Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 100


Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis.

Nganga R, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Johnson KA, Parikh RY, Gangaraju V, Peterson Y, Dany M, Stahelin RV, Voelkel-Johnson C, Szulc ZM, Bieberich E, Ogretmen B.

J Biol Chem. 2018 Nov 12. pii: jbc.RA118.005865. doi: 10.1074/jbc.RA118.005865. [Epub ahead of print]


Non-Peptidic Cell-Penetrating Motifs for Mitochondrion-Specific Cargo Delivery.

Appiah Kubi G, Qian Z, Amiar S, Sahni A, Stahelin RV, Pei D.

Angew Chem Int Ed Engl. 2018 Oct 30. doi: 10.1002/anie.201811940. [Epub ahead of print]


Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility.

Kuc N, Doermann A, Shirey C, Lee DD, Lowe CW, Awasthi N, Schwarz RE, Stahelin RV, Schwarz MA.

Biochem Pharmacol. 2018 Oct;156:458-466. doi: 10.1016/j.bcp.2018.09.017. Epub 2018 Sep 15.


Investigation of the phosphatidylserine binding properties of the lipid biosensor, Lactadherin C2 (LactC2), in different membrane environments.

Del Vecchio K, Stahelin RV.

J Bioenerg Biomembr. 2018 Feb;50(1):1-10. doi: 10.1007/s10863-018-9745-0. Epub 2018 Feb 10.


The unmasking of the lipid binding face of sphingosine kinase 1.

Stahelin RV.

J Lipid Res. 2018 Mar;59(3):401-403. doi: 10.1194/jlr.C083907. Epub 2018 Jan 30. No abstract available.


Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.

Bhattacharjee S, Coppens I, Mbengue A, Suresh N, Ghorbal M, Slouka Z, Safeukui I, Tang HY, Speicher DW, Stahelin RV, Mohandas N, Haldar K.

Blood. 2018 Mar 15;131(11):1234-1247. doi: 10.1182/blood-2017-11-814665. Epub 2018 Jan 23.


A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV.

J Biol Chem. 2018 Mar 2;293(9):3335-3349. doi: 10.1074/jbc.M117.816280. Epub 2018 Jan 18.


Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments.

Gc JB, Pokhrel R, Bhattarai N, Johnson KA, Gerstman BS, Stahelin RV, Chapagain PP.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):176-181. doi: 10.1016/j.bbrc.2017.09.052. Epub 2017 Sep 13.


SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.

Ahn G, Kim H, Kim DH, Hanh H, Yoon Y, Singaram I, Wijesinghe KJ, Johnson KA, Zhuang X, Liang Z, Stahelin RV, Jiang L, Cho W, Kang BH, Hwang I.

Plant Cell. 2017 Jun;29(6):1388-1405. doi: 10.1105/tpc.17.00108. Epub 2017 Jun 5.


Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer.

Bhattarai N, Gc JB, Gerstman BS, Stahelin RV, Chapagain PP.

RSC Adv. 2017 Apr 26;7(37):22741-22748. doi: 10.1039/c7ra02940c.


Bright red-emitting pyrene derivatives with a large Stokes shift for nucleus staining.

Abeywickrama CS, Wijesinghe KJ, Stahelin RV, Pang Y.

Chem Commun (Camb). 2017 May 30;53(43):5886-5889. doi: 10.1039/c7cc03417b.


Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry.

Wijesinghe KJ, Urata S, Bhattarai N, Kooijman EE, Gerstman BS, Chapagain PP, Li S, Stahelin RV.

J Biol Chem. 2017 Apr 14;292(15):6108-6122. doi: 10.1074/jbc.M116.758300. Epub 2017 Feb 6.


Notes and tips for improving quality of lipid-protein overlay assays.

Shirey CM, Scott JL, Stahelin RV.

Anal Biochem. 2017 Jan 1;516:9-12. doi: 10.1016/j.ab.2016.10.009. Epub 2016 Oct 11.


Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate.

Shirey CM, Ward KE, Stahelin RV.

Chem Phys Lipids. 2016 Oct;200:32-41. doi: 10.1016/j.chemphyslip.2016.06.004. Epub 2016 Jun 16.


The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P2 lipids in the plasma membrane.

Gc JB, Gerstman BS, Stahelin RV, Chapagain PP.

Phys Chem Chem Phys. 2016 Oct 19;18(41):28409-28417.


Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization.

Gc JB, Johnson KA, Husby ML, Frick CT, Gerstman BS, Stahelin RV, Chapagain PP.

Protein Sci. 2016 Sep;25(9):1648-58. doi: 10.1002/pro.2969. Epub 2016 Jul 4.


Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40.

Wijesinghe KJ, Stahelin RV.

J Virol. 2015 Dec 30;90(6):3074-85. doi: 10.1128/JVI.02607-15.


Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression.

Oda S, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO.

J Virol. 2015 Dec 9;90(4):1839-48. doi: 10.1128/JVI.01597-15. Print 2016 Feb 15.


Using Surface Plasmon Resonance to Quantitatively Assess Lipid-Protein Interactions.

Del Vecchio K, Stahelin RV.

Methods Mol Biol. 2016;1376:141-53. doi: 10.1007/978-1-4939-3170-5_12.


Time to Fold: Tom1 Uses New Tricks to Regulate Lipid Binding of Tollip.

Stahelin RV.

Structure. 2015 Oct 6;23(10):1781-1782. doi: 10.1016/j.str.2015.09.003.


The Ebola Virus: From Basic Research to a Global Health Crisis.

Stahelin RV.

PLoS Pathog. 2015 Aug 13;11(8):e1005093. doi: 10.1371/journal.ppat.1005093. eCollection 2015 Aug. No abstract available.


Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.

Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV.

J Virol. 2015 Sep;89(18):9440-53. doi: 10.1128/JVI.01087-15. Epub 2015 Jul 1.


Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.

Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B.

Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998.


A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.

Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K.

Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412. Epub 2015 Apr 15.


A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress.

Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV.

Viruses. 2014 Oct 17;6(10):3837-54. doi: 10.3390/v6103837.


The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes.

Soni SP, Stahelin RV.

J Biol Chem. 2014 Nov 28;289(48):33590-7. doi: 10.1074/jbc.M114.586396. Epub 2014 Oct 14.


Membrane binding and bending in Ebola VP40 assembly and egress.

Stahelin RV.

Front Microbiol. 2014 Jun 18;5:300. doi: 10.3389/fmicb.2014.00300. eCollection 2014. Review.


Ready, set, go! How protein kinase C manages dynamic signaling.

Stahelin RV.

Chem Biol. 2014 Apr 24;21(4):433-434. doi: 10.1016/j.chembiol.2014.04.003.


Cellular and molecular interactions of phosphoinositides and peripheral proteins.

Stahelin RV, Scott JL, Frick CT.

Chem Phys Lipids. 2014 Sep;182:3-18. doi: 10.1016/j.chemphyslip.2014.02.002. Epub 2014 Feb 17. Review.


Could the Ebola virus matrix protein VP40 be a drug target?

Stahelin RV.

Expert Opin Ther Targets. 2014 Feb;18(2):115-20. doi: 10.1517/14728222.2014.863877. Epub 2013 Nov 28.


Monitoring peripheral protein oligomerization on biological membranes.

Stahelin RV.

Methods Cell Biol. 2013;117:359-71. doi: 10.1016/B978-0-12-408143-7.00019-0.


A new model of interfacial kinetics for phospholipases.

Stahelin RV.

Biophys J. 2013 Jul 2;105(1):1-2. doi: 10.1016/j.bpj.2013.03.044. No abstract available.


Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex.

Hankins JL, Ward KE, Linton SS, Barth BM, Stahelin RV, Fox TE, Kester M.

J Biol Chem. 2013 Jul 5;288(27):19726-38. doi: 10.1074/jbc.M113.481622. Epub 2013 May 21.


The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress.

Soni SP, Adu-Gyamfi E, Yong SS, Jee CS, Stahelin RV.

Biophys J. 2013 May 7;104(9):1940-9. doi: 10.1016/j.bpj.2013.03.021.


Surface plasmon resonance: a useful technique for cell biologists to characterize biomolecular interactions.

Stahelin RV.

Mol Biol Cell. 2013 Apr;24(7):883-6. doi: 10.1091/mbc.E12-10-0713.


Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface.

Jiang RH, Stahelin RV, Bhattacharjee S, Haldar K.

Trends Microbiol. 2013 Mar;21(3):145-56. doi: 10.1016/j.tim.2012.12.004. Epub 2013 Jan 30. Review.


The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress.

Adu-Gyamfi E, Soni SP, Xue Y, Digman MA, Gratton E, Stahelin RV.

J Biol Chem. 2013 Feb 22;288(8):5779-89. doi: 10.1074/jbc.M112.443960. Epub 2013 Jan 6.


The molecular basis of ceramide-1-phosphate recognition by C2 domains.

Ward KE, Bhardwaj N, Vora M, Chalfant CE, Lu H, Stahelin RV.

J Lipid Res. 2013 Mar;54(3):636-48. doi: 10.1194/jlr.M031088. Epub 2012 Dec 31.


Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein.

Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV.

Biophys J. 2012 Nov 7;103(9):L41-3. doi: 10.1016/j.bpj.2012.09.026.


Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B.

EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25.


Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites.

Bhattacharjee S, Stahelin RV, Haldar K.

Trends Parasitol. 2012 Dec;28(12):555-62. doi: 10.1016/ Epub 2012 Oct 16. Review.


C2 domain membrane penetration by group IVA cytosolic phospholipase A₂ induces membrane curvature changes.

Ward KE, Ropa JP, Adu-Gyamfi E, Stahelin RV.

J Lipid Res. 2012 Dec;53(12):2656-66. doi: 10.1194/jlr.M030718. Epub 2012 Sep 18.


PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte.

Bhattacharjee S, Speicher KD, Stahelin RV, Speicher DW, Haldar K.

Mol Biochem Parasitol. 2012 Oct;185(2):106-13. doi: 10.1016/j.molbiopara.2012.07.004. Epub 2012 Jul 22.


Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.

Stahelin RV, Kong KF, Raha S, Tian W, Melowic HR, Ward KE, Murray D, Altman A, Cho W.

J Biol Chem. 2012 Aug 31;287(36):30518-28. doi: 10.1074/jbc.M112.391557. Epub 2012 Jul 11.


Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis.

Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV.

Biophys J. 2012 Jun 6;102(11):2517-25. doi: 10.1016/j.bpj.2012.04.022. Epub 2012 Jun 5.


Emerging methodologies to investigate lipid-protein interactions.

Scott JL, Musselman CA, Adu-Gyamfi E, Kutateladze TG, Stahelin RV.

Integr Biol (Camb). 2012 Mar;4(3):247-58. doi: 10.1039/c2ib00143h. Epub 2012 Feb 10. Review.


Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell.

Bhattacharjee S, Stahelin RV, Speicher KD, Speicher DW, Haldar K.

Cell. 2012 Jan 20;148(1-2):201-12. doi: 10.1016/j.cell.2011.10.051.


Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

He J, Gajewiak J, Scott JL, Gong D, Ali M, Best MD, Prestwich GD, Stahelin RV, Kutateladze TG.

Chem Biol. 2011 Oct 28;18(10):1312-9. doi: 10.1016/j.chembiol.2011.07.022.


Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme.

Lamour NF, Wijesinghe DS, Mietla JA, Ward KE, Stahelin RV, Chalfant CE.

J Biol Chem. 2011 Dec 16;286(50):42808-17. doi: 10.1074/jbc.M111.310169. Epub 2011 Oct 18.

Supplemental Content

Loading ...
Support Center