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GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.

Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS.

Development. 2019 Nov 5;146(21). pii: dev184218. doi: 10.1242/dev.184218.


VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.

Yang Y, Cha B, Motawe ZY, Srinivasan RS, Scallan JP.

Cell Rep. 2019 Aug 27;28(9):2397-2412.e4. doi: 10.1016/j.celrep.2019.07.072.


Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance.

Choi D, Park E, Jung E, Cha B, Lee S, Yu J, Kim PM, Lee S, Hong YJ, Koh CJ, Cho CW, Wu Y, Li Jeon N, Wong AK, Shin L, Kumar SR, Bermejo-Moreno I, Srinivasan RS, Cho IT, Hong YK.

JCI Insight. 2019 Mar 7;4(5). pii: 125068. doi: 10.1172/jci.insight.125068. eCollection 2019 Mar 7.


Mechanisms of Connexin-Related Lymphedema.

Castorena-Gonzalez JA, Zawieja SD, Li M, Srinivasan RS, Simon AM, de Wit C, de la Torre R, Martinez-Lemus LA, Hennig GW, Davis MJ.

Circ Res. 2018 Sep 28;123(8):964-985. doi: 10.1161/CIRCRESAHA.117.312576.


Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.

Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS.

Cell Rep. 2018 Oct 16;25(3):571-584.e5. doi: 10.1016/j.celrep.2018.09.049.


Correlative Fluorescence and Scanning Electron Microscopy to Study Lymphovenous Valve Development.

Geng X, Srinivasan RS.

Methods Mol Biol. 2018;1846:85-96. doi: 10.1007/978-1-4939-8712-2_6.


Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.

Wu H, Rahman HNA, Dong Y, Liu X, Lee Y, Wen A, To KH, Xiao L, Birsner AE, Bazinet L, Wong S, Song K, Brophy ML, Mahamud MR, Chang B, Cai X, Pasula S, Kwak S, Yang W, Bischoff J, Xu J, Bielenberg DR, Dixon JB, D'Amato RJ, Srinivasan RS, Chen H.

J Clin Invest. 2018 Aug 31;128(9):4025-4043. doi: 10.1172/JCI96063. Epub 2018 Aug 13.


Intraluminal valves: development, function and disease.

Geng X, Cha B, Mahamud MR, Srinivasan RS.

Dis Model Mech. 2017 Nov 1;10(11):1273-1287. doi: 10.1242/dmm.030825. Review.


Risk factors for hepatocellular carcinoma.

Ponzetto A, Srinivasan RS.

Hepatology. 2017 Mar;65(3):1074. doi: 10.1002/hep.28854. Epub 2016 Nov 15. No abstract available.


Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.

Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS.

Genes Dev. 2016 Jun 15;30(12):1454-69. doi: 10.1101/gad.282400.116. Epub 2016 Jun 16.


CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.

Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT.

J Clin Invest. 2016 Jun 1;126(6):2254-66. doi: 10.1172/JCI84652. Epub 2016 May 3.


Motif mimetic of epsin perturbs tumor growth and metastasis.

Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87344. Epub 2016 Mar 21. No abstract available.


Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

Munger SJ, Geng X, Srinivasan RS, Witte MH, Paul DL, Simon AM.

Dev Biol. 2016 Apr 15;412(2):173-90. doi: 10.1016/j.ydbio.2016.02.033. Epub 2016 Mar 4.


Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis.

Rahman HNA, Wu H, Dong Y, Pasula S, Wen A, Sun Y, Brophy ML, Tessneer KL, Cai X, McManus J, Chang B, Kwak S, Rahman NS, Xu W, Fernandes C, Mcdaniel JM, Xia L, Smith L, Srinivasan RS, Chen H.

Circ Res. 2016 Mar 18;118(6):957-969. doi: 10.1161/CIRCRESAHA.115.307679. Epub 2016 Feb 15.


Motif mimetic of epsin perturbs tumor growth and metastasis.

Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H.

J Clin Invest. 2015 Dec;125(12):4349-64. doi: 10.1172/JCI80349. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.


Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.

Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MKM, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS.

Dev Biol. 2016 Jan 1;409(1):218-233. doi: 10.1016/j.ydbio.2015.10.022. Epub 2015 Nov 2.


Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function.

Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H.

Sci Signal. 2014 Oct 14;7(347):ra97. doi: 10.1126/scisignal.2005413.


The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors.

Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G.

Genes Dev. 2014 Oct 1;28(19):2175-87. doi: 10.1101/gad.216226.113.


Molecular and cellular mechanisms of lymphatic vascular maturation.

Chen H, Griffin C, Xia L, Srinivasan RS.

Microvasc Res. 2014 Nov;96:16-22. doi: 10.1016/j.mvr.2014.06.002. Epub 2014 Jun 11. Review.


Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.

Yang Y, García-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G.

Blood. 2012 Sep 13;120(11):2340-8. doi: 10.1182/blood-2012-05-428607. Epub 2012 Aug 2.


Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.

Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald DM.

Am J Pathol. 2012 Jun;180(6):2561-75. doi: 10.1016/j.ajpath.2012.02.019. Epub 2012 Apr 23.


In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.

Liu Z, Owen T, Fang J, Srinivasan RS, Zuo J.

Dev Dyn. 2012 Apr;241(4):684-96. doi: 10.1002/dvdy.23754. Epub 2012 Feb 21.


RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice.

Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD.

J Clin Invest. 2012 Feb;122(2):733-47. doi: 10.1172/JCI46116. Epub 2012 Jan 9.


Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves.

Srinivasan RS, Oliver G.

Genes Dev. 2011 Oct 15;25(20):2187-97. doi: 10.1101/gad.16974811.


A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis.

Yin X, Truty J, Lawrence R, Johns SC, Srinivasan RS, Handel TM, Fuster MM.

Mol Cancer. 2010 Dec 20;9:316. doi: 10.1186/1476-4598-9-316.


The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.

Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G.

Genes Dev. 2010 Apr 1;24(7):696-707. doi: 10.1101/gad.1859310.


Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell.

Oliver G, Srinivasan RS.

Development. 2010 Feb;137(3):363-72. doi: 10.1242/dev.035360. Review.


Lymphatic vasculature development: current concepts.

Oliver G, Srinivasan RS.

Ann N Y Acad Sci. 2008;1131:75-81. doi: 10.1196/annals.1413.006. Review.


Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.

Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B.

Dev Dyn. 2008 Jan;237(1):51-61.


Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature.

Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G.

Genes Dev. 2007 Oct 1;21(19):2422-32.


Bacterial etiology of diabetic foot infections in South India.

Shankar EM, Mohan V, Premalatha G, Srinivasan RS, Usha AR.

Eur J Intern Med. 2005 Dec;16(8):567-70.


Phenotypes of isolates of Pseudomonas aeruginosa in a diabetes care center.

Muthu SE, Aberna RA, Mohan V, Premalatha G, Srinivasan RS, Thyagarajan SP, Rao UA.

Arch Med Res. 2006 Jan;37(1):95-101.


Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.

Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G.

Nat Genet. 2005 Oct;37(10):1072-81. Epub 2005 Sep 18.


The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells.

Srinivasan RS, Nesbit JB, Marrero L, Erfurth F, LaRussa VF, Hemenway CS.

Leukemia. 2004 Aug;18(8):1364-72.


The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor.

Srinivasan RS, de Erkenez AC, Hemenway CS.

Oncogene. 2003 May 29;22(22):3395-406.


Mathematical model of diffusion-limited evolution of multiple gas bubbles in tissue.

Srinivasan RS, Gerth WA, Powell MR.

Ann Biomed Eng. 2003 Apr;31(4):471-81.


Mathematical model of diffusion-limited gas bubble dynamics in unstirred tissue with finite volume.

Srinivasan RS, Gerth WA, Powell MR.

Ann Biomed Eng. 2002 Feb;30(2):232-46.


A mathematical model of diffusion-limited gas bubble dynamics in tissue with varying diffusion region thickness.

Srinivasan RS, Gerth WA, Powell MR.

Respir Physiol. 2000 Oct;123(1-2):153-64.


Mathematical models of diffusion-limited gas bubble dynamics in tissue.

Srinivasan RS, Gerth WA, Powell MR.

J Appl Physiol (1985). 1999 Feb;86(2):732-41.


Increase of LBNP tolerance using elastic compression stockings.

Melçhior FM, Thullier PH, Lejeune D, Kerguélen M, Srinivasan RS.

Aviat Space Environ Med. 1996 Dec;67(12):1161-5.


Simulation of cardiovascular response to lower body negative pressure from 0 to -40 mmHg.

Melchior FM, Srinivasan RS, Thullier PH, Clère JM.

J Appl Physiol (1985). 1994 Aug;77(2):630-40.


Application of physiologically based pharmacokinetic models for assessing drug disposition in space.

Srinivasan RS, Bourne DW, Putcha L.

J Clin Pharmacol. 1994 Jun;34(6):692-8. Review.


The effect of blood volume loss on cardiovascular response to lower body negative pressure using a mathematical model.

Karam EH, Srinivasan RS, Charles JB, Fortney SM.

J Gravit Physiol. 1994 May;1(1):P96-7.


Computer simulation of the effect of dDAVP with saline loading on fluid balance after 24-hour head-down tilt.

Srinivasan RS, Simanonok KE, Charles JB.

J Gravit Physiol. 1994 May;1(1):P106-7.


A comprehensive Guyton model analysis of physiologic responses to preadapting the blood volume as a countermeasure to fluid shifts.

Simanonok KE, Srinivasan RS, Myrick EE, Blomkalns AL, Charles JB.

J Clin Pharmacol. 1994 May;34(5):440-53. Review.


Mathematical modelling of the human cardiovascular system in the presence of stenosis.

Sud VK, Srinivasan RS, Charles JB, Bungo MW.

Phys Med Biol. 1993 Mar;38(3):369-78.


A mathematical model of the cardiovascular response to +Gz acceleration.

Melchior FM, Srinivasan RS, Ossard G, Clère J-M.

Physiologist. 1993;36(1 Suppl):S62-3.


Simulation of the fluid retention effects of a vasopressin analog using the Guyton model of circulation.

Srinivasan RS, Simanonok KE, Fortney SM, Charles JB.

Physiologist. 1993;36(1 Suppl):S114-5.


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