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Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes.

Xiao S, Tang YS, Kusumanchi P, Stabler SP, Zhang Y, Antony AC.

J Nutr. 2018 Mar 1;148(3):389-400. doi: 10.1093/jn/nxx060.


Methylene-tetrahydrofolate reductase contributes to allergic airway disease.

Eyring KR, Pedersen BS, Maclean KN, Stabler SP, Yang IV, Schwartz DA.

PLoS One. 2018 Jan 12;13(1):e0190916. doi: 10.1371/journal.pone.0190916. eCollection 2018.


Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans.

McDonald MK, Fritz JA, Jia D, Scheuchner D, Snyder FF, Stanislaus A, Curle J, Li L, Stabler SP, Allen RH, Mains PE, Gravel RA.

Mol Genet Metab. 2017 Dec;122(4):160-171. doi: 10.1016/j.ymgme.2017.11.002. Epub 2017 Nov 11.


Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR.

FASEB J. 2018 Mar;32(3):1265-1280. doi: 10.1096/fj.201700586R. Epub 2018 Jan 3.


Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.

Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN.

Mol Genet Metab. 2017 Apr;120(4):325-336. doi: 10.1016/j.ymgme.2017.02.010. Epub 2017 Mar 2.


Potential Misdiagnosis of Hyperhomocysteinemia due to Cystathionine Beta-Synthase Deficiency During Pregnancy.

Stabler SP, Freehauf C, Allen RH, Thomas J, Gallagher R.

JIMD Rep. 2017;37:55-61. doi: 10.1007/8904_2017_15. Epub 2017 Mar 9.


Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.

Tang YS, Khan RA, Xiao S, Hansen DK, Stabler SP, Kusumanchi P, Jayaram HN, Antony AC.

J Nutr. 2017 Apr;147(4):482-498. doi: 10.3945/jn.116.241364. Epub 2017 Mar 1.


Molecular and biochemical investigations of patients with intermediate or severe hyperhomocysteinemia.

Sørensen JT, Gaustadnes M, Stabler SP, Allen RH, Mudd SH, Hvas AM.

Mol Genet Metab. 2016 Mar;117(3):344-50. doi: 10.1016/j.ymgme.2015.12.010. Epub 2015 Dec 23.


Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.

Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN.

Biol Open. 2015 Aug 14;4(9):1154-62. doi: 10.1242/bio.013433.


The effects of folate intake on DNA and single-carbon pathway metabolism in the fruit fly Drosophila melanogaster compared to mammals.

Blatch SA, Stabler SP, Harrison JF.

Comp Biochem Physiol B Biochem Mol Biol. 2015 Nov;189:34-9. doi: 10.1016/j.cbpb.2015.07.007. Epub 2015 Jul 26.


Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites.

Davenport C, Yan J, Taesuwan S, Shields K, West AA, Jiang X, Perry CA, Malysheva OV, Stabler SP, Allen RH, Caudill MA.

J Nutr Biochem. 2015 Sep;26(9):903-11. doi: 10.1016/j.jnutbio.2015.03.004. Epub 2015 Apr 15.


Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes.

Bae S, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Stabler SP, Allen RH, Caudill MA.

J Nutr. 2015 Jul;145(7):1507-14. doi: 10.3945/jn.115.210757. Epub 2015 May 20.


Association of Transcobalamin II (TCN2) and Transcobalamin II-Receptor (TCblR) Genetic Variations With Cobalamin Deficiency Parameters in Elderly Women.

Kurnat-Thoma EL, Pangilinan F, Matteini AM, Wong B, Pepper GA, Stabler SP, Guralnik JM, Brody LC.

Biol Res Nurs. 2015 Jul;17(4):444-54. doi: 10.1177/1099800415569506. Epub 2015 Feb 5.


Anemias due to essential nutrient deficiencies.

Stabler SP.

World Rev Nutr Diet. 2015;111:164-8. doi: 10.1159/000362319. Epub 2014 Nov 17. No abstract available.


Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression.

Quintana AM, Geiger EA, Achilly N, Rosenblatt DS, Maclean KN, Stabler SP, Artinger KB, Appel B, Shaikh TH.

Dev Biol. 2014 Dec 1;396(1):94-106. doi: 10.1016/j.ydbio.2014.09.026. Epub 2014 Oct 2.


Supplementing lactating dairy cows with a vitamin B12 precursor, 5,6-dimethylbenzimidazole, increases the apparent ruminal synthesis of vitamin B12.

Brito A, Chiquette J, Stabler SP, Allen RH, Girard CL.

Animal. 2015 Jan;9(1):67-75. doi: 10.1017/S1751731114002201. Epub 2014 Aug 29.


Altered hepatic sulfur metabolism in cystathionine β-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.

Jiang H, Stabler SP, Allen RH, Abman SH, Maclean KN.

FASEB J. 2014 Sep;28(9):4044-54. doi: 10.1096/fj.14-253633. Epub 2014 Jun 2.


Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.

Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Brenna JT, Stabler SP, Allen RH, Gregory JF 3rd, Caudill MA.

Am J Clin Nutr. 2013 Dec;98(6):1459-67. doi: 10.3945/ajcn.113.066092. Epub 2013 Oct 16.


Metabolic profiling of total homocysteine and related compounds in hyperhomocysteinemia: utility and limitations in diagnosing the cause of puzzling thrombophilia in a family.

Stabler SP, Korson M, Jethva R, Allen RH, Kraus JP, Spector EB, Wagner C, Mudd SH.

JIMD Rep. 2013;11:149-63. doi: 10.1007/8904_2013_235. Epub 2013 Jun 4.


Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.

Abarinov EV, Beaudin AE, Field MS, Perry CA, Allen RH, Stabler SP, Stover PJ.

J Nutr. 2013 Jul;143(7):1028-35. doi: 10.3945/jn.113.174417. Epub 2013 May 22.


Vitamin B12 deficiency.

Stabler SP.

N Engl J Med. 2013 May 23;368(21):2041-2. doi: 10.1056/NEJMc1304350. No abstract available.


Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.

Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Green RC, Allen RH, Stabler SP, Poon LW; Georgia Centenarian.

Exp Aging Res. 2013;39(2):125-44. doi: 10.1080/0361073X.2013.761869.


Clinical practice. Vitamin B12 deficiency.

Stabler SP.

N Engl J Med. 2013 Jan 10;368(2):149-60. doi: 10.1056/NEJMcp1113996. Review. No abstract available.


Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.

Field MS, Shields KS, Abarinov EV, Malysheva OV, Allen RH, Stabler SP, Ash JA, Strupp BJ, Stover PJ, Caudill MA.

J Nutr. 2013 Jan;143(1):41-5. doi: 10.3945/jn.112.169821. Epub 2012 Nov 28.


Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in Dehalococcoides mccartyi.

Yi S, Seth EC, Men YJ, Stabler SP, Allen RH, Alvarez-Cohen L, Taga ME.

Appl Environ Microbiol. 2012 Nov;78(21):7745-52. doi: 10.1128/AEM.02150-12. Epub 2012 Aug 24.


Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.

Maclean KN, Greiner LS, Evans JR, Sood SK, Lhotak S, Markham NE, Stabler SP, Allen RH, Austin RC, Balasubramaniam V, Jiang H.

J Biol Chem. 2012 Sep 14;287(38):31994-2005. doi: 10.1074/jbc.M112.355172. Epub 2012 Aug 1.


Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

Flores KG, Stidley CA, Mackey AJ, Picchi MA, Stabler SP, Siegfried JM, Byers T, Berwick M, Belinsky SA, Leng S.

Carcinogenesis. 2012 Aug;33(8):1542-7. doi: 10.1093/carcin/bgs194. Epub 2012 Jun 4.


Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.

Jiang H, Stabler SP, Allen RH, Maclean KN.

Mol Genet Metab. 2012 Sep;107(1-2):55-65. doi: 10.1016/j.ymgme.2012.04.025. Epub 2012 May 5.


Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.

Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RH, Caudill MA.

Am J Clin Nutr. 2012 May;95(5):1060-71. doi: 10.3945/ajcn.111.022772. Epub 2012 Mar 14.


Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.

Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ.

Am J Clin Nutr. 2012 Apr;95(4):882-91. doi: 10.3945/ajcn.111.030783. Epub 2012 Feb 29.


Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.

Xiao S, Tang YS, Khan RA, Zhang Y, Kusumanchi P, Stabler SP, Jayaram HN, Antony AC.

J Biol Chem. 2012 Apr 6;287(15):12559-77. doi: 10.1074/jbc.M111.317040. Epub 2012 Feb 17.


Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.

Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP.

Mol Genet Metab. 2012 Mar;105(3):395-403. doi: 10.1016/j.ymgme.2011.11.190. Epub 2011 Dec 2.


Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.

Mudd SH, Wagner C, Luka Z, Stabler SP, Allen RH, Schroer R, Wood T, Wang J, Wong LJ.

Mol Genet Metab. 2012 Feb;105(2):228-36. doi: 10.1016/j.ymgme.2011.11.006. Epub 2011 Nov 12.


The oldest old: red blood cell and plasma folate in African American and white octogenarians and centenarians in Georgia.

Hausman DB, Johnson MA, Davey A, Woodard JL, Poon LW, Allen RH, Stabler SP; Georgia Centenarian Study.

J Nutr Health Aging. 2011 Nov;15(9):744-50.


Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.

MacFarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ.

J Biol Chem. 2011 Dec 23;286(51):44015-22. doi: 10.1074/jbc.M111.307629. Epub 2011 Nov 4.


S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.

Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Richards JR, Halsted CH.

Alcohol Clin Exp Res. 2011 Nov;35(11):1960-5. doi: 10.1111/j.1530-0277.2011.01547.x.


Prevalence and predictors of anemia in a population-based study of octogenarians and centenarians in Georgia.

Haslam A, Hausman DB, Johnson MA, Davey A, Poon LW, Allen RH, Stabler SP; Georgia Centenarian Study.

J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):100-6. doi: 10.1093/gerona/glr151. Epub 2011 Sep 5.


Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria.

Keating AK, Freehauf C, Jiang H, Brodsky GL, Stabler SP, Allen RH, Graham DK, Thomas JA, Van Hove JL, Maclean KN.

Mol Genet Metab. 2011 Aug;103(4):330-7. doi: 10.1016/j.ymgme.2011.04.012. Epub 2011 May 5.


B-vitamin deficiency is protective against DSS-induced colitis in mice.

Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF 3rd, Stabler SP, Burrin DG.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G249-59. doi: 10.1152/ajpgi.00076.2011. Epub 2011 May 19.


Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.

Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ.

Am J Clin Nutr. 2011 Apr;93(4):789-98. doi: 10.3945/ajcn.110.002766. Epub 2011 Feb 23.


MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.

Yan J, Wang W, Gregory JF 3rd, Malysheva O, Brenna JT, Stabler SP, Allen RH, Caudill MA.

Am J Clin Nutr. 2011 Feb;93(2):348-55. doi: 10.3945/ajcn.110.005975. Epub 2010 Dec 1.


Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia.

Fernández-Irigoyen J, Santamaría E, Chien YH, Hwu WL, Korman SH, Faghfoury H, Schulze A, Hoganson GE, Stabler SP, Allen RH, Wagner C, Mudd SH, Corrales FJ.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):172-7. doi: 10.1016/j.ymgme.2010.07.009. Epub 2010 Jul 15.


Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Crnic LS, Allen RH, Stabler SP, Elleder M, Kraus JP.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):163-71. doi: 10.1016/j.ymgme.2010.06.007. Epub 2010 Jun 22.


A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP, Elleder M, Rozen R, Patterson D, Kraus JP.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):153-62. doi: 10.1016/j.ymgme.2010.06.010. Epub 2010 Jun 23.


Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.

Medici V, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Virata MC, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Rahim N, Richards JR, Rossaro L, Halsted CH.

J Hepatol. 2010 Sep;53(3):551-7. doi: 10.1016/j.jhep.2010.03.029. Epub 2010 May 31.


Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia.

Johnson MA, Hausman DB, Davey A, Poon LW, Allen RH, Stabler SP; Georgia Centenarian Study.

J Nutr Health Aging. 2010 May;14(5):339-45.


Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty.

Matteini AM, Walston JD, Bandeen-Roche K, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD.

J Nutr Health Aging. 2010 Jan;14(1):73-7.


Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population.

Bor MV, von Castel-Roberts KM, Kauwell GP, Stabler SP, Allen RH, Maneval DR, Bailey LB, Nexo E.

Am J Clin Nutr. 2010 Mar;91(3):571-7. doi: 10.3945/ajcn.2009.28082. Epub 2010 Jan 13.


Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study.

Guerra-Shinohara EM, Pereira PM, Kubota AM, Silva TA, Reis JL, Miyashita GS, D'Almeida V, Allen RH, Stabler SP.

Clin Chim Acta. 2010 Mar;411(5-6):423-7. doi: 10.1016/j.cca.2009.12.014. Epub 2009 Dec 28.


Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria.

Vanderjagt DJ, Ujah IA, Patel A, Kellywood J, Crossey MJ, Allen RH, Stabler SP, Obande OS, Glew RH.

J Obstet Gynaecol. 2009 May;29(4):288-95.


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