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Items: 8

1.

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers.

Stalnecker CA, Der CJ.

Sci Signal. 2020 Mar 24;13(624). pii: eaay6013. doi: 10.1126/scisignal.aay6013. Review.

PMID:
32209699
2.

The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled.

Li Y, Ramachandran S, Nguyen TT, Stalnecker CA, Cerione RA, Erickson JW.

J Biol Chem. 2020 Jan 31;295(5):1328-1337. doi: 10.1074/jbc.RA119.010314. Epub 2019 Dec 23.

PMID:
31871054
3.

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.

Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA.

Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 201911954. doi: 10.1073/pnas.1911954116. [Epub ahead of print]

PMID:
31843902
4.

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ.

Nat Med. 2019 Apr;25(4):628-640. doi: 10.1038/s41591-019-0368-8. Epub 2019 Mar 4.

5.

Balancing redox stress: anchorage-independent growth requires reductive carboxylation.

Stalnecker CA, Cluntun AA, Cerione RA.

Transl Cancer Res. 2016 Sep;5(Suppl 3):S433-S437. doi: 10.21037/tcr.2016.09.02. No abstract available.

6.

Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.

Stalnecker CA, Erickson JW, Cerione RA.

J Biol Chem. 2017 Apr 14;292(15):6095-6107. doi: 10.1074/jbc.M116.758219. Epub 2017 Feb 14.

7.

Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.

Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S.

J Biol Chem. 2016 Sep 30;291(40):20900-20910. Epub 2016 Aug 19.

8.

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.

Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9. doi: 10.1073/pnas.1414056112. Epub 2014 Dec 29.

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