 Mar 7.

34.

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.

Romines KR, Freeman GA, Schaller LT, Cowan JR, Gonzales SS, Tidwell JH, Andrews CW 3rd, Stammers DK, Hazen RJ, Ferris RG, Short SA, Chan JH, Boone LR.

J Med Chem. 2006 Jan 26;49(2):727-39.

PMID:
16420058
35.

Molecular architecture and ligand recognition determinants for T4 RNA ligase.

El Omari K, Ren J, Bird LE, Bona MK, Klarmann G, LeGrice SF, Stammers DK.

J Biol Chem. 2006 Jan 20;281(3):1573-9. Epub 2005 Nov 1.

36.

GTP cyclohydrolase II structure and mechanism.

Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK.

J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22.

37.

Crystal structure of nitrogen regulatory protein IIANtr from Neisseria meningitidis.

Ren J, Sainsbury S, Berrow NS, Alderton D, Nettleship JE, Stammers DK, Saunders NJ, Owens RJ.

BMC Struct Biol. 2005 Aug 10;5:13.

38.

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization.

Walter TS, Diprose JM, Mayo CJ, Siebold C, Pickford MG, Carter L, Sutton GC, Berrow NS, Brown J, Berry IM, Stewart-Jones GB, Grimes JM, Stammers DK, Esnouf RM, Jones EY, Owens RJ, Stuart DI, Harlos K.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):651-7. Epub 2005 May 26.

PMID:
15930615
39.

Sample preparation and mass-spectrometric characterization of crystal-derived protein samples.

Nettleship JE, Walter TS, Aplin R, Stammers DK, Owens RJ.

Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):643-5. Epub 2005 Apr 20.

PMID:
15858278
40.

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.

El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK.

J Biol Chem. 2005 May 6;280(18):18229-36. Epub 2005 Feb 22.

41.
42.

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.

Lamb HK, Ren J, Park A, Johnson C, Leslie K, Cocklin S, Thompson P, Mee C, Cooper A, Stammers DK, Hawkins AR.

Protein Sci. 2004 Dec;13(12):3127-38. Epub 2004 Nov 10.

43.

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH.

J Med Chem. 2004 Nov 18;47(24):5923-36.

PMID:
15537347
44.

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK.

J Med Chem. 2004 Nov 18;47(24):5912-22.

PMID:
15537346
45.

Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.

Nichols CE, Ren J, Leslie K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK.

J Mol Biol. 2004 Oct 22;343(3):533-46.

PMID:
15465043
46.

Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.

Dhaliwal B, Nichols CE, Ren J, Lockyer M, Charles I, Hawkins AR, Stammers DK.

FEBS Lett. 2004 Sep 10;574(1-3):49-54.

47.

High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate beta-semialdehyde dehydrogenase.

Nichols CE, Dhaliwal B, Lockyer M, Hawkins AR, Stammers DK.

J Mol Biol. 2004 Aug 13;341(3):797-806.

PMID:
15288787
48.

Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.

Park A, Lamb HK, Nichols C, Moore JD, Brown KA, Cooper A, Charles IG, Stammers DK, Hawkins AR.

Protein Sci. 2004 Aug;13(8):2108-19.

49.

Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments.

Nichols CE, Lockyer M, Hawkins AR, Stammers DK.

Proteins. 2004 Aug 15;56(3):625-8. No abstract available.

PMID:
15229896
50.

The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.

Auwerx J, Stevens M, Van Rompay AR, Bird LE, Ren J, De Clercq E, Oberg B, Stammers DK, Karlsson A, Balzarini J.

J Virol. 2004 Jul;78(14):7427-37.

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