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Items: 1 to 50 of 141

1.

The ER protein TLC domain 3B2 and its enzymatic product lactosylceramide enhance chondrocyte maturation.

Antonyan L, Martineau C, St-Arnaud R.

Connect Tissue Res. 2019 Aug 28:1-7. doi: 10.1080/03008207.2019.1657425. [Epub ahead of print]

PMID:
31462087
2.

Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.

Nguyen-Yamamoto L, Tanaka KI, St-Arnaud R, Goltzman D.

JCI Insight. 2019 Jul 11;4(13). pii: 126467. doi: 10.1172/jci.insight.126467. eCollection 2019 Jul 11.

3.

Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.

Addison WN, Pellicelli M, St-Arnaud R.

J Biol Chem. 2019 May 17;294(20):8184-8196. doi: 10.1074/jbc.RA118.006920. Epub 2019 Apr 4.

PMID:
30948508
4.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29.

5.

Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3.

Kaufmann M, Martineau C, Arabian A, Traynor M, St-Arnaud R, Jones G.

J Steroid Biochem Mol Biol. 2019 Apr;188:23-28. doi: 10.1016/j.jsbmb.2018.12.001. Epub 2018 Dec 13.

PMID:
30553931
6.

Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol.

Ryan BA, Alhani K, Sellars KB, Kirby BJ, St-Arnaud R, Kaufmann M, Jones G, Kovacs CS.

J Bone Miner Res. 2019 Apr;34(4):669-680. doi: 10.1002/jbmr.3642. Epub 2019 Jan 2.

PMID:
30508318
7.

Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2.

Martineau C, Naja RP, Husseini A, Hamade B, Kaufmann M, Akhouayri O, Arabian A, Jones G, St-Arnaud R.

J Clin Invest. 2018 Aug 1;128(8):3546-3557. doi: 10.1172/JCI98093. Epub 2018 Jul 16.

8.

Lrp6 is a target of the PTH-activated αNAC transcriptional coregulator.

Pellicelli M, Hariri H, Miller JA, St-Arnaud R.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3.

PMID:
29413898
9.

Endogenous Calcitriol Synthesis Controls the Humoral IgE Response in Mice.

Lindner J, Rausch S, Treptow S, Geldmeyer-Hilt K, Krause T, St-Arnaud R, Arabian A, Radbruch A, Hartmann S, Worm M, Heine G.

J Immunol. 2017 Dec 15;199(12):3952-3958. doi: 10.4049/jimmunol.1602080. Epub 2017 Nov 6.

10.

Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss.

Starczak Y, Reinke DC, Barratt KR, Ryan JW, Russell PK, Clarke MV, St-Arnaud R, Morris HA, Davey RA, Atkins GJ, Anderson PH.

J Steroid Biochem Mol Biol. 2018 Mar;177:77-82. doi: 10.1016/j.jsbmb.2017.10.022. Epub 2017 Oct 28.

PMID:
29107736
11.

Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice.

Gillies BR, Ryan BA, Tonkin BA, Poulton IJ, Ma Y, Kirby BJ, St-Arnaud R, Sims NA, Kovacs CS.

J Bone Miner Res. 2018 Jan;33(1):16-26. doi: 10.1002/jbmr.3217. Epub 2017 Aug 2.

12.

Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.

Dejaeger M, Böhm AM, Dirckx N, Devriese J, Nefyodova E, Cardoen R, St-Arnaud R, Tournoy J, Luyten FP, Maes C.

J Bone Miner Res. 2017 Oct;32(10):2087-2102. doi: 10.1002/jbmr.3190. Epub 2017 Jun 30.

13.

Cyp24a1 Attenuation Limits Progression of BrafV600E -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720.

Zou M, Baitei EY, BinEssa HA, Al-Mohanna FA, Parhar RS, St-Arnaud R, Kimura S, Pritchard C, Alzahrani AS, Assiri AM, Meyer BF, Shi Y.

Cancer Res. 2017 Apr 15;77(8):2161-2172. doi: 10.1158/0008-5472.CAN-16-2066. Epub 2017 Feb 27.

14.

FIAT Deletion Increases Bone Mass But Does Not Prevent High-Fat-Diet-Induced Metabolic Complications.

Hekmatnejad B, Yu VW, Addison W, Mandic V, Pellicelli M, Arabian A, St-Arnaud R.

Endocrinology. 2017 Feb 1;158(2):264-276. doi: 10.1210/en.2016-1867.

15.

CYP24A1-deficiency does not affect bone regeneration in distraction osteogenesis.

Husseini A, St-Arnaud R.

J Steroid Biochem Mol Biol. 2017 Oct;173:168-172. doi: 10.1016/j.jsbmb.2016.11.003. Epub 2016 Nov 5.

PMID:
27825991
16.

Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.

Nguyen-Yamamoto L, Karaplis AC, St-Arnaud R, Goltzman D.

J Am Soc Nephrol. 2017 Feb;28(2):586-597. doi: 10.1681/ASN.2016010066. Epub 2016 Aug 17.

17.

Tumoral Vitamin D Synthesis by CYP27B1 1-α-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-κB Modulation.

Li J, Luco AL, Ochietti B, Fadhil I, Camirand A, Reinhardt TA, St-Arnaud R, Muller W, Kremer R.

Endocrinology. 2016 Jun;157(6):2204-16. doi: 10.1210/en.2015-1824. Epub 2016 Apr 27.

PMID:
27119753
18.

CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders.

Bai X, Miao D, Xiao S, Qiu D, St-Arnaud R, Petkovich M, Gupta A, Goltzman D, Karaplis AC.

J Clin Invest. 2016 Feb;126(2):667-80. doi: 10.1172/JCI81928. Epub 2016 Jan 19.

19.

Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

Kusunoki Y, Matsui I, Hamano T, Shimomura A, Mori D, Yonemoto S, Takabatake Y, Tsubakihara Y, St-Arnaud R, Isaka Y, Rakugi H.

Kidney Int. 2015 Nov;88(5):1013-29. doi: 10.1038/ki.2015.210. Epub 2015 Jul 15.

20.

Abnormal calcium handling and exaggerated cardiac dysfunction in mice with defective vitamin d signaling.

Choudhury S, Bae S, Ke Q, Lee JY, Singh SS, St-Arnaud R, Monte FD, Kang PM.

PLoS One. 2014 Sep 30;9(9):e108382. doi: 10.1371/journal.pone.0108382. eCollection 2014.

21.

Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD.

Kaufmann M, Gallagher JC, Peacock M, Schlingmann KP, Konrad M, DeLuca HF, Sigueiro R, Lopez B, Mourino A, Maestro M, St-Arnaud R, Finkelstein JS, Cooper DP, Jones G.

J Clin Endocrinol Metab. 2014 Jul;99(7):2567-74. doi: 10.1210/jc.2013-4388. Epub 2014 Mar 26.

22.

The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass.

Pellicelli M, Miller JA, Arabian A, Gauthier C, Akhouayri O, Wu JY, Kronenberg HM, St-Arnaud R.

Mol Cell Biol. 2014 May;34(9):1622-33. doi: 10.1128/MCB.01434-13. Epub 2014 Feb 18.

23.

Altered gene dosage confirms the genetic interaction between FIAT and αNAC.

Hekmatnejad B, Mandic V, Yu VW, Akhouayri O, Arabian A, St-Arnaud R.

Gene. 2014 Apr 1;538(2):328-33. doi: 10.1016/j.gene.2014.01.009. Epub 2014 Jan 17.

24.

SUMOylated αNAC potentiates transcriptional repression by FIAT.

Hekmatnejad B, Akhouayri O, Jafarov T, St-Arnaud R.

J Cell Biochem. 2014 May;115(5):866-73. doi: 10.1002/jcb.24729.

PMID:
24375853
25.

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

El-Hoss J, Arabian A, Dedhar S, St-Arnaud R.

Gene. 2014 Jan 1;533(1):246-52. doi: 10.1016/j.gene.2013.09.074. Epub 2013 Oct 2.

PMID:
24095779
26.

Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts.

Hekmatnejad B, Gauthier C, St-Arnaud R.

J Cell Biochem. 2013 Aug;114(8):1863-70. doi: 10.1002/jcb.24528.

PMID:
23463631
27.

Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype.

Vasheghani F, Monemdjou R, Fahmi H, Zhang Y, Perez G, Blati M, St-Arnaud R, Pelletier JP, Beier F, Martel-Pelletier J, Kapoor M.

Am J Pathol. 2013 Apr;182(4):1099-106. doi: 10.1016/j.ajpath.2012.12.012. Epub 2013 Jan 30.

PMID:
23375622
28.

CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via caspase-3 increased expression and activation.

Tourigny A, Charbonneau F, Xing P, Boukrab R, Rousseau G, St-Arnaud R, Brezniceanu ML.

PLoS One. 2012;7(10):e48652. doi: 10.1371/journal.pone.0048652. Epub 2012 Oct 31.

29.

αNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression.

Jafarov T, Alexander JW, St-Arnaud R.

Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1208-16. doi: 10.1016/j.bbagrm.2012.10.005. Epub 2012 Oct 22.

PMID:
23092676
30.

Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model.

Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M.

Arthritis Rheum. 2012 May;64(5):1551-61. doi: 10.1002/art.33490.

31.

Combinatorial control of ATF4-dependent gene transcription in osteoblasts.

St-Arnaud R, Hekmatnejad B.

Ann N Y Acad Sci. 2011 Nov;1237:11-8. doi: 10.1111/j.1749-6632.2011.06197.x. Review.

PMID:
22082360
32.

Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia.

St-Arnaud R, Arabian A, Akhouayri O, Knutson JC, Strugnell SA.

Nephron Exp Nephrol. 2011;119(3):e67-74. doi: 10.1159/000329663. Epub 2011 Aug 18.

PMID:
21849802
33.

Vitamin D metabolism, cartilage and bone fracture repair.

St-Arnaud R, Naja RP.

Mol Cell Endocrinol. 2011 Dec 5;347(1-2):48-54. doi: 10.1016/j.mce.2011.05.018. Epub 2011 Jun 1. Review.

PMID:
21664253
34.

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.

Dossa T, Arabian A, Windle JJ, Dedhar S, Teitelbaum SL, Ross FP, Roodman GD, St-Arnaud R.

J Cell Biochem. 2010 Jul 1;110(4):960-7. doi: 10.1002/jcb.22609.

35.

FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1.

St-Arnaud R, Mandic V, Elchaarani B.

Ann N Y Acad Sci. 2010 Mar;1192:338-43. doi: 10.1111/j.1749-6632.2009.05211.x.

PMID:
20392257
36.

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ.

Oncogene. 2010 Jun 10;29(23):3374-85. doi: 10.1038/onc.2010.86. Epub 2010 Mar 22.

PMID:
20305688
37.

CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24.

St-Arnaud R.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):254-6. doi: 10.1016/j.jsbmb.2010.02.002. Epub 2010 Feb 6.

PMID:
20144713
38.

FIAT control of osteoblast activity.

St-Arnaud R, Mandic V.

J Cell Biochem. 2010 Feb 15;109(3):453-9. doi: 10.1002/jcb.22435. Review.

PMID:
20013796
39.

25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.

Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):162-70. doi: 10.1016/j.jsbmb.2009.11.011. Epub 2009 Nov 26.

PMID:
19944755
40.

Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo.

Meury T, Akhouayri O, Jafarov T, Mandic V, St-Arnaud R.

Mol Cell Biol. 2010 Jan;30(1):43-53. doi: 10.1128/MCB.00378-09.

41.

Are endogenous BMPs necessary for bone healing during distraction osteogenesis?

Alam N, St-Arnaud R, Lauzier D, Rosen V, Hamdy RC.

Clin Orthop Relat Res. 2009 Dec;467(12):3190-8. doi: 10.1007/s11999-009-1065-6.

42.

Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development.

Naja RP, Dardenne O, Arabian A, St Arnaud R.

Endocrinology. 2009 Sep;150(9):4024-32. doi: 10.1210/en.2008-1410. Epub 2009 May 28.

PMID:
19477943
43.

FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes.

Yu VW, Akhouayri O, St-Arnaud R.

Gene Expr Patterns. 2009 Jun;9(5):335-40. doi: 10.1016/j.gep.2009.02.002. Epub 2009 Feb 14.

44.

FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions.

Yu VW, El-Hoss J, St-Arnaud R.

J Cell Biochem. 2009 Jan 1;106(1):186-92. doi: 10.1002/jcb.21995.

PMID:
19016261
46.

Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK.

Hepatology. 2008 Dec;48(6):1932-41. doi: 10.1002/hep.22537.

47.

A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion.

Tucker KL, Sage T, Stevens JM, Jordan PA, Jones S, Barrett NE, St-Arnaud R, Frampton J, Dedhar S, Gibbins JM.

Blood. 2008 Dec 1;112(12):4523-31. doi: 10.1182/blood-2008-03-148502. Epub 2008 Sep 4.

48.

FIAT represses bone matrix mineralization by interacting with ATF4 through its second leucine zipper.

Yu VW, Gauthier C, St-Arnaud R.

J Cell Biochem. 2008 Oct 15;105(3):859-65. doi: 10.1002/jcb.21881.

49.

The direct role of vitamin D on bone homeostasis.

St-Arnaud R.

Arch Biochem Biophys. 2008 May 15;473(2):225-30. doi: 10.1016/j.abb.2008.03.038. Epub 2008 Apr 6. Review.

PMID:
18424254
50.

Characterizing the BMP pathway in a wild type mouse model of distraction osteogenesis.

Haque T, Hamade F, Alam N, Kotsiopriftis M, Lauzier D, St-Arnaud R, Hamdy RC.

Bone. 2008 Jun;42(6):1144-53. doi: 10.1016/j.bone.2008.01.028. Epub 2008 Feb 20.

PMID:
18372226

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