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Items: 31


Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus.

Kong CM, Subramanian A, Biswas A, Stunkel W, Chong YS, Bongso A, Fong CY.

Stem Cell Rev Rep. 2019 Jun;15(3):415-426. doi: 10.1007/s12015-019-9872-y.


Metabolic Remodeling during Liver Regeneration.

Caldez MJ, Van Hul N, Koh HWL, Teo XQ, Fan JJ, Tan PY, Dewhurst MR, Too PG, Talib SZA, Chiang BE, Stünkel W, Yu H, Lee P, Fuhrer T, Choi H, Björklund M, Kaldis P.

Dev Cell. 2018 Nov 19;47(4):425-438.e5. doi: 10.1016/j.devcel.2018.09.020. Epub 2018 Oct 18.


Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore.

Tan ALM, Langley SR, Tan CF, Chai JF, Khoo CM, Leow MK, Khoo EYH, Moreno-Moral A, Pravenec M, Rotival M, Sadananthan SA, Velan SS, Venkataraman K, Chong YS, Lee YS, Sim X, Stunkel W, Liu MH, Tai ES, Petretto E.

J Clin Endocrinol Metab. 2019 Feb 1;104(2):465-486. doi: 10.1210/jc.2018-00309.


Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.

Banik A, Kandilya D, Ramya S, Stünkel W, Chong YS, Dheen ST.

Genes (Basel). 2017 May 24;8(6). pii: E150. doi: 10.3390/genes8060150. Review.


miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice.

Ng R, Hussain NA, Zhang Q, Chang C, Li H, Fu Y, Cao L, Han W, Stunkel W, Xu F.

Cell Rep. 2017 May 9;19(6):1229-1246. doi: 10.1016/j.celrep.2017.04.035.


Gestational Diabetes Alters Functions in Offspring's Umbilical Cord Cells With Implications for Cardiovascular Health.

Amrithraj AI, Kodali A, Nguyen L, Teo AKK, Chang CW, Karnani N, Ng KL, Gluckman PD, Chong YS, Stünkel W.

Endocrinology. 2017 Jul 1;158(7):2102-2112. doi: 10.1210/en.2016-1889.


E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants.

Tan PY, Chang CW, Duan K, Poidinger M, Ng KL, Chong YS, Gluckman PD, Stünkel W.

PLoS One. 2016 Sep 15;11(9):e0163035. doi: 10.1371/journal.pone.0163035. eCollection 2016.


Tissues Derived From Reprogrammed Wharton's Jelly Stem Cells of the Umbilical Cord Provide an Ideal Platform to Study the Effects of Glucose, Zika Virus, and Other Agents on the Fetus.

Fong CY, Biswas A, Stunkel W, Chong YS, Bongso A.

J Cell Biochem. 2017 Mar;118(3):437-441. doi: 10.1002/jcb.25733. Epub 2016 Oct 17.


The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.

Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stünkel W.

Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18.


ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.

Joseph R, Poschmann J, Sukarieh R, Too PG, Julien SG, Xu F, Teh AL, Holbrook JD, Ng KL, Chong YS, Gluckman PD, Prabhakar S, Stünkel W.

Mol Endocrinol. 2015 Jun;29(6):909-20. doi: 10.1210/me.2015-1020. Epub 2015 Apr 27.


Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells.

Sukarieh R, Joseph R, Leow SC, Li Y, Löffler M, Aris IM, Tan JH, Teh AL, Chen L, Holbrook JD, Ng KL, Lee YS, Chong YS, Summers SA, Gluckman PD, Stünkel W.

Hum Reprod. 2014 Oct 10;29(10):2287-301. doi: 10.1093/humrep/deu209. Epub 2014 Aug 16.


Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes.

Cheong CY, Chng K, Lim MK, Amrithraj AI, Joseph R, Sukarieh R, Chee Tan Y, Chan L, Tan JH, Chen L, Pan H, Holbrook JD, Meaney MJ, Seng Chong Y, Gluckman PD, Stünkel W.

J Hum Genet. 2014 Sep;59(9):504-11. doi: 10.1038/jhg.2014.63. Epub 2014 Aug 7.


Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).

Ong ML, Tan PY, MacIsaac JL, Mah SM, Buschdorf JP, Cheong CY, Stunkel W, Chan L, Gluckman PD, Chng K, Kobor MS, Meaney MJ, Holbrook JD.

G3 (Bethesda). 2014 May 8;4(7):1227-34. doi: 10.1534/g3.114.010967.


The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.

Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stünkel W, Kobor MS, Meaney MJ, Gluckman PD, Holbrook JD.

Genome Res. 2014 Jul;24(7):1064-74. doi: 10.1101/gr.171439.113. Epub 2014 Apr 7.


Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study.

Soh SE, Tint MT, Gluckman PD, Godfrey KM, Rifkin-Graboi A, Chan YH, Stünkel W, Holbrook JD, Kwek K, Chong YS, Saw SM; GUSTO Study Group.

Int J Epidemiol. 2014 Oct;43(5):1401-9. doi: 10.1093/ije/dyt125. Epub 2013 Aug 2. No abstract available.


Measuring the methylome in clinical samples: improved processing of the Infinium Human Methylation450 BeadChip Array.

Pan H, Chen L, Dogra S, Teh AL, Tan JH, Lim YI, Lim YC, Jin S, Lee YK, Ng PY, Ong ML, Barton S, Chong YS, Meaney MJ, Gluckman PD, Stunkel W, Ding C, Holbrook JD.

Epigenetics. 2012 Oct;7(10):1173-87. doi: 10.4161/epi.22102. Epub 2012 Sep 10.


Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.

Stünkel W, Pan H, Chew SB, Tng E, Tan JH, Chen L, Joseph R, Cheong CY, Ong ML, Lee YS, Chong YS, Saw SM, Meaney MJ, Kwek K, Sheppard AM, Gluckman PD; GUSTO Study Group, Holbrook JD.

PLoS One. 2012;7(7):e39744. doi: 10.1371/journal.pone.0039744. Epub 2012 Jul 10.


Sirtuin 1 (SIRT1): the misunderstood HDAC.

Stünkel W, Campbell RM.

J Biomol Screen. 2011 Dec;16(10):1153-69. doi: 10.1177/1087057111422103. Epub 2011 Nov 15. Review.


N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

Wang H, Yu N, Song H, Chen D, Zou Y, Deng W, Lye PL, Chang J, Ng M, Sun ET, Sangthongpitag K, Wang X, Wu X, Khng HH, Fang L, Goh SK, Ong WC, Bonday Z, Stünkel W, Poulsen A, Entzeroth M.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1403-8. doi: 10.1016/j.bmcl.2009.01.041. Epub 2009 Jan 19.


Function of the SIRT1 protein deacetylase in cancer.

Stünkel W, Peh BK, Tan YC, Nayagam VM, Wang X, Salto-Tellez M, Ni B, Entzeroth M, Wood J.

Biotechnol J. 2007 Nov;2(11):1360-8.


SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents.

Nayagam VM, Wang X, Tan YC, Poulsen A, Goh KC, Ng T, Wang H, Song HY, Ni B, Entzeroth M, Stünkel W.

J Biomol Screen. 2006 Dec;11(8):959-67. Epub 2006 Nov 12.


Programming the transcriptional state of replicating methylated dna.

Stunkel W, Ait-Si-Ali S, Jones PL, Wolffe AP.

J Biol Chem. 2001 Jun 8;276(23):20743-9. Epub 2001 Mar 6.


A novel YY1-independent silencer represses the activity of the human papillomavirus type 16 enhancer.

O'Connor MJ, Stünkel W, Zimmermann H, Koh CH, Bernard HU.

J Virol. 1998 Dec;72(12):10083-92.


The mouse mammary tumour virus promoter positioned on a tetramer of histones H3 and H4 binds nuclear factor 1 and OTF1.

Spangenberg C, Eisfeld K, Stünkel W, Luger K, Flaus A, Richmond TJ, Truss M, Beato M.

J Mol Biol. 1998 May 15;278(4):725-39.


Human TFIIIA alone is sufficient to prevent nucleosomal repression of a homologous 5S gene.

Stünkel W, Kober I, Kauer M, Taimor G, Seifart KH.

Nucleic Acids Res. 1995 Jan 11;23(1):109-16.


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