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Items: 10


A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery.

Sjögren AK, Breitholtz K, Ahlberg E, Milton L, Forsgard M, Persson M, Stahl SH, Wilmer MJ, Hornberg JJ.

Arch Toxicol. 2018 Oct;92(10):3175-3190. doi: 10.1007/s00204-018-2284-y. Epub 2018 Aug 24.


Perspective on the Application of Microphysiological Systems to Drug Transporter Studies.

Caetano-Pinto P, Stahl SH.

Drug Metab Dispos. 2018 Nov;46(11):1647-1657. doi: 10.1124/dmd.118.082750. Epub 2018 Aug 22. Review.


Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Battista C, Yang K, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA.

Toxicol Sci. 2018 Nov 1;166(1):123-130. doi: 10.1093/toxsci/kfy191.


Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM.

Mol Pharmacol. 2018 Jul;94(1):689-699. doi: 10.1124/mol.117.111153. Epub 2018 May 2.


Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.

Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA.

Clin Pharmacol Ther. 2017 Apr;101(4):501-509. doi: 10.1002/cpt.619. Epub 2017 Feb 17.


A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.

Sison-Young RL, Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HHJ, Labbe G, Hoët D, Dorau M, Schofield CA, Lovatt CA, Holder JC, Stahl SH, Richert L, Kitteringham NR, Jones RP, Elmasry M, Weaver RJ, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Park BK.

Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. Epub 2016 Jun 25.


Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Stahl SH, Yates JW, Nicholls AW, Kenna JG, Coen M, Ortega F, Nicholson JK, Wilson ID.

Drug Discov Today Technol. 2015 Aug;15:9-14. doi: 10.1016/j.ddtec.2015.06.003. Epub 2015 Jul 16. Review.


Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.

Barber JA, Stahl SH, Summers C, Barrett G, Park BK, Foster JR, Kenna JG.

Toxicol Sci. 2015 Nov;148(1):48-59. doi: 10.1093/toxsci/kfv159. Epub 2015 Jul 27.


Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.

Kenna JG, Stahl SH, Eakins JA, Foster AJ, Andersson LC, Bergare J, Billger M, Elebring M, Elmore CS, Thompson RA.

J Pharmacol Exp Ther. 2015 Feb;352(2):281-90. doi: 10.1124/jpet.114.220491. Epub 2014 Dec 2.


Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI.

Woodhead JL, Yang K, Brouwer KL, Siler SQ, Stahl SH, Ambroso JL, Baker D, Watkins PB, Howell BA.

CPT Pharmacometrics Syst Pharmacol. 2014 Jul 9;3:e123. doi: 10.1038/psp.2014.21.

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