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Items: 12



Sreevalsan S, Safe S.

Curr Colorectal Cancer Rep. 2013 Dec;9(4):350-357.


Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.

Nair V, Sreevalsan S, Basha R, Abdelrahim M, Abudayyeh A, Rodrigues Hoffman A, Safe S.

J Biol Chem. 2014 Oct 3;289(40):27692-701. doi: 10.1074/jbc.M114.592576. Epub 2014 Aug 20.


Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target.

Safe S, Imanirad P, Sreevalsan S, Nair V, Jutooru I.

Expert Opin Ther Targets. 2014 Jul;18(7):759-69. doi: 10.1517/14728222.2014.914173. Epub 2014 May 3. Review.


The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.

Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S.

Mol Cancer Res. 2014 Apr;12(4):527-538. doi: 10.1158/1541-7786.MCR-13-0567. Epub 2014 Feb 10.


The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.

Sreevalsan S, Safe S.

Mol Cancer Ther. 2013 Nov;12(11):2483-93. doi: 10.1158/1535-7163.MCT-13-0486. Epub 2013 Sep 12.


Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S.

Carcinogenesis. 2013 Dec;34(12):2870-9. doi: 10.1093/carcin/bgt231. Epub 2013 Jun 26.


Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.

Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S.

Int J Cancer. 2013 Feb 15;132(4):795-806. doi: 10.1002/ijc.27730. Epub 2012 Aug 3. Erratum in: Int J Cancer. 2015 Sep 15;137(6):E9.


Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.

Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH.

Anticancer Res. 2011 Nov;31(11):3799-807.


Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.

Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.


GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.

Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S.

Mol Cancer Res. 2011 Feb;9(2):195-202. doi: 10.1158/1541-7786.MCR-10-0363. Epub 2010 Dec 14.


Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.

Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.

Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.

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