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Items: 16


The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.

Yoshigae Y, Sridar C, Kent UM, Hollenberg PF.

Drug Metab Dispos. 2013 Apr;41(4):858-69. doi: 10.1124/dmd.112.050609. Epub 2013 Jan 31.


Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches.

Sridar C, Hanna I, Hollenberg PF.

Xenobiotica. 2013 Apr;43(4):336-45. doi: 10.3109/00498254.2012.719089. Epub 2012 Sep 3.


Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.

Sridar C, D'Agostino J, Hollenberg PF.

Drug Metab Dispos. 2012 Dec;40(12):2280-8. doi: 10.1124/dmd.112.047266. Epub 2012 Aug 31.


Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts.

Sridar C, Kenaan C, Hollenberg PF.

Drug Metab Dispos. 2012 Dec;40(12):2256-66. doi: 10.1124/dmd.112.046979. Epub 2012 Aug 30.


Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

Sridar C, Snider NT, Hollenberg PF.

Drug Metab Dispos. 2011 May;39(5):782-8. doi: 10.1124/dmd.110.036707. Epub 2011 Feb 2.


Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.

Kent UM, Sridar C, Spahlinger G, Hollenberg PF.

Chem Res Toxicol. 2008 Oct;21(10):1956-63. doi: 10.1021/tx800138v. Epub 2008 Aug 26.


The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

Snider NT, Sikora MJ, Sridar C, Feuerstein TJ, Rae JM, Hollenberg PF.

J Pharmacol Exp Ther. 2008 Nov;327(2):538-45. doi: 10.1124/jpet.108.141796. Epub 2008 Aug 12.


Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether.

Sridar C, Kent UM, Noon K, McCall A, Alworth B, Foroozesh M, Hollenberg PF.

Drug Metab Dispos. 2008 Nov;36(11):2234-43. doi: 10.1124/dmd.108.021493. Epub 2008 Jul 24.


Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.

Kobayashi Y, Sridar C, Kent UM, Puppali SG, Rimoldi JM, Zhang H, Waskell L, Hollenberg PF.

Drug Metab Dispos. 2006 Dec;34(12):2102-10. Epub 2006 Sep 22.


Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.

Sridar C, Kobayashi Y, Brevig H, Kent UM, Puppali SG, Rimoldi JM, Hollenberg PF.

Drug Metab Dispos. 2006 Nov;34(11):1849-55. Epub 2006 Aug 1.


Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism.

Sridar C, Harleton E, Hollenberg PF.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):386-93. Epub 2005 Sep 2.


The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.

Bumpus NN, Sridar C, Kent UM, Hollenberg PF.

Drug Metab Dispos. 2005 Jun;33(6):795-802. Epub 2005 Mar 15.


Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.

Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF.

Drug Metab Dispos. 2004 Jun;32(6):587-94.


Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.

Sridar C, Kent UM, Notley LM, Gillam EM, Hollenberg PF.

J Pharmacol Exp Ther. 2002 Jun;301(3):945-52.

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