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Direct Access to 9-Chloro-1H-benzo[b]furo[3,4-e]azepin-1-ones via Palladium(II)-Catalyzed Intramolecular syn-Oxypalladation/Olefin Insertion/sp2-C-H Bond Activation Cascade.

Karuppasamy M, Vachan BS, Vinoth P, Muthukrishnan I, Nagarajan S, Ielo L, Pace V, Banik S, Maheswari CU, Sridharan V.

Org Lett. 2019 Jul 16. doi: 10.1021/acs.orglett.9b01482. [Epub ahead of print]


A Pilot Randomized Controlled Trial of a Web-Based Growth Mindset Intervention to Enhance the Effectiveness of a Smartphone App for Smoking Cessation.

Sridharan V, Shoda Y, Heffner J, Bricker J.

JMIR Mhealth Uhealth. 2019 Jul 9;7(7):e14602. doi: 10.2196/14602.


Heterogeneous Amberlyst-15-catalyzed synthesis of complex hybrid heterocycles containing [1,6]-naphthyridine under metal-free green conditions.

Muthukrishnan I, Vachan BS, Karuppasamy M, Eniyaval A, Uma Maheswari C, Nagarajan S, Menéndez JC, Sridharan V.

Org Biomol Chem. 2019 Jul 17;17(28):6872-6879. doi: 10.1039/c9ob01256g.


Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Drew A, Sridharan V, Boerma M, Tackett AJ, Zawieja D, Willey JS, Delp M, Pecaut MJ.

Sci Rep. 2019 Jun 3;9(1):8215. doi: 10.1038/s41598-019-44696-0.


Palladium-Catalyzed Regioselective Syn-Chloropalladation-Olefin Insertion-Oxidative Chlorination Cascade: Synthesis of Dichlorinated Tetrahydroquinolines.

Vinoth P, Karuppasamy M, Vachan BS, Muthukrishnan I, Maheswari CU, Nagarajan S, Pace V, Roller A, Bhuvanesh N, Sridharan V.

Org Lett. 2019 May 3;21(9):3465-3469. doi: 10.1021/acs.orglett.9b01295. Epub 2019 Apr 19.


Progress in the Chemistry of Tetrahydroquinolines.

Muthukrishnan I, Sridharan V, Menéndez JC.

Chem Rev. 2019 Apr 24;119(8):5057-5191. doi: 10.1021/acs.chemrev.8b00567. Epub 2019 Apr 9.


Addiction Mindsets and Psychological Processes of Quitting Smoking.

Sridharan V, Shoda Y, Heffner JL, Bricker J.

Subst Use Misuse. 2019;54(7):1086-1095. doi: 10.1080/10826084.2018.1555259. Epub 2019 Mar 20.


Diastereoselective ABB' Three-Component Synthesis of Highly Functionalized Spirooxindoles Bearing Five Consecutive Asymmetric Carbons.

Vivekanand T, Vachan BS, Karuppasamy M, Muthukrishnan I, Maheswari CU, Nagarajan S, Bhuvanesh N, Sridharan V.

J Org Chem. 2019 Apr 5;84(7):4009-4016. doi: 10.1021/acs.joc.8b03270. Epub 2019 Mar 21.


Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice.

Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW, Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M.

Life Sci Space Res (Amst). 2019 Feb;20:72-84. doi: 10.1016/j.lssr.2019.01.003. Epub 2019 Jan 15.


Supramolecular Gel Formation Based on Glycolipids Derived from Renewable Resources.

Lalitha K, Gayathri K, Prasad YS, Saritha R, Thamizhanban A, Maheswari CU, Sridharan V, Nagarajan S.

Gels. 2017 Dec 24;4(1). pii: E1. doi: 10.3390/gels4010001.


Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.

Chen X, Ebelle DL, Wright BJ, Sridharan V, Hooper E, Walters KJ.

J Mol Biol. 2019 Mar 1;431(5):939-955. doi: 10.1016/j.jmb.2019.01.021. Epub 2019 Jan 18.


Late Effects of 16O-Particle Radiation on Female Social and Cognitive Behavior and Hippocampal Physiology.

Kiffer F, Alexander T, Anderson JE, Groves T, Wang J, Sridharan V, Boerma M, Allen AR.

Radiat Res. 2019 Mar;191(3):278-294. doi: 10.1667/RR15092.1. Epub 2019 Jan 21.


Resilience of the Eastern African electricity sector to climate driven changes in hydropower generation.

Sridharan V, Broad O, Shivakumar A, Howells M, Boehlert B, Groves DG, Rogner HH, Taliotis C, Neumann JE, Strzepek KM, Lempert R, Joyce B, Huber-Lee A, Cervigni R.

Nat Commun. 2019 Jan 17;10(1):302. doi: 10.1038/s41467-018-08275-7.


Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation.

Howe A, Kiffer F, Alexander TC, Sridharan V, Wang J, Ntagwabira F, Rodriguez A, Boerma M, Allen AR.

Int J Mol Sci. 2019 Jan 7;20(1). pii: E188. doi: 10.3390/ijms20010188.


Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System.

Mao XW, Boerma M, Rodriguez D, Campbell-Beachler M, Jones T, Stanbouly S, Sridharan V, Nishiyama NC, Wroe A, Nelson GA.

Radiat Res. 2018 Nov 15. doi: 10.1667/RR15219.1. [Epub ahead of print]


Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments.

Skinner CM, Miousse IR, Ewing LE, Sridharan V, Cao M, Lin H, Williams DK, Avula B, Haider S, Chittiboyina AG, Khan IA, ElSohly MA, Boerma M, Gurley BJ, Koturbash I.

Food Chem Toxicol. 2018 Dec;122:21-32. doi: 10.1016/j.fct.2018.09.067. Epub 2018 Sep 30.


Three-Component Synthesis of a Library of m-Terphenyl Derivatives with Embedded β-Aminoester Moieties.

Rocchi D, González JF, Gómez-Carpintero J, González-Ruiz V, Martín MA, Sridharan V, Menéndez JC.

ACS Comb Sci. 2018 Dec 10;20(12):722-731. doi: 10.1021/acscombsci.8b00137. Epub 2018 Oct 8.


Radiologic predictors of immune checkpoint inhibitor response in advanced head and neck squamous cell carcinoma.

Sridharan V, Rahman RM, Huang RY, Chau NG, Lorch JH, Uppaluri R, Haddad RI, Hanna GJ, Schoenfeld JD.

Oral Oncol. 2018 Oct;85:29-34. doi: 10.1016/j.oraloncology.2018.08.005. Epub 2018 Aug 17.


Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.

Mao XW, Byrum S, Nishiyama NC, Pecaut MJ, Sridharan V, Boerma M, Tackett AJ, Shiba D, Shirakawa M, Takahashi S, Delp MD.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2546. doi: 10.3390/ijms19092546.


Late effects of 1H irradiation on hippocampal physiology.

Kiffer F, Howe AK, Carr H, Wang J, Alexander T, Anderson JE, Groves T, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR.

Life Sci Space Res (Amst). 2018 May;17:51-62. doi: 10.1016/j.lssr.2018.03.004. Epub 2018 Mar 15.


Lipase-Catalyzed Synthesis of Furan-Based Oligoesters and their Self-Assembly-Assisted Polymerization.

Muthusamy K, Lalitha K, Prasad YS, Thamizhanban A, Sridharan V, Maheswari CU, Nagarajan S.

ChemSusChem. 2018 Jul 20;11(14):2453-2463. doi: 10.1002/cssc.201800446. Epub 2018 Jul 3.


Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells.

Mao XW, Boerma M, Rodriguez D, Campbell-Beachler M, Jones T, Stanbouly S, Sridharan V, Wroe A, Nelson GA.

Radiat Res. 2018 Jul;190(1):45-52. doi: 10.1667/RR14977.1. Epub 2018 May 9.


Trajectories of 12-Month Usage Patterns for Two Smoking Cessation Websites: Exploring How Users Engage Over Time.

Bricker JB, Sridharan V, Zhu Y, Mull KE, Heffner JL, Watson NL, McClure JB, Di C.

J Med Internet Res. 2018 Apr 20;20(4):e10143. doi: 10.2196/10143.


Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice.

Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

PLoS One. 2017 Dec 12;12(12):e0189466. doi: 10.1371/journal.pone.0189466. eCollection 2017.


Effects of 1H + 16O Charged Particle Irradiation on Short-Term Memory and Hippocampal Physiology in a Murine Model.

Kiffer F, Carr H, Groves T, Anderson JE, Alexander T, Wang J, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR.

Radiat Res. 2018 Jan;189(1):53-63. doi: 10.1667/RR14843.1. Epub 2017 Nov 14.


Disassembly of Bacterial Biofilms by the Self-Assembled Glycolipids Derived from Renewable Resources.

Prasad YS, Miryala S, Lalitha K, Ranjitha K, Barbhaiwala S, Sridharan V, Maheswari CU, Srinandan CS, Nagarajan S.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40047-40058. doi: 10.1021/acsami.7b12225. Epub 2017 Nov 10.


Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.

Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK.

Microbiome. 2017 Aug 18;5(1):105. doi: 10.1186/s40168-017-0325-z.


Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice.

Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

Int J Radiat Biol. 2017 Dec;93(12):1312-1320. doi: 10.1080/09553002.2017.1356941. Epub 2017 Aug 7.


Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.

Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M.

PLoS One. 2017 Jul 5;12(7):e0180594. doi: 10.1371/journal.pone.0180594. eCollection 2017.


Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.

Lu X, Nowicka U, Sridharan V, Liu F, Randles L, Hymel D, Dyba M, Tarasov SG, Tarasova NI, Zhao XZ, Hamazaki J, Murata S, Burke TR Jr, Walters KJ.

Nat Commun. 2017 Jun 9;8:15540. doi: 10.1038/ncomms15540.


Salivary and serum HPV antibody levels before and after definitive treatment in patients with oropharyngeal squamous cell carcinoma.

Hanna GJ, Sridharan V, Margalit DN, La Follette SK, Chau NG, Rabinowits G, Lorch JH, Haddad RI, Tishler RB, Anderson KS, Schoenfeld JD.

Cancer Biomark. 2017;19(2):129-136. doi: 10.3233/CBM-160071.


Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model.

Sridharan V, Seawright JW, Antonawich FJ, Garnett M, Cao M, Singh P, Boerma M.

Radiat Res. 2017 Mar;187(3):361-366. doi: 10.1667/RR14643.1. Epub 2017 Feb 23.


Morphology transition in helical tubules of a supramolecular gel driven by metal ions.

Lalitha K, Sridharan V, Maheswari CU, Vemula PK, Nagarajan S.

Chem Commun (Camb). 2017 Jan 26;53(9):1538-1541. doi: 10.1039/c6cc09120b.


Effects of ionizing radiation on the heart.

Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M.

Mutat Res. 2016 Oct - Dec;770(Pt B):319-327. doi: 10.1016/j.mrrev.2016.07.003. Epub 2016 Jul 10. Review.


Merkel Cell Carcinoma: A Population Analysis on Survival.

Sridharan V, Muralidhar V, Margalit DN, Tishler RB, DeCaprio JA, Thakuria M, Rabinowits G, Schoenfeld JD.

J Natl Compr Canc Netw. 2016 Oct;14(10):1247-1257.


Synthesis of 6,12-Epiminodibenzo[b,f][1,5]diazocines via an Ytterbium Triflate-Catalyzed, AB2 Three-Component Reaction.

Muthukrishnan I, Karuppasamy M, Nagarajan S, Maheswari CU, Pace V, Menéndez JC, Sridharan V.

J Org Chem. 2016 Oct 21;81(20):9687-9694. Epub 2016 Oct 5.


Metal-free oxidative amidation of aldehydes with aminopyridines employing aqueous hydrogen peroxide.

Sankari Devi E, Alanthadka A, Tamilselvi A, Nagarajan S, Sridharan V, Maheswari CU.

Org Biomol Chem. 2016 Sep 21;14(35):8228-31. doi: 10.1039/c6ob01454b. Epub 2016 Aug 15.


Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer.

Sridharan V, Margalit DN, Lynch SA, Severgnini M, Zhou J, Chau NG, Rabinowits G, Lorch JH, Hammerman PS, Hodi FS, Haddad RI, Tishler RB, Schoenfeld JD.

Br J Cancer. 2016 Jul 12;115(2):252-60. doi: 10.1038/bjc.2016.166. Epub 2016 Jul 5.


Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.

Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

PLoS One. 2016 Jul 1;11(7):e0158097. doi: 10.1371/journal.pone.0158097. eCollection 2016.


Palladium-Catalyzed Internal Nucleophile-Assisted Hydration-Olefin Insertion Cascade: Diastereoselective Synthesis of 2,3-Dihydro-1H-inden-1-ones.

Vinoth P, Nagarajan S, Maheswari CU, Sudalai A, Pace V, Sridharan V.

Org Lett. 2016 Jul 15;18(14):3442-5. doi: 10.1021/acs.orglett.6b01623. Epub 2016 Jun 29.


Effects of definitive chemoradiation on circulating immunologic angiogenic cytokines in head and neck cancer patients.

Sridharan V, Margalit DN, Lynch SA, Severgnini M, Hodi FS, Haddad RI, Tishler RB, Schoenfeld JD.

J Immunother Cancer. 2016 Jun 21;4:32. doi: 10.1186/s40425-016-0138-9. eCollection 2016.


Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes.

Sridharan V, Gjini E, Liao X, Chau NG, Haddad RI, Severgnini M, Hammerman P, El-Naggar A, Freeman GJ, Hodi FS, Rodig SJ, Dranoff G, Schoenfeld JD.

Cancer Immunol Res. 2016 Aug;4(8):679-87. doi: 10.1158/2326-6066.CIR-16-0031. Epub 2016 Jun 16.


Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart.

Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M.

Radiother Oncol. 2016 May;119(2):259-64. doi: 10.1016/j.radonc.2016.03.027. Epub 2016 Apr 9.


Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M.

Mutat Res. 2016 May;787:43-53. doi: 10.1016/j.mrfmmm.2016.02.009. Epub 2016 Mar 2.


A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation.

Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA, Boerma M.

Life Sci Space Res (Amst). 2016 Feb;8:8-13. doi: 10.1016/j.lssr.2015.12.001. Epub 2015 Dec 14.


High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis.

Sridharan V, Heimiller J, Robida MD, Singh R.

PLoS One. 2016 Mar 4;11(3):e0150768. doi: 10.1371/journal.pone.0150768. eCollection 2016.


Space radiation and cardiovascular disease risk.

Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M.

World J Cardiol. 2015 Dec 26;7(12):882-8. doi: 10.4330/wjc.v7.i12.882. Review.

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