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Items: 1 to 50 of 168

1.

Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems.

Schneider JP, Nazarov S, Adaixo R, Liuzzo M, Ringel PD, Stahlberg H, Basler M.

EMBO J. 2019 Sep 16;38(18):e100825. doi: 10.15252/embj.2018100825. Epub 2019 Aug 12.

2.

"Differential Visual Proteomics": Enabling the Proteome-Wide Comparison of Protein Structures of Single-Cells.

Syntychaki A, Rima L, Schmidli C, Stohler T, Bieri A, Sütterlin R, Stahlberg H, Castaño-Díez D, Braun T.

J Proteome Res. 2019 Sep 6;18(9):3521-3531. doi: 10.1021/acs.jproteome.9b00447. Epub 2019 Aug 12.

PMID:
31355640
3.

Imaging of post-mortem human brain tissue using electron and X-ray microscopy.

Lewis AJ, Genoud C, Pont M, van de Berg WD, Frank S, Stahlberg H, Shahmoradian SH, Al-Amoudi A.

Curr Opin Struct Biol. 2019 Jul 23;58:138-148. doi: 10.1016/j.sbi.2019.06.003. [Epub ahead of print] Review.

4.

Microfluidic protein isolation and sample preparation for high-resolution cryo-EM.

Schmidli C, Albiez S, Rima L, Righetto R, Mohammed I, Oliva P, Kovacik L, Stahlberg H, Braun T.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15007-15012. doi: 10.1073/pnas.1907214116. Epub 2019 Jul 10.

5.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit.

Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G.

Elife. 2019 Jun 28;8. pii: e46041. doi: 10.7554/eLife.46041.

6.

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.

Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME.

Nat Neurosci. 2019 Jul;22(7):1099-1109. doi: 10.1038/s41593-019-0423-2. Epub 2019 Jun 24.

PMID:
31235907
7.

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav5989. doi: 10.1126/scitranslmed.aav5989.

PMID:
31189721
8.

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.

Piper SJ, Brillault L, Rothnagel R, Croll TI, Box JK, Chassagnon I, Scherer S, Goldie KN, Jones SA, Schepers F, Hartley-Tassell L, Ve T, Busby JN, Dalziel JE, Lott JS, Hankamer B, Stahlberg H, Hurst MRH, Landsberg MJ.

Nat Commun. 2019 Apr 26;10(1):1952. doi: 10.1038/s41467-019-09890-8.

9.

Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.

Righetto RD, Biyani N, Kowal J, Chami M, Stahlberg H.

Nat Commun. 2019 Apr 12;10(1):1722. doi: 10.1038/s41467-019-09661-5.

10.

Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases.

Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L.

Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.

11.

Supramolecular architectures of molecularly thin yet robust free-standing layers.

Moradi M, Opara NL, Tulli LG, Wäckerlin C, Dalgarno SJ, Teat SJ, Baljozovic M, Popova O, van Genderen E, Kleibert A, Stahlberg H, Abrahams JP, Padeste C, Corvini PF, Jung TA, Shahgaldian P.

Sci Adv. 2019 Feb 22;5(2):eaav4489. doi: 10.1126/sciadv.aav4489. eCollection 2019 Feb.

12.

Molecular structure and function of myelin protein P0 in membrane stacking.

Raasakka A, Ruskamo S, Kowal J, Han H, Baumann A, Myllykoski M, Fasano A, Rossano R, Riccio P, Bürck J, Ulrich AS, Stahlberg H, Kursula P.

Sci Rep. 2019 Jan 24;9(1):642. doi: 10.1038/s41598-018-37009-4.

13.

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.

Navarro PP, Genoud C, Castaño-Díez D, Graff-Meyer A, Lewis AJ, de Gier Y, Lauer ME, Britschgi M, Bohrmann B, Frank S, Hench J, Schweighauser G, Rozemuller AJM, van de Berg WDJ, Stahlberg H, Shahmoradian SH.

Sci Rep. 2018 Dec 21;8(1):18046. doi: 10.1038/s41598-018-36223-4.

14.

TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.

Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M.

Nat Neurosci. 2019 Jan;22(1):65-77. doi: 10.1038/s41593-018-0294-y. Epub 2018 Dec 17.

PMID:
30559480
15.

Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions.

Subramanian RH, Smith SJ, Alberstein RG, Bailey JB, Zhang L, Cardone G, Suominen L, Chami M, Stahlberg H, Baker TS, Tezcan FA.

ACS Cent Sci. 2018 Nov 28;4(11):1578-1586. doi: 10.1021/acscentsci.8b00745. Epub 2018 Nov 15.

16.

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.

Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP.

Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov 7.

17.

Demonstration of femtosecond X-ray pump X-ray probe diffraction on protein crystals.

Opara NL, Mohacsi I, Makita M, Castano-Diez D, Diaz A, Juranić P, Marsh M, Meents A, Milne CJ, Mozzanica A, Padeste C, Panneels V, Sikorski M, Song S, Stahlberg H, Vartiainen I, Vera L, Wang M, Willmott PR, David C.

Struct Dyn. 2018 Oct 1;5(5):054303. doi: 10.1063/1.5050618. eCollection 2018 Sep.

18.

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel.

Marchesi A, Gao X, Adaixo R, Rheinberger J, Stahlberg H, Nimigean C, Scheuring S.

Nat Commun. 2018 Sep 28;9(1):3978. doi: 10.1038/s41467-018-06414-8.

19.

Structure of a PSI-LHCI-cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions.

Steinbeck J, Ross IL, Rothnagel R, Gäbelein P, Schulze S, Giles N, Ali R, Drysdale R, Sierecki E, Gambin Y, Stahlberg H, Takahashi Y, Hippler M, Hankamer B.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10517-10522. doi: 10.1073/pnas.1809973115. Epub 2018 Sep 25.

20.

Protocols for Subtomogram Averaging of Membrane Proteins in the Dynamo Software Package.

Navarro PP, Stahlberg H, Castaño-Díez D.

Front Mol Biosci. 2018 Sep 4;5:82. doi: 10.3389/fmolb.2018.00082. eCollection 2018.

21.

Miniaturized Sample Preparation for Transmission Electron Microscopy.

Schmidli C, Rima L, Arnold SA, Stohler T, Syntychaki A, Bieri A, Albiez S, Goldie KN, Chami M, Stahlberg H, Braun T.

J Vis Exp. 2018 Jul 27;(137). doi: 10.3791/57310.

22.

Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402.

23.

Structural basis for regulation of human acetyl-CoA carboxylase.

Hunkeler M, Hagmann A, Stuttfeld E, Chami M, Guri Y, Stahlberg H, Maier T.

Nature. 2018 Jun;558(7710):470-474. doi: 10.1038/s41586-018-0201-4. Epub 2018 Jun 13.

PMID:
29899443
24.

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.

Seuring C, Ayyer K, Filippaki E, Barthelmess M, Longchamp JN, Ringler P, Pardini T, Wojtas DH, Coleman MA, Dörner K, Fuglerud S, Hammarin G, Habenstein B, Langkilde AE, Loquet A, Meents A, Riek R, Stahlberg H, Boutet S, Hunter MS, Koglin J, Liang M, Ginn HM, Millane RP, Frank M, Barty A, Chapman HN.

Nat Commun. 2018 May 9;9(1):1836. doi: 10.1038/s41467-018-04116-9.

25.

Image processing techniques for high-resolution structure determination from badly ordered 2D crystals.

Biyani N, Scherer S, Righetto RD, Kowal J, Chami M, Stahlberg H.

J Struct Biol. 2018 Aug;203(2):120-134. doi: 10.1016/j.jsb.2018.03.013. Epub 2018 Apr 22.

26.

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.

Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP.

Nat Struct Mol Biol. 2018 Apr;25(4):333-340. doi: 10.1038/s41594-018-0049-1. Epub 2018 Apr 2.

PMID:
29610494
27.

Miniaturizing EM Sample Preparation: Opportunities, Challenges, and "Visual Proteomics".

Arnold SA, Müller SA, Schmidli C, Syntychaki A, Rima L, Chami M, Stahlberg H, Goldie KN, Braun T.

Proteomics. 2018 Mar;18(5-6):e1700176. doi: 10.1002/pmic.201700176. Review.

PMID:
29441686
28.

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1973-E1982. doi: 10.1073/pnas.1717044115. Epub 2018 Feb 13.

29.

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.

Sedzicki J, Tschon T, Low SH, Willemart K, Goldie KN, Letesson JJ, Stahlberg H, Dehio C.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210799. doi: 10.1242/jcs.210799.

30.

Application of hot-melt extrusion technology in immediate-release abuse-deterrent formulations.

Wening K, Schwier S, Stahlberg HJ, Galia E.

J Opioid Manag. 2017 Nov/Dec;13(6):473-484. doi: 10.5055/jom.2017.0422.

PMID:
29308593
31.

Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end.

Nazarov S, Schneider JP, Brackmann M, Goldie KN, Stahlberg H, Basler M.

EMBO J. 2018 Feb 15;37(4). pii: e97103. doi: 10.15252/embj.201797103. Epub 2017 Dec 18.

32.

High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.

Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.

Structure. 2018 Jan 2;26(1):20-27.e3. doi: 10.1016/j.str.2017.11.012. Epub 2017 Dec 14.

33.

MRCZ - A file format for cryo-TEM data with fast compression.

McLeod RA, Diogo Righetto R, Stewart A, Stahlberg H.

J Struct Biol. 2018 Mar;201(3):252-257. doi: 10.1016/j.jsb.2017.11.012. Epub 2017 Nov 23.

34.

Cryo-EM structure of the extended type VI secretion system sheath-tube complex.

Wang J, Brackmann M, Castaño-Díez D, Kudryashev M, Goldie KN, Maier T, Stahlberg H, Basler M.

Nat Microbiol. 2017 Nov;2(11):1507-1512. doi: 10.1038/s41564-017-0020-7. Epub 2017 Sep 25.

PMID:
28947741
35.

Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study.

DeLemos B, Richards HM, Vandenbossche J, Ariyawansa J, Natarajan J, Alexander B, Ramakrishna T, Murtaugh T, Stahlberg HJ.

Clin Pharmacol Drug Dev. 2017 Nov;6(6):592-603. doi: 10.1002/cpdd.378. Epub 2017 Sep 7.

PMID:
28881493
36.

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.

Sejwal K, Chami M, Rémigy H, Vancraenenbroeck R, Sibran W, Sütterlin R, Baumgartner P, McLeod R, Chartier-Harlin MC, Baekelandt V, Stahlberg H, Taymans JM.

Sci Rep. 2017 Aug 17;7(1):8667. doi: 10.1038/s41598-017-09126-z.

37.

Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor.

Hassaïne G, Deluz C, Grasso L, Wyss R, Hovius R, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Peclinovska L, Minniberger S, Mebarki L, Li XD, Vogel H, Nury H.

Methods Mol Biol. 2017;1635:139-168. doi: 10.1007/978-1-4939-7151-0_8.

PMID:
28755368
38.

Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography.

Shahmoradian SH, Tsai EHR, Diaz A, Guizar-Sicairos M, Raabe J, Spycher L, Britschgi M, Ruf A, Stahlberg H, Holler M.

Sci Rep. 2017 Jul 24;7(1):6291. doi: 10.1038/s41598-017-05587-4.

39.

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.

Raasakka A, Ruskamo S, Kowal J, Barker R, Baumann A, Martel A, Tuusa J, Myllykoski M, Bürck J, Ulrich AS, Stahlberg H, Kursula P.

Sci Rep. 2017 Jul 10;7(1):4974. doi: 10.1038/s41598-017-05364-3.

40.

Lipid Internal Dynamics Probed in Nanodiscs.

Martinez D, Decossas M, Kowal J, Frey L, Stahlberg H, Dufourc EJ, Riek R, Habenstein B, Bibow S, Loquet A.

Chemphyschem. 2017 Oct 6;18(19):2651-2657. doi: 10.1002/cphc.201700450. Epub 2017 Jun 30.

41.

Structure of the human multidrug transporter ABCG2.

Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP.

Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May 29.

PMID:
28554189
42.

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress.

Devos S, Van Putte W, Vitse J, Van Driessche G, Stremersch S, Van Den Broek W, Raemdonck K, Braeckmans K, Stahlberg H, Kudryashev M, Savvides SN, Devreese B.

Environ Microbiol. 2017 Oct;19(10):3930-3937. doi: 10.1111/1462-2920.13793. Epub 2017 Jun 22.

PMID:
28488744
43.

Focus: The interface between data collection and data processing in cryo-EM.

Biyani N, Righetto RD, McLeod R, Caujolle-Bert D, Castano-Diez D, Goldie KN, Stahlberg H.

J Struct Biol. 2017 May;198(2):124-133. doi: 10.1016/j.jsb.2017.03.007. Epub 2017 Mar 23.

44.

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms.

Guichard P, Hamel V, Le Guennec M, Banterle N, Iacovache I, Nemčíková V, Flückiger I, Goldie KN, Stahlberg H, Lévy D, Zuber B, Gönczy P.

Nat Commun. 2017 Mar 23;8:14813. doi: 10.1038/ncomms14813.

45.

Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different.

Seuring C, Verasdonck J, Ringler P, Cadalbert R, Stahlberg H, Böckmann A, Meier BH, Riek R.

J Phys Chem B. 2017 Mar 2;121(8):1783-1792. doi: 10.1021/acs.jpcb.6b10624. Epub 2017 Feb 20.

PMID:
28075583
46.

Robust image alignment for cryogenic transmission electron microscopy.

McLeod RA, Kowal J, Ringler P, Stahlberg H.

J Struct Biol. 2017 Mar;197(3):279-293. doi: 10.1016/j.jsb.2016.12.006. Epub 2016 Dec 27.

PMID:
28038834
47.

Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.

Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R.

Nat Struct Mol Biol. 2017 Feb;24(2):187-193. doi: 10.1038/nsmb.3345. Epub 2016 Dec 26.

PMID:
28024148
48.

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts.

Arnold SA, Albiez S, Bieri A, Syntychaki A, Adaixo R, McLeod RA, Goldie KN, Stahlberg H, Braun T.

J Struct Biol. 2017 Mar;197(3):220-226. doi: 10.1016/j.jsb.2016.11.002. Epub 2016 Nov 15.

49.

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor.

Rheinberger J, Hassaine G, Chami M, Stahlberg H, Vogel H, Li X.

Micron. 2017 Jan;92:19-24. doi: 10.1016/j.micron.2016.10.004. Epub 2016 Oct 22.

PMID:
27825023
50.

Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.

Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S.

Nat Commun. 2016 Sep 20;7:12789. doi: 10.1038/ncomms12789.

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