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Items: 1 to 50 of 66

1.

Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity.

Srivastava RAK.

J Diabetes Metab Disord. 2018 Nov 29;17(2):381-391. doi: 10.1007/s40200-018-0378-y. eCollection 2018 Dec.

2.

Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells.

Srivastava NS, Srivastava RAK.

Phytomedicine. 2019 Jan;52:117-128. doi: 10.1016/j.phymed.2018.09.224. Epub 2018 Sep 28.

PMID:
30599890
3.

Lack of Correlation of Plasma HDL With Fecal Cholesterol and Plasma Cholesterol Efflux Capacity Suggests Importance of HDL Functionality in Attenuation of Atherosclerosis.

Srivastava N, Cefalu AB, Averna M, Srivastava RAK.

Front Physiol. 2018 Sep 11;9:1222. doi: 10.3389/fphys.2018.01222. eCollection 2018.

4.

Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain.

Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL.

Front Pharmacol. 2018 May 11;9:471. doi: 10.3389/fphar.2018.00471. eCollection 2018.

5.

Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.

Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL.

Mol Cell Biochem. 2018 Dec;449(1-2):167-183. doi: 10.1007/s11010-018-3353-5. Epub 2018 Apr 11.

7.

Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease.

Srivastava RAK.

Mol Cell Biochem. 2018 Mar;440(1-2):167-187. doi: 10.1007/s11010-017-3165-z. Epub 2017 Aug 21. Review.

PMID:
28828539
8.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

Shi Y, Li J, Kennedy LJ, Tao S, Hernández AS, Lai Z, Chen S, Wong H, Zhu J, Trehan A, Lim NK, Zhang H, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Muckelbauer J, Chang C, Krystek SR, Li YX, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. doi: 10.1021/acsmedchemlett.6b00033. eCollection 2016 Jun 9.

9.
10.

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

Jahagirdar R, Zhang H, Azhar S, Tobin J, Attwell S, Yu R, Wu J, McLure KG, Hansen HC, Wagner GS, Young PR, Srivastava RA, Wong NC, Johansson J.

Atherosclerosis. 2014 Sep;236(1):91-100. doi: 10.1016/j.atherosclerosis.2014.06.008. Epub 2014 Jun 28.

PMID:
25016363
11.

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK.

Filippov S, Pinkosky SL, Lister RJ, Pawloski C, Hanselman JC, Cramer CT, Srivastava RA, Hurley TR, Bradshaw CD, Spahr MA, Newton RS.

J Lipid Res. 2013 Aug;54(8):2095-108. doi: 10.1194/jlr.M035212. Epub 2013 May 24.

12.

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.

Pinkosky SL, Filippov S, Srivastava RA, Hanselman JC, Bradshaw CD, Hurley TR, Cramer CT, Spahr MA, Brant AF, Houghton JL, Baker C, Naples M, Adeli K, Newton RS.

J Lipid Res. 2013 Jan;54(1):134-51. doi: 10.1194/jlr.M030528. Epub 2012 Nov 1.

13.

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases.

Srivastava RA, Pinkosky SL, Filippov S, Hanselman JC, Cramer CT, Newton RS.

J Lipid Res. 2012 Dec;53(12):2490-514. doi: 10.1194/jlr.R025882. Epub 2012 Jul 13. Review.

14.

Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

Srivastava RA.

Atherosclerosis. 2011 Jan;214(1):86-93. doi: 10.1016/j.atherosclerosis.2010.10.033. Epub 2010 Nov 2.

PMID:
21093860
15.

Differential regulation of human apolipoprotein AI and high-density lipoprotein by fenofibrate in hapoAI and hapoAI-CIII-AIV transgenic mice.

Srivastava RA, He S, Newton RS.

Biochim Biophys Acta. 2011 Feb;1811(2):76-83. doi: 10.1016/j.bbalip.2010.11.004. Epub 2010 Nov 23.

PMID:
21081177
16.

Anti-hyperlipidemic and insulin sensitizing activities of fenofibrate reduces aortic lipid deposition in hyperlipidemic Golden Syrian hamster.

Srivastava RA, He S.

Mol Cell Biochem. 2010 Dec;345(1-2):197-206. doi: 10.1007/s11010-010-0573-8. Epub 2010 Aug 27.

PMID:
20740305
17.

The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN-inhibitable protease cleavage during translocation.

Srivastava N, Cefalu AB, Noto D, Schonfeld G, Averna M, Srivastava RA.

Biochem Biophys Res Commun. 2010 Aug 6;398(4):665-70. doi: 10.1016/j.bbrc.2010.06.130. Epub 2010 Jul 6.

PMID:
20609357
18.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W, Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y, Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

J Med Chem. 2010 Apr 8;53(7):2854-64. doi: 10.1021/jm9016812.

PMID:
20218621
19.
20.

Dietary cholesterol and estrogen administration elevate brain apolipoprotein E in mice by different mechanisms.

Srivastava N, Averna M, Srivastava RA.

Indian J Biochem Biophys. 2008 Dec;45(6):410-5.

PMID:
19239128
21.

Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.

Mukherjee R, Locke KT, Miao B, Meyers D, Monshizadegan H, Zhang R, Search D, Grimm D, Flynn M, O'Malley KM, Zhang L, Li J, Shi Y, Kennedy LJ, Blanar M, Cheng PT, Tino J, Srivastava RA.

J Pharmacol Exp Ther. 2008 Dec;327(3):716-26. doi: 10.1124/jpet.108.143271. Epub 2008 Sep 17.

PMID:
18799592
22.

Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.

Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL.

Mol Cell Biochem. 2006 Apr;285(1-2):35-50. Epub 2006 Feb 14.

PMID:
16477380
23.
26.

Dietary cholate increases plasma levels of apolipoprotein B in mice by posttranscriptional mechanisms.

Srivastava RA, Averna M, Srivastava N, Pape ME.

Int J Biochem Cell Biol. 2001 Dec;33(12):1215-26.

PMID:
11606258
27.

Estrogen increases hepatic lipase levels in inbred strains of mice: a possible mechanism for estrogen-dependent lowering of high density lipoprotein.

Srivastava N, Chowdhury PR, Averna M, Srivastava RA.

Mol Cell Biochem. 2001 Apr;220(1-2):87-93.

PMID:
11451387
28.

High density lipoprotein, apolipoprotein A-I, and coronary artery disease.

Srivastava RA, Srivastava N.

Mol Cell Biochem. 2000 Jun;209(1-2):131-44. Review.

PMID:
10942211
29.

Apolipoprotein E gene expression is reduced in apolipoprotein A-I transgenic mice.

Srivastava RA.

Mol Cell Biochem. 2000 Jun;209(1-2):125-9.

PMID:
10942210
30.
31.

Regulation of the apolipoprotein B in heterozygous hypobetalipoproteinemic knock-out mice expressing truncated apoB, B81. Low production and enhanced clearance of apoB cause low levels of apoB.

Srivastava RA, Toth L, Srivastava N, Hinsdale ME, Maeda N, Cefalu AB, Averna M, Schonfeld G.

Mol Cell Biochem. 1999 Dec;202(1-2):37-46.

PMID:
10705993
33.

Measurements of rate of transcription in isolated nuclei by nuclear "run-off" assay.

Srivastava RA, Schonfeld G.

Methods Mol Biol. 1998;86:201-7. No abstract available.

PMID:
9664471
34.

Analysis of RNA by Northern blotting using riboprobes.

Srivastava RA.

Methods Mol Biol. 1998;86:103-12. No abstract available.

PMID:
9664460
35.

Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway.

Srivastava RA, Srivastava N, Averna M, Lin RC, Korach KS, Lubahn DB, Schonfeld G.

J Biol Chem. 1997 Dec 26;272(52):33360-6.

36.
37.

Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms.

Srivastava RA, Krul ES, Lin RC, Schonfeld G.

Mol Cell Biochem. 1997 Aug;173(1-2):161-8.

PMID:
9278267
38.

Alcohol increases plasma levels of cholesterol diet-induced atherogenic lipoproteins and aortic atherosclerosis in rabbits.

Shaish A, Pape M, Rea T, Srivastava RA, Latour MA, Hopkins D, Schonfeld G.

Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1091-7.

PMID:
9194759
39.

A new apolipoprotein B truncation (apo B-43.7) in familial hypobetalipoproteinemia: genetic and metabolic studies.

Srivastava N, Noto D, Averna M, Pulai J, Srivastava RA, Cole TG, Latour MA, Patterson BW, Schonfeld G.

Metabolism. 1996 Oct;45(10):1296-304.

PMID:
8843188
40.

The multifaceted roles of the RNA processing enzyme ribonuclease III.

Srivastava RA, Srivastava N.

Indian J Biochem Biophys. 1996 Aug;33(4):253-60. Review.

PMID:
8936814
41.

Expression, purification and properties of recombinant E. coli ribonuclease III.

Srivastava N, Srivastava RA.

Biochem Mol Biol Int. 1996 May;39(1):171-80.

PMID:
8799339
42.
43.

Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen.

Srivastava RA, Bhasin N, Srivastava N.

Biochem Mol Biol Int. 1996 Feb;38(1):91-101.

PMID:
8932523
44.
45.
46.
47.

Regulation of the apolipoprotein AIV gene expression by estrogen differs in rat and mouse.

Srivastava RA, Kitchens RT, Schonfeld G.

Eur J Biochem. 1994 Jun 1;222(2):507-14.

48.

Measurements of rate of transcription in isolated nuclei by nuclear "run-off" assay.

Srivastava RA, Schonfeld G.

Methods Mol Biol. 1994;31:281-8. Review. No abstract available.

PMID:
7921025
49.

Quantification of absolute amounts of cellular messenger RNA by RNA-excess solution hybridization.

Srivastava RA, Schonfeld G.

Methods Mol Biol. 1994;31:273-9. Review. No abstract available.

PMID:
7921024
50.

In vivo regulation of low-density lipoprotein receptors by estrogen differs at the post-transcriptional level in rat and mouse.

Srivastava RA, Baumann D, Schonfeld G.

Eur J Biochem. 1993 Sep 1;216(2):527-38. Erratum in: Eur J Biochem 1994 Feb 1;219(3):1087.

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