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Items: 1 to 50 of 161

1.

DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling.

Dhar SK, Bakthavatchalu V, Dhar B, Chen J, Tadahide I, Zhu H, Gao T, St Clair DK.

Oncogene. 2018 Jul 23. doi: 10.1038/s41388-018-0404-z. [Epub ahead of print]

PMID:
30038268
2.

Extracellular redox state shift: A novel approach to target prostate cancer invasion.

Zhong W, Weiss HL, Jayswal RD, Hensley PJ, Downes LM, St Clair DK, Chaiswing L.

Free Radic Biol Med. 2018 Mar;117:99-109. doi: 10.1016/j.freeradbiomed.2018.01.023. Epub 2018 Feb 2.

PMID:
29421238
3.

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.

Chaiswing L, St Clair WH, St Clair DK.

Antioxid Redox Signal. 2018 Feb 21. doi: 10.1089/ars.2017.7485. [Epub ahead of print]

PMID:
29325444
4.

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.

Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.

Oncotarget. 2017 Aug 24;8(44):77436-77452. doi: 10.18632/oncotarget.20497. eCollection 2017 Sep 29.

5.

Hematopoietic Stem Cells: Normal Versus Malignant.

Carroll D, St Clair DK.

Antioxid Redox Signal. 2017 Dec 20. doi: 10.1089/ars.2017.7326. [Epub ahead of print]

PMID:
29084438
6.

Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury.

Yarana C, Carroll D, Chen J, Chaiswing L, Zhao Y, Noel T, Alstott M, Bae Y, Dressler EV, Moscow JA, Butterfield DA, Zhu H, St Clair DK.

Clin Cancer Res. 2018 Apr 1;24(7):1644-1653. doi: 10.1158/1078-0432.CCR-17-2046. Epub 2017 Oct 25.

PMID:
29070527
7.

Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses.

Yarana C, St Clair DK.

Antioxidants (Basel). 2017 Sep 28;6(4). pii: E75. doi: 10.3390/antiox6040075. Review.

8.

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect.

Xu Y, Miriyala S, Fang F, Bakthavatchalu V, Noel T, Schnell DM, Wang C, St Clair WH, St Clair DK.

Oncogene. 2017 Jul 13;36(28):4087. doi: 10.1038/onc.2016.513. Epub 2017 Mar 13.

PMID:
28288137
9.

A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.

Zhao Y, Carroll DW, You Y, Chaiswing L, Wen R, Batinic-Haberle I, Bondada S, Liang Y, St Clair DK.

Redox Biol. 2017 Aug;12:129-138. doi: 10.1016/j.redox.2017.02.005. Epub 2017 Feb 10.

10.

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.

Indo HP, Hawkins CL, Nakanishi I, Matsumoto KI, Matsui H, Suenaga S, Davies MJ, St Clair DK, Ozawa T, Majima HJ.

Handb Exp Pharmacol. 2017;240:439-456. doi: 10.1007/164_2016_117.

PMID:
28176043
11.

RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.

Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH.

Cancer Res. 2017 Mar 15;77(6):1345-1356. doi: 10.1158/0008-5472.CAN-16-0785. Epub 2017 Jan 20.

12.

Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1).

Oben KZ, Gachuki BW, Alhakeem SS, McKenna MK, Liang Y, St Clair DK, Rangnekar VM, Bondada S.

PLoS One. 2017 Jan 12;12(1):e0169767. doi: 10.1371/journal.pone.0169767. eCollection 2017.

13.

Dysregulation of cytokine mediated chemotherapy induced cognitive impairment.

Ren X, St Clair DK, Butterfield DA.

Pharmacol Res. 2017 Mar;117:267-273. doi: 10.1016/j.phrs.2017.01.001. Epub 2017 Jan 4. Review.

PMID:
28063894
14.

Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture.

Li L, Chen J, Xiong G, St Clair DK, Xu W, Xu R.

J Cell Sci. 2017 Jan 1;130(1):190-202. doi: 10.1242/jcs.186031. Epub 2016 Sep 21.

15.

Simultaneous quantitation of oxidized and reduced glutathione via LC-MS/MS: An insight into the redox state of hematopoietic stem cells.

Carroll D, Howard D, Zhu H, Paumi CM, Vore M, Bondada S, Liang Y, Wang C, St Clair DK.

Free Radic Biol Med. 2016 Aug;97:85-94. doi: 10.1016/j.freeradbiomed.2016.05.005. Epub 2016 May 19.

16.

Chasing great paths of Helmut Sies "Oxidative Stress".

Majima HJ, Indo HP, Nakanishi I, Suenaga S, Matsumoto K, Matsui H, Minamiyama Y, Ichikawa H, Yen HC, Hawkins CL, Davies MJ, Ozawa T, St Clair DK.

Arch Biochem Biophys. 2016 Apr 1;595:54-60. doi: 10.1016/j.abb.2015.10.023.

PMID:
27095216
17.

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Latif AA, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St Clair DK.

Free Radic Biol Med. 2016 Feb;91:68-80. doi: 10.1016/j.freeradbiomed.2015.12.002. Epub 2015 Dec 9.

18.

Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction.

Miriyala S, Chandra M, Maxey B, Day A, St Clair DK, Panchatcharam M.

Int J Biochem Cell Biol. 2015 Nov;68:70-7. doi: 10.1016/j.biocel.2015.08.015. Epub 2015 Aug 28.

19.

Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53.

Barone E, Cenini G, Di Domenico F, Noel T, Wang C, Perluigi M, St Clair DK, Butterfield DA.

J Neurosci Res. 2015 Nov;93(11):1728-39. doi: 10.1002/jnr.23627. Epub 2015 Aug 6.

20.

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion.

Indo HP, Matsui H, Chen J, Zhu H, Hawkins CL, Davies MJ, Yarana C, St Clair DK, Majima HJ.

J Clin Biochem Nutr. 2015 Jul;57(1):13-20. doi: 10.3164/jcbn.14-146. Epub 2015 May 22.

21.

Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy.

Keeney JT, Miriyala S, Noel T, Moscow JA, St Clair DK, Butterfield DA.

Cancer Lett. 2015 Oct 28;367(2):157-61. doi: 10.1016/j.canlet.2015.07.023. Epub 2015 Jul 28.

22.

Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression.

Kinugasa H, Whelan KA, Tanaka K, Natsuizaka M, Long A, Guo A, Chang S, Kagawa S, Srinivasan S, Guha M, Yamamoto K, St Clair DK, Avadhani NG, Diehl JA, Nakagawa H.

Oncogene. 2015 Oct 8;34(41):5229-39. doi: 10.1038/onc.2014.449. Epub 2015 Feb 9.

23.

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect.

Xu Y, Miriyala S, Fang F, Bakthavatchalu V, Noel T, Schnell DM, Wang C, St Clair WH, St Clair DK.

Oncogene. 2015 Aug 6;34(32):4229-37. doi: 10.1038/onc.2014.355. Epub 2014 Nov 3. Erratum in: Oncogene. 2017 Jul 13;36(28):4087.

24.

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T.

Nat Med. 2014 May;20(5):555-60. doi: 10.1038/nm.3520. Epub 2014 Apr 20.

PMID:
24747747
25.

Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.

Holley AK, Xu Y, Noel T, Bakthavatchalu V, Batinic-Haberle I, St Clair DK.

Antioxid Redox Signal. 2014 May 20;20(15):2347-60. doi: 10.1089/ars.2013.5204.

26.

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.

Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar SK, Cai J, Klein JB, Sultana R, Butterfield DA, Vore M, Batinic-Haberle I, Bondada S, St Clair DK.

Free Radic Biol Med. 2014 Jul;72:55-65. doi: 10.1016/j.freeradbiomed.2014.03.001. Epub 2014 Mar 12.

27.

Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice.

Cole MP, Tangpong J, Oberley TD, Chaiswing L, Kiningham KK, St Clair DK.

PLoS One. 2014 Feb 25;9(2):e89251. doi: 10.1371/journal.pone.0089251. eCollection 2014.

28.

Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.

Holley AK, Miao L, St Clair DK, St Clair WH.

Antioxid Redox Signal. 2014 Apr 1;20(10):1567-89. doi: 10.1089/ars.2012.5000. Epub 2014 Feb 14. Review.

29.

Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment.

Miao L, Holley AK, Zhao Y, St Clair WH, St Clair DK.

Antioxid Redox Signal. 2014 Mar 20;20(9):1481-500. doi: 10.1089/ars.2013.5637. Epub 2014 Jan 22. Review.

30.

FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.

Dhar SK, Zhang J, Gal J, Xu Y, Miao L, Lynn BC, Zhu H, Kasarskis EJ, St Clair DK.

Antioxid Redox Signal. 2014 Apr 1;20(10):1550-66. doi: 10.1089/ars.2012.4984. Epub 2013 Sep 20.

31.

Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria.

Ibrahim WH, Habib HM, Kamal H, St Clair DK, Chow CK.

Free Radic Biol Med. 2013 Dec;65:143-9. doi: 10.1016/j.freeradbiomed.2013.06.026. Epub 2013 Jun 20.

PMID:
23792772
32.

Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

Holley AK, Dhar SK, St Clair DK.

Mitochondrion. 2013 May;13(3):170-88. doi: 10.1016/j.mito.2012.07.104. Epub 2012 Jul 20. Review.

33.

Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE.

Indo HP, Inanami O, Koumura T, Suenaga S, Yen HC, Kakinuma S, Matsumoto K, Nakanishi I, St Clair W, St Clair DK, Matsui H, Cornette R, Gusev O, Okuda T, Nakagawa Y, Ozawa T, Majima HJ.

Free Radic Res. 2012 Aug;46(8):1029-43. doi: 10.3109/10715762.2012.698012. Epub 2012 Jun 25.

PMID:
22656864
34.

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.

Duncan MJ, Smith JT, Franklin KM, Beckett TL, Murphy MP, St Clair DK, Donohue KD, Striz M, O'Hara BF.

Exp Neurol. 2012 Aug;236(2):249-58. doi: 10.1016/j.expneurol.2012.05.011. Epub 2012 May 22.

PMID:
22634208
35.

Manganese superoxide dismutase regulation and cancer.

Dhar SK, St Clair DK.

Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2209-22. doi: 10.1016/j.freeradbiomed.2012.03.009. Epub 2012 Apr 25. Review.

PMID:
22561706
36.

Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme.

Liu S, Bae Y, Leggas M, Daily A, Bhatnagar S, Miriyala S, St Clair DK, Moscow JA.

J Pharmacol Exp Ther. 2012 Jun;341(3):775-83. doi: 10.1124/jpet.112.191817. Epub 2012 Mar 19.

37.

Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-κB-mediated mechanism.

Xu Y, Fang F, St Clair DK, St Clair WH.

PLoS One. 2012;7(3):e32905. doi: 10.1371/journal.pone.0032905. Epub 2012 Mar 5.

38.

The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

Jungsuwadee P, Zhao T, Stolarczyk EI, Paumi CM, Butterfield DA, St Clair DK, Vore M.

Pharmacogenet Genomics. 2012 Apr;22(4):273-84. doi: 10.1097/FPC.0b013e328350e270.

39.

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.

Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA.

Antioxid Redox Signal. 2012 Jun 15;16(12):1407-20. doi: 10.1089/ars.2011.4124. Epub 2012 Feb 21.

40.
41.

Global effects of adriamycin treatment on mouse splenic protein levels.

Evans AR, Miriyala S, St Clair DK, Butterfield DA, Robinson RA.

J Proteome Res. 2012 Feb 3;11(2):1054-64. doi: 10.1021/pr200798g. Epub 2012 Jan 4.

PMID:
22112237
42.

Manganese superoxide dismutase: guardian of the powerhouse.

Holley AK, Bakthavatchalu V, Velez-Roman JM, St Clair DK.

Int J Mol Sci. 2011;12(10):7114-62. doi: 10.3390/ijms12107114. Epub 2011 Oct 21. Review.

43.

Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.

Dhar SK, Tangpong J, Chaiswing L, Oberley TD, St Clair DK.

Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.

44.
45.

Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.

Bakthavatchalu V, Dey S, Xu Y, Noel T, Jungsuwadee P, Holley AK, Dhar SK, Batinic-Haberle I, St Clair DK.

Oncogene. 2012 Apr 26;31(17):2129-39. doi: 10.1038/onc.2011.407. Epub 2011 Sep 12.

46.

Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.

Sultana R, Robinson RA, Di Domenico F, Abdul HM, St Clair DK, Markesbery WR, Cai J, Pierce WM, Butterfield DA.

J Proteomics. 2011 Oct 19;74(11):2430-40. doi: 10.1016/j.jprot.2011.06.015. Epub 2011 Jun 25.

47.

p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury.

Velez JM, Miriyala S, Nithipongvanitch R, Noel T, Plabplueng CD, Oberley T, Jungsuwadee P, Van Remmen H, Vore M, St Clair DK.

PLoS One. 2011 Mar 30;6(3):e18005. doi: 10.1371/journal.pone.0018005.

48.

Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress.

Gilliam LA, St Clair DK.

Antioxid Redox Signal. 2011 Nov 1;15(9):2543-63. doi: 10.1089/ars.2011.3965. Epub 2011 Jun 15. Review.

49.

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain.

Aluise CD, Miriyala S, Noel T, Sultana R, Jungsuwadee P, Taylor TJ, Cai J, Pierce WM, Vore M, Moscow JA, St Clair DK, Butterfield DA.

Free Radic Biol Med. 2011 Jun 1;50(11):1630-8. doi: 10.1016/j.freeradbiomed.2011.03.009. Epub 2011 Mar 21.

PMID:
21421044
50.

Mitochondrial superoxide dismutase--signals of distinction.

Miriyala S, Holley AK, St Clair DK.

Anticancer Agents Med Chem. 2011 Feb;11(2):181-90. Review.

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