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Items: 1 to 50 of 78

1.

Agglutinin-Like Sequence (ALS) Genes in the Candida parapsilosis Species Complex: Blurring the Boundaries Between Gene Families That Encode Cell-Wall Proteins.

Oh SH, Smith B, Miller AN, Staker B, Fields C, Hernandez A, Hoyer LL.

Front Microbiol. 2019 Apr 26;10:781. doi: 10.3389/fmicb.2019.00781. eCollection 2019.

2.

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.

3.

Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties.

Dumais M, Davies DR, Lin T, Staker BL, Myler PJ, Van Voorhis WC.

Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):373-384. doi: 10.1107/S2053230X18007392. Epub 2018 May 31.

4.

Crystal structure of chorismate mutase from Burkholderia thailandensis.

Asojo OA, Dranow DM, Serbzhinskiy D, Subramanian S, Staker B, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):294-299. doi: 10.1107/S2053230X1800506X. Epub 2018 Apr 16.

5.

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications.

Helgren TR, Seven ES, Chen C, Edwards TE, Staker BL, Abendroth J, Myler PJ, Horn JR, Hagen TJ.

Bioorg Med Chem Lett. 2018 May 1;28(8):1376-1380. doi: 10.1016/j.bmcl.2018.03.002. Epub 2018 Mar 15.

6.

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.

Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.

7.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.

Moen SO, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD.

Sci Rep. 2017 Mar 16;7(1):223. doi: 10.1038/s41598-017-00367-6.

8.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.

Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE.

Sci Rep. 2017 Jan 25;7:41074. doi: 10.1038/srep41074.

9.

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.

Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ.

Bioorg Med Chem. 2017 Feb 1;25(3):813-824. doi: 10.1016/j.bmc.2016.11.013. Epub 2016 Nov 10.

10.

The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Cala AR, Nadeau MT, Abendroth J, Staker BL, Reers AR, Weatherhead AW, Dobson RC, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):885-891. Epub 2016 Nov 25.

11.

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ.

Mol Microbiol. 2017 Feb;103(4):618-634. doi: 10.1111/mmi.13577. Epub 2016 Dec 23.

12.

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution.

Naqvi KF, Staker BL, Dobson RC, Serbzhinskiy D, Sankaran B, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):2-9. doi: 10.1107/S2053230X15023213. Epub 2016 Jan 1.

13.

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.

Gillespie JJ, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Rahman MS, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen AT.

MBio. 2015 Dec 8;6(6):e01867-15. doi: 10.1128/mBio.01867-15.

14.

Recent contributions of structure-based drug design to the development of antibacterial compounds.

Staker BL, Buchko GW, Myler PJ.

Curr Opin Microbiol. 2015 Oct;27:133-8. doi: 10.1016/j.mib.2015.09.003. Review.

15.

Advances in Bacterial Methionine Aminopeptidase Inhibition.

Helgren TR, Wangtrakuldee P, Staker BL, Hagen TJ.

Curr Top Med Chem. 2016;16(4):397-414. Review.

16.

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.

Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi: 10.1107/S2053230X15006883. Epub 2015 Apr 21.

17.

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.

Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):594-9. doi: 10.1107/S2053230X15004677. Epub 2015 Apr 21.

18.

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):572-6. doi: 10.1107/S2053230X1500237X. Epub 2015 Apr 21.

19.

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.

Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):566-71. doi: 10.1107/S2053230X15001831. Epub 2015 Apr 21.

20.

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.

Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi: 10.1107/S2053230X1500179X. Epub 2015 Apr 21.

21.

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.

Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):522-30. doi: 10.1107/S2053230X14028210. Epub 2015 Apr 18.

22.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.

23.

Increasing the structural coverage of tuberculosis drug targets.

Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ.

Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19.

24.

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.

Moen SO, Abendroth J, Fairman JW, Baydo RO, Bullen J, Kirkwood JL, Barnes SR, Raymond AC, Begley DW, Henkel G, McCormack K, Tam VC, Phan I, Staker BL, Stacy R, Myler PJ, Lorimer D, Edwards TE.

Sci Rep. 2014 Aug 4;4:5944. doi: 10.1038/srep05944.

25.

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.

Linford AS, Jiang NM, Edwards TE, Sherman NE, Van Voorhis WC, Stewart LJ, Myler PJ, Staker BL, Petri WA Jr.

Mol Biochem Parasitol. 2014 Jan;193(1):33-44. doi: 10.1016/j.molbiopara.2014.01.003. Epub 2014 Feb 15.

26.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.

Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD.

Antimicrob Agents Chemother. 2014;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23.

27.

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.

J Biol Chem. 2014 Jan 24;289(4):2139-47. doi: 10.1074/jbc.M113.525683. Epub 2013 Dec 4.

28.

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.

Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6860-3. doi: 10.1016/j.bmcl.2013.09.101. Epub 2013 Oct 8.

29.

Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.

Armour BL, Barnes SR, Moen SO, Smith E, Raymond AC, Fairman JW, Stewart LJ, Staker BL, Begley DW, Edwards TE, Lorimer DD.

J Vis Exp. 2013 Jun 28;(76). doi: 10.3791/4225.

30.

Combining functional and structural genomics to sample the essential Burkholderia structome.

Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC.

PLoS One. 2013;8(1):e53851. doi: 10.1371/journal.pone.0053851. Epub 2013 Jan 31.

31.

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.

Edwards TE, Abramov AB, Smith ER, Baydo RO, Leonard JT, Leibly DJ, Thompkins KB, Clifton MC, Gardberg AS, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ.

BMC Struct Biol. 2011 Oct 13;11:39. doi: 10.1186/1472-6807-11-39.

32.

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans.

Clifton MC, Abendroth J, Edwards TE, Leibly DJ, Gillespie AK, Ferrell M, Dieterich SH, Exley I, Staker BL, Myler PJ, Van Voorhis WC, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1154-8. doi: 10.1107/S1744309111029575. Epub 2011 Aug 16.

33.

Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution.

Subramanian S, Abendroth J, Phan IQ, Olsen C, Staker BL, Napuli A, Van Voorhis WC, Stacy R, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1118-22. doi: 10.1107/S1744309111030673. Epub 2011 Aug 16.

34.

Structure of aldose reductase from Giardia lamblia.

Ferrell M, Abendroth J, Zhang Y, Sankaran B, Edwards TE, Staker BL, Van Voorhis WC, Stewart LJ, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1113-7. doi: 10.1107/S1744309111030879. Epub 2011 Aug 16.

35.

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative β-lactamase-like protein' from Brucella melitensis.

Abendroth J, Sankaran B, Edwards TE, Gardberg AS, Dieterich S, Bhandari J, Napuli AJ, Van Voorhis WC, Staker BL, Myler PJ, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1106-12. doi: 10.1107/S1744309111010220. Epub 2011 Aug 16.

36.

Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.

Buchko GW, Edwards TE, Abendroth J, Arakaki TL, Law L, Napuli AJ, Hewitt SN, Van Voorhis WC, Stewart LJ, Staker BL, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1078-83. doi: 10.1107/S1744309111011559. Epub 2011 Aug 16.

37.

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.

Begley DW, Edwards TE, Raymond AC, Smith ER, Hartley RC, Abendroth J, Sankaran B, Lorimer DD, Myler PJ, Staker BL, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1070-7. doi: 10.1107/S1744309111029009. Epub 2011 Aug 16.

38.

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.

Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1060-9. doi: 10.1107/S1744309111014436. Epub 2011 Aug 13.

39.

Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi.

Gardberg A, Sankaran B, Davies D, Bhandari J, Staker B, Stewart L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1055-9. doi: 10.1107/S1744309111021841. Epub 2011 Aug 13.

40.

Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate.

Gardberg A, Abendroth J, Bhandari J, Sankaran B, Staker B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1051-4. doi: 10.1107/S174430911101894X. Epub 2011 Aug 13.

41.

An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.

Davies DR, Staker BL, Abendroth JA, Edwards TE, Hartley R, Leonard J, Kim H, Rychel AL, Hewitt SN, Myler PJ, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1044-50. doi: 10.1107/S1744309111030405. Epub 2011 Aug 13.

42.

Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.

Edwards TE, Bryan CM, Leibly DJ, Dieterich SH, Abendroth J, Sankaran B, Sivam D, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1038-43. doi: 10.1107/S1744309111009493. Epub 2011 Aug 13.

43.

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei.

Edwards TE, Leibly DJ, Bhandari J, Statnekov JB, Phan I, Dieterich SH, Abendroth J, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1032-7. doi: 10.1107/S1744309111004349. Epub 2011 Aug 13.

44.

The Protein Maker: an automated system for high-throughput parallel purification.

Smith ER, Begley DW, Anderson V, Raymond AC, Haffner TE, Robinson JI, Edwards TE, Duncan N, Gerdts CJ, Mixon MB, Nollert P, Staker BL, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1015-21. doi: 10.1107/S1744309111028776. Epub 2011 Aug 13.

45.

Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease.

Raymond A, Haffner T, Ng N, Lorimer D, Staker B, Stewart L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):992-7. doi: 10.1107/S1744309111026698. Epub 2011 Aug 13.

46.

Gene Composer in a structural genomics environment.

Lorimer D, Raymond A, Mixon M, Burgin A, Staker B, Stewart L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):985-91. doi: 10.1107/S1744309111027424. Epub 2011 Aug 13.

47.

Structural genomics of infectious disease drug targets: the SSGCID.

Stacy R, Begley DW, Phan I, Staker BL, Van Voorhis WC, Varani G, Buchko GW, Stewart LJ, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):979-84. doi: 10.1107/S1744309111029204. Epub 2011 Aug 13.

48.

Fragment screening of infectious disease targets in a structural genomics environment.

Begley DW, Davies DR, Hartley RC, Edwards TE, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ.

Methods Enzymol. 2011;493:533-56. doi: 10.1016/B978-0-12-381274-2.00021-2.

49.

Predicting the success of fragment screening by X-ray crystallography.

Davies DR, Begley DW, Hartley RC, Staker BL, Stewart LJ.

Methods Enzymol. 2011;493:91-114. doi: 10.1016/B978-0-12-381274-2.00004-2.

PMID:
21371588
50.

SAD phasing using iodide ions in a high-throughput structural genomics environment.

Abendroth J, Gardberg AS, Robinson JI, Christensen JS, Staker BL, Myler PJ, Stewart LJ, Edwards TE.

J Struct Funct Genomics. 2011 Jul;12(2):83-95. doi: 10.1007/s10969-011-9101-7. Epub 2011 Feb 27.

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