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Items: 42


Community members in activated sludge as determined by molecular probe technology.

Xu W, Brand VR, Suresh S, Jensen MA, Davis RW, Criddle CS, St Onge RP, Hyman RW.

Water Res. 2020 Jan 1;168:115104. doi: 10.1016/j.watres.2019.115104. Epub 2019 Oct 10.


Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.

Tang MC, Fischer CR, Chari JV, Tan D, Suresh S, Chu A, Miranda M, Smith J, Zhang Z, Garg NK, St Onge RP, Tang Y.

J Am Chem Soc. 2019 May 22;141(20):8198-8206. doi: 10.1021/jacs.9b01083. Epub 2019 May 10.


Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 May;15(5):549. doi: 10.1038/s41589-019-0255-0.


Improved discovery of genetic interactions using CRISPRiSeq across multiple environments.

Jaffe M, Dziulko A, Smith JD, St Onge RP, Levy SF, Sherlock G.

Genome Res. 2019 Apr;29(4):668-681. doi: 10.1101/gr.246603.118. Epub 2019 Feb 19.


PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 Apr;15(4):358-366. doi: 10.1038/s41589-019-0228-3. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 Mar 4;:.


A biosensor-based approach reveals links between efflux pump expression and cell cycle regulation in pleiotropic drug resistance of yeast.

Li J, Kolberg K, Schlecht U, St Onge RP, Aparicio AM, Horecka J, Davis RW, Hillenmeyer ME, Harvey CJB.

J Biol Chem. 2019 Jan 25;294(4):1257-1266. doi: 10.1074/jbc.RA118.003904. Epub 2018 Dec 4.


Multiplexed precision genome editing with trackable genomic barcodes in yeast.

Roy KR, Smith JD, Vonesch SC, Lin G, Tu CS, Lederer AR, Chu A, Suresh S, Nguyen M, Horecka J, Tripathi A, Burnett WT, Morgan MA, Schulz J, Orsley KM, Wei W, Aiyar RS, Davis RW, Bankaitis VA, Haber JE, Salit ML, St Onge RP, Steinmetz LM.

Nat Biotechnol. 2018 Jul;36(6):512-520. doi: 10.1038/nbt.4137. Epub 2018 May 7.


HEx: A heterologous expression platform for the discovery of fungal natural products.

Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, Aiyar RS, Steinmetz LM, Davis RW, Medema MH, Sattely E, Khosla C, St Onge RP, Tang Y, Hillenmeyer ME.

Sci Adv. 2018 Apr 11;4(4):eaar5459. doi: 10.1126/sciadv.aar5459. eCollection 2018 Apr.


Quantitative analysis of protein interaction network dynamics in yeast.

Celaj A, Schlecht U, Smith JD, Xu W, Suresh S, Miranda M, Aparicio AM, Proctor M, Davis RW, Roth FP, St Onge RP.

Mol Syst Biol. 2017 Jul 13;13(7):934. doi: 10.15252/msb.20177532.


A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions.

Schlecht U, Liu Z, Blundell JR, St Onge RP, Levy SF.

Nat Commun. 2017 May 25;8:15586. doi: 10.1038/ncomms15586.


A method for high-throughput production of sequence-verified DNA libraries and strain collections.

Smith JD, Schlecht U, Xu W, Suresh S, Horecka J, Proctor MJ, Aiyar RS, Bennett RA, Chu A, Li YF, Roy K, Davis RW, Steinmetz LM, Hyman RW, Levy SF, St Onge RP.

Mol Syst Biol. 2017 Feb 13;13(2):913. doi: 10.15252/msb.20167233.


Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae.

Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top077701.


Identification of Chemical-Genetic Interactions via Parallel Analysis of Barcoded Yeast Strains.

Suresh S, Schlecht U, Xu W, Miranda M, Davis RW, Nislow C, Giaever G, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot088054.


Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo.

Fu BX, St Onge RP, Fire AZ, Smith JD.

Nucleic Acids Res. 2016 Jun 20;44(11):5365-77. doi: 10.1093/nar/gkw417. Epub 2016 May 19.


Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.


Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM.

Nat Commun. 2014 Dec 18;5:5585. doi: 10.1038/ncomms6585.


Targeted and highly multiplexed detection of microorganisms by employing an ensemble of molecular probes.

Xu W, Krishnakumar S, Miranda M, Jensen MA, Fukushima M, Palm C, Fung E, Davis RW, St Onge RP, Hyman RW.

Appl Environ Microbiol. 2014 Jul;80(14):4153-61. doi: 10.1128/AEM.00666-14. Epub 2014 May 2.


Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.


A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP.

BMC Genomics. 2014 Apr 5;15:263. doi: 10.1186/1471-2164-15-263.


PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nile AH, Tripathi A, Yuan P, Mousley CJ, Suresh S, Wallace IM, Shah SD, Pohlhaus DT, Temple B, Nislow C, Giaever G, Tropsha A, Davis RW, St Onge RP, Bankaitis VA.

Nat Chem Biol. 2014 Jan;10(1):76-84. doi: 10.1038/nchembio.1389. Epub 2013 Nov 24.


Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.

Schlecht U, St Onge RP, Walther T, François JM, Davis RW.

PLoS One. 2012;7(8):e42853. doi: 10.1371/journal.pone.0042853. Epub 2012 Aug 8.


Multiplex assay for condition-dependent changes in protein-protein interactions.

Schlecht U, Miranda M, Suresh S, Davis RW, St Onge RP.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9213-8. doi: 10.1073/pnas.1204952109. Epub 2012 May 21.


Molecular probe technology detects bacteria without culture.

Hyman RW, St Onge RP, Kim H, Tamaresis JS, Miranda M, Aparicio AM, Fukushima M, Pourmand N, Giudice LC, Davis RW.

BMC Microbiol. 2012 Mar 9;12:29. doi: 10.1186/1471-2180-12-29.


Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.


A yeast-based assay identifies drugs active against human mitochondrial disorders.

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi: 10.1073/pnas.1101478108. Epub 2011 Jun 29.


The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Tamble CM, St Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS.

Mol Biosyst. 2011 Jun;7(6):2019-30. doi: 10.1039/c0mb00298d. Epub 2011 Apr 12.


Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP.

Nat Methods. 2011 Feb;8(2):159-64. doi: 10.1038/nmeth.1550. Epub 2011 Jan 9.


Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

Oh J, Fung E, Schlecht U, Davis RW, Giaever G, St Onge RP, Deutschbauer A, Nislow C.

PLoS Pathog. 2010 Oct 7;6(10):e1001140. doi: 10.1371/journal.ppat.1001140.


Exploring gene function and drug action using chemogenomic dosage assays.

Ericson E, Hoon S, St Onge RP, Giaever G, Nislow C.

Methods Enzymol. 2010;470:233-55. doi: 10.1016/S0076-6879(10)70010-0. Epub 2010 Mar 1.


Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Smith AM, Heisler LE, St Onge RP, Farias-Hesson E, Wallace IM, Bodeau J, Harris AN, Perry KM, Giaever G, Pourmand N, Nislow C.

Nucleic Acids Res. 2010 Jul;38(13):e142. doi: 10.1093/nar/gkq368. Epub 2010 May 11.


Multiplex identification of microbes.

Hyman RW, St Onge RP, Allen EA, Miranda M, Aparicio AM, Fukushima M, Davis RW.

Appl Environ Microbiol. 2010 Jun;76(12):3904-10. doi: 10.1128/AEM.02785-09. Epub 2010 Apr 23.


The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.


Yeast chemical genomics and drug discovery: an update.

Hoon S, St Onge RP, Giaever G, Nislow C.

Trends Pharmacol Sci. 2008 Oct;29(10):499-504. doi: 10.1016/ Epub 2008 Aug 26. Review.


An integrated platform of genomic assays reveals small-molecule bioactivities.

Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, Nislow C.

Nat Chem Biol. 2008 Aug;4(8):498-506. doi: 10.1038/nchembio.100. Epub 2008 Jul 11. Erratum in: Nat Chem Biol.2008 Oct;4(10):632.. StOnge, Robert P [corrected to St Onge,Robert P].


The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W, Proctor M, St Onge RP, Tyers M, Koller D, Altman RB, Davis RW, Nislow C, Giaever G.

Science. 2008 Apr 18;320(5874):362-5. doi: 10.1126/science.1150021.


Defining genetic interaction.

Mani R, St Onge RP, Hartman JL 4th, Giaever G, Roth FP.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3461-6. doi: 10.1073/pnas.0712255105. Epub 2008 Feb 27.


Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS.

J Nat Prod. 2007 Mar;70(3):383-90. Epub 2007 Feb 10.


Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

St Onge RP, Mani R, Oh J, Proctor M, Fung E, Davis RW, Nislow C, Roth FP, Giaever G.

Nat Genet. 2007 Feb;39(2):199-206. Epub 2007 Jan 7.


Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

Lee W, St Onge RP, Proctor M, Flaherty P, Jordan MI, Arkin AP, Davis RW, Nislow C, Giaever G.

PLoS Genet. 2005 Aug;1(2):e24. Epub 2005 Aug 19.


A role for the phosphorylation of hRad9 in checkpoint signaling.

St Onge RP, Besley BD, Pelley JL, Davey S.

J Biol Chem. 2003 Jul 18;278(29):26620-8. Epub 2003 May 6.


DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.

St Onge RP, Besley BD, Park M, Casselman R, Davey S.

J Biol Chem. 2001 Nov 9;276(45):41898-905. Epub 2001 Sep 10.


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