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Items: 45

1.

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.

Johnston MJ, Nikolic A, Ninkovic N, Guilhamon P, Cavalli FMG, Seaman S, Zemp FJ, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida MM, Coutinho FJ, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Dirks PB, Pugh TJ, Morrissy S, St Croix B, Mahoney DJ, Lupien M, Gallo M.

Genome Res. 2019 Aug;29(8):1211-1222. doi: 10.1101/gr.246520.118. Epub 2019 Jun 27.

2.

Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth.

Evans DJ, Wasinger AM, Brey RN, Dunleavey JM, St Croix B, Bann JG.

Front Oncol. 2018 Nov 6;8:506. doi: 10.3389/fonc.2018.00506. eCollection 2018. Review.

3.

Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.

Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B.

J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4.

4.

TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer.

Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N.

Cancer Res. 2018 Jan 15;78(2):489-500. doi: 10.1158/0008-5472.CAN-16-1911. Epub 2017 Nov 28. Erratum in: Cancer Res. 2018 Jun 15;78(12):3403.

5.

Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines.

Wallace J, Lutgen V, Avasarala S, St Croix B, Winn RA, Al-Harthi L.

Immunology. 2018 Feb;153(2):203-213. doi: 10.1111/imm.12830. Epub 2017 Oct 12.

6.

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B.

Cancer Cell. 2017 Apr 10;31(4):501-515.e8. doi: 10.1016/j.ccell.2017.03.005.

7.

Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia.

Andersen NJ, Boguslawski EA, Naidu AS, Szot C, Bromberg-White JL, Kits K, Kuk CY, Holton LE, St Croix B, Chambers CM, Duesbery NS.

PLoS One. 2016 Jan 19;11(1):e0146586. doi: 10.1371/journal.pone.0146586. eCollection 2016.

8.

CD146: the unveiling of a pro-angiogenic netrin receptor.

St Croix B.

Cell Res. 2015 May;25(5):533-4. doi: 10.1038/cr.2015.42. Epub 2015 Apr 7.

9.

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.

Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR.

Matrix Biol. 2015 Mar;42:56-73. doi: 10.1016/j.matbio.2014.12.002. Epub 2015 Jan 5.

10.

GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.

Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B.

Cell Rep. 2015 Jan 13;10(2):123-30. doi: 10.1016/j.celrep.2014.12.020. Epub 2014 Dec 31.

11.

Chemoprevention of metastasis.

Emenaker NJ, Zudaire E, St Croix B.

Oncotarget. 2014 Aug 30;5(16):6556-7. No abstract available.

12.

Immuno-PET imaging of tumor endothelial marker 8 (TEM8).

Kuo F, Histed S, Xu B, Bhadrasetty V, Szajek LP, Williams MR, Wong K, Wu H, Lane K, Coble V, Vasalatiy O, Griffiths GL, Paik CH, Elbuluk O, Szot C, Chaudhary A, St Croix B, Choyke P, Jagoda EM.

Mol Pharm. 2014 Nov 3;11(11):3996-4006. doi: 10.1021/mp500056d. Epub 2014 Jul 11.

13.

COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models.

Xu L, Stevens J, Hilton MB, Seaman S, Conrads TP, Veenstra TD, Logsdon D, Morris H, Swing DA, Patel NL, Kalen J, Haines DC, Zudaire E, St Croix B.

Sci Transl Med. 2014 Jun 25;6(242):242ra84. doi: 10.1126/scitranslmed.3008455.

14.

Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B.

Cell Rep. 2013 May 30;3(5):1457-64. doi: 10.1016/j.celrep.2013.04.019. Epub 2013 May 16.

15.

Mutations in ANTXR1 cause GAPO syndrome.

Stránecký V, Hoischen A, Hartmannová H, Zaki MS, Chaudhary A, Zudaire E, Nosková L, Barešová V, Přistoupilová A, Hodaňová K, Sovová J, Hůlková H, Piherová L, Hehir-Kwa JY, de Silva D, Senanayake MP, Farrag S, Zeman J, Martásek P, Baxová A, Afifi HH, St Croix B, Brunner HG, Temtamy S, Kmoch S.

Am J Hum Genet. 2013 May 2;92(5):792-9. doi: 10.1016/j.ajhg.2013.03.023. Epub 2013 Apr 18.

16.

A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.

Tang Z, Feng M, Gao W, Phung Y, Chen W, Chaudhary A, St Croix B, Qian M, Dimitrov DS, Ho M.

Mol Cancer Ther. 2013 Apr;12(4):416-26. doi: 10.1158/1535-7163.MCT-12-0731. Epub 2013 Jan 31.

17.

Selective blockade of tumor angiogenesis.

Chaudhary A, St Croix B.

Cell Cycle. 2012 Jun 15;11(12):2253-9. doi: 10.4161/cc.20374. Epub 2012 Jun 15.

18.

TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.

Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, Tschantz WR, Zhang XM, Saha S, Fleming T, St Croix B.

Cancer Cell. 2012 Feb 14;21(2):212-26. doi: 10.1016/j.ccr.2012.01.004.

19.
20.

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. doi: 10.1073/pnas.1017192108. Epub 2011 Mar 18.

21.

The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.

Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, Frankel AE, St Croix B.

Biochim Biophys Acta. 2011 Jan;1813(1):39-49. doi: 10.1016/j.bbamcr.2010.11.013. Epub 2010 Dec 1.

22.

Age-related properties of the tumour vasculature in renal cell carcinoma.

Meehan B, Appu S, St Croix B, Rak-Poznanska K, Klotz L, Rak J.

BJU Int. 2011 Feb;107(3):416-24. doi: 10.1111/j.1464-410X.2010.09569.x. Epub 2010 Aug 27.

23.

Host-derived tumor endothelial marker 8 promotes the growth of melanoma.

Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B.

Cancer Res. 2009 Aug 1;69(15):6021-6. doi: 10.1158/0008-5472.CAN-09-1086. Epub 2009 Jul 21.

24.

Serial analysis of gene expression (SAGE): experimental method and data analysis.

Blackshaw S, St Croix B, Polyak K, Kim JB, Cai L.

Curr Protoc Hum Genet. 2007 Apr;Chapter 11:Unit 11.7. doi: 10.1002/0471142905.hg1107s53.

PMID:
18428405
25.

Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition.

Dang DT, Chun SY, Burkitt K, Abe M, Chen S, Havre P, Mabjeesh NJ, Heath EI, Vogelzang NJ, Cruz-Correa M, Blayney DW, Ensminger WD, St Croix B, Dang NH, Dang LH.

Cancer Res. 2008 Mar 15;68(6):1872-80. doi: 10.1158/0008-5472.CAN-07-1589.

26.

Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy.

Klement H, St Croix B, Milsom C, May L, Guo Q, Yu JL, Klement P, Rak J.

Am J Pathol. 2007 Oct;171(4):1342-51. Epub 2007 Sep 6.

27.

Genes that distinguish physiological and pathological angiogenesis.

Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B.

Cancer Cell. 2007 Jun;11(6):539-54.

28.

Large-scale identification of novel transcripts in the human genome.

Peters BA, St Croix B, Sjöblom T, Cummins JM, Silliman N, Ptak J, Saha S, Kinzler KW, Hatzis C, Velculescu VE.

Genome Res. 2007 Mar;17(3):287-92. Epub 2007 Jan 31.

29.

Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.

Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C, Vogelstein B, St Croix B, Kinzler KW, Huso DL.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3351-6. Epub 2006 Feb 21.

30.

Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.

Nanda A, Buckhaults P, Seaman S, Agrawal N, Boutin P, Shankara S, Nacht M, Teicher B, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.

Cancer Res. 2004 Dec 1;64(23):8507-11.

31.

TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).

Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.

Cancer Res. 2004 Feb 1;64(3):817-20.

32.

Tumor endothelial markers: new targets for cancer therapy.

Nanda A, St Croix B.

Curr Opin Oncol. 2004 Jan;16(1):44-9. Review.

PMID:
14685092
33.

Identifying tumor origin using a gene expression-based classification map.

Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM.

Cancer Res. 2003 Jul 15;63(14):4144-9.

34.

A phosphatase associated with metastasis of colorectal cancer.

Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B.

Science. 2001 Nov 9;294(5545):1343-6. Epub 2001 Oct 11.

35.

Secreted and cell surface genes expressed in benign and malignant colorectal tumors.

Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW.

Cancer Res. 2001 Oct 1;61(19):6996-7001.

36.

Cell surface tumor endothelial markers are conserved in mice and humans.

Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B.

Cancer Res. 2001 Sep 15;61(18):6649-55.

37.

Transcriptional response to hypoxia in human tumors.

Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel AJ, Riggins GJ.

J Natl Cancer Inst. 2001 Sep 5;93(17):1337-43.

PMID:
11535709
38.

Genes expressed in human tumor endothelium.

St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW.

Science. 2000 Aug 18;289(5482):1197-202.

39.

Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.

St Croix B, Man S, Kerbel RS.

Cancer Lett. 1998 Sep 11;131(1):35-44. Review.

PMID:
9839618
40.

E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).

St Croix B, Sheehan C, Rak JW, Flørenes VA, Slingerland JM, Kerbel RS.

J Cell Biol. 1998 Jul 27;142(2):557-71.

41.

Cell adhesion and drug resistance in cancer.

St Croix B, Kerbel RS.

Curr Opin Oncol. 1997 Nov;9(6):549-56. Review.

PMID:
9370076
42.

Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors.

Kerbel RS, St Croix B, Florenes VA, Rak J.

Hum Cell. 1996 Dec;9(4):257-64. Review.

PMID:
9183656
43.

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents.

St Croix B, Flørenes VA, Rak JW, Flanagan M, Bhattacharya N, Slingerland JM, Kerbel RS.

Nat Med. 1996 Nov;2(11):1204-10.

PMID:
8898746
44.

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy.

Rak JW, St Croix BD, Kerbel RS.

Anticancer Drugs. 1995 Feb;6(1):3-18. Review.

PMID:
7538829
45.

Multicellular resistance: a new paradigm to explain aspects of acquired drug resistance of solid tumors.

Kerbel RS, Rak J, Kobayashi H, Man MS, St Croix B, Graham CH.

Cold Spring Harb Symp Quant Biol. 1994;59:661-72. Review. No abstract available.

PMID:
7587127

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