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IRF1 and IRF2 regulate the non-canonical inflammasome.

Thygesen SJ, Stacey KJ.

EMBO Rep. 2019 Sep;20(9):e48891. doi: 10.15252/embr.201948891. Epub 2019 Aug 5.


Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages.

Thygesen SJ, Takizawa KE, Robertson AAB, Sester DP, Stacey KJ.

Immunol Cell Biol. 2019 Jan;97(1):17-28. doi: 10.1111/imcb.12193. Epub 2018 Aug 19.


Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes.

Bitto NJ, Baker PJ, Dowling JK, Wray-McCann G, De Paoli A, Tran LS, Leung PL, Stacey KJ, Mansell A, Masters SL, Ferrero RL.

Immunol Cell Biol. 2018 Nov;96(10):1120-1130. doi: 10.1111/imcb.12190. Epub 2018 Aug 14.


Plugging the Leak in Dengue Shock.

Watterson D, Modhiran N, Muller DA, Stacey KJ, Young PR.

Adv Exp Med Biol. 2018;1062:89-106. doi: 10.1007/978-981-10-8727-1_7. Review.


Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K.

J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6.


Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.

Sagulenko V, Vitak N, Vajjhala PR, Vince JE, Stacey KJ.

J Mol Biol. 2018 Jan 19;430(2):238-247. doi: 10.1016/j.jmb.2017.10.028. Epub 2017 Oct 31.


Bacterial membrane vesicles transport their DNA cargo into host cells.

Bitto NJ, Chapman R, Pidot S, Costin A, Lo C, Choi J, D'Cruze T, Reynolds EC, Dashper SG, Turnbull L, Whitchurch CB, Stinear TP, Stacey KJ, Ferrero RL.

Sci Rep. 2017 Aug 1;7(1):7072. doi: 10.1038/s41598-017-07288-4.


Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.


The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.

Vajjhala PR, Ve T, Bentham A, Stacey KJ, Kobe B.

Mol Immunol. 2017 Jun;86:23-37. doi: 10.1016/j.molimm.2017.02.012. Epub 2017 Feb 27. Review.


Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.

Modhiran N, Watterson D, Blumenthal A, Baxter AG, Young PR, Stacey KJ.

Immunol Cell Biol. 2017 May;95(5):491-495. doi: 10.1038/icb.2017.5. Epub 2017 Feb 21.


Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H.

Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13.


Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN.

Immunity. 2016 Aug 16;45(2):333-45. doi: 10.1016/j.immuni.2016.07.017.


Assessment of Inflammasome Formation by Flow Cytometry.

Sester DP, Zamoshnikova A, Thygesen SJ, Vajjhala PR, Cridland SO, Schroder K, Stacey KJ.

Curr Protoc Immunol. 2016 Aug 1;114:14.40.1-14.40.29. doi: 10.1002/cpim.13.


Correction: Response to Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice".

Sester DP, Stacey KJ.

J Immunol. 2016 Jul 15;197(2):676. doi: 10.4049/jimmunol.1600898. No abstract available.


Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.

Kapetanovic R, Bokil NJ, Achard ME, Ong CL, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ.

FASEB J. 2016 May;30(5):1901-12. doi: 10.1096/fj.201500061. Epub 2016 Feb 2.


Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides.

Thygesen SJ, Sester DP, Cridland SO, Wilton SD, Stacey KJ.

Immunol Cell Biol. 2016 May;94(5):520-4. doi: 10.1038/icb.2016.3. Epub 2016 Feb 2.


Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages.

Vitak N, Hume DA, Chappell KJ, Sester DP, Stacey KJ.

Dev Comp Immunol. 2016 Jun;59:145-52. doi: 10.1016/j.dci.2016.01.023. Epub 2016 Jan 29.


Methods for Delivering DNA to Intracellular Receptors.

Stacey KJ, Idris A, Sagulenko V, Vitak N, Sester DP.

Methods Mol Biol. 2016;1390:93-106. doi: 10.1007/978-1-4939-3335-8_6.


Response to Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice".

Sester DP, Stacey KJ.

J Immunol. 2015 Nov 15;195(10):4552-3. doi: 10.4049/jimmunol.1501930. No abstract available. Erratum in: J Immunol. 2016 Jul 15;197(2):676.


The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.

Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ.

J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14.


Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.

Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, Hume DA, Stacey KJ, Young PR.

Sci Transl Med. 2015 Sep 9;7(304):304ra142. doi: 10.1126/scitranslmed.aaa3863.


Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.

Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ.

J Immunol. 2015 Aug 1;195(3):1233-41. doi: 10.4049/jimmunol.1402859. Epub 2015 Jun 26.


Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.

Schaale K, Peters KM, Murthy AM, Fritzsche AK, Phan MD, Totsika M, Robertson AA, Nichols KB, Cooper MA, Stacey KJ, Ulett GC, Schroder K, Schembri MA, Sweet MJ.

Mucosal Immunol. 2016 Jan;9(1):124-36. doi: 10.1038/mi.2015.44. Epub 2015 May 20.


A novel pathway of cell death in response to cytosolic DNA in Drosophila cells.

Vitak N, Johnson KN, Sester DP, Stacey KJ.

J Innate Immun. 2015;7(2):212-22. doi: 10.1159/000368276. Epub 2014 Nov 29.


A novel flow cytometric method to assess inflammasome formation.

Sester DP, Thygesen SJ, Sagulenko V, Vajjhala PR, Cridland JA, Vitak N, Chen KW, Osborne GW, Schroder K, Stacey KJ.

J Immunol. 2015 Jan 1;194(1):455-62. doi: 10.4049/jimmunol.1401110. Epub 2014 Nov 17.


The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge.

Chen KW, Groß CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ, Schroder K.

Cell Rep. 2014 Jul 24;8(2):570-82. doi: 10.1016/j.celrep.2014.06.028. Epub 2014 Jul 17.


Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.

Vajjhala PR, Kaiser S, Smith SJ, Ong QR, Soh SL, Stacey KJ, Hill JM.

J Biol Chem. 2014 Aug 22;289(34):23504-19. doi: 10.1074/jbc.M114.553305. Epub 2014 Jul 8.


Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.


Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.

Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H.

Cell Rep. 2013 Jul 25;4(2):327-39. doi: 10.1016/j.celrep.2013.06.024. Epub 2013 Jul 11.


Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection.

Aachoui Y, Sagulenko V, Miao EA, Stacey KJ.

Curr Opin Microbiol. 2013 Jun;16(3):319-26. doi: 10.1016/j.mib.2013.04.004. Epub 2013 May 23. Review.


AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ.

Cell Death Differ. 2013 Sep;20(9):1149-60. doi: 10.1038/cdd.2013.37. Epub 2013 May 3.


DEC-205 is a cell surface receptor for CpG oligonucleotides.

Lahoud MH, Ahmet F, Zhang JG, Meuter S, Policheni AN, Kitsoulis S, Lee CN, O'Keeffe M, Sullivan LC, Brooks AG, Berry R, Rossjohn J, Mintern JD, Vega-Ramos J, Villadangos JA, Nicola NA, Nussenzweig MC, Stacey KJ, Shortman K, Heath WR, Caminschi I.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16270-5. doi: 10.1073/pnas.1208796109. Epub 2012 Sep 17.


Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.

Liu XQ, Stacey KJ, Horne-Debets JM, Cridland JA, Fischer K, Narum D, Mackay F, Pierce SK, Wykes MN.

Eur J Immunol. 2012 Dec;42(12):3291-301. doi: 10.1002/eji.201242689. Epub 2012 Oct 16.


Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction.

Schroder K, Sagulenko V, Zamoshnikova A, Richards AA, Cridland JA, Irvine KM, Stacey KJ, Sweet MJ.

Immunobiology. 2012 Dec;217(12):1325-9. doi: 10.1016/j.imbio.2012.07.020. Epub 2012 Jul 27.


The mammalian PYHIN gene family: phylogeny, evolution and expression.

Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ.

BMC Evol Biol. 2012 Aug 7;12:140.


Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages.

Bokil NJ, Totsika M, Carey AJ, Stacey KJ, Hancock V, Saunders BM, Ravasi T, Ulett GC, Schembri MA, Sweet MJ.

Immunobiology. 2011 Nov;216(11):1164-71. doi: 10.1016/j.imbio.2011.05.011. Epub 2011 May 24.


The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes.

Roberts TL, Dunn JA, Sweet MJ, Hume DA, Stacey KJ.

Mol Immunol. 2011 Apr;48(8):1027-34. doi: 10.1016/j.molimm.2011.01.011. Epub 2011 Feb 16.


Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.

van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, Ovchinnikov DA, Perkins AC, Cook AD, Hamilton JA, Hertzog PJ, Stacey KJ, Kellie S, Hume DA, Sweet MJ.

PLoS One. 2011 Jan 7;6(1):e15723. doi: 10.1371/journal.pone.0015723.


B cells do not take up bacterial DNA: an essential role for antigen in exposure of DNA to toll-like receptor-9.

Roberts TL, Turner ML, Dunn JA, Lenert P, Ross IL, Sweet MJ, Stacey KJ.

Immunol Cell Biol. 2011 May;89(4):517-25. doi: 10.1038/icb.2010.112. Epub 2010 Oct 5.


A clear link between endogenous retroviral LTR activity and Hodgkin's lymphoma.

Stacey KJ, Sagulenko V.

Cell Res. 2010 Aug;20(8):869-71. doi: 10.1038/cr.2010.96. Epub 2010 Jul 6. No abstract available.


A visual framework for sequence analysis using n-grams and spectral rearrangement.

Maetschke SR, Kassahn KS, Dunn JA, Han SP, Curley EZ, Stacey KJ, Ragan MA.

Bioinformatics. 2010 Mar 15;26(6):737-44. doi: 10.1093/bioinformatics/btq042. Epub 2010 Feb 3.


HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.

Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ.

Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009 Jan 8.


TLR9-independent effects of inhibitory oligonucleotides on macrophage responses to S. typhimurium.

Trieu A, Bokil N, Dunn JA, Roberts TL, Xu D, Liew FY, Hume DA, Stacey KJ, Sweet MJ.

Immunol Cell Biol. 2009 Mar-Apr;87(3):218-25. doi: 10.1038/icb.2008.95. Epub 2008 Dec 2.


Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages.

Schroder K, Spille M, Pilz A, Lattin J, Bode KA, Irvine KM, Burrows AD, Ravasi T, Weighardt H, Stacey KJ, Decker T, Hume DA, Dalpke AH, Sweet MJ.

J Immunol. 2007 Sep 15;179(6):3495-503.


Plasmodium strain determines dendritic cell function essential for survival from malaria.

Wykes MN, Liu XQ, Beattie L, Stanisic DI, Stacey KJ, Smyth MJ, Thomas R, Good MF.

PLoS Pathog. 2007 Jul;3(7):e96.


PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages.

Schroder K, Lichtinger M, Irvine KM, Brion K, Trieu A, Ross IL, Ravasi T, Stacey KJ, Rehli M, Hume DA, Sweet MJ.

J Leukoc Biol. 2007 Jun;81(6):1577-90. Epub 2007 Mar 14.


DNA motifs suppressing TLR9 responses.

Trieu A, Roberts TL, Dunn JA, Sweet MJ, Stacey KJ.

Crit Rev Immunol. 2006;26(6):527-44. Review.


CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway.

Sester DP, Brion K, Trieu A, Goodridge HS, Roberts TL, Dunn J, Hume DA, Stacey KJ, Sweet MJ.

J Immunol. 2006 Oct 1;177(7):4473-80.


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