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Items: 1 to 50 of 239

1.

Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium.

Lee S, Ishitsuka A, Noguchi M, Hirohama M, Fujiyasu Y, Petric PP, Schwemmle M, Staeheli P, Nagata K, Kawaguchi A.

Sci Immunol. 2019 Oct 25;4(40). pii: eaau4643. doi: 10.1126/sciimmunol.aau4643.

PMID:
31653718
2.

Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines.

Ye L, Ohnemus A, Ong LC, Gad HH, Hartmann R, Lycke N, Staeheli P.

J Virol. 2019 Nov 13;93(23). pii: e01262-19. doi: 10.1128/JVI.01262-19. Print 2019 Dec 1.

PMID:
31511392
3.

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection.

Bradley KC, Finsterbusch K, Schnepf D, Crotta S, Llorian M, Davidson S, Fuchs SY, Staeheli P, Wack A.

Cell Rep. 2019 Jul 2;28(1):245-256.e4. doi: 10.1016/j.celrep.2019.05.105.

4.

Interferon-λ orchestrates innate and adaptive mucosal immune responses.

Ye L, Schnepf D, Staeheli P.

Nat Rev Immunol. 2019 Oct;19(10):614-625. doi: 10.1038/s41577-019-0182-z. Epub 2019 Jun 14. Review.

PMID:
31201377
5.

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin.

Ye L, Schnepf D, Becker J, Ebert K, Tanriver Y, Bernasconi V, Gad HH, Hartmann R, Lycke N, Staeheli P.

Nat Immunol. 2019 May;20(5):593-601. doi: 10.1038/s41590-019-0345-x. Epub 2019 Mar 18.

PMID:
30886417
6.

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections.

Bernasconi V, Bernocchi B, Ye L, Lê MQ, Omokanye A, Carpentier R, Schön K, Saelens X, Staeheli P, Betbeder D, Lycke N.

Front Immunol. 2018 Sep 12;9:2060. doi: 10.3389/fimmu.2018.02060. eCollection 2018.

7.

Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1.

Staeheli P, Haller O.

J Virol. 2018 Nov 27;92(24). pii: e00709-18. doi: 10.1128/JVI.00709-18. Print 2018 Dec 15. Review.

8.

Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice.

Kolpe A, Schepens B, Ye L, Staeheli P, Saelens X.

Antiviral Res. 2018 Oct;158:244-254. doi: 10.1016/j.antiviral.2018.08.017. Epub 2018 Sep 1.

PMID:
30179634
9.

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice.

Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgärtner W, Wacker F, Kalinke U.

PLoS Pathog. 2018 Aug 3;14(8):e1007235. doi: 10.1371/journal.ppat.1007235. eCollection 2018 Aug.

10.

Publisher Correction: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2018 Jul 18;9:16231. doi: 10.1038/ncomms16231.

11.

The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success.

Haller O, Arnheiter H, Pavlovic J, Staeheli P.

Annu Rev Virol. 2018 Sep 29;5(1):33-51. doi: 10.1146/annurev-virology-092917-043525. Epub 2018 Jun 29. Review.

PMID:
29958082
12.

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.

Klinkhammer J, Schnepf D, Ye L, Schwaderlapp M, Gad HH, Hartmann R, Garcin D, Mahlakõiv T, Staeheli P.

Elife. 2018 Apr 13;7. pii: e33354. doi: 10.7554/eLife.33354.

13.

Defective RNA sensing by RIG-I in severe influenza virus infection.

Jørgensen SE, Christiansen M, Ryø LB, Gad HH, Gjedsted J, Staeheli P, Mikkelsen JG, Storgaard M, Hartmann R, Mogensen TH.

Clin Exp Immunol. 2018 Jun;192(3):366-376. doi: 10.1111/cei.13120. Epub 2018 Mar 24.

14.

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A.

Nat Immunol. 2018 Feb;19(2):130-140. doi: 10.1038/s41590-017-0013-y. Epub 2017 Dec 18.

15.

License to kill: IFN-λ regulates antifungal activity of neutrophils.

Schnepf D, Staeheli P.

Sci Immunol. 2017 Nov 17;2(17). pii: eaap9614. doi: 10.1126/sciimmunol.aap9614. Epub 2017 Nov 17.

PMID:
29150440
16.

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

17.

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.

Deeg CM, Hassan E, Mutz P, Rheinemann L, Götz V, Magar L, Schilling M, Kallfass C, Nürnberger C, Soubies S, Kochs G, Haller O, Schwemmle M, Staeheli P.

J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.

18.

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2017 Feb 15;8. doi: 10.1038/ncomms14278. Erratum in: Nat Commun. 2018 Jul 18;9:16231.

19.

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke S, Ehrhardt K, Kolpe A, El Bakkouri K, Deng L, Grootaert H, Schoonooghe S, Smet A, Bentahir M, Roose K, Schotsaert M, Schepens B, Callewaert N, Nimmerjahn F, Staeheli P, Hengel H, Saelens X.

J Virol. 2017 Mar 13;91(7). pii: e02500-16. doi: 10.1128/JVI.02500-16. Print 2017 Apr 1.

20.

Viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection.

Runge S, Olbert M, Herden C, Malberg S, Römer-Oberdörfer A, Staeheli P, Rubbenstroth D.

Vaccine. 2017 Jan 23;35(4):557-563. doi: 10.1016/j.vaccine.2016.12.022. Epub 2016 Dec 22.

PMID:
28017426
21.

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation.

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D.

J Invest Dermatol. 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6.

22.

Viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canaries.

Olbert M, Römer-Oberdörfer A, Herden C, Malberg S, Runge S, Staeheli P, Rubbenstroth D.

Sci Rep. 2016 Nov 10;6:36840. doi: 10.1038/srep36840.

23.

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.

Nürnberger C, Zimmermann V, Gerhardt M, Staeheli P.

J Virol. 2016 Nov 14;90(23):10682-10692. doi: 10.1128/JVI.01213-16. Print 2016 Dec 1.

24.

Synergistic antiviral activity of ribavirin and interferon-α against parrot bornaviruses in avian cells.

Reuter A, Horie M, Höper D, Ohnemus A, Narr A, Rinder M, Beer M, Staeheli P, Rubbenstroth D.

J Gen Virol. 2016 Sep;97(9):2096-2103. doi: 10.1099/jgv.0.000555. Epub 2016 Jul 20.

PMID:
27439314
25.

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A.

Science. 2016 Apr 22;352(6284):463-6. doi: 10.1126/science.aaf3926.

26.

Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.

Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P.

J Virol. 2015 Dec 9;90(4):2031-8. doi: 10.1128/JVI.02979-15. Print 2016 Feb 15.

27.

Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.

Verhelst J, Spitaels J, Nürnberger C, De Vlieger D, Ysenbaert T, Staeheli P, Fiers W, Saelens X.

J Virol. 2015 Nov;89(21):10879-90. doi: 10.1128/JVI.01744-15. Epub 2015 Aug 19.

28.

Host microbiota constantly control maturation and function of microglia in the CNS.

Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M.

Nat Neurosci. 2015 Jul;18(7):965-77. doi: 10.1038/nn.4030. Epub 2015 Jun 1.

29.

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.

Hernández PP, Mahlakoiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hoelscher C, Dumoutier L, Renauld JC, Suerbaum S, Staeheli P, Diefenbach A.

Nat Immunol. 2015 Jul;16(7):698-707. doi: 10.1038/ni.3180. Epub 2015 May 25.

30.

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis E Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Nat Commun. 2015 May 19;6:7090. doi: 10.1038/ncomms8090.

31.

Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections.

Mahlakõiv T, Hernandez P, Gronke K, Diefenbach A, Staeheli P.

PLoS Pathog. 2015 Apr 7;11(4):e1004782. doi: 10.1371/journal.ppat.1004782. eCollection 2015 Apr.

32.

The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus.

Wendel I, Rubbenstroth D, Doedt J, Kochs G, Wilhelm J, Staeheli P, Klenk HD, Matrosovich M.

J Virol. 2015 Apr;89(8):4170-9. doi: 10.1128/JVI.03194-14. Epub 2015 Jan 28.

33.

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.

Anggakusuma, Frentzen A, Gürlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Schmid-Burgk J, Schmidt T, Hornung V, Kuehnel F, Pietschmann T.

J Virol. 2015 Apr;89(7):3833-45. doi: 10.1128/JVI.03129-14. Epub 2015 Jan 21.

34.

Mx GTPases: dynamin-like antiviral machines of innate immunity.

Haller O, Staeheli P, Schwemmle M, Kochs G.

Trends Microbiol. 2015 Mar;23(3):154-63. doi: 10.1016/j.tim.2014.12.003. Epub 2015 Jan 6. Review.

PMID:
25572883
35.

Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions.

Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C.

Nat Commun. 2014 Dec 9;5:5645. doi: 10.1038/ncomms6645.

36.

S. mansoni bolsters anti-viral immunity in the murine respiratory tract.

Scheer S, Krempl C, Kallfass C, Frey S, Jakob T, Mouahid G, Moné H, Schmitt-Gräff A, Staeheli P, Lamers MC.

PLoS One. 2014 Nov 14;9(11):e112469. doi: 10.1371/journal.pone.0112469. eCollection 2014.

37.

Impact of antigenic diversity on laboratory diagnosis of Avian bornavirus infections in birds.

Zimmermann V, Rinder M, Kaspers B, Staeheli P, Rubbenstroth D.

J Vet Diagn Invest. 2014 Nov;26(6):769-77. doi: 10.1177/1040638714547258. Epub 2014 Aug 18.

PMID:
25135010
38.

Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection.

Spanier J, Lienenklaus S, Paijo J, Kessler A, Borst K, Heindorf S, Baker DP, Kröger A, Weiss S, Detje CN, Staeheli P, Kalinke U.

J Immunol. 2014 Sep 15;193(6):3045-54. doi: 10.4049/jimmunol.1400959. Epub 2014 Aug 15.

39.

No contact transmission of avian bornavirus in experimentally infected cockatiels (Nymphicus hollandicus) and domestic canaries (Serinus canaria forma domestica).

Rubbenstroth D, Brosinski K, Rinder M, Olbert M, Kaspers B, Korbel R, Staeheli P.

Vet Microbiol. 2014 Aug 6;172(1-2):146-56. doi: 10.1016/j.vetmic.2014.05.011. Epub 2014 May 13.

PMID:
24933163
40.

STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.

Semper C, Leitner NR, Lassnig C, Parrini M, Mahlakõiv T, Rammerstorfer M, Lorenz K, Rigler D, Müller S, Kolbe T, Vogl C, Rülicke T, Staeheli P, Decker T, Müller M, Strobl B.

Mol Cell Biol. 2014 Jun;34(12):2235-48. doi: 10.1128/MCB.00295-14. Epub 2014 Apr 7.

41.

Human but not mouse hepatocytes respond to interferon-lambda in vivo.

Hermant P, Demarez C, Mahlakõiv T, Staeheli P, Meuleman P, Michiels T.

PLoS One. 2014 Jan 31;9(1):e87906. doi: 10.1371/journal.pone.0087906. eCollection 2014.

42.

Discovery of a new avian bornavirus genotype in estrildid finches (Estrildidae) in Germany.

Rubbenstroth D, Schmidt V, Rinder M, Legler M, Corman VM, Staeheli P.

Vet Microbiol. 2014 Jan 31;168(2-4):318-23. doi: 10.1016/j.vetmic.2013.11.032. Epub 2013 Dec 16.

PMID:
24389254
43.

Antiviral activity of lambda interferon in chickens.

Reuter A, Soubies S, Härtle S, Schusser B, Kaspers B, Staeheli P, Rubbenstroth D.

J Virol. 2014 Mar;88(5):2835-43. doi: 10.1128/JVI.02764-13. Epub 2013 Dec 26.

44.

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia.

Crotta S, Davidson S, Mahlakoiv T, Desmet CJ, Buckwalter MR, Albert ML, Staeheli P, Wack A.

PLoS Pathog. 2013;9(11):e1003773. doi: 10.1371/journal.ppat.1003773. Epub 2013 Nov 21.

45.

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.

Xiao H, Killip MJ, Staeheli P, Randall RE, Jackson D.

J Virol. 2013 Dec;87(23):13053-8. doi: 10.1128/JVI.02220-13. Epub 2013 Sep 18.

46.

Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.

Lohrmann F, Dijkman R, Stertz S, Thiel V, Haller O, Staeheli P, Kochs G.

J Virol. 2013 Oct;87(20):11300-3. doi: 10.1128/JVI.01271-13. Epub 2013 Aug 7.

47.

Reverse genetics identifies the product of open reading frame 4 as an essential particle assembly factor of Nyamanini virus.

Herrel M, Haag L, Nilsson J, Staeheli P, Schneider U.

J Virol. 2013 Jul;87(14):8257-60. doi: 10.1128/JVI.00163-13. Epub 2013 May 22.

48.

Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection.

Knuschke T, Sokolova V, Rotan O, Wadwa M, Tenbusch M, Hansen W, Staeheli P, Epple M, Buer J, Westendorf AM.

J Immunol. 2013 Jun 15;190(12):6221-9. doi: 10.4049/jimmunol.1202654. Epub 2013 May 10.

49.

Nyamiviridae: proposal for a new family in the order Mononegavirales.

Kuhn JH, Bekal S, Caì Y, Clawson AN, Domier LL, Herrel M, Jahrling PB, Kondo H, Lambert KN, Mihindukulasuriya KA, Nowotny N, Radoshitzky SR, Schneider U, Staeheli P, Suzuki N, Tesh RB, Wang D, Wang LF, Dietzgen RG.

Arch Virol. 2013 Oct;158(10):2209-26. doi: 10.1007/s00705-013-1674-y. Epub 2013 May 1.

50.

Avian bornaviruses are widely distributed in canary birds (Serinus canaria f. domestica).

Rubbenstroth D, Rinder M, Stein M, Höper D, Kaspers B, Brosinski K, Horie M, Schmidt V, Legler M, Korbel R, Staeheli P.

Vet Microbiol. 2013 Aug 30;165(3-4):287-95. doi: 10.1016/j.vetmic.2013.03.024. Epub 2013 Apr 9.

PMID:
23631925

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