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Making the Consult Interaction More Than a Transaction: Helping Fellows Be Better Teachers and Residents Be Better Learners.

Winn AS, Stafford DEJ, Miloslavsky EM, McSparron JI, Grover AS, Boyer D.

J Pediatr. 2019 Jun;209:3-4.e2. doi: 10.1016/j.jpeds.2019.04.003. No abstract available.


Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model.

Cooley B, Broze GJ Jr, Mann DM, Lin FC, Pedersen LG, Stafford DW.

Blood. 2019 May 30;133(22):2445-2451. doi: 10.1182/blood.2018884015. Epub 2019 Apr 16.


Resolving the full spectrum of human genome variation using Linked-Reads.

Marks P, Garcia S, Barrio AM, Belhocine K, Bernate J, Bharadwaj R, Bjornson K, Catalanotti C, Delaney J, Fehr A, Fiddes IT, Galvin B, Heaton H, Herschleb J, Hindson C, Holt E, Jabara CB, Jett S, Keivanfar N, Kyriazopoulou-Panagiotopoulou S, Lek M, Lin B, Lowe A, Mahamdallie S, Maheshwari S, Makarewicz T, Marshall J, Meschi F, O'Keefe CJ, Ordonez H, Patel P, Price A, Royall A, Ruark E, Seal S, Schnall-Levin M, Shah P, Stafford D, Williams S, Wu I, Xu AW, Rahman N, MacArthur D, Church DM.

Genome Res. 2019 Apr;29(4):635-645. doi: 10.1101/gr.234443.118. Epub 2019 Mar 20.


Complementary networks of cortical somatostatin interneurons enforce layer specific control.

Naka A, Veit J, Shababo B, Chance RK, Risso D, Stafford D, Snyder B, Egladyous A, Chu D, Sridharan S, Mossing DP, Paninski L, Ngai J, Adesnik H.

Elife. 2019 Mar 18;8. pii: e43696. doi: 10.7554/eLife.43696.


Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.

Magli A, Baik J, Mills LJ, Kwak IY, Dillon BS, Mondragon Gonzalez R, Stafford DA, Swanson SA, Stewart R, Thomson JA, Garry DJ, Dynlacht BD, Perlingeiro RCR.

PLoS Biol. 2019 Feb 26;17(2):e3000153. doi: 10.1371/journal.pbio.3000153. eCollection 2019 Feb.


MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression.

Zahn NM, Huber AT, Mikulsky BN, Stepanski ME, Kehoe AS, Li G, Schussman M, Rashid Roni MS, Kodali R, Cook JM, Stafford DC, Steeber DA, Arnold LA.

Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):75-84. doi: 10.1111/bcpt.13206. Epub 2019 Feb 21.


Pediatric Endocrinology Trainees' Education and Knowledge About Insulin Pumps and Continuous Glucose Monitors.

Marks BE, Wolfsdorf JI, Waldman G, Stafford DE, Garvey KC.

Diabetes Technol Ther. 2019 Mar;21(3):105-109. doi: 10.1089/dia.2018.0331. Epub 2019 Jan 25.


Undernutrition and growth in the developing world.

Nijjar JK, Stafford D.

Curr Opin Endocrinol Diabetes Obes. 2019 Feb;26(1):32-38. doi: 10.1097/MED.0000000000000461.


A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo.

Yocum GT, Perez-Zoghbi JF, Danielsson J, Kuforiji AS, Zhang Y, Li G, Rashid Roni MS, Kodali R, Stafford DC, Arnold LA, Cook JM, Emala CW Sr.

Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L385-L390. doi: 10.1152/ajplung.00356.2018. Epub 2018 Nov 29.


A Case of Emotional Trauma in the Setting of Neurodevelopmental Disability.

Hauptman AJ, Acar D, Hammerness P, Fogler JM, Stafford D.

Harv Rev Psychiatry. 2018 Nov/Dec;26(6):384-391. doi: 10.1097/HRP.0000000000000209. No abstract available.


Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu.

Chen X, Jin DY, Stafford DW, Tie JK.

Blood. 2018 Nov 1;132(18):1974-1984. doi: 10.1182/blood-2018-05-846592. Epub 2018 Aug 8.


Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition.

Wu S, Chen X, Jin DY, Stafford DW, Pedersen LG, Tie JK.

Blood. 2018 Aug 9;132(6):647-657. doi: 10.1182/blood-2018-01-830901. Epub 2018 May 9.


Exposure, hazard, and survival analysis of diffusion on social networks.

Wu J, Crawford FW, Kim DA, Stafford D, Christakis NA.

Stat Med. 2018 Jul 30;37(17):2561-2585. doi: 10.1002/sim.7658. Epub 2018 Apr 29.


A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.

Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2018 May 7;15(5):1766-1777. doi: 10.1021/acs.molpharmaceut.7b01013. Epub 2018 Apr 2.


Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions.

Sinhadri BCS, Jin DY, Stafford DW, Tie JK.

Sci Rep. 2017 Dec 15;7(1):17632. doi: 10.1038/s41598-017-18008-3.


Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors.

Jin DY, Ingram BO, Stafford DW, Tie JK.

Blood. 2017 Aug 17;130(7):948-951. doi: 10.1182/blood-2017-05-782367. Epub 2017 Jul 5. No abstract available.


Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.

McCandless SE, Yanovski JA, Miller J, Fu C, Bird LM, Salehi P, Chan CL, Stafford D, Abuzzahab MJ, Viskochil D, Barlow SE, Angulo M, Myers SE, Whitman BY, Styne D, Roof E, Dykens EM, Scheimann AO, Malloy J, Zhuang D, Taylor K, Hughes TE, Kim DD, Butler MG.

Diabetes Obes Metab. 2017 Dec;19(12):1751-1761. doi: 10.1111/dom.13021. Epub 2017 Jul 13.


Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.

Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2017 Jun 5;14(6):2088-2098. doi: 10.1021/acs.molpharmaceut.7b00183. Epub 2017 May 1.


Exploiting social influence to magnify population-level behaviour change in maternal and child health: study protocol for a randomised controlled trial of network targeting algorithms in rural Honduras.

Shakya HB, Stafford D, Hughes DA, Keegan T, Negron R, Broome J, McKnight M, Nicoll L, Nelson J, Iriarte E, Ordonez M, Airoldi E, Fowler JH, Christakis NA.

BMJ Open. 2017 Mar 13;7(3):e012996. doi: 10.1136/bmjopen-2016-012996.


Functional Study of the Vitamin K Cycle Enzymes in Live Cells.

Tie JK, Stafford DW.

Methods Enzymol. 2017;584:349-394. doi: 10.1016/bs.mie.2016.10.015. Epub 2016 Nov 22.


Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.

Stafford DA, Dichmann DS, Chang JK, Harland RM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):101-106. doi: 10.1073/pnas.1612069113. Epub 2016 Dec 16.


Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM.

J Med Chem. 2016 Dec 8;59(23):10800-10806. Epub 2016 Nov 28.


Optimization of substituted imidazobenzodiazepines as novel asthma treatments.

Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA.

Eur J Med Chem. 2017 Jan 27;126:550-560. doi: 10.1016/j.ejmech.2016.11.045. Epub 2016 Nov 24.


Splice-Site Mutation of Exon 3 Deletion in the Gamma-Glutamyl Carboxylase Gene Causes Inactivation of the Enzyme.

Jin DY, Vermeer C, Stafford DW, Tie JK.

J Invest Dermatol. 2016 Nov;136(11):2314-2317. doi: 10.1016/j.jid.2016.05.128. Epub 2016 Jul 6. No abstract available.


Extravascular FIX and coagulation.

Stafford DW.

Thromb J. 2016 Oct 4;14(Suppl 1):35. eCollection 2016. Review.


Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells.

Yuan NY, Poe MM, Witzigmann C, Cook JM, Stafford D, Arnold LA.

J Pharmacol Toxicol Methods. 2016 Nov - Dec;82:109-114. doi: 10.1016/j.vascn.2016.08.006. Epub 2016 Aug 18.


The High Direct Medical Costs of Prader-Willi Syndrome.

Shoffstall AJ, Gaebler JA, Kreher NC, Niecko T, Douglas D, Strong TV, Miller JL, Stafford DE, Butler MG.

J Pediatr. 2016 Aug;175:137-43. doi: 10.1016/j.jpeds.2016.05.018. Epub 2016 Jun 6.


Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.

Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10.


Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice.

Cooley B, Funkhouser W, Monroe D, Ezzell A, Mann DM, Lin FC, Monahan PE, Stafford DW.

Blood. 2016 Jul 14;128(2):286-92. doi: 10.1182/blood-2016-01-696104. Epub 2016 Apr 22.


Intimate partner violence norms cluster within households: an observational social network study in rural Honduras.

Shakya HB, Hughes DA, Stafford D, Christakis NA, Fowler JH, Silverman JG.

BMC Public Health. 2016 Mar 8;16:233. doi: 10.1186/s12889-016-2893-4.


Fellows as Teachers: Raising the Educational Bar.

Miloslavsky EM, Boyer D, Winn AS, Stafford DE, McSparron JI.

Ann Am Thorac Soc. 2016 Apr;13(4):465-8. doi: 10.1513/AnnalsATS.201601-026PS.


Haplotyping germline and cancer genomes with high-throughput linked-read sequencing.

Zheng GX, Lau BT, Schnall-Levin M, Jarosz M, Bell JM, Hindson CM, Kyriazopoulou-Panagiotopoulou S, Masquelier DA, Merrill L, Terry JM, Mudivarti PA, Wyatt PW, Bharadwaj R, Makarewicz AJ, Li Y, Belgrader P, Price AD, Lowe AJ, Marks P, Vurens GM, Hardenbol P, Montesclaros L, Luo M, Greenfield L, Wong A, Birch DE, Short SW, Bjornson KP, Patel P, Hopmans ES, Wood C, Kaur S, Lockwood GK, Stafford D, Delaney JP, Wu I, Ordonez HS, Grimes SM, Greer S, Lee JY, Belhocine K, Giorda KM, Heaton WH, McDermott GP, Bent ZW, Meschi F, Kondov NO, Wilson R, Bernate JA, Gauby S, Kindwall A, Bermejo C, Fehr AN, Chan A, Saxonov S, Ness KD, Hindson BJ, Ji HP.

Nat Biotechnol. 2016 Mar;34(3):303-11. doi: 10.1038/nbt.3432. Epub 2016 Feb 1.


Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.

Tie JK, Carneiro JD, Jin DY, Martinhago CD, Vermeer C, Stafford DW.

Blood. 2016 Apr 14;127(15):1847-55. doi: 10.1182/blood-2015-10-677633. Epub 2016 Jan 12.


A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.

Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM.

Int J Med Chem. 2015;2015:430248. doi: 10.1155/2015/430248. Epub 2015 Nov 10. Review.


Structural and functional insights into enzymes of the vitamin K cycle.

Tie JK, Stafford DW.

J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29. Review.


Transcranial direct current stimulation reduces food-craving and measures of hyperphagia behavior in participants with Prader-Willi syndrome.

Bravo GL, Poje AB, Perissinotti I, Marcondes BF, Villamar MF, Manzardo AM, Luque L, LePage JF, Stafford D, Fregni F, Butler MG.

Am J Med Genet B Neuropsychiatr Genet. 2016 Mar;171B(2):266-75. doi: 10.1002/ajmg.b.32401. Epub 2015 Nov 21.


Children with hyperthyroidism younger than age 7 require higher mg/kg doses of methimazole to normalize free T4 compared to older children.

Stafford D, Vaidyanathan P, Kaplowitz P.

J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1339-42. doi: 10.1515/jpem-2015-0024.


Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.

Cioffi CL, Racz B, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Zhu L, Kitchen DB, Barnes KD, Dobri N, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K.

J Med Chem. 2015 Aug 13;58(15):5863-88. doi: 10.1021/acs.jmedchem.5b00423. Epub 2015 Aug 4.


Pharmacy support in developing prescribing skills.

McGuire A, McEwan T, Stafford D, Ker J.

Clin Teach. 2015 Dec;12(6):408-12. doi: 10.1111/tct.12324. Epub 2015 Jun 14.


Social network targeting to maximise population behaviour change: a cluster randomised controlled trial.

Kim DA, Hwong AR, Stafford D, Hughes DA, O'Malley AJ, Fowler JH, Christakis NA.

Lancet. 2015 Jul 11;386(9989):145-53. doi: 10.1016/S0140-6736(15)60095-2. Epub 2015 May 4.


Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.

Monahan PE, Sun J, Gui T, Hu G, Hannah WB, Wichlan DG, Wu Z, Grieger JC, Li C, Suwanmanee T, Stafford DW, Booth CJ, Samulski JJ, Kafri T, McPhee SW, Samulski RJ.

Hum Gene Ther. 2015 Feb;26(2):69-81. doi: 10.1089/hum.2014.106. Epub 2015 Jan 21.


Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.

Cioffi CL, Dobri N, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Golden KC, Zhu L, Kitchen DB, Barnes KD, Racz B, Qin Q, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K.

J Med Chem. 2014 Sep 25;57(18):7731-57. doi: 10.1021/jm5010013. Epub 2014 Sep 11.


Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.

Tie JK, Jin DY, Stafford DW.

J Biol Chem. 2014 Mar 28;289(13):9396-407. doi: 10.1074/jbc.M113.534446. Epub 2014 Feb 13.


Follistatin interacts with Noggin in the development of the axial skeleton.

Stafford DA, Monica SD, Harland RM.

Mech Dev. 2014 Feb;131:78-85.


A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry.

Parker CH, Morgan CR, Rand KD, Engen JR, Jorgenson JW, Stafford DW.

Biochemistry. 2014 Mar 11;53(9):1511-20. doi: 10.1021/bi401536m. Epub 2014 Feb 26.


A D-amino acid containing peptide as a potent, noncovalent inhibitor of α5β1 integrin in human prostate cancer invasion and lung colonization.

Veine DM, Yao H, Stafford DR, Fay KS, Livant DL.

Clin Exp Metastasis. 2014 Apr;31(4):379-93. doi: 10.1007/s10585-013-9634-1. Epub 2014 Jan 25.


FVIIa as used pharmacologically is not TF dependent in hemophilia B mice.

Feng D, Whinna H, Monroe D, Stafford DW.

Blood. 2014 Mar 13;123(11):1764-6. doi: 10.1182/blood-2013-08-522987. Epub 2014 Jan 14.


Membrane topology for human vitamin K epoxide reductase.

Wu S, Tie JK, Stafford DW, Pedersen LG.

J Thromb Haemost. 2014 Jan;12(1):112-4. doi: 10.1111/jth.12450. No abstract available.


Evidence of clinically significant extravascular stores of factor IX.

Feng D, Stafford KA, Broze GJ, Stafford DW.

J Thromb Haemost. 2013 Dec;11(12):2176-8. doi: 10.1111/jth.12421. No abstract available.

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