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Items: 1 to 50 of 152

1.

A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.

Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA.

J Gen Physiol. 2017 May 1;149(5):577-593. doi: 10.1085/jgp.201611742. Epub 2017 Mar 30.

2.

In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1.

Napp J, Pardo LA, Hartung F, Tietze LF, Stühmer W, Alves F.

Eur Biophys J. 2016 Oct;45(7):721-733. Epub 2016 Jul 21.

3.

Gating Modulation of the Tumor-Related Kv10.1 Channel by Mibefradil.

Gómez-Lagunas F, Carrillo E, Pardo LA, Stühmer W.

J Cell Physiol. 2017 Aug;232(8):2019-2032. doi: 10.1002/jcp.25448. Epub 2017 Jan 11.

PMID:
27255432
4.

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.

Aprile-Garcia F, Metzger MW, Paez-Pereda M, Stadler H, Acuña M, Liberman AC, Senin SA, Gerez J, Hoijman E, Refojo D, Mitkovski M, Panhuysen M, Stühmer W, Holsboer F, Deussing JM, Arzt E.

PLoS One. 2016 Mar 17;11(3):e0151862. doi: 10.1371/journal.pone.0151862. eCollection 2016.

5.

SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments.

Martin S, Lazzarini M, Dullin C, Balakrishnan S, Gomes FV, Ninkovic M, El Hady A, Pardo LA, Stühmer W, Del-Bel E.

Mol Neurobiol. 2017 Mar;54(2):1078-1091. doi: 10.1007/s12035-015-9680-6. Epub 2016 Jan 23.

6.

Support Immersion Endoscopy in Post-Extraction Alveolar Bone Chambers: A New Window for Microscopic Bone Imaging In Vivo.

Engelke W, Lazzarini M, Stühmer W, Beltrán V.

PLoS One. 2015 Dec 29;10(12):e0145767. doi: 10.1371/journal.pone.0145767. eCollection 2015.

7.

Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival.

Martínez R, Stühmer W, Martin S, Schell J, Reichmann A, Rohde V, Pardo L.

BMC Cancer. 2015 Nov 3;15:839. doi: 10.1186/s12885-015-1848-y.

8.

Growing neuronal islands on multi-electrode arrays using an accurate positioning-μCP device.

Samhaber R, Schottdorf M, El Hady A, Bröking K, Daus A, Thielemann C, Stühmer W, Wolf F.

J Neurosci Methods. 2016 Jan 15;257:194-203. doi: 10.1016/j.jneumeth.2015.09.022. Epub 2015 Oct 1.

PMID:
26432934
9.

CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration.

Tristão FS, Lazzarini M, Martin S, Amar M, Stühmer W, Kirchhoff F, Gomes LA, Lanfumey L, Prediger RD, Sepulveda JE, Del-Bel EA, Raisman-Vozari R.

Neurotox Res. 2016 Apr;29(3):364-80. doi: 10.1007/s12640-015-9557-5. Epub 2015 Sep 24.

PMID:
26403659
10.

Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.

Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH.

Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15.

PMID:
26078285
11.

Exocytosis from chromaffin cells: hydrostatic pressure slows vesicle fusion.

Stühmer W.

Philos Trans R Soc Lond B Biol Sci. 2015 Jul 5;370(1672). pii: 20140192. doi: 10.1098/rstb.2014.0192. Review.

12.

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.

Lörinczi É, Gómez-Posada JC, de la Peña P, Tomczak AP, Fernández-Trillo J, Leipscher U, Stühmer W, Barros F, Pardo LA.

Nat Commun. 2015 Mar 30;6:6672. doi: 10.1038/ncomms7672.

13.

KV 10.1 opposes activity-dependent increase in Ca²⁺ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.

Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA.

J Physiol. 2015 Jan 1;593(1):181-96. doi: 10.1113/jphysiol.2014.281600. Epub 2014 Nov 25.

14.

Potassium channels in cell cycle and cell proliferation.

Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA.

Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130094. doi: 10.1098/rstb.2013.0094. Print 2014 Mar 19. Review.

15.

The roles of K(+) channels in cancer.

Pardo LA, Stühmer W.

Nat Rev Cancer. 2014 Jan;14(1):39-48. doi: 10.1038/nrc3635. Epub 2013 Dec 12. Review.

PMID:
24336491
16.

Hippocampal ether-à-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition.

Issy AC, Fonseca JR, Pardo LA, Stühmer W, Del Bel EA.

Neurosci Lett. 2014 Jan 24;559:13-7. doi: 10.1016/j.neulet.2013.11.026. Epub 2013 Nov 24.

17.

KV10.1 K(+)-channel plasma membrane discrete domain partitioning and its functional correlation in neurons.

Jiménez-Garduño AM, Mitkovski M, Alexopoulos IK, Sánchez A, Stühmer W, Pardo LA, Ortega A.

Biochim Biophys Acta. 2014 Mar;1838(3):921-31. doi: 10.1016/j.bbamem.2013.11.007. Epub 2013 Nov 22.

18.

Optogenetic stimulation effectively enhances intrinsically generated network synchrony.

El Hady A, Afshar G, Bröking K, Schlüter OM, Geisel T, Stühmer W, Wolf F.

Front Neural Circuits. 2013 Oct 22;7:167. doi: 10.3389/fncir.2013.00167. eCollection 2013.

19.

Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model.

Lazzarini M, Martin S, Mitkovski M, Vozari RR, Stühmer W, Bel ED.

Glia. 2013 Jul;61(7):1084-100. doi: 10.1002/glia.22496. Epub 2013 Apr 17.

PMID:
23595698
20.

RNA interference with EAG1 enhances interferon gamma injury to glioma cells in vitro.

Cunha LC, Del Bel E, Pardo L, Stühmer W, Titze-DE-Almeida R.

Anticancer Res. 2013 Mar;33(3):865-70.

PMID:
23482755
21.

TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.

Valero ML, Mello de Queiroz F, Stühmer W, Viana F, Pardo LA.

PLoS One. 2012;7(12):e51825. doi: 10.1371/journal.pone.0051825. Epub 2012 Dec 14.

22.

Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking.

Ninkovic M, Mitkovski M, Kohl T, Stühmer W, Pardo LA.

FEBS Lett. 2012 Sep 21;586(19):3077-84. doi: 10.1016/j.febslet.2012.07.055. Epub 2012 Jul 25.

23.

Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy.

Pardo LA, Gómez-Varela D, Major F, Sansuk K, Leurs R, Downie BR, Tietze LF, Stühmer W.

Curr Med Chem. 2012;19(5):675-82. Review.

PMID:
22204340
24.

Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion.

Ferreira NR, Mitkovski M, Stühmer W, Pardo LA, Del Bel EA.

Neurotox Res. 2012 Apr;21(3):317-33. doi: 10.1007/s12640-011-9286-3. Epub 2011 Nov 3.

PMID:
22048886
25.

Rapid internalization of the oncogenic K+ channel K(V)10.1.

Kohl T, Lörinczi E, Pardo LA, Stühmer W.

PLoS One. 2011;6(10):e26329. doi: 10.1371/journal.pone.0026329. Epub 2011 Oct 12.

26.

Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia.

de Oliveira RM, Martin S, de Oliveira CL, Milani H, Schiavon AP, Joca S, Pardo LA, Stühmer W, Del Bel EA.

J Neurosci Res. 2012 Mar;90(3):632-40. doi: 10.1002/jnr.22772. Epub 2011 Oct 18.

PMID:
22006722
27.

Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody.

Hartung F, Stühmer W, Pardo LA.

Mol Cancer. 2011 Sep 7;10:109. doi: 10.1186/1476-4598-10-109.

28.

Eag1 potassium channels as markers of cervical dysplasia.

Ortiz CS, Montante-Montes D, Saqui-Salces M, Hinojosa LM, Gamboa-Dominguez A, Hernández-Gallegos E, Martínez-Benítez B, Del Rosario Solís-Pancoatl M, Garcia-Villa E, Ramírez A, Aguilar-Guadarrama R, Gariglio P, Pardo LA, Stühmer W, Camacho J.

Oncol Rep. 2011 Dec;26(6):1377-83. doi: 10.3892/or.2011.1441. Epub 2011 Aug 31.

PMID:
21887469
29.

Nucleofection induces non-specific changes in the metabolic activity of transfected cells.

Mello de Queiroz F, Sánchez A, Agarwal JR, Stühmer W, Pardo LA.

Mol Biol Rep. 2012 Mar;39(3):2187-94. doi: 10.1007/s11033-011-0967-z. Epub 2011 Jun 5.

30.

Functional K(v)10.1 channels localize to the inner nuclear membrane.

Chen Y, Sánchez A, Rubio ME, Kohl T, Pardo LA, Stühmer W.

PLoS One. 2011 May 3;6(5):e19257. doi: 10.1371/journal.pone.0019257.

31.

A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.

Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H.

EMBO Mol Med. 2011 Jun;3(6):309-19. doi: 10.1002/emmm.201100135. Epub 2011 Mar 24.

32.

K(+) channels as therapeutic targets in oncology.

Stühmer W, Pardo LA.

Future Med Chem. 2010 May;2(5):745-55. doi: 10.4155/fmc.10.24. Review.

PMID:
21426201
33.

Apolipoprotein A-I as a candidate serum marker for the response to lithium treatment in bipolar disorder.

Sussulini A, Dihazi H, Banzato CE, Arruda MA, Stühmer W, Ehrenreich H, Jahn O, Kratzin HD.

Proteomics. 2011 Jan;11(2):261-9. doi: 10.1002/pmic.201000371. Epub 2010 Dec 20.

PMID:
21204253
34.

The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients.

Ribbe K, Friedrichs H, Begemann M, Grube S, Papiol S, Kästner A, Gerchen MF, Ackermann V, Tarami A, Treitz A, Flögel M, Adler L, Aldenhoff JB, Becker-Emner M, Becker T, Czernik A, Dose M, Folkerts H, Freese R, Günther R, Herpertz S, Hesse D, Kruse G, Kunze H, Franz M, Löhrer F, Maier W, Mielke A, Müller-Isberner R, Oestereich C, Pajonk FG, Pollmächer T, Schneider U, Schwarz HJ, Kröner-Herwig B, Havemann-Reinecke U, Frahm J, Stühmer W, Falkai P, Brose N, Nave KA, Ehrenreich H.

BMC Psychiatry. 2010 Nov 10;10:91. doi: 10.1186/1471-244X-10-91.

35.

Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats.

Martin S, Lino-de-Oliveira C, Joca SR, Weffort de Oliveira R, Echeverry MB, Da Silva CA, Pardo L, Stühmer W, Bel ED.

Genes Brain Behav. 2010 Nov;9(8):918-24. doi: 10.1111/j.1601-183X.2010.00632.x.

36.

Calmodulin interaction with hEAG1 visualized by FRET microscopy.

Gonçalves JT, Stühmer W.

PLoS One. 2010 May 27;5(5):e10873. doi: 10.1371/journal.pone.0010873.

37.

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells.

Mazurek MP, Prasad PD, Gopal E, Fraser SP, Bolt L, Rizaner N, Palmer CP, Foster CS, Palmieri F, Ganapathy V, Stühmer W, Djamgoz MB, Mycielska ME.

EMBO Rep. 2010 Jun;11(6):431-7. doi: 10.1038/embor.2010.51. Epub 2010 May 7.

38.

Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots.

Gómez-Varela D, Kohl T, Schmidt M, Rubio ME, Kawabe H, Nehring RB, Schäfer S, Stühmer W, Pardo LA.

PLoS One. 2010 Jan 25;5(1):e8858. doi: 10.1371/journal.pone.0008858.

39.

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia.

Agarwal JR, Griesinger F, Stühmer W, Pardo LA.

Mol Cancer. 2010 Jan 27;9:18. doi: 10.1186/1476-4598-9-18.

40.

Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice.

Alves F, Dullin C, Napp J, Missbach-Guentner J, Jannasch K, Mathejczyk J, Pardo LA, Stühmer W, Tietze LF.

Eur J Radiol. 2009 May;70(2):286-93. doi: 10.1016/j.ejrad.2009.01.048. Epub 2009 Mar 13. Review.

PMID:
19285818
41.

Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors.

Downie BR, Sánchez A, Knötgen H, Contreras-Jurado C, Gymnopoulos M, Weber C, Stühmer W, Pardo LA.

J Biol Chem. 2008 Dec 26;283(52):36234-40. doi: 10.1074/jbc.M801830200. Epub 2008 Oct 16.

42.

Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain.

Martin S, Lino de Oliveira C, Mello de Queiroz F, Pardo LA, Stühmer W, Del Bel E.

Neuroscience. 2008 Aug 26;155(3):833-44. doi: 10.1016/j.neuroscience.2008.05.019. Epub 2008 Jul 22.

PMID:
18650019
43.

Morphologic changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography.

Missbach-Guentner J, Dullin C, Kimmina S, Zientkowska M, Domeyer-Missbach M, Malz C, Grabbe E, Stühmer W, Alves F.

Neoplasia. 2008 Jul;10(7):663-73.

44.

The voltage dependence of hEag currents is not determined solely by membrane-spanning domains.

Lörinczi E, Napp J, Contreras-Jurado C, Pardo LA, Stühmer W.

Eur Biophys J. 2009 Mar;38(3):279-84. doi: 10.1007/s00249-008-0319-7. Epub 2008 Apr 1.

PMID:
18379771
45.

Eag1: an emerging oncological target.

Pardo LA, Stühmer W.

Cancer Res. 2008 Mar 15;68(6):1611-3. doi: 10.1158/0008-5472.CAN-07-5710. Review.

46.

Flat-panel detector-based volume computed tomography: a novel 3D imaging technique to monitor osteolytic bone lesions in a mouse tumor metastasis model.

Missbach-Guentner J, Dullin C, Zientkowska M, Domeyer-Missbach M, Kimmina S, Obenauer S, Kauer F, Stühmer W, Grabbe E, Vogel WF, Alves F.

Neoplasia. 2007 Sep;9(9):755-65.

47.

Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture.

Cohen L, Ilan N, Gur M, Stühmer W, Gordon D, Gurevitz M.

J Biol Chem. 2007 Oct 5;282(40):29424-30. Epub 2007 Aug 8.

48.

Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity.

Gómez-Varela D, Zwick-Wallasch E, Knötgen H, Sánchez A, Hettmann T, Ossipov D, Weseloh R, Contreras-Jurado C, Rothe M, Stühmer W, Pardo LA.

Cancer Res. 2007 Aug 1;67(15):7343-9.

49.

Re-expression of a developmentally restricted potassium channel in autoimmune demyelination: Kv1.4 is implicated in oligodendroglial proliferation.

Herrero-Herranz E, Pardo LA, Bunt G, Gold R, Stühmer W, Linker RA.

Am J Pathol. 2007 Aug;171(2):589-98. Epub 2007 Jun 28.

50.

The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control.

Gordon D, Karbat I, Ilan N, Cohen L, Kahn R, Gilles N, Dong K, Stühmer W, Tytgat J, Gurevitz M.

Toxicon. 2007 Mar 15;49(4):452-72. Epub 2006 Nov 28. Review.

PMID:
17215013

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