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Items: 1 to 50 of 646

1.

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response.

Bobowski-Gerard M, Zummo FP, Staels B, Lefebvre P, Eeckhoute J.

Cells. 2018 Sep 13;7(9). pii: E137. doi: 10.3390/cells7090137.

2.

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis.

Devos M, Mogilenko DA, Fleury S, Gilbert B, Becquart C, Quemener S, Dehondt H, Tougaard P, Staels B, Bachert C, Vandenabeele P, Van Loo G, Staumont-Salle D, Declercq W, Dombrowicz D.

J Invest Dermatol. 2018 Aug 14. pii: S0022-202X(18)32472-2. doi: 10.1016/j.jid.2018.06.191. [Epub ahead of print]

PMID:
30118730
3.

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool.

Mayeuf-Louchart A, Hardy D, Thorel Q, Roux P, Gueniot L, Briand D, Mazeraud A, Bouglé A, Shorte SL, Staels B, Chrétien F, Duez H, Danckaert A.

Skelet Muscle. 2018 Aug 6;8(1):25. doi: 10.1186/s13395-018-0171-0.

4.

Peri-operative acute kidney injury upon cardiac surgery time-of-day.

Ninni S, Seunes C, Ortmans S, Mouton S, Modine T, Koussa M, Jegou B, Edme JL, Staels B, Montaigne D, Coisne A.

Int J Cardiol. 2018 Jul 19. pii: S0167-5273(17)37562-9. doi: 10.1016/j.ijcard.2018.07.081. [Epub ahead of print]

PMID:
30077533
5.

Molecular actions of PPARα in lipid metabolism and inflammation.

Bougarne N, Weyers B, Desmet SJ, Deckers J, Ray DW, Staels B, De Bosscher K.

Endocr Rev. 2018 Jul 17. doi: 10.1210/er.2018-00064. [Epub ahead of print]

PMID:
30020428
6.

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7789-7794. doi: 10.1073/pnas.1722295115. Epub 2018 Jul 9.

7.

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.

Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P.

J Hepatol. 2018 Jul 5. pii: S0168-8278(18)32175-5. doi: 10.1016/j.jhep.2018.06.022. [Epub ahead of print]

8.

Obesity Paradox in the Clinical Significance of Effective Prosthetic Orifice Area after Aortic Valve Replacement.

Coisne A, Ninni S, Edmé JL, Modine T, Mouton S, Pilato R, Ridon H, Richardson M, Klein C, Ortmans S, Seunes C, Madika AL, Ledieu G, Jacquelinet M, Boutie B, Altes A, Vincent F, Koussa M, Jegou B, Vincentelli A, Juthier F, Robin E, Staels B, Lancellotti P, Montaigne D.

JACC Cardiovasc Imaging. 2018 Jun 9. pii: S1936-878X(18)30376-0. doi: 10.1016/j.jcmg.2018.04.018. [Epub ahead of print] No abstract available.

PMID:
29909098
9.

Daytime variations in perioperative myocardial injury - Authors' reply.

Montaigne D, Coisne A, Marechal X, Lefebvre P, Staels B.

Lancet. 2018 May 26;391(10135):2106. doi: 10.1016/S0140-6736(18)30758-X. Epub 2018 May 24. No abstract available.

PMID:
29856343
10.

Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support.

Vincent F, Rauch A, Loobuyck V, Robin E, Nix C, Vincentelli A, Smadja DM, Leprince P, Amour J, Lemesle G, Spillemaeker H, Debry N, Latremouille C, Jansen P, Capel A, Moussa M, Rousse N, Schurtz G, Delhaye C, Paris C, Jeanpierre E, Dupont A, Corseaux D, Rosa M, Sottejeau Y, Barth S, Mourran C, Gomane V, Coisne A, Richardson M, Caron C, Preda C, Ung A, Carpentier A, Hubert T, Denis C, Staels B, Lenting PJ, Van Belle E, Susen S.

J Am Coll Cardiol. 2018 May 15;71(19):2106-2118. doi: 10.1016/j.jacc.2018.02.075.

PMID:
29747831
11.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.

Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, Bricambert J, Saussenthaler S, Anthony E, Jha P, Derop J, Sand O, Rabearivelo I, Leloire A, Pigeyre M, Daujat-Chavanieu M, Gerbal-Chaloin S, Dayeh T, Lassailly G, Mathurin P, Staels B, Auwerx J, Schürmann A, Postic C, Schafmayer C, Hampe J, Bonnefond A, Pattou F, Froguel P.

Diabetes. 2018 Jul;67(7):1310-1321. doi: 10.2337/db17-1539. Epub 2018 May 4.

12.

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity.

Lancel S, Hesselink MK, Woldt E, Rouillé Y, Dorchies E, Delhaye S, Duhem C, Thorel Q, Mayeuf-Louchart A, Pourcet B, Montel V, Schaart G, Beton N, Picquet F, Briand O, Salles JP, Duez H, Schrauwen P, Bastide B, Bailleul B, Staels B, Sebti Y.

JCI Insight. 2018 May 3;3(9). pii: 98081. doi: 10.1172/jci.insight.98081. [Epub ahead of print]

13.

Alternative macrophages in atherosclerosis: not always protective!

Pourcet B, Staels B.

J Clin Invest. 2018 Mar 1;128(3):910-912. doi: 10.1172/JCI120123. Epub 2018 Feb 19.

14.

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

Pourcet B, Zecchin M, Ferri L, Beauchamp J, Sitaula S, Billon C, Delhaye S, Vanhoutte J, Mayeuf-Louchart A, Thorel Q, Haas JT, Eeckhoute J, Dombrowicz D, Duhem C, Boulinguiez A, Lancel S, Sebti Y, Burris TP, Staels B, Duez HM.

Gastroenterology. 2018 Apr;154(5):1449-1464.e20. doi: 10.1053/j.gastro.2017.12.019. Epub 2017 Dec 24.

15.

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.

Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, Berthier A, Gheeraert C, Piveteau C, Deprez R, Eeckhoute J, Duez H, Lacroix D, Deprez B, Jegou B, Koussa M, Edme JL, Lefebvre P, Staels B.

Lancet. 2018 Jan 6;391(10115):59-69. doi: 10.1016/S0140-6736(17)32132-3. Epub 2017 Oct 26.

PMID:
29107324
16.

Organizing combinatorial transcription factor recruitment at cis-regulatory modules.

Dubois-Chevalier J, Mazrooei P, Lupien M, Staels B, Lefebvre P, Eeckhoute J.

Transcription. 2018;9(4):233-239. doi: 10.1080/21541264.2017.1394424. Epub 2017 Nov 28.

PMID:
29105538
17.

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass.

Mayeuf-Louchart A, Thorel Q, Delhaye S, Beauchamp J, Duhem C, Danckaert A, Lancel S, Pourcet B, Woldt E, Boulinguiez A, Ferri L, Zecchin M, Staels B, Sebti Y, Duez H.

Sci Rep. 2017 Oct 30;7(1):14383. doi: 10.1038/s41598-017-14596-2.

18.

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.

Firmin FF, Oger F, Gheeraert C, Dubois-Chevalier J, Vercoutter-Edouart AS, Alzaid F, Mazuy C, Dehondt H, Alexandre J, Derudas B, Dhalluin Q, Ploton M, Berthier A, Woitrain E, Lefebvre T, Venteclef N, Pattou F, Staels B, Eeckhoute J, Lefebvre P.

Sci Rep. 2017 Oct 26;7(1):14087. doi: 10.1038/s41598-017-14570-y.

19.

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice.

Auger F, Martin F, Pétrault O, Samaillie J, Hennebelle T, Trabelsi MS, Bailleul F, Staels B, Bordet R, Duriez P.

Metab Brain Dis. 2018 Feb;33(1):63-77. doi: 10.1007/s11011-017-0133-y. Epub 2017 Oct 16.

PMID:
29034440
20.

Fasting the Microbiota to Improve Metabolism?

Haas JT, Staels B.

Cell Metab. 2017 Oct 3;26(4):584-585. doi: 10.1016/j.cmet.2017.09.013.

PMID:
28978420
21.

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects.

Legry V, Francque S, Haas JT, Verrijken A, Caron S, Chávez-Talavera O, Vallez E, Vonghia L, Dirinck E, Verhaegen A, Kouach M, Lestavel S, Lefebvre P, Van Gaal L, Tailleux A, Paumelle R, Staels B.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3783-3794. doi: 10.1210/jc.2017-01397.

PMID:
28938455
22.

Ffar2 expression regulates leukaemic cell growth in vivo.

Bindels LB, Porporato PE, Ducastel S, Sboarina M, Neyrinck AM, Dewulf EM, Feron O, Lestavel S, Cani PD, Staels B, Sonveaux P, Delzenne NM.

Br J Cancer. 2017 Oct 24;117(9):1336-1340. doi: 10.1038/bjc.2017.307. Epub 2017 Sep 5.

23.

The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue.

Wouters K, Deleye Y, Hannou SA, Vanhoutte J, Maréchal X, Coisne A, Tagzirt M, Derudas B, Bouchaert E, Duhem C, Vallez E, Schalkwijk CG, Pattou F, Montaigne D, Staels B, Paumelle R.

Diab Vasc Dis Res. 2017 Nov;14(6):516-524. doi: 10.1177/1479164117728012. Epub 2017 Sep 2.

24.

Circadian control of metabolism and pathological consequences of clock perturbations.

Mayeuf-Louchart A, Zecchin M, Staels B, Duez H.

Biochimie. 2017 Dec;143:42-50. doi: 10.1016/j.biochi.2017.07.017. Epub 2017 Aug 2. Review.

PMID:
28778719
25.

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.

Lefebvre P, Lalloyer F, Baugé E, Pawlak M, Gheeraert C, Dehondt H, Vanhoutte J, Woitrain E, Hennuyer N, Mazuy C, Bobowski-Gérard M, Zummo FP, Derudas B, Driessen A, Hubens G, Vonghia L, Kwanten WJ, Michielsen P, Vanwolleghem T, Eeckhoute J, Verrijken A, Van Gaal L, Francque S, Staels B.

JCI Insight. 2017 Jul 6;2(13). pii: 92264. doi: 10.1172/jci.insight.92264. [Epub ahead of print]

26.

Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.

27.

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N.

Eur J Med Chem. 2017 Sep 8;137:310-326. doi: 10.1016/j.ejmech.2017.06.006. Epub 2017 Jun 12.

PMID:
28609708
28.

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Staels B.

Am J Cardiol. 2017 Jul 1;120(1S):S28-S36. doi: 10.1016/j.amjcard.2017.05.013. Epub 2017 May 30. Review.

29.

Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

Boulinguiez A, Staels B, Duez H, Lancel S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):901-916. doi: 10.1016/j.bbalip.2017.05.011. Epub 2017 May 18. Review.

30.

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Staels B.

Am J Med. 2017 Jun;130(6S):S30-S39. doi: 10.1016/j.amjmed.2017.04.009. Review.

31.

Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity.

Chinetti-Gbaguidi G, Daoudi M, Rosa M, Vinod M, Louvet L, Copin C, Fanchon M, Vanhoutte J, Derudas B, Belloy L, Haulon S, Zawadzki C, Susen S, Massy ZA, Eeckhoute J, Staels B.

Circ Res. 2017 Jun 23;121(1):19-30. doi: 10.1161/CIRCRESAHA.116.310262. Epub 2017 Apr 24.

PMID:
28438779
32.

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.

Lasalle M, Hoguet V, Hennuyer N, Leroux F, Piveteau C, Belloy L, Lestavel S, Vallez E, Dorchies E, Duplan I, Sevin E, Culot M, Gosselet F, Boulahjar R, Herledan A, Staels B, Deprez B, Tailleux A, Charton J.

J Med Chem. 2017 May 25;60(10):4185-4211. doi: 10.1021/acs.jmedchem.6b01873. Epub 2017 May 5.

PMID:
28414465
33.

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.

Dubois-Chevalier J, Dubois V, Dehondt H, Mazrooei P, Mazuy C, Sérandour AA, Gheeraert C, Guillaume P, Baugé E, Derudas B, Hennuyer N, Paumelle R, Marot G, Carroll JS, Lupien M, Staels B, Lefebvre P, Eeckhoute J.

Genome Res. 2017 Jun;27(6):985-996. doi: 10.1101/gr.217075.116. Epub 2017 Apr 11.

34.

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.

Catry E, Bindels LB, Tailleux A, Lestavel S, Neyrinck AM, Goossens JF, Lobysheva I, Plovier H, Essaghir A, Demoulin JB, Bouzin C, Pachikian BD, Cani PD, Staels B, Dessy C, Delzenne NM.

Gut. 2018 Feb;67(2):271-283. doi: 10.1136/gutjnl-2016-313316. Epub 2017 Apr 4.

35.

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

Dubois V, Eeckhoute J, Lefebvre P, Staels B.

J Clin Invest. 2017 Apr 3;127(4):1202-1214. doi: 10.1172/JCI88894. Epub 2017 Apr 3. Review.

36.

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways.

Rosa M, Paris C, Sottejeau Y, Corseaux D, Robin E, Tagzirt M, Juthier F, Jashari R, Rauch A, Vincentelli A, Staels B, Van Belle E, Susen S, Dupont A.

Acta Diabetol. 2017 Jun;54(6):551-560. doi: 10.1007/s00592-017-0980-3. Epub 2017 Mar 18.

PMID:
28314924
37.

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.

Chávez-Talavera O, Tailleux A, Lefebvre P, Staels B.

Gastroenterology. 2017 May;152(7):1679-1694.e3. doi: 10.1053/j.gastro.2017.01.055. Epub 2017 Feb 15. Review.

PMID:
28214524
38.

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

Simic B, Mocharla P, Crucet M, Osto E, Kratzer A, Stivala S, Kühnast S, Speer T, Doycheva P, Princen HM, van der Hoorn JW, Jukema JW, Giral H, Tailleux A, Landmesser U, Staels B, Lüscher TF.

Atherosclerosis. 2017 Feb;257:186-194. doi: 10.1016/j.atherosclerosis.2017.01.011. Epub 2017 Jan 16.

PMID:
28152406
39.

Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages.

Chinetti-Gbaguidi G, Copin C, Derudas B, Marx N, Eechkoute J, Staels B.

PPAR Res. 2016;2016:2756781. doi: 10.1155/2016/2756781. Epub 2016 Dec 27.

40.

Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs.

Chávez-Talavera O, Baud G, Spinelli V, Daoudi M, Kouach M, Goossens JF, Vallez E, Caiazzo R, Ghunaim M, Hubert T, Lestavel S, Tailleux A, Staels B, Pattou F.

Int J Obes (Lond). 2017 Apr;41(4):664-668. doi: 10.1038/ijo.2017.7. Epub 2017 Jan 17.

PMID:
28093571
41.

Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis.

Ferret-Sena V, Maia E Silva A, Sena A, Cavaleiro I, Vale J, Derudas B, Chinetti-Gbaguidi G, Staels B.

PPAR Res. 2016;2016:5716415. doi: 10.1155/2016/5716415. Epub 2016 Dec 18.

42.

Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals.

Le Guével R, Oger F, Martinez-Jimenez CP, Bizot M, Gheeraert C, Firmin F, Ploton M, Kretova M, Palierne G, Staels B, Barath P, Talianidis I, Lefebvre P, Eeckhoute J, Salbert G.

ACS Chem Biol. 2017 Mar 17;12(3):654-663. doi: 10.1021/acschembio.6b00593. Epub 2017 Jan 13.

PMID:
28059499
43.

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model.

Joubert M, Jagu B, Montaigne D, Marechal X, Tesse A, Ayer A, Dollet L, Le May C, Toumaniantz G, Manrique A, Charpentier F, Staels B, Magré J, Cariou B, Prieur X.

Diabetes. 2017 Apr;66(4):1030-1040. doi: 10.2337/db16-0733. Epub 2017 Jan 4.

44.

Topical ivermectin improves allergic skin inflammation.

Ventre E, Rozières A, Lenief V, Albert F, Rossio P, Laoubi L, Dombrowicz D, Staels B, Ulmann L, Julia V, Vial E, Jomard A, Hacini-Rachinel F, Nicolas JF, Vocanson M.

Allergy. 2017 Aug;72(8):1212-1221. doi: 10.1111/all.13118. Epub 2017 Feb 6.

PMID:
28052336
45.

PPARβ in macrophages and atherosclerosis.

Chinetti-Gbaguidi G, Staels B.

Biochimie. 2017 May;136:59-64. doi: 10.1016/j.biochi.2016.12.008. Epub 2016 Dec 21. Review.

46.

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation.

Bosviel R, Joumard-Cubizolles L, Chinetti-Gbaguidi G, Bayle D, Copin C, Hennuyer N, Duplan I, Staels B, Zanoni G, Porta A, Balas L, Galano JM, Oger C, Mazur A, Durand T, Gladine C.

Free Radic Biol Med. 2017 Feb;103:146-154. doi: 10.1016/j.freeradbiomed.2016.12.018. Epub 2016 Dec 14.

PMID:
27988338
47.

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.

Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, Abderrahmani A.

Mol Metab. 2016 Oct 5;5(12):1200-1207. doi: 10.1016/j.molmet.2016.09.011. eCollection 2016 Dec.

48.

Intestinal bile acid receptors are key regulators of glucose homeostasis.

Trabelsi MS, Lestavel S, Staels B, Collet X.

Proc Nutr Soc. 2017 Aug;76(3):192-202. doi: 10.1017/S0029665116002834. Epub 2016 Nov 16. Review.

PMID:
27846919
49.

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

Gross B, Pawlak M, Lefebvre P, Staels B.

Nat Rev Endocrinol. 2017 Jan;13(1):36-49. doi: 10.1038/nrendo.2016.135. Epub 2016 Sep 16. Review.

PMID:
27636730
50.

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia.

Dugardin C, Briand O, Touche V, Schonewille M, Moreau F, Le May C, Groen AK, Staels B, Lestavel S.

Acta Diabetol. 2017 Feb;54(2):191-199. doi: 10.1007/s00592-016-0936-z. Epub 2016 Oct 28.

PMID:
27796655

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