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Two year analysis of Clostridium difficile ribotypes associated with increased severity.

Herbert R, Hatcher J, Jauneikaite E, Gharbi M, Stephanie d'Arc, Obaray N, Rickards T, Rebec M, Blandy O, Hope R, Thomas A, Bamford K, Jepson A, Sriskandan S.

J Hosp Infect. 2019 Jun 17. pii: S0195-6701(19)30252-X. doi: 10.1016/j.jhin.2019.06.003. [Epub ahead of print]


Sampling and diversity of Escherichia coli from the enteric microbiota in patients with Escherichia coli bacteraemia.

Mosavie M, Blandy O, Jauneikaite E, Caldas I, Ellington MJ, Woodford N, Sriskandan S.

BMC Res Notes. 2019 Jun 13;12(1):335. doi: 10.1186/s13104-019-4369-y.


A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP.

Goldblatt J, Lawrenson RA, Muir L, Dattani S, Hoffland A, Tsuchiya T, Kanegasaki S, Sriskandan S, Pease JE.

J Immunol. 2019 Jun 1;202(11):3246-3255. doi: 10.4049/jimmunol.1801688. Epub 2019 Apr 22.


Treatment potential of pathogen-reactive antibodies sequentially purified from pooled human immunoglobulin.

Reglinski M, Sriskandan S.

BMC Res Notes. 2019 Apr 15;12(1):228. doi: 10.1186/s13104-019-4262-8.


Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death and reduced immunoglobulin release.

Davies FJ, Olme C, Lynskey NN, Turner CE, Sriskandan S.

Clin Exp Immunol. 2019 Jul;197(1):83-94. doi: 10.1111/cei.13282. Epub 2019 Mar 13.


Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR.

Reglinski M, Sriskandan S, Turner CE.

J Infect. 2019 May;78(5):358-363. doi: 10.1016/j.jinf.2019.02.005. Epub 2019 Feb 20.


Supervised machine learning for the prediction of infection on admission to hospital: a prospective observational cohort study.

Rawson TM, Hernandez B, Moore LSP, Blandy O, Herrero P, Gilchrist M, Gordon A, Toumazou C, Sriskandan S, Georgiou P, Holmes AH.

J Antimicrob Chemother. 2019 Apr 1;74(4):1108-1115. doi: 10.1093/jac/dky514.


Factors that impact on the burden of Escherichia coli bacteraemia: multivariable regression analysis of 2011-2015 data from West London.

Blandy O, Honeyford K, Gharbi M, Thomas A, Ramzan F, Ellington MJ, Hope R, Holmes AH, Johnson AP, Aylin P, Woodford N, Sriskandan S.

J Hosp Infect. 2019 Feb;101(2):120-128. doi: 10.1016/j.jhin.2018.10.024. Epub 2018 Nov 4.


Cohort study protocol: Bioresource in Adult Infectious Diseases (BioAID).

Shallcross LJ, Mentzer A, Rahman S, Cooke GS, Sriskandan S, Noursadeghi M.

Wellcome Open Res. 2018 Aug 8;3:97. doi: 10.12688/wellcomeopenres.14690.1. eCollection 2018.


Familial Transmission of emm12 Group A Streptococcus.

Mearkle R, Balasegaram S, Sriskandan S, Chalker V, Lamagni T.

Emerg Infect Dis. 2018 Nov;24(11):2133-2134. doi: 10.3201/eid2411.171743. No abstract available.


Severe group A streptococcal infections in mothers and their newborns in London and the South East, 2010-2016: assessment of risk and audit of public health management.

Leonard A, Wright A, Saavedra-Campos M, Lamagni T, Cordery R, Nicholls M, Domoney C, Sriskandan S, Balasegaram S.

BJOG. 2019 Jan;126(1):44-53. doi: 10.1111/1471-0528.15415. Epub 2018 Sep 9.


Impact of contusion injury on intramuscular emm1 group a streptococcus infection and lymphatic spread.

Lamb LE, Siggins MK, Scudamore C, Macdonald W, Turner CE, Lynskey NN, Tan LKK, Sriskandan S.

Virulence. 2018;9(1):1074-1084. doi: 10.1080/21505594.2018.1482180.


Modelling invasive group A streptococcal disease using bioluminescence.

Lamb LE, Zhi X, Alam F, Pyzio M, Scudamore CL, Wiles S, Sriskandan S.

BMC Microbiol. 2018 Jun 19;18(1):60. doi: 10.1186/s12866-018-1200-1.


Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.

Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S.

Clin Infect Dis. 2018 Oct 15;67(9):1434-1436. doi: 10.1093/cid/ciy401.


Development of an opsonophagocytic killing assay for group a streptococcus.

Jones S, Moreland NJ, Zancolli M, Raynes J, Loh JMS, Smeesters PR, Sriskandan S, Carapetis JR, Fraser JD, Goldblatt D.

Vaccine. 2018 Jun 18;36(26):3756-3763. doi: 10.1016/j.vaccine.2018.05.056.


Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenes.

Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB, Sriskandan S.

Sci Rep. 2018 Apr 13;8(1):5950. doi: 10.1038/s41598-018-24216-2.


High prevalence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacteriaceae in the UK and Ireland.

Taylor E, Sriskandan S, Woodford N, Hopkins KL.

Int J Antimicrob Agents. 2018 Aug;52(2):278-282. doi: 10.1016/j.ijantimicag.2018.03.016. Epub 2018 Mar 27.


Serial Clustering of Late-Onset Group B Streptococcal Infections in the Neonatal Unit: A Genomic Re-evaluation of Causality.

Jauneikaite E, Kapatai G, Davies F, Gozar I, Coelho J, Bamford KB, Simone B, Begum L, Katiyo S, Patel B, Hoffman P, Lamagni T, Brannigan ET, Holmes AH, Kadhani T, Galletly T, Martin K, Lyall H, Chow Y, Godambe S, Chalker V, Sriskandan S.

Clin Infect Dis. 2018 Aug 31;67(6):854-860. doi: 10.1093/cid/ciy174.


Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom.

Sharma H, Smith D, Turner CE, Game L, Pichon B, Hope R, Hill R, Kearns A, Sriskandan S.

Emerg Infect Dis. 2018 Feb;24(2). doi: 10.3201/eid2402.170606.


Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

Lynskey NN, Reglinski M, Calay D, Siggins MK, Mason JC, Botto M, Sriskandan S.

PLoS Pathog. 2017 Aug 14;13(8):e1006493. doi: 10.1371/journal.ppat.1006493. eCollection 2017 Aug.


Household transmission of invasive group A Streptococcus infections in England: a population-based study, 2009, 2011 to 2013.

Mearkle R, Saavedra-Campos M, Lamagni T, Usdin M, Coelho J, Chalker V, Sriskandan S, Cordery R, Rawlings C, Balasegaram S.

Euro Surveill. 2017 May 11;22(19). pii: 30532. doi: 10.2807/1560-7917.ES.2017.22.19.30532.


Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus.

Afshar B, Turner CE, Lamagni TL, Smith KC, Al-Shahib A, Underwood A, Holden MTG, Efstratiou A, Sriskandan S.

Virulence. 2017 Oct 3;8(7):1390-1400. doi: 10.1080/21505594.2017.1325070. Epub 2017 May 1.


Corrigendum: Emergence of a novel lineage containing a prophage in emm/M3 group A Streptococcus associated with upsurge in invasive disease in the UK.

Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S, Efstratiou A.

Microb Genom. 2016 Nov 30;2(11):e000097. doi: 10.1099/mgen.0.000097. eCollection 2016 Nov.


Emergence of a novel lineage containing a prophage in emm/M3 group A Streptococcus associated with upsurge in invasive disease in the UK.

Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S, Efstratiou A.

Microb Genom. 2016 Jun 24;2(6):e000059. doi: 10.1099/mgen.0.000059. eCollection 2016 Jun. Erratum in: Microb Genom. 2016 Nov 30;2(11):e000097.


Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically relevant UK isolates of Staphylococcus aureus.

Smith DS, Siggins MK, Gierula M, Pichon B, Turner CE, Lynskey NN, Mosavie M, Kearns AM, Edwards RJ, Sriskandan S.

Microb Genom. 2016 Feb 23;2(2):e000049. doi: 10.1099/mgen.0.000049. eCollection 2016 Feb.


Asymptomatic group A Streptococcal throat carriage in Royal Marines recruits and Young Officers.

Pearson M, Fallowfield JL, Davey T, Thorpe NM, Allsopp AJ, Shaw A, Wilson DR, Sriskandan S, Lamb LE.

J Infect. 2017 Jun;74(6):585-589. doi: 10.1016/j.jinf.2017.03.001. Epub 2017 Mar 23.


Nosocomial Outbreak of Drug-Resistant Streptococcus pneumoniae Serotype 9V in an Adult Respiratory Medicine Ward.

Jauneikaite E, Khan-Orakzai Z, Kapatai G, Bloch S, Singleton J, Atkin S, Shah V, Hatcher J, Samarasinghe D, Sheppard C, Fry NK, Satta G, Sriskandan S.

J Clin Microbiol. 2017 Mar;55(3):776-782. doi: 10.1128/JCM.02405-16. Epub 2016 Dec 14.


Scarlet Fever Upsurge in England and Molecular-Genetic Analysis in North-West London, 2014.

Turner CE, Pyzio M, Song B, Lamagni T, Meltzer M, Chow JY, Efstratiou A, Curtis S, Sriskandan S.

Emerg Infect Dis. 2016 Jun;22(6):1075-8. doi: 10.3201/eid2206.151726.


Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation.

Reglinski M, Lynskey NN, Sriskandan S.

J Microbiol Methods. 2016 May;124:69-71. doi: 10.1016/j.mimet.2016.03.015. Epub 2016 Mar 24.


Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG.

Reglinski M, Lynskey NN, Choi YJ, Edwards RJ, Sriskandan S.

J Infect. 2016 Apr;72(4):450-9. doi: 10.1016/j.jinf.2016.02.002. Epub 2016 Feb 12.


Turner et al. Reply to "Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions".

Turner CE, Lamagni T, Holden MT, David S, Jones MD, Game L, Efstratiou A, Sriskandan S.

MBio. 2015 Dec 1;6(6):e01883-15. doi: 10.1128/mBio.01883-15. No abstract available.


Identification of the Streptococcus pyogenes surface antigens recognised by pooled human immunoglobulin.

Reglinski M, Gierula M, Lynskey NN, Edwards RJ, Sriskandan S.

Sci Rep. 2015 Oct 28;5:15825. doi: 10.1038/srep15825.


Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.

Lynskey NN, Banerji S, Johnson LA, Holder KA, Reglinski M, Wing PA, Rigby D, Jackson DG, Sriskandan S.

PLoS Pathog. 2015 Sep 9;11(9):e1005137. doi: 10.1371/journal.ppat.1005137. eCollection 2015 Sep.


The effect of trauma on invasive group A streptococcal disease.

Lamb L, McDonald W, Scudamore C, Tan L, Lynskey N, Sriskandan S.

Lancet. 2015 Feb 26;385 Suppl 1:S60. doi: 10.1016/S0140-6736(15)60375-0.


Corynebacterium ulcerans cutaneous diphtheria.

Moore LSP, Leslie A, Meltzer M, Sandison A, Efstratiou A, Sriskandan S.

Lancet Infect Dis. 2015 Sep;15(9):1100-1107. doi: 10.1016/S1473-3099(15)00225-X. Epub 2015 Jul 16. Review.


Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom.

Turner CE, Abbott J, Lamagni T, Holden MT, David S, Jones MD, Game L, Efstratiou A, Sriskandan S.

MBio. 2015 Jul 14;6(4):e00622. doi: 10.1128/mBio.00622-15.


Panton-Valentine leucocidin expression by Staphylococcus aureus exposed to common antibiotics.

Turner CE, Sriskandan S.

J Infect. 2015 Sep;71(3):338-46. doi: 10.1016/j.jinf.2015.05.008. Epub 2015 May 28.


A truncation in the regulator RocA underlies heightened capsule expression in serotype M3 group A streptococci.

Lynskey NN, Turner CE, Heng LS, Sriskandan S.

Infect Immun. 2015 Apr;83(4):1732-3. doi: 10.1128/IAI.02892-14. No abstract available.


Bromine, bear-claw scratch fasciotomies, and the Eagle effect: management of group A streptococcal necrotising fasciitis and its association with trauma.

Lamb LE, Sriskandan S, Tan LK.

Lancet Infect Dis. 2015 Jan;15(1):109-21. doi: 10.1016/S1473-3099(14)70922-3. Review.


The cost of hospital care for management of invasive group A streptococcal infections in England.

Hughes GJ, VAN Hoek AJ, Sriskandan S, Lamagni TL.

Epidemiol Infect. 2015 Jun;143(8):1719-30. doi: 10.1017/S0950268814002489. Epub 2014 Sep 29.


Ebola and other viral haemorrhagic fevers: a local operational approach.

Moore LS, Moore M, Sriskandan S.

Br J Hosp Med (Lond). 2014 Sep;75(9):515-22. doi: 10.12968/hmed.2014.75.9.515. Review. No abstract available.


Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.

Moreland NJ, Waddington CS, Williamson DA, Sriskandan S, Smeesters PR, Proft T, Steer AC, Walker MJ, Baker EN, Baker MG, Lennon D, Dunbar R, Carapetis J, Fraser JD.

Vaccine. 2014 Jun 24;32(30):3713-20. doi: 10.1016/j.vaccine.2014.05.017. Epub 2014 May 14.


Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.

Ascough S, Ingram RJ, Chu KK, Reynolds CJ, Musson JA, Doganay M, Metan G, Ozkul Y, Baillie L, Sriskandan S, Moore SJ, Gallagher TB, Dyson H, Williamson ED, Robinson JH, Maillere B, Boyton RJ, Altmann DM.

PLoS Pathog. 2014 May 1;10(5):e1004085. doi: 10.1371/journal.ppat.1004085. eCollection 2014 May.


Editorial commentary: step on the GAS: are we almost there for clindamycin and intravenous immunoglobulin?

Tan LK, Sriskandan S.

Clin Infect Dis. 2014 Aug 1;59(3):366-8. doi: 10.1093/cid/ciu307. Epub 2014 Apr 29. No abstract available.


Current views of haemolytic streptococcal pathogenesis.

Tan LK, Eccersley LR, Sriskandan S.

Curr Opin Infect Dis. 2014 Apr;27(2):155-64. doi: 10.1097/QCO.0000000000000047. Review.


RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci.

Lynskey NN, Goulding D, Gierula M, Turner CE, Dougan G, Edwards RJ, Sriskandan S.

PLoS Pathog. 2013;9(12):e1003842. doi: 10.1371/journal.ppat.1003842. Epub 2013 Dec 19.


Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.

Alam FM, Bateman C, Turner CE, Wiles S, Sriskandan S.

PLoS One. 2013 Nov 20;8(11):e82123. doi: 10.1371/journal.pone.0082123. eCollection 2013.


The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.

Reglinski M, Sriskandan S.

Virulence. 2014 Jan 1;5(1):127-36. doi: 10.4161/viru.26400. Epub 2013 Oct 9. Review.


Inactivation of the CovR/S virulence regulator impairs infection in an improved murine model of Streptococcus pyogenes naso-pharyngeal infection.

Alam FM, Turner CE, Smith K, Wiles S, Sriskandan S.

PLoS One. 2013 Apr 25;8(4):e61655. doi: 10.1371/journal.pone.0061655. Print 2013. Erratum in: PLoS One. 2013;8(9):doi/10.1371/annotation/1144e132-9e69-47bb-8e65-1414dbb01db7.


Molecular analysis of an outbreak of lethal postpartum sepsis caused by Streptococcus pyogenes.

Turner CE, Dryden M, Holden MT, Davies FJ, Lawrenson RA, Farzaneh L, Bentley SD, Efstratiou A, Sriskandan S.

J Clin Microbiol. 2013 Jul;51(7):2089-95. doi: 10.1128/JCM.00679-13. Epub 2013 Apr 24.

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