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The NG2 Proteoglycan in Pericyte Biology.

Stallcup WB.

Adv Exp Med Biol. 2018;1109:5-19. doi: 10.1007/978-3-030-02601-1_2. Review.


Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis.

Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK.

Nat Commun. 2018 Aug 21;9(1):2862. doi: 10.1038/s41467-018-05099-3.


Dissecting the multifactorial nature of demyelinating disease.

Kucharova K, Stallcup WB.

Neural Regen Res. 2018 Apr;13(4):628-632. doi: 10.4103/1673-5374.230281. Review.


Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.

Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA.

J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.


Distinct NG2 proteoglycan-dependent roles of resident microglia and bone marrow-derived macrophages during myelin damage and repair.

Kucharova K, Stallcup WB.

PLoS One. 2017 Nov 2;12(11):e0187530. doi: 10.1371/journal.pone.0187530. eCollection 2017.


Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis.

You WK, Stallcup WB.

Cancers (Basel). 2017 Jul 28;9(8). pii: E97. doi: 10.3390/cancers9080097.


NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations.

Stallcup WB.

Cancers (Basel). 2017 Mar 31;9(4). pii: E31. doi: 10.3390/cancers9040031. Review.


Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.

Guimarães-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM.

Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5. doi: 10.1016/j.stem.2016.12.006. Epub 2017 Jan 19.


Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F516-F532. doi: 10.1152/ajprenal.00604.2016. Epub 2017 Jan 4.


Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M.

Nature. 2016 Oct 20;538(7625):350-355. doi: 10.1038/nature19799. Epub 2016 Sep 28.


Tumor-Targeted Multimodal Optical Imaging with Versatile Cadmium-Free Quantum Dots.

Liu X, Braun GB, Zhong H, Hall DJ, Han W, Qin M, Zhao C, Wang M, She ZG, Cao C, Sailor MJ, Stallcup WB, Ruoslahti E, Sugahara KN.

Adv Funct Mater. 2016 Jan 13;26(2):267-276. Epub 2015 Dec 2.


Role of NG2 proteoglycan in macrophage recruitment to brain tumors and sites of CNS demyelination.

Cejudo-Martin P, Kucharova K, Stallcup WB.

Trends Cell Mol Biol. 2016;11:55-65.


NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells.

She ZG, Chang Y, Pang HB, Han W, Chen HZ, Smith JW, Stallcup WB.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):49-59. doi: 10.1161/ATVBAHA.115.306074. Epub 2015 Nov 5.


NG2 Proteoglycan-Dependent Contributions of Pericytes and Macrophages to Brain Tumor Vascularization and Progression.

Stallcup WB, You WK, Kucharova K, Cejudo-Martin P, Yotsumoto F.

Microcirculation. 2016 Feb;23(2):122-33. doi: 10.1111/micc.12251. Review.


Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.

Feutlinske F, Browarski M, Ku MC, Trnka P, Waiczies S, Niendorf T, Stallcup WB, Glass R, Krause E, Maritzen T.

Nat Commun. 2015 Oct 5;6:8535. doi: 10.1038/ncomms9535.


NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair.

Kucharova K, Stallcup WB.

J Neuroinflammation. 2015 Sep 4;12:161. doi: 10.1186/s12974-015-0385-6.


NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization.

Yotsumoto F, You WK, Cejudo-Martin P, Kucharova K, Sakimura K, Stallcup WB.

Oncoimmunology. 2015 Jan 22;4(4):e1001204. eCollection 2015 Apr.


The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

Blouw B, Patel M, Iizuka S, Abdullah C, You WK, Huang X, Li JL, Diaz B, Stallcup WB, Courtneidge SA.

PLoS One. 2015 Mar 31;10(3):e0121003. doi: 10.1371/journal.pone.0121003. eCollection 2015.


Entrapment via synaptic-like connections between NG2 proteoglycan+ cells and dystrophic axons in the lesion plays a role in regeneration failure after spinal cord injury.

Filous AR, Tran A, Howell CJ, Busch SA, Evans TA, Stallcup WB, Kang SH, Bergles DE, Lee SI, Levine JM, Silver J.

J Neurosci. 2014 Dec 3;34(49):16369-84. doi: 10.1523/JNEUROSCI.1309-14.2014.


Shedding of NG2 by MMP-13 attenuates anoikis.

Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila YL.

DNA Cell Biol. 2014 Dec;33(12):854-62. doi: 10.1089/dna.2014.2399.


Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.

Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM.

J Clin Invest. 2014 Jul;124(7):2921-34. doi: 10.1172/JCI74783. Epub 2014 Jun 17.


Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration.

Gu X, Fliesler SJ, Zhao YY, Stallcup WB, Cohen AW, Elliott MH.

Am J Pathol. 2014 Feb;184(2):541-55. doi: 10.1016/j.ajpath.2013.10.022. Epub 2013 Dec 8.


NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function.

You WK, Yotsumoto F, Sakimura K, Adams RH, Stallcup WB.

Angiogenesis. 2014 Jan;17(1):61-76. doi: 10.1007/s10456-013-9378-1. Epub 2013 Aug 8.


NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion.

Cattaruzza S, Nicolosi PA, Braghetta P, Pazzaglia L, Benassi MS, Picci P, Lacrima K, Zanocco D, Rizzo E, Stallcup WB, Colombatti A, Perris R.

J Mol Cell Biol. 2013 Jun;5(3):176-93. doi: 10.1093/jmcb/mjt010. Epub 2013 Apr 3.


Bidirectional myoblast-pericyte plasticity.

Stallcup WB.

Dev Cell. 2013 Mar 25;24(6):563-4. doi: 10.1016/j.devcel.2013.02.018.


Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury.

Tigges U, Komatsu M, Stallcup WB.

J Vasc Res. 2013;50(2):134-44. doi: 10.1159/000345524. Epub 2012 Dec 18.


Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells.

Cattaruzza S, Ozerdem U, Denzel M, Ranscht B, Bulian P, Cavallaro U, Zanocco D, Colombatti A, Stallcup WB, Perris R.

Angiogenesis. 2013 Apr;16(2):309-27. doi: 10.1007/s10456-012-9316-7. Epub 2012 Nov 4.


Cell proliferation along vascular islands during microvascular network growth.

Kelly-Goss MR, Winterer ER, Stapor PC, Yang M, Sweat RS, Stallcup WB, Schmid-Schönbein GW, Murfee WL.

BMC Physiol. 2012 Jun 21;12:7. doi: 10.1186/1472-6793-12-7.


Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan.

Gibby K, You WK, Kadoya K, Helgadottir H, Young LJ, Ellies LG, Chang Y, Cardiff RD, Stallcup WB.

Breast Cancer Res. 2012 Apr 24;14(2):R67.


Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.

Chang Y, She ZG, Sakimura K, Roberts A, Kucharova K, Rowitch DH, Stallcup WB.

PLoS One. 2012;7(1):e30637. doi: 10.1371/journal.pone.0030637. Epub 2012 Jan 25.


Collagen VI ablation retards brain tumor progression due to deficits in assembly of the vascular basal lamina.

You WK, Bonaldo P, Stallcup WB.

Am J Pathol. 2012 Mar;180(3):1145-58. doi: 10.1016/j.ajpath.2011.11.006. Epub 2011 Dec 23.


Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord.

Kucharova K, Chang Y, Boor A, Yong VW, Stallcup WB.

J Neuroinflammation. 2011 Nov 13;8:158. doi: 10.1186/1742-2094-8-158.


Non-stem cell origin for oligodendroglioma.

Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA.

Cancer Cell. 2010 Dec 14;18(6):669-82. doi: 10.1016/j.ccr.2010.10.033.



Sharma G, She ZG, Valenta DT, Stallcup WB, Smith JW.

Nano Life. 2010 Sep;1(3-4):207-214.


Lymphatic/Blood endothelial cell connections at the capillary level in adult rat mesentery.

Robichaux JL, Tanno E, Rappleye JW, Ceballos M, Stallcup WB, Schmid-Schönbein GW, Murfee WL.

Anat Rec (Hoboken). 2010 Oct;293(10):1629-38. doi: 10.1002/ar.21195. Epub 2010 Jul 20.


Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse.

Huang FJ, You WK, Bonaldo P, Seyfried TN, Pasquale EB, Stallcup WB.

Dev Biol. 2010 Aug 15;344(2):1035-46. doi: 10.1016/j.ydbio.2010.06.023. Epub 2010 Jun 27.


MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells.

Qi Y, Liang J, She ZG, Cai Y, Wang J, Lei T, Stallcup WB, Fu M.

FEBS Lett. 2010 Jul 16;584(14):3065-72. doi: 10.1016/j.febslet.2010.05.040. Epub 2010 May 24.


Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.

Matsumoto Y, Matsumoto K, Irie F, Fukushi J, Stallcup WB, Yamaguchi Y.

J Biol Chem. 2010 Jun 18;285(25):19227-34. doi: 10.1074/jbc.M110.105338. Epub 2010 Apr 19.


Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen.

Bluemel C, Hausmann S, Fluhr P, Sriskandarajah M, Stallcup WB, Baeuerle PA, Kufer P.

Cancer Immunol Immunother. 2010 Aug;59(8):1197-209. doi: 10.1007/s00262-010-0844-y. Epub 2010 Mar 23.


The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelination.

Kucharova K, Stallcup WB.

Neuroscience. 2010 Mar 10;166(1):185-94. doi: 10.1016/j.neuroscience.2009.12.014. Epub 2009 Dec 16.


Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate.

Skihar V, Silva C, Chojnacki A, Döring A, Stallcup WB, Weiss S, Yong VW.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17992-7. doi: 10.1073/pnas.0909607106. Epub 2009 Oct 6.


Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice.

She ZG, Zheng W, Wei YS, Chen HZ, Wang AB, Li HL, Liu G, Zhang R, Liu JJ, Stallcup WB, Zhou Z, Liu DP, Liang CC.

Circ Res. 2009 May 22;104(10):1160-8. doi: 10.1161/CIRCRESAHA.108.192229. Epub 2009 Apr 9.


A role for the NG2 proteoglycan in glioma progression.

Stallcup WB, Huang FJ.

Cell Adh Migr. 2008 Jul-Sep;2(3):192-201. Epub 2008 Jul 13. Review.


A myocardial lineage derives from Tbx18 epicardial cells.

Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM.

Nature. 2008 Jul 3;454(7200):104-8. doi: 10.1038/nature06969. Epub 2008 May 14.


The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling.

Chekenya M, Krakstad C, Svendsen A, Netland IA, Staalesen V, Tysnes BB, Selheim F, Wang J, Sakariassen PØ, Sandal T, Lønning PE, Flatmark T, Enger PØ, Bjerkvig R, Sioud M, Stallcup WB.

Oncogene. 2008 Sep 4;27(39):5182-94. doi: 10.1038/onc.2008.157. Epub 2008 May 12.


NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.

Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL.

Cell Death Differ. 2008 May;15(5):899-907. doi: 10.1038/cdd.2008.22. Epub 2008 Feb 22.


FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages.

Tigges U, Hyer EG, Scharf J, Stallcup WB.

Development. 2008 Feb;135(3):523-32. doi: 10.1242/dev.002071. Epub 2008 Jan 2.


NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouse.

Kadoya K, Fukushi J, Matsumoto Y, Yamaguchi Y, Stallcup WB.

J Histochem Cytochem. 2008 Mar;56(3):295-303. Epub 2007 Nov 26.


Reversal of cellular roles in angiogenesis: implications for anti-angiogenic therapy.

Virgintino D, Ozerdem U, Girolamo F, Roncali L, Stallcup WB, Perris R.

J Vasc Res. 2008;45(2):129-31. Epub 2007 Oct 17. No abstract available.

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