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Items: 1 to 50 of 165

1.

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.

Bardenbacher M, Ruder B, Britzen-Laurent N, Schmid B, Waldner M, Naschberger E, Scharl M, Müller W, Günther C, Becker C, Stürzl M, Tripal P.

Stem Cell Res. 2019 Mar;35:101383. doi: 10.1016/j.scr.2019.101383. Epub 2019 Feb 7.

2.

PU.1 controls fibroblast polarization and tissue fibrosis.

Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL, Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A.

Nature. 2019 Feb;566(7744):344-349. doi: 10.1038/s41586-019-0896-x. Epub 2019 Jan 30.

PMID:
30700907
3.

β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M.

Int J Cancer. 2019 Aug 1;145(3):678-685. doi: 10.1002/ijc.32137. Epub 2019 Jan 29.

PMID:
30653264
4.

Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma.

Schellerer VS, Langheinrich MC, Zver V, Grützmann R, Stürzl M, Gefeller O, Naschberger E, Merkel S.

Int J Colorectal Dis. 2019 Feb;34(2):309-317. doi: 10.1007/s00384-018-3198-0. Epub 2018 Nov 23.

5.

Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU.

Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12.

PMID:
30420784
6.

Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis.

Ellmann S, Langer V, Britzen-Laurent N, Hildner K, Huber C, Tripal P, Seyler L, Waldner M, Uder M, Stürzl M, Bäuerle T.

PLoS One. 2018 Oct 26;13(10):e0206576. doi: 10.1371/journal.pone.0206576. eCollection 2018.

7.

IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD.

Unterer B, Wiesmann V, Gunasekaran M, Sticht H, Tenkerian C, Behrens J, Leone M, Engel FB, Britzen-Laurent N, Naschberger E, Wittenberg T, Stürzl M.

Biochem J. 2018 Sep 25;475(18):2955-2967. doi: 10.1042/BCJ20180123.

8.

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells.

Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C.

Mucosal Immunol. 2018 Nov;11(6):1621-1629. doi: 10.1038/s41385-018-0068-6. Epub 2018 Aug 13.

PMID:
30104627
9.

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol.

Naschberger E, Regensburger D, Tenkerian C, Langheinrich M, Engel FB, Geppert C, Hartmann A, Grützmann R, Schellerer VS, Stürzl M.

J Vis Exp. 2018 Apr 4;(134). doi: 10.3791/57400.

PMID:
29683458
10.

Predicting Clinical Outcomes in Colorectal Cancer Using Machine Learning.

Gründner J, Prokosch HU, Stürzl M, Croner R, Christoph J, Toddenroth D.

Stud Health Technol Inform. 2018;247:101-105.

PMID:
29677931
11.

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L.

J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.

12.

Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation.

Hecht M, Harrer T, Körber V, Sarpong EO, Moser F, Fiebig N, Schwegler M, Stürzl M, Fietkau R, Distel LV.

Oncol Lett. 2018 Feb;15(2):1728-1736. doi: 10.3892/ol.2017.7523. Epub 2017 Dec 5.

13.

Usability and Suitability of the Omics-Integrating Analysis Platform tranSMART for Translational Research and Education.

Christoph J, Knell C, Bosserhoff A, Naschberger E, Stürzl M, Rübner M, Seuss H, Ruh M, Prokosch HU, Sedlmayr B.

Appl Clin Inform. 2017 Oct;8(4):1173-1183. doi: 10.4338/ACI-2017-05-RA-0085. Epub 2017 Dec 21.

14.

Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation.

López-Posadas R, Stürzl M, Atreya I, Neurath MF, Britzen-Laurent N.

Front Immunol. 2017 Oct 5;8:1240. doi: 10.3389/fimmu.2017.01240. eCollection 2017. Review.

15.

Cocultivation of Mesenchymal Stem Cells and Endothelial Progenitor Cells Reveals Antiapoptotic and Proangiogenic Effects.

Steiner D, Köhn K, Beier JP, Stürzl M, Horch RE, Arkudas A.

Cells Tissues Organs. 2017;204(5-6):218-227. doi: 10.1159/000478654. Epub 2017 Jul 27.

PMID:
28746930
16.

Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1.

Shydlovskyi S, Zienert AY, Ince S, Dovengerds C, Hohendahl A, Dargazanli JM, Blum A, Günther SD, Kladt N, Stürzl M, Schauss AC, Kutsch M, Roux A, Praefcke GJK, Herrmann C.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5559-E5568. doi: 10.1073/pnas.1620959114. Epub 2017 Jun 23.

17.

Predictive value of PD-L1 based on mRNA level in the treatment of stage IV melanoma with ipilimumab.

Brüggemann C, Kirchberger MC, Goldinger SM, Weide B, Konrad A, Erdmann M, Schadendorf D, Croner RS, Krähenbühl L, Kähler KC, Hafner C, Leisgang W, Kiesewetter F, Dummer R, Schuler G, Stürzl M, Heinzerling L.

J Cancer Res Clin Oncol. 2017 Oct;143(10):1977-1984. doi: 10.1007/s00432-017-2450-2. Epub 2017 Jun 14.

PMID:
28616701
18.

Two Years of tranSMART in a University Hospital for Translational Research and Education.

Christoph J, Knell C, Naschberger E, Stürzl M, Maier C, Prokosch HU, Sedlmayr M.

Stud Health Technol Inform. 2017;236:70-79.

PMID:
28508781
19.

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.

He GW, Günther C, Thonn V, Yu YQ, Martini E, Buchen B, Neurath MF, Stürzl M, Becker C.

J Exp Med. 2017 Jun 5;214(6):1655-1662. doi: 10.1084/jem.20160442. Epub 2017 May 5.

20.

Noninvasive Bioluminescence Imaging of AKT Kinase Activity in Subcutaneous and Orthotopic NSCLC Xenografts: Correlation of AKT Activity with Tumor Growth Kinetics.

Suchowski K, Pöschinger T, Rehemtulla A, Stürzl M, Scheuer W.

Neoplasia. 2017 Apr;19(4):310-320. doi: 10.1016/j.neo.2017.02.005. Epub 2017 Mar 9.

21.

Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity.

Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Stürzl M, Britzen-Laurent N.

J Cell Mol Med. 2017 Sep;21(9):1954-1966. doi: 10.1111/jcmm.13116. Epub 2017 Mar 8.

22.

Azidothymidine Sensitizes Primary Effusion Lymphoma Cells to Kaposi Sarcoma-Associated Herpesvirus-Specific CD4+ T Cell Control and Inhibits vIRF3 Function.

Williamson SJ, Nicol SM, Stürzl M, Sabbah S, Hislop AD.

PLoS Pathog. 2016 Nov 28;12(11):e1006042. doi: 10.1371/journal.ppat.1006042. eCollection 2016 Nov.

23.

Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma.

Naschberger E, Liebl A, Schellerer VS, Schütz M, Britzen-Laurent N, Kölbel P, Schaal U, Haep L, Regensburger D, Wittmann T, Klein-Hitpass L, Rau TT, Dietel B, Méniel VS, Clarke AR, Merkel S, Croner RS, Hohenberger W, Stürzl M.

J Clin Invest. 2016 Nov 1;126(11):4187-4204. doi: 10.1172/JCI78260. Epub 2016 Oct 10.

24.

Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases.

Britzen-Laurent N, Herrmann C, Naschberger E, Croner RS, Stürzl M.

World J Gastroenterol. 2016 Jul 28;22(28):6434-43. doi: 10.3748/wjg.v22.i28.6434. Review.

25.

A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.

Bonsignore L, Passelli K, Pelzer C, Perroud M, Konrad A, Thurau M, Stürzl M, Dai L, Trillo-Tinoco J, Del Valle L, Qin Z, Thome M.

Leukemia. 2017 Mar;31(3):614-624. doi: 10.1038/leu.2016.239. Epub 2016 Aug 19.

26.

IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.

Kesselring R, Glaesner J, Hiergeist A, Naschberger E, Neumann H, Brunner SM, Wege AK, Seebauer C, Köhl G, Merkl S, Croner RS, Hackl C, Stürzl M, Neurath MF, Gessner A, Schlitt HJ, Geissler EK, Fichtner-Feigl S.

Cancer Cell. 2016 May 9;29(5):684-696. doi: 10.1016/j.ccell.2016.03.014. Epub 2016 Apr 14.

27.

Identification of Predictive Markers for Response to Neoadjuvant Chemoradiation in Rectal Carcinomas by Proteomic Isotope Coded Protein Label (ICPL) Analysis.

Croner RS, Sevim M, Metodiev MV, Jo P, Ghadimi M, Schellerer V, Brunner M, Geppert C, Rau T, Stürzl M, Naschberger E, Matzel KE, Hohenberger W, Lottspeich F, Kellermann J.

Int J Mol Sci. 2016 Feb 4;17(2):209. doi: 10.3390/ijms17020209.

28.

MiRNA-21 Expression Decreases from Primary Tumors to Liver Metastases in Colorectal Carcinoma.

Feiersinger F, Nolte E, Wach S, Rau TT, Vassos N, Geppert C, Konrad A, Merkel S, Taubert H, Stürzl M, Croner RS.

PLoS One. 2016 Feb 4;11(2):e0148580. doi: 10.1371/journal.pone.0148580. eCollection 2016.

29.

Cell death inhibition by KSHV.

Murtadak V, Becker C, Stürzl M.

Aging (Albany NY). 2015 Oct;7(10):750-1. No abstract available.

30.

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein.

Wu JJ, Li W, Shao Y, Avey D, Fu B, Gillen J, Hand T, Ma S, Liu X, Miley W, Konrad A, Neipel F, Stürzl M, Whitby D, Li H, Zhu F.

Cell Host Microbe. 2015 Sep 9;18(3):333-44. doi: 10.1016/j.chom.2015.07.015. Epub 2015 Aug 27.

31.

Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice.

Haep L, Britzen-Laurent N, Weber TG, Naschberger E, Schaefer A, Kremmer E, Foersch S, Vieth M, Scheuer W, Wirtz S, Waldner M, Stürzl M.

Inflamm Bowel Dis. 2015 Oct;21(10):2360-71. doi: 10.1097/MIB.0000000000000490.

PMID:
26164664
32.

Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS.

Lancrajan I, Schneider-Stock R, Naschberger E, Schellerer VS, Stürzl M, Enz R.

J Cell Mol Med. 2015 Jul;19(7):1656-71. doi: 10.1111/jcmm.12540. Epub 2015 Mar 30.

33.

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ.

Gastroenterology. 2015 Jul;149(1):177-189.e10. doi: 10.1053/j.gastro.2015.03.016. Epub 2015 Mar 19.

PMID:
25797700
34.

Activation of NF-κB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-κB-inducing kinase, IκB kinases, and phosphorylation of p65.

Hävemeier A, Gramolelli S, Pietrek M, Jochmann R, Stürzl M, Schulz TF.

J Virol. 2014 Nov;88(22):13161-72. doi: 10.1128/JVI.01766-14. Epub 2014 Sep 3.

35.

Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations.

Kraus C, Rau TT, Lux P, Erlenbach-Wünsch K, Löhr S, Krumbiegel M, Thiel CT, Stöhr R, Agaimy A, Croner RS, Stürzl M, Hohenberger W, Hartmann A, Reis A.

Int J Cancer. 2015 Mar 15;136(6):E559-68. doi: 10.1002/ijc.29149. Epub 2014 Aug 30.

36.

The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response.

Bussey KA, Reimer E, Todt H, Denker B, Gallo A, Konrad A, Ottinger M, Adler H, Stürzl M, Brune W, Brinkmann MM.

J Virol. 2014 Aug;88(16):9245-59. doi: 10.1128/JVI.00841-14. Epub 2014 Jun 4.

37.

Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis.

Croner RS, Stürzl M, Rau TT, Metodieva G, Geppert CI, Naschberger E, Lausen B, Metodiev MV.

Int J Cancer. 2014 Dec 15;135(12):2878-86. doi: 10.1002/ijc.28929. Epub 2014 May 12.

38.

Molecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study.

Croner RS, Geppert CI, Bader FG, Nitsche U, Späth C, Rosenberg R, Zettl A, Matias-Guiu X, Tarragona J, Güller U, Stürzl M, Zuber M.

Br J Cancer. 2014 May 13;110(10):2544-50. doi: 10.1038/bjc.2014.170. Epub 2014 Apr 10.

39.

Structural proteins of Kaposi's sarcoma-associated herpesvirus antagonize p53-mediated apoptosis.

Chudasama P, Konrad A, Jochmann R, Lausen B, Holz P, Naschberger E, Neipel F, Britzen-Laurent N, Stürzl M.

Oncogene. 2015 Jan 29;34(5):639-49. doi: 10.1038/onc.2013.595. Epub 2014 Jan 27.

PMID:
24469037
40.

Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.

Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A.

PLoS Pathog. 2014 Jan;10(1):e1003863. doi: 10.1371/journal.ppat.1003863. Epub 2014 Jan 16.

41.

Prognostic value of β1 integrin expression in colorectal liver metastases.

Vassos N, Rau T, Merkel S, Feiersinger F, Geppert CI, Stürzl M, Hohenberger W, Croner RS.

Int J Clin Exp Pathol. 2013 Dec 15;7(1):288-300. eCollection 2014.

42.

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.

Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schütz G, Schmid JA, Zlabinger GJ, Naschberger E, Stürzl M, Stockinger H.

J Immunol. 2014 Jan 15;192(2):771-81. doi: 10.4049/jimmunol.1300377. Epub 2013 Dec 13.

43.

Validation of the reliability of computational O-GlcNAc prediction.

Jochmann R, Holz P, Sticht H, Stürzl M.

Biochim Biophys Acta. 2014 Feb;1844(2):416-21. doi: 10.1016/j.bbapap.2013.12.002. Epub 2013 Dec 9.

PMID:
24332980
44.

Evaluating predictive modeling algorithms to assess patient eligibility for clinical trials from routine data.

Köpcke F, Lubgan D, Fietkau R, Scholler A, Nau C, Stürzl M, Croner R, Prokosch HU, Toddenroth D.

BMC Med Inform Decis Mak. 2013 Dec 9;13:134. doi: 10.1186/1472-6947-13-134.

45.

Tumor-associated fibroblasts isolated from colorectal cancer tissues exhibit increased ICAM-1 expression and affinity for monocytes.

Schellerer VS, Langheinrich M, Hohenberger W, Croner RS, Merkel S, Rau TT, Stürzl M, Naschberger E.

Oncol Rep. 2014 Jan;31(1):255-61. doi: 10.3892/or.2013.2860. Epub 2013 Nov 20.

PMID:
24253852
46.

Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor.

Ostler N, Britzen-Laurent N, Liebl A, Naschberger E, Lochnit G, Ostler M, Forster F, Kunzelmann P, Ince S, Supper V, Praefcke GJ, Schubert DW, Stockinger H, Herrmann C, Stürzl M.

Mol Cell Biol. 2014 Jan;34(2):196-209. doi: 10.1128/MCB.00664-13. Epub 2013 Nov 4.

47.

IFN-γ-driven intratumoral microenvironment exhibits superior prognostic effect compared with an IFN-α-driven microenvironment in patients with colon carcinoma.

Grenz S, Naschberger E, Merkel S, Britzen-Laurent N, Schaal U, Konrad A, Aigner M, Rau TT, Hartmann A, Croner RS, Hohenberger W, Stürzl M.

Am J Pathol. 2013 Dec;183(6):1897-1909. doi: 10.1016/j.ajpath.2013.08.025. Epub 2013 Oct 8.

PMID:
24121019
48.

Expression and localization of axin 2 in colorectal carcinoma and its clinical implication.

Schaal U, Grenz S, Merkel S, Rau TT, Hadjihannas MV, Kremmer E, Chudasama P, Croner RS, Behrens J, Stürzl M, Naschberger E.

Int J Colorectal Dis. 2013 Nov;28(11):1469-78. doi: 10.1007/s00384-013-1709-6. Epub 2013 May 24.

PMID:
23702820
49.

O-GlcNAc transferase inhibits KSHV propagation and modifies replication relevant viral proteins as detected by systematic O-GlcNAcylation analysis.

Jochmann R, Pfannstiel J, Chudasama P, Kuhn E, Konrad A, Stürzl M.

Glycobiology. 2013 Oct;23(10):1114-30. doi: 10.1093/glycob/cwt028. Epub 2013 Apr 11.

PMID:
23580777
50.

Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific activation of the human CD83 promoter in dendritic cells.

Stein MF, Lang S, Winkler TH, Deinzer A, Erber S, Nettelbeck DM, Naschberger E, Jochmann R, Stürzl M, Slany RK, Werner T, Steinkasserer A, Knippertz I.

Mol Cell Biol. 2013 Apr;33(7):1331-44. doi: 10.1128/MCB.01051-12. Epub 2013 Jan 22.

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