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Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NMI, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402. [Epub ahead of print]


Structural basis for regulation of human acetyl-CoA carboxylase.

Hunkeler M, Hagmann A, Stuttfeld E, Chami M, Guri Y, Stahlberg H, Maier T.

Nature. 2018 Jun;558(7710):470-474. doi: 10.1038/s41586-018-0201-4. Epub 2018 Jun 13.


Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.

Seuring C, Ayyer K, Filippaki E, Barthelmess M, Longchamp JN, Ringler P, Pardini T, Wojtas DH, Coleman MA, Dörner K, Fuglerud S, Hammarin G, Habenstein B, Langkilde AE, Loquet A, Meents A, Riek R, Stahlberg H, Boutet S, Hunter MS, Koglin J, Liang M, Ginn HM, Millane RP, Frank M, Barty A, Chapman HN.

Nat Commun. 2018 May 9;9(1):1836. doi: 10.1038/s41467-018-04116-9.


Image processing techniques for high-resolution structure determination from badly ordered 2D crystals.

Biyani N, Scherer S, Righetto RD, Kowal J, Chami M, Stahlberg H.

J Struct Biol. 2018 Aug;203(2):120-134. doi: 10.1016/j.jsb.2018.03.013. Epub 2018 Apr 22.


Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.

Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP.

Nat Struct Mol Biol. 2018 Apr;25(4):333-340. doi: 10.1038/s41594-018-0049-1. Epub 2018 Apr 2.


Miniaturizing EM Sample Preparation: Opportunities, Challenges, and "Visual Proteomics".

Arnold SA, Müller SA, Schmidli C, Syntychaki A, Rima L, Chami M, Stahlberg H, Goldie KN, Braun T.

Proteomics. 2018 Mar;18(5-6):e1700176. doi: 10.1002/pmic.201700176. Review.


Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1973-E1982. doi: 10.1073/pnas.1717044115. Epub 2018 Feb 13.


3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.

Sedzicki J, Tschon T, Low SH, Willemart K, Goldie KN, Letesson JJ, Stahlberg H, Dehio C.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210799. doi: 10.1242/jcs.210799.


Application of hot-melt extrusion technology in immediate-release abuse-deterrent formulations.

Wening K, Schwier S, Stahlberg HJ, Galia E.

J Opioid Manag. 2017 Nov/Dec;13(6):473-484. doi: 10.5055/jom.2017.0422.


Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end.

Nazarov S, Schneider JP, Brackmann M, Goldie KN, Stahlberg H, Basler M.

EMBO J. 2018 Feb 15;37(4). pii: e97103. doi: 10.15252/embj.201797103. Epub 2017 Dec 18.


High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.

Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.

Structure. 2018 Jan 2;26(1):20-27.e3. doi: 10.1016/j.str.2017.11.012. Epub 2017 Dec 14.


MRCZ - A file format for cryo-TEM data with fast compression.

McLeod RA, Diogo Righetto R, Stewart A, Stahlberg H.

J Struct Biol. 2018 Mar;201(3):252-257. doi: 10.1016/j.jsb.2017.11.012. Epub 2017 Nov 23.


Cryo-EM structure of the extended type VI secretion system sheath-tube complex.

Wang J, Brackmann M, Castaño-Díez D, Kudryashev M, Goldie KN, Maier T, Stahlberg H, Basler M.

Nat Microbiol. 2017 Nov;2(11):1507-1512. doi: 10.1038/s41564-017-0020-7. Epub 2017 Sep 25.


Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study.

DeLemos B, Richards HM, Vandenbossche J, Ariyawansa J, Natarajan J, Alexander B, Ramakrishna T, Murtaugh T, Stahlberg HJ.

Clin Pharmacol Drug Dev. 2017 Nov;6(6):592-603. doi: 10.1002/cpdd.378. Epub 2017 Sep 7.


Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.

Sejwal K, Chami M, Rémigy H, Vancraenenbroeck R, Sibran W, Sütterlin R, Baumgartner P, McLeod R, Chartier-Harlin MC, Baekelandt V, Stahlberg H, Taymans JM.

Sci Rep. 2017 Aug 17;7(1):8667. doi: 10.1038/s41598-017-09126-z.


Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor.

Hassaïne G, Deluz C, Grasso L, Wyss R, Hovius R, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Peclinovska L, Minniberger S, Mebarki L, Li XD, Vogel H, Nury H.

Methods Mol Biol. 2017;1635:139-168. doi: 10.1007/978-1-4939-7151-0_8.


Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography.

Shahmoradian SH, Tsai EHR, Diaz A, Guizar-Sicairos M, Raabe J, Spycher L, Britschgi M, Ruf A, Stahlberg H, Holler M.

Sci Rep. 2017 Jul 24;7(1):6291. doi: 10.1038/s41598-017-05587-4.


Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.

Raasakka A, Ruskamo S, Kowal J, Barker R, Baumann A, Martel A, Tuusa J, Myllykoski M, Bürck J, Ulrich AS, Stahlberg H, Kursula P.

Sci Rep. 2017 Jul 10;7(1):4974. doi: 10.1038/s41598-017-05364-3.


Lipid Internal Dynamics Probed in Nanodiscs.

Martinez D, Decossas M, Kowal J, Frey L, Stahlberg H, Dufourc EJ, Riek R, Habenstein B, Bibow S, Loquet A.

Chemphyschem. 2017 Oct 6;18(19):2651-2657. doi: 10.1002/cphc.201700450. Epub 2017 Jun 30.


Structure of the human multidrug transporter ABCG2.

Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP.

Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May 29.


Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress.

Devos S, Van Putte W, Vitse J, Van Driessche G, Stremersch S, Van Den Broek W, Raemdonck K, Braeckmans K, Stahlberg H, Kudryashev M, Savvides SN, Devreese B.

Environ Microbiol. 2017 Oct;19(10):3930-3937. doi: 10.1111/1462-2920.13793. Epub 2017 Jun 22.


Focus: The interface between data collection and data processing in cryo-EM.

Biyani N, Righetto RD, McLeod R, Caujolle-Bert D, Castano-Diez D, Goldie KN, Stahlberg H.

J Struct Biol. 2017 May;198(2):124-133. doi: 10.1016/j.jsb.2017.03.007. Epub 2017 Mar 23.


Cell-free reconstitution reveals centriole cartwheel assembly mechanisms.

Guichard P, Hamel V, Le Guennec M, Banterle N, Iacovache I, Nemčíková V, Flückiger I, Goldie KN, Stahlberg H, Lévy D, Zuber B, Gönczy P.

Nat Commun. 2017 Mar 23;8:14813. doi: 10.1038/ncomms14813.


Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different.

Seuring C, Verasdonck J, Ringler P, Cadalbert R, Stahlberg H, Böckmann A, Meier BH, Riek R.

J Phys Chem B. 2017 Mar 2;121(8):1783-1792. doi: 10.1021/acs.jpcb.6b10624. Epub 2017 Feb 20.


Robust image alignment for cryogenic transmission electron microscopy.

McLeod RA, Kowal J, Ringler P, Stahlberg H.

J Struct Biol. 2017 Mar;197(3):279-293. doi: 10.1016/j.jsb.2016.12.006. Epub 2016 Dec 27.


Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.

Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R.

Nat Struct Mol Biol. 2017 Feb;24(2):187-193. doi: 10.1038/nsmb.3345. Epub 2016 Dec 26.


Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts.

Arnold SA, Albiez S, Bieri A, Syntychaki A, Adaixo R, McLeod RA, Goldie KN, Stahlberg H, Braun T.

J Struct Biol. 2017 Mar;197(3):220-226. doi: 10.1016/j.jsb.2016.11.002. Epub 2016 Nov 15.


Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor.

Rheinberger J, Hassaine G, Chami M, Stahlberg H, Vogel H, Li X.

Micron. 2017 Jan;92:19-24. doi: 10.1016/j.micron.2016.10.004. Epub 2016 Oct 22.


Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.

Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S.

Nat Commun. 2016 Sep 20;7:12789. doi: 10.1038/ncomms12789.


Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins.

Abeyrathne PD, Chami M, Stahlberg H.

Biochimie. 2016 Sep-Oct;128-129:154-62. doi: 10.1016/j.biochi.2016.08.008. Epub 2016 Aug 21. Review.


GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.

Sborgi L, Rühl S, Mulvihill E, Pipercevic J, Heilig R, Stahlberg H, Farady CJ, Müller DJ, Broz P, Hiller S.

EMBO J. 2016 Aug 15;35(16):1766-78. doi: 10.15252/embj.201694696. Epub 2016 Jul 14.


Dynamo Catalogue: Geometrical tools and data management for particle picking in subtomogram averaging of cryo-electron tomograms.

Castaño-Díez D, Kudryashev M, Stahlberg H.

J Struct Biol. 2017 Feb;197(2):135-144. doi: 10.1016/j.jsb.2016.06.005. Epub 2016 Jun 8.


Structure of the T4 baseplate and its function in triggering sheath contraction.

Taylor NM, Prokhorov NS, Guerrero-Ferreira RC, Shneider MM, Browning C, Goldie KN, Stahlberg H, Leiman PG.

Nature. 2016 May 19;533(7603):346-52. doi: 10.1038/nature17971.


Total Sample Conditioning and Preparation of Nanoliter Volumes for Electron Microscopy.

Arnold SA, Albiez S, Opara N, Chami M, Schmidli C, Bieri A, Padeste C, Stahlberg H, Braun T.

ACS Nano. 2016 May 24;10(5):4981-8. doi: 10.1021/acsnano.6b01328. Epub 2016 Apr 19.


Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs.

Plath F, Ringler P, Graff-Meyer A, Stahlberg H, Lauer ME, Rufer AC, Graewert MA, Svergun D, Gellermann G, Finkler C, Stracke JO, Koulov A, Schnaible V.

MAbs. 2016 Jul;8(5):928-40. doi: 10.1080/19420862.2016.1168960. Epub 2016 Mar 31.


Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.

Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH.

Nature. 2016 Mar 31;531(7596):598-603. doi: 10.1038/nature17416.


Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

Lauer ME, Graff-Meyer A, Rufer AC, Maugeais C, von der Mark E, Matile H, D'Arcy B, Magg C, Ringler P, Müller SA, Scherer S, Dernick G, Thoma R, Hennig M, Niesor EJ, Stahlberg H.

J Struct Biol. 2016 May;194(2):191-8. doi: 10.1016/j.jsb.2016.02.016. Epub 2016 Feb 12.


Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles.

Eichmann C, Campioni S, Kowal J, Maslennikov I, Gerez J, Liu X, Verasdonck J, Nespovitaya N, Choe S, Meier BH, Picotti P, Rizo J, Stahlberg H, Riek R.

J Biol Chem. 2016 Apr 15;291(16):8516-27. doi: 10.1074/jbc.M115.707968. Epub 2016 Feb 4.


The lipidome associated with the γ-secretase complex is required for its integrity and activity.

Ayciriex S, Gerber H, Osuna GM, Chami M, Stahlberg H, Shevchenko A, Fraering PC.

Biochem J. 2016 Feb 1;473(3):321-34. doi: 10.1042/BJ20150448.


The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles.

Kudryashev M, Castaño-Díez D, Deluz C, Hassaine G, Grasso L, Graf-Meyer A, Vogel H, Stahlberg H.

Structure. 2016 Jan 5;24(1):165-170. doi: 10.1016/j.str.2015.11.004. Epub 2015 Dec 24.


Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

Sborgi L, Ravotti F, Dandey VP, Dick MS, Mazur A, Reckel S, Chami M, Scherer S, Huber M, Böckmann A, Egelman EH, Stahlberg H, Broz P, Meier BH, Hiller S.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13237-42. doi: 10.1073/pnas.1507579112. Epub 2015 Oct 13.


Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.

Beckert B, Kedrov A, Sohmen D, Kempf G, Wild K, Sinning I, Stahlberg H, Wilson DN, Beckmann R.

Nat Struct Mol Biol. 2015 Oct;22(10):767-73. doi: 10.1038/nsmb.3086. Epub 2015 Sep 7.


3D reconstruction of two-dimensional crystals.

Stahlberg H, Biyani N, Engel A.

Arch Biochem Biophys. 2015 Sep 1;581:68-77. doi: 10.1016/ Epub 2015 Jun 17. Review.


CTF Challenge: Result summary.

Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, Quintana A, Sorzano CO, Stahlberg H, Vargas J, Voss NR, Chiu W, Carazo JM.

J Struct Biol. 2015 Jun;190(3):348-59. doi: 10.1016/j.jsb.2015.04.003. Epub 2015 Apr 23.


Structure of the type VI secretion system contractile sheath.

Kudryashev M, Wang RY, Brackmann M, Scherer S, Maier T, Baker D, DiMaio F, Stahlberg H, Egelman EH, Basler M.

Cell. 2015 Feb 26;160(5):952-962. doi: 10.1016/j.cell.2015.01.037.


Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation.

Kudryashev M, Diepold A, Amstutz M, Armitage JP, Stahlberg H, Cornelis GR.

Mol Microbiol. 2015 Mar;95(5):875-84. doi: 10.1111/mmi.12908. Epub 2015 Jan 30.


Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R.

Cell Rep. 2014 Nov 6;9(3):810-21. doi: 10.1016/j.celrep.2014.09.055. Epub 2014 Oct 30.


X-ray structure of the mouse serotonin 5-HT3 receptor.

Hassaine G, Deluz C, Grasso L, Wyss R, Tol MB, Hovius R, Graff A, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Li XD, Poitevin F, Vogel H, Nury H.

Nature. 2014 Aug 21;512(7514):276-81. doi: 10.1038/nature13552. Epub 2014 Aug 3.


The ultrastructure of Chlorobaculum tepidum revealed by cryo-electron tomography.

Kudryashev M, Aktoudianaki A, Dedoglou D, Stahlberg H, Tsiotis G.

Biochim Biophys Acta. 2014 Oct;1837(10):1635-42. doi: 10.1016/j.bbabio.2014.06.002. Epub 2014 Jun 17.


Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports.

Kowal JŁ, Kowal JK, Wu D, Stahlberg H, Palivan CG, Meier WP.

Biomaterials. 2014 Aug;35(26):7286-94. doi: 10.1016/j.biomaterials.2014.05.043. Epub 2014 Jun 6.


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