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Items: 1 to 50 of 243

1.

Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy.

Frati G, Luciani M, Meneghini V, De Cicco S, Ståhlman M, Blomqvist M, Grossi S, Filocamo M, Morena F, Menegon A, Martino S, Gritti A.

Cell Death Dis. 2018 Jun 13;9(6):698. doi: 10.1038/s41419-018-0737-0.

2.

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.

Bouter K, Bakker GJ, Levin E, Hartstra AV, Kootte RS, Udayappan SD, Katiraei S, Bahler L, Gilijamse PW, Tremaroli V, Stahlman M, Holleman F, van Riel NAW, Verberne HJ, Romijn JA, Dallinga-Thie GM, Serlie MJ, Ackermans MT, Kemper EM, Willems van Dijk K, Backhed F, Groen AK, Nieuwdorp M.

Clin Transl Gastroenterol. 2018 May 25;9(5):155. doi: 10.1038/s41424-018-0025-4.

3.

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.

Sütt S, Cansby E, Paul A, Amrutkar M, Nunez Duran E, Kulkarni NM, Ståhlman M, Borén J, Laurencikiene J, Howell BW, Enerbäck S, Mahlapuu M.

J Endocrinol. 2018 May 24. pii: JOE-18-0182. doi: 10.1530/JOE-18-0182. [Epub ahead of print]

PMID:
29794231
4.

Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis.

Al-Dury S, Wahlström A, Wahlin S, Langedijk J, Elferink RO, Ståhlman M, Marschall HU.

Sci Rep. 2018 Apr 27;8(1):6658. doi: 10.1038/s41598-018-25214-0.

5.

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS.

Novakova L, Singh AK, Malmeström C, Zetterberg H, Ståhlman M, Axelsson M, Adiels M, Borén J, Lycke J, Cardell SL, Blomqvist M.

J Neurochem. 2018 Apr 20. doi: 10.1111/jnc.14452. [Epub ahead of print]

PMID:
29676479
6.

Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2-/- mice by modulating composition, signalling and excretion of faecal bile acids.

Fuchs CD, Paumgartner G, Mlitz V, Kunczer V, Halilbasic E, Leditznig N, Wahlström A, Ståhlman M, Thüringer A, Kashofer K, Stojakovic T, Marschall HU, Trauner M.

Gut. 2018 Apr 10. pii: gutjnl-2017-314553. doi: 10.1136/gutjnl-2017-314553. [Epub ahead of print]

7.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.

PMID:
29456073
8.

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.

Nuñez-Durán E, Aghajan M, Amrutkar M, Sütt S, Cansby E, Booten SL, Watt A, Ståhlman M, Stefan N, Häring HU, Staiger H, Borén J, Marschall HU, Mahlapuu M.

Hepatol Commun. 2017 Nov 20;2(1):69-83. doi: 10.1002/hep4.1128. eCollection 2018 Jan.

9.

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F.

Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7. doi: 10.1016/j.chom.2017.11.004. Epub 2017 Dec 21.

PMID:
29276171
10.

Cyp3a11 is not essential for the formation of murine bile acids.

Wahlström A, Al-Dury S, Ståhlman M, Bäckhed F, Marschall HU.

Biochem Biophys Rep. 2017 Mar 8;10:70-75. doi: 10.1016/j.bbrep.2017.02.011. eCollection 2017 Jul.

11.

The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids.

Devkota R, Svensk E, Ruiz M, Ståhlman M, Borén J, Pilon M.

PLoS Genet. 2017 Sep 8;13(9):e1007004. doi: 10.1371/journal.pgen.1007004. eCollection 2017 Sep.

12.

Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier.

Van Hul M, Geurts L, Plovier H, Druart C, Everard A, Ståhlman M, Rhimi M, Chira K, Teissedre PL, Delzenne NM, Maguin E, Guilbot A, Brochot A, Gérard P, Bäckhed F, Cani PD.

Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E334-E352. doi: 10.1152/ajpendo.00107.2017. Epub 2017 Sep 5.

PMID:
28874357
13.

Network analyses identify liver-specific targets for treating liver diseases.

Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.

Mol Syst Biol. 2017 Aug 21;13(8):938. doi: 10.15252/msb.20177703.

14.

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC.

Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12.

PMID:
28811250
15.

High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS.

Blomqvist M, Borén J, Zetterberg H, Blennow K, Månsson JE, Ståhlman M.

J Lipid Res. 2017 Jul;58(7):1482-1489. doi: 10.1194/jlr.D076588. Epub 2017 May 26.

PMID:
28550076
16.

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.

Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernàndez-Real JM, Bäckhed F.

Nat Med. 2017 Jul;23(7):850-858. doi: 10.1038/nm.4345. Epub 2017 May 22.

PMID:
28530702
17.

The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model.

Lindqvist A, Ekelund M, Garcia-Vaz E, Ståhlman M, Pierzynowski S, Gomez MF, Rehfeld JF, Groop L, Hedenbro J, Wierup N, Spégel P.

PLoS One. 2017 Mar 3;12(3):e0173137. doi: 10.1371/journal.pone.0173137. eCollection 2017.

18.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

19.

Crosstalk between Bile Acids and Gut Microbiota and Its Impact on Farnesoid X Receptor Signalling.

Wahlström A, Kovatcheva-Datchary P, Ståhlman M, Bäckhed F, Marschall HU.

Dig Dis. 2017;35(3):246-250. doi: 10.1159/000450982. Epub 2017 Mar 1. Review.

PMID:
28249261
20.

NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.

Krones E, Eller K, Pollheimer MJ, Racedo S, Kirsch AH, Frauscher B, Wahlström A, Ståhlman M, Trauner M, Grahammer F, Huber TB, Wagner K, Rosenkranz AR, Marschall HU, Fickert P.

J Hepatol. 2017 Jul;67(1):110-119. doi: 10.1016/j.jhep.2017.02.019. Epub 2017 Feb 27.

PMID:
28242240
21.

Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled trial.

Mobini R, Tremaroli V, Ståhlman M, Karlsson F, Levin M, Ljungberg M, Sohlin M, Bertéus Forslund H, Perkins R, Bäckhed F, Jansson PA.

Diabetes Obes Metab. 2017 Apr;19(4):579-589. doi: 10.1111/dom.12861. Epub 2017 Feb 7.

PMID:
28009106
22.

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.

Chursa U, Nuñez-Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, Olsson BM, Borén J, Johansson ME, Bäckhed F, Johansson BR, Sihlbom C, Mahlapuu M.

Diabetologia. 2017 Mar;60(3):553-567. doi: 10.1007/s00125-016-4171-5. Epub 2016 Dec 16.

PMID:
27981357
23.

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota.

Wahlström A, Kovatcheva-Datchary P, Ståhlman M, Khan MT, Bäckhed F, Marschall HU.

J Lipid Res. 2017 Feb;58(2):412-419. doi: 10.1194/jlr.M072819. Epub 2016 Dec 12.

24.

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.

Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.

Biochim Biophys Acta. 2016 Nov;1861(11):1643-1651. doi: 10.1016/j.bbalip.2016.07.009. Epub 2016 Jul 27.

PMID:
27476102
25.

STK25 is a critical determinant in nonalcoholic steatohepatitis.

Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M.

FASEB J. 2016 Oct;30(10):3628-3643. Epub 2016 Jul 15.

PMID:
27421788
26.

Perilipin 5 is protective in the ischemic heart.

Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC.

Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16.

27.

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure.

Ziętak M, Kovatcheva-Datchary P, Markiewicz LH, Ståhlman M, Kozak LP, Bäckhed F.

Cell Metab. 2016 Jun 14;23(6):1216-1223. doi: 10.1016/j.cmet.2016.05.001.

28.

The BUME method: a new rapid and simple chloroform-free method for total lipid extraction of animal tissue.

Löfgren L, Forsberg GB, Ståhlman M.

Sci Rep. 2016 Jun 10;6:27688. doi: 10.1038/srep27688.

29.

Correction: Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition.

Svensk E, Devkota R, Ståhlman M, Ranji P, Rauthan M, Magnusson F, Hammarsten S, Johansson M, Borén J, Pilon M.

PLoS Genet. 2016 Jun 3;12(6):e1006112. doi: 10.1371/journal.pgen.1006112. eCollection 2016 Jun.

30.

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.

Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD.

Gut. 2017 Apr;66(4):620-632. doi: 10.1136/gutjnl-2015-310904. Epub 2016 May 5.

31.

Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition.

Svensk E, Devkota R, Ståhlman M, Ranji P, Rauthan M, Magnusson F, Hammarsten S, Johansson M, Borén J, Pilon M.

PLoS Genet. 2016 Apr 15;12(4):e1005982. doi: 10.1371/journal.pgen.1005982. eCollection 2016 Apr. Erratum in: PLoS Genet. 2016 Jun;12(6):e1006112.

32.

Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation.

Edsfeldt A, Dunér P, Ståhlman M, Mollet IG, Asciutto G, Grufman H, Nitulescu M, Persson AF, Fisher RM, Melander O, Orho-Melander M, Borén J, Nilsson J, Gonçalves I.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1132-40. doi: 10.1161/ATVBAHA.116.305675. Epub 2016 Apr 7.

33.

A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids.

Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A.

Nat Protoc. 2016 Apr;11(4):747-63. doi: 10.1038/nprot.2016.040. Epub 2016 Mar 17.

34.

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

Klevstig M, Ståhlman M, Lundqvist A, Scharin Täng M, Fogelstrand P, Adiels M, Andersson L, Kolesnick R, Jeppsson A, Borén J, Levin MC.

J Mol Cell Cardiol. 2016 Apr;93:69-72. doi: 10.1016/j.yjmcc.2016.02.019. Epub 2016 Feb 28.

35.

Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis.

Svahn SL, Ulleryd MA, Grahnemo L, Ståhlman M, Borén J, Nilsson S, Jansson JO, Johansson ME.

Infect Immun. 2016 Mar 24;84(4):1205-1213. doi: 10.1128/IAI.01391-15. Print 2016 Apr.

36.

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.

Sommer F, Ståhlman M, Ilkayeva O, Arnemo JM, Kindberg J, Josefsson J, Newgard CB, Fröbert O, Bäckhed F.

Cell Rep. 2016 Feb 23;14(7):1655-1661. doi: 10.1016/j.celrep.2016.01.026. Epub 2016 Feb 4.

37.

Microbiota-induced obesity requires farnesoid X receptor.

Parséus A, Sommer N, Sommer F, Caesar R, Molinaro A, Ståhlman M, Greiner TU, Perkins R, Bäckhed F.

Gut. 2017 Mar;66(3):429-437. doi: 10.1136/gutjnl-2015-310283. Epub 2016 Jan 6.

38.

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans.

Amrutkar M, Kern M, Nuñez-Durán E, Ståhlman M, Cansby E, Chursa U, Stenfeldt E, Borén J, Blüher M, Mahlapuu M.

Diabetologia. 2016 Feb;59(2):341-53. doi: 10.1007/s00125-015-3801-7. Epub 2015 Nov 9.

PMID:
26553096
39.

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.

Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M.

J Hepatol. 2016 Mar;64(3):674-81. doi: 10.1016/j.jhep.2015.10.024. Epub 2015 Oct 31.

40.

Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.

Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD.

Hepatology. 2016 Jan;63(1):95-106. doi: 10.1002/hep.28124. Epub 2015 Oct 10.

41.

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation.

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F.

Cell Metab. 2015 Aug 4;22(2):228-38. doi: 10.1016/j.cmet.2015.07.009.

42.

p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.

Chaudhari A, Krumlinde D, Lundqvist A, Akyürek LM, Bandaru S, Skålén K, Ståhlman M, Borén J, Wettergren Y, Ejeskär K, Rotter Sopasakis V.

Mol Cell Biol. 2015 Oct;35(19):3258-73. doi: 10.1128/MCB.00471-15. Epub 2015 Jul 13.

43.

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.

Amrutkar M, Cansby E, Chursa U, Nuñez-Durán E, Chanclón B, Ståhlman M, Fridén V, Mannerås-Holm L, Wickman A, Smith U, Bäckhed F, Borén J, Howell BW, Mahlapuu M.

Diabetes. 2015 Aug;64(8):2791-804. doi: 10.2337/db15-0060. Epub 2015 Apr 6.

44.

Atrial fibrillation in patients admitted to coronary care units in western Sweden - focus on obesity and lipotoxicity.

Gizurarson S, Ståhlman M, Jeppsson A, Shao Y, Redfors B, Bergfeldt L, Borén J, Omerovic E.

J Electrocardiol. 2015 Sep-Oct;48(5):853-60. doi: 10.1016/j.jelectrocard.2014.12.010. Epub 2014 Dec 13.

PMID:
25666738
45.

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH.

Amrutkar M, Cansby E, Nuñez-Durán E, Pirazzi C, Ståhlman M, Stenfeldt E, Smith U, Borén J, Mahlapuu M.

FASEB J. 2015 Apr;29(4):1564-76. doi: 10.1096/fj.14-264937. Epub 2015 Jan 21.

PMID:
25609431
46.

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity.

Everard A, Lazarevic V, Gaïa N, Johansson M, Ståhlman M, Backhed F, Delzenne NM, Schrenzel J, François P, Cani PD.

ISME J. 2014 Oct;8(10):2116-30. doi: 10.1038/ismej.2014.45. Epub 2014 Apr 3.

47.

Ceramides are associated with inflammatory processes in human mediastinal adipose tissue.

Gertow J, Kjellqvist S, Ståhlman M, Cheung L, Gottfries J, Werngren O, Borén J, Franco-Cereceda A, Eriksson P, Fisher RM.

Nutr Metab Cardiovasc Dis. 2014 Feb;24(2):124-31. doi: 10.1016/j.numecd.2013.05.004. Epub 2013 Oct 7.

PMID:
24113394
48.

PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans.

Svensk E, Ståhlman M, Andersson CH, Johansson M, Borén J, Pilon M.

PLoS Genet. 2013;9(9):e1003801. doi: 10.1371/journal.pgen.1003801. Epub 2013 Sep 12.

49.

Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particles.

Ståhlman M, Fagerberg B, Adiels M, Ekroos K, Chapman JM, Kontush A, Borén J.

Biochim Biophys Acta. 2013 Nov;1831(11):1609-17. doi: 10.1016/j.bbalip.2013.07.009. Epub 2013 Jul 27.

PMID:
23896361
50.

Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion.

Drevinge C, Karlsson LO, Ståhlman M, Larsson T, Perman Sundelin J, Grip L, Andersson L, Borén J, Levin MC.

PLoS One. 2013 Apr 26;8(4):e61942. doi: 10.1371/journal.pone.0061942. Print 2013.

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