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Items: 1 to 50 of 373

1.

Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe.

Raveane A, Aneli S, Montinaro F, Athanasiadis G, Barlera S, Birolo G, Boncoraglio G, Di Blasio AM, Di Gaetano C, Pagani L, Parolo S, Paschou P, Piazza A, Stamatoyannopoulos G, Angius A, Brucato N, Cucca F, Hellenthal G, Mulas A, Peyret-Guzzon M, Zoledziewska M, Baali A, Bycroft C, Cherkaoui M, Chiaroni J, Di Cristofaro J, Dina C, Dugoujon JM, Galan P, Giemza J, Kivisild T, Mazieres S, Melhaoui M, Metspalu M, Myers S, Pereira L, Ricaut FX, Brisighelli F, Cardinali I, Grugni V, Lancioni H, Pascali VL, Torroni A, Semino O, Matullo G, Achilli A, Olivieri A, Capelli C.

Sci Adv. 2019 Sep 4;5(9):eaaw3492. doi: 10.1126/sciadv.aaw3492. eCollection 2019 Sep.

2.

Genetic history of the population of Crete.

Drineas P, Tsetsos F, Plantinga A, Lazaridis I, Yannaki E, Razou A, Kanaki K, Michalodimitrakis M, Perez-Jimenez F, De Silvestro G, Renda MC, Stamatoyannopoulos JA, Kidd KK, Browning BL, Paschou P, Stamatoyannopoulos G.

Ann Hum Genet. 2019 Nov;83(6):373-388. doi: 10.1111/ahg.12328. Epub 2019 Jun 13.

3.

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing.

Li C, Psatha N, Sova P, Gil S, Wang H, Kim J, Kulkarni C, Valensisi C, Hawkins RD, Stamatoyannopoulos G, Lieber A.

Blood. 2018 Jun 28;131(26):2915-2928. doi: 10.1182/blood-2018-03-838540. Epub 2018 May 22.

4.

Genetic origins of the Minoans and Mycenaeans.

Lazaridis I, Mittnik A, Patterson N, Mallick S, Rohland N, Pfrengle S, Furtwängler A, Peltzer A, Posth C, Vasilakis A, McGeorge PJP, Konsolaki-Yannopoulou E, Korres G, Martlew H, Michalodimitrakis M, Özsait M, Özsait N, Papathanasiou A, Richards M, Roodenberg SA, Tzedakis Y, Arnott R, Fernandes DM, Hughey JR, Lotakis DM, Navas PA, Maniatis Y, Stamatoyannopoulos JA, Stewardson K, Stockhammer P, Pinhasi R, Reich D, Krause J, Stamatoyannopoulos G.

Nature. 2017 Aug 10;548(7666):214-218. doi: 10.1038/nature23310. Epub 2017 Aug 2.

5.

Genetics of the peloponnesean populations and the theory of extinction of the medieval peloponnesean Greeks.

Stamatoyannopoulos G, Bose A, Teodosiadis A, Tsetsos F, Plantinga A, Psatha N, Zogas N, Yannaki E, Zalloua P, Kidd KK, Browning BL, Stamatoyannopoulos J, Paschou P, Drineas P.

Eur J Hum Genet. 2017 May;25(5):637-645. doi: 10.1038/ejhg.2017.18. Epub 2017 Mar 8.

6.

Evidence for the in vivo safety of insulated foamy viral vectors.

Browning DL, Everson EM, Leap DJ, Hocum JD, Wang H, Stamatoyannopoulos G, Trobridge GD.

Gene Ther. 2017 Mar;24(3):187-198. doi: 10.1038/gt.2016.88. Epub 2016 Dec 26.

7.

Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in patients with β-thalassemia major.

Constantinou VC, Bouinta A, Karponi G, Zervou F, Papayanni PG, Stamatoyannopoulos G, Anagnostopoulos A, Yannaki E.

Transfusion. 2017 Apr;57(4):1031-1039. doi: 10.1111/trf.13951. Epub 2016 Dec 17.

8.

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D.

Nature. 2016 Oct 13;538(7624):201-206. doi: 10.1038/nature18964. Epub 2016 Sep 21.

9.

Functional footprinting of regulatory DNA.

Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, Bauer DE, Holmes MC, Orkin SH, Papayannopoulou T, Stamatoyannopoulos G, Rebar EJ, Gregory PD, Urnov FD, Stamatoyannopoulos JA.

Nat Methods. 2015 Oct;12(10):927-30. doi: 10.1038/nmeth.3554. Epub 2015 Aug 31.

10.

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Blobel GA, Bodine D, Brand M, Crispino J, de Bruijn MF, Nathan D, Papayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD.

Exp Hematol. 2015 Oct;43(10):821-37. doi: 10.1016/j.exphem.2015.06.008. Epub 2015 Jul 2. Review.

11.

Plerixafor+G-CSF-mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy.

Karponi G, Psatha N, Lederer CW, Adair JE, Zervou F, Zogas N, Kleanthous M, Tsatalas C, Anagnostopoulos A, Sadelain M, Rivière I, Stamatoyannopoulos G, Yannaki E.

Blood. 2015 Jul 30;126(5):616-9. doi: 10.1182/blood-2015-03-629618. Epub 2015 Jun 18.

12.

Functional validation of a constitutive autonomous silencer element.

Qi H, Liu M, Emery DW, Stamatoyannopoulos G.

PLoS One. 2015 Apr 24;10(4):e0124588. doi: 10.1371/journal.pone.0124588. eCollection 2015.

13.

Genomic discovery of potent chromatin insulators for human gene therapy.

Liu M, Maurano MT, Wang H, Qi H, Song CZ, Navas PA, Emery DW, Stamatoyannopoulos JA, Stamatoyannopoulos G.

Nat Biotechnol. 2015 Feb;33(2):198-203. doi: 10.1038/nbt.3062. Epub 2015 Jan 12.

PMID:
25580597
14.

Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model.

Psatha N, Sgouramali E, Gkountis A, Siametis A, Baliakas P, Constantinou V, Athanasiou E, Arsenakis M, Anagnostopoulos A, Papayannopoulou T, Stamatoyannopoulos G, Yannaki E.

Hum Gene Ther Methods. 2014 Dec;25(6):317-27. doi: 10.1089/hgtb.2014.005.

15.

Maritime route of colonization of Europe.

Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9211-6. doi: 10.1073/pnas.1320811111. Epub 2014 Jun 9.

16.

Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.

Yannaki E, Karponi G, Zervou F, Constantinou V, Bouinta A, Tachynopoulou V, Kotta K, Jonlin E, Papayannopoulou T, Anagnostopoulos A, Stamatoyannopoulos G.

Hum Gene Ther. 2013 Oct;24(10):852-60. doi: 10.1089/hum.2013.163.

17.

Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors.

Xiong Q, Zhang Z, Chang KH, Qu H, Wang H, Qi H, Li Y, Ruan X, Yang Y, Yang Y, Li Y, Sandstrom R, Sabo PJ, Li Q, Stamatoyannopoulos G, Stamatoyannopoulos JA, Fang X.

BMC Genomics. 2013 Aug 28;14:587. doi: 10.1186/1471-2164-14-587.

18.

A European population in Minoan Bronze Age Crete.

Hughey JR, Paschou P, Drineas P, Mastropaolo D, Lotakis DM, Navas PA, Michalodimitrakis M, Stamatoyannopoulos JA, Stamatoyannopoulos G.

Nat Commun. 2013;4:1861. doi: 10.1038/ncomms2871.

19.

The accessible chromatin landscape of the human genome.

Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, Canfield TK, Diegel M, Dunn D, Ebersol AK, Frum T, Giste E, Johnson AK, Johnson EM, Kutyavin T, Lajoie B, Lee BK, Lee K, London D, Lotakis D, Neph S, Neri F, Nguyen ED, Qu H, Reynolds AP, Roach V, Safi A, Sanchez ME, Sanyal A, Shafer A, Simon JM, Song L, Vong S, Weaver M, Yan Y, Zhang Z, Zhang Z, Lenhard B, Tewari M, Dorschner MO, Hansen RS, Navas PA, Stamatoyannopoulos G, Iyer VR, Lieb JD, Sunyaev SR, Akey JM, Sabo PJ, Kaul R, Furey TS, Dekker J, Crawford GE, Stamatoyannopoulos JA.

Nature. 2012 Sep 6;489(7414):75-82. doi: 10.1038/nature11232.

20.

A search for β thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans.

Hughey JR, Du M, Li Q, Michalodimitrakis M, Stamatoyannopoulos G.

Blood Cells Mol Dis. 2012 Jan 15;48(1):7-10. doi: 10.1016/j.bcmd.2011.09.006. Epub 2011 Oct 14.

21.

Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.

Liu M, Li CL, Stamatoyannopoulos G, Dorschner MO, Humbert R, Stamatoyannopoulos JA, Emery DW.

Hum Gene Ther. 2012 Feb;23(2):231-7. doi: 10.1089/hum.2010.177. Epub 2011 Dec 14.

22.

Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects.

Yannaki E, Papayannopoulou T, Jonlin E, Zervou F, Karponi G, Xagorari A, Becker P, Psatha N, Batsis I, Kaloyannidis P, Tahynopoulou V, Constantinou V, Bouinta A, Kotta K, Athanassiadou A, Anagnostopoulos A, Fassas A, Stamatoyannopoulos G.

Mol Ther. 2012 Jan;20(1):230-8. doi: 10.1038/mt.2011.195. Epub 2011 Sep 27. Erratum in: Mol Ther. 2012 Feb;20(2):469.

23.

Thalassaemia.

Higgs DR, Engel JD, Stamatoyannopoulos G.

Lancet. 2012 Jan 28;379(9813):373-83. doi: 10.1016/S0140-6736(11)60283-3. Epub 2011 Sep 9. Review.

PMID:
21908035
24.

Gene therapy for β-thalassaemia: the continuing challenge.

Yannaki E, Emery DW, Stamatoyannopoulos G.

Expert Rev Mol Med. 2010 Oct 1;12:e31. doi: 10.1017/S1462399410001626. Review.

PMID:
20883576
25.

Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease.

Yannaki E, Stamatoyannopoulos G.

Ann N Y Acad Sci. 2010 Aug;1202:59-63. doi: 10.1111/j.1749-6632.2010.05576.x. Review.

PMID:
20712773
26.

The birth of the American Society of Gene Therapy.

Stamatoyannopoulos G.

Mol Ther. 2010 Mar;18(3):462-5. doi: 10.1038/mt.2010.11. No abstract available.

27.

Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.

Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M.

Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6. doi: 10.1016/j.bcmd.2009.10.008. Epub 2009 Nov 14.

PMID:
19914848
28.

The higher structure of chromatin in the LCR of the beta-globin locus changes during development.

Fang X, Yin W, Xiang P, Han H, Stamatoyannopoulos G, Li Q.

J Mol Biol. 2009 Nov 27;394(2):197-208. doi: 10.1016/j.jmb.2009.09.046. Epub 2009 Sep 23.

29.

Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.

Li CL, Xiong D, Stamatoyannopoulos G, Emery DW.

Mol Ther. 2009 Apr;17(4):716-24. doi: 10.1038/mt.2009.7. Epub 2009 Feb 24.

30.

Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region.

Sova P, Wang H, Bomsztyk K, Stamatoyannopoulos G, Lieber A.

Hum Gene Ther. 2008 Feb;19(2):153-66. doi: 10.1089/hum.2007.091.

PMID:
18177253
31.

Histone acetylation at the human beta-globin locus changes with developmental age.

Yin W, Barkess G, Fang X, Xiang P, Cao H, Stamatoyannopoulos G, Li Q.

Blood. 2007 Dec 1;110(12):4101-7. Epub 2007 Sep 19.

32.

MicroRNA expression dynamics during murine and human erythroid differentiation.

Zhan M, Miller CP, Papayannopoulou T, Stamatoyannopoulos G, Song CZ.

Exp Hematol. 2007 Jul;35(7):1015-25.

33.

Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.

Aker M, Tubb J, Groth AC, Bukovsky AA, Bell AC, Felsenfeld G, Kiem HP, Stamatoyannopoulos G, Emery DW.

Hum Gene Ther. 2007 Apr;18(4):333-43.

PMID:
17411365
34.

Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.

Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ.

J Mol Biol. 2007 Mar 2;366(4):1064-73. Epub 2006 Dec 22.

35.

Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching.

Di Baldassarre A, Di Rico M, Di Noia A, Bonfini T, Iacone A, Marchisio M, Miscia S, Alfani E, Migliaccio AR, Stamatoyannopoulos G, Migliaccio G.

J Cell Biochem. 2007 May 15;101(2):411-24.

PMID:
17212360
36.

The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis.

Emery DW, Gavriilidis G, Asano H, Stamatoyannopoulos G.

J Cell Biochem. 2007 Mar 1;100(4):1045-55.

PMID:
17131378
37.

Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter.

Olave IA, Doneanu C, Fang X, Stamatoyannopoulos G, Li Q.

J Biol Chem. 2007 Jan 12;282(2):853-62. Epub 2006 Nov 17.

38.
39.

Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.

Li Q, Fang X, Olave I, Han H, Yu M, Xiang P, Stamatoyannopoulos G.

Nucleic Acids Res. 2006;34(14):3909-16. Epub 2006 Aug 12.

40.

Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

Cao H, Stamatoyannopoulos G.

Am J Hematol. 2006 Dec;81(12):981-3.

41.

Effects of human gamma-globin in murine beta-thalassaemia.

Nishino T, Cao H, Stamatoyannopoulos G, Emery DW.

Br J Haematol. 2006 Jul;134(1):100-8.

42.

Autonomous silencing as well as competition controls gamma-globin gene expression during development.

Yu M, Han H, Xiang P, Li Q, Stamatoyannopoulos G.

Mol Cell Biol. 2006 Jul;26(13):4775-81.

43.

Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.

Aker M, Tubb J, Miller DG, Stamatoyannopoulos G, Emery DW.

Mol Ther. 2006 Aug;14(2):226-35. Epub 2006 May 2.

44.

Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.

Navas PA, Li Q, Peterson KR, Stamatoyannopoulos G.

Exp Biol Med (Maywood). 2006 Mar;231(3):328-34.

45.
46.

Investigations of the induction of the goat beta(C) globin gene by erythropoietin: studies in transgenic mice.

Yu M, Li Q, Stamatoyannopoulos G.

Blood Cells Mol Dis. 2005 Nov-Dec;35(3):332-8. Epub 2005 Oct 10.

PMID:
16216538
47.

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.

Harju S, Navas PA, Stamatoyannopoulos G, Peterson KR.

Mol Cell Biol. 2005 Oct;25(20):8765-78.

48.

Prospects for developing a molecular cure for thalassemia.

Stamatoyannopoulos G.

Hematology. 2005;10 Suppl 1:255-7. Review. No abstract available.

PMID:
16188685
49.

Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.

Xiang P, Han H, Barkess G, Olave I, Fang X, Yin W, Stamatoyannopoulos G, Li Q.

Hum Mol Genet. 2005 Oct 15;14(20):3047-56. Epub 2005 Sep 9.

PMID:
16155112
50.

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.

Fang X, Sun J, Xiang P, Yu M, Navas PA, Peterson KR, Stamatoyannopoulos G, Li Q.

Mol Cell Biol. 2005 Aug;25(16):7033-41.

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