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Items: 1 to 50 of 168

1.

Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells.

Yossipof TE, Bazak ZR, Kenigsbuch-Sredni D, Caspi RR, Kalechman Y, Sredni B.

Front Immunol. 2019 May 29;10:979. doi: 10.3389/fimmu.2019.00979. eCollection 2019.

2.

AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

Bing SJ, Shemesh I, Chong WP, Horai R, Jittayasothorn Y, Silver PB, Sredni B, Caspi RR.

J Autoimmun. 2019 Jun;100:52-61. doi: 10.1016/j.jaut.2019.02.006. Epub 2019 Mar 8.

PMID:
30853312
3.

The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') tellurate reduces anxiety-like behavior and corticosterone levels of submissive mice.

Gross M, Stanciu E, Kenigsbuch-Sredni D, Sredni B, Pinhasov A.

Behav Pharmacol. 2017 Sep;28(6):458-465. doi: 10.1097/FBP.0000000000000319.

PMID:
28590303
4.

The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation.

Hachmo Y, Kalechman Y, Skornick I, Gafter U, Caspi RR, Sredni B.

Front Immunol. 2017 Mar 7;8:240. doi: 10.3389/fimmu.2017.00240. eCollection 2017.

5.

Ligand-Substitution Reactions of the Tellurium Compound AS-101 in Physiological Aqueous and Alcoholic Solutions.

Silberman A, Albeck M, Sredni B, Albeck A.

Inorg Chem. 2016 Nov 7;55(21):10847-10850. Epub 2016 Oct 11.

PMID:
27726342
6.

The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.

Dardik R, Livnat T, Halpert G, Jawad S, Nisgav Y, Azar-Avivi S, Liu B, Nussenblatt RB, Weinberger D, Sredni B.

Mol Vis. 2016 May 28;22:548-62. eCollection 2016.

7.

The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation.

Silberman A, Kalechman Y, Hirsch S, Erlich Z, Sredni B, Albeck A.

Chembiochem. 2016 May 17;17(10):918-27. doi: 10.1002/cbic.201500614. Epub 2016 Apr 25.

PMID:
26991356
8.

The immunomodulator, ammonium trichloro[1,2-ethanediolato-O,O']-tellurate, suppresses the propagation of herpes simplex virus 2 by reducing the infectivity of the virus progeny.

Sheinboim D, Hindiyeh M, Mendelson E, Albeck M, Sredni B, Dovrat S.

Int J Mol Med. 2015 Jul;36(1):231-8. doi: 10.3892/ijmm.2015.2197. Epub 2015 Apr 24.

PMID:
25936393
9.

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Shaham L, Vendramini E, Ge Y, Goren Y, Birger Y, Tijssen MR, McNulty M, Geron I, Schwartzman O, Goldberg L, Chou ST, Pitman H, Weiss MJ, Michaeli S, Sredni B, Göttgens B, Crispino JD, Taub JW, Izraeli S.

Blood. 2015 Feb 19;125(8):1292-301. doi: 10.1182/blood-2014-06-581892. Epub 2014 Dec 22. Erratum in: Blood. 2016 Apr 21;127(16):2042.

10.

AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway.

Shemesh II, Rozen-Zvi B, Kalechman Y, Gafter U, Sredni B.

PLoS One. 2014 Dec 4;9(12):e114287. doi: 10.1371/journal.pone.0114287. eCollection 2014.

11.

Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane-Induced Death by AS101 via Inhibition of the VLA-4-IL10-Survivin Axis.

Danoch H, Kalechman Y, Albeck M, Longo DL, Sredni B.

Mol Cancer Res. 2015 Mar;13(3):411-22. doi: 10.1158/1541-7786.MCR-14-0459. Epub 2014 Oct 28.

12.

The effect of the novel tellurium compound AS101 on autoimmune diseases.

Halpert G, Sredni B.

Autoimmun Rev. 2014 Dec;13(12):1230-5. doi: 10.1016/j.autrev.2014.08.003. Epub 2014 Aug 19. Review.

PMID:
25153485
13.

The immunomodulator AS101 suppresses production of inflammatory cytokines and ameliorates the pathogenesis of experimental autoimmune encephalomyelitis.

Xie L, Chen J, McMickle A, Awar N, Nady S, Sredni B, Drew PD, Yu S.

J Neuroimmunol. 2014 Aug 15;273(1-2):31-41. doi: 10.1016/j.jneuroim.2014.05.015. Epub 2014 Jun 7.

14.

Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis.

Halpert G, Eitan T, Voronov E, Apte RN, Rath-Wolfson L, Albeck M, Kalechman Y, Sredni B.

J Biol Chem. 2014 Jun 13;289(24):17215-27. doi: 10.1074/jbc.M113.536664. Epub 2014 Apr 24.

15.

Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state.

Layani-Bazar A, Skornick I, Berrebi A, Pauker MH, Noy E, Silberman A, Albeck M, Longo DL, Kalechman Y, Sredni B.

Cancer Res. 2014 Jun 1;74(11):3092-103. doi: 10.1158/0008-5472.CAN-13-2159. Epub 2014 Apr 3.

16.

Antibacterial effects of the tellurium compound OTD on E. coli isolates.

Yalew R, Kenigsbuch-Sredni D, Sredni B, Nitzan Y.

Arch Microbiol. 2014 Jan;196(1):51-61. doi: 10.1007/s00203-013-0941-3. Epub 2013 Dec 10.

PMID:
24322541
17.

Tellurium compound AS101 ameliorates experimental autoimmune encephalomyelitis by VLA-4 inhibition and suppression of monocyte and T cell infiltration into the CNS.

Lee JH, Halperin-Sheinfeld M, Baatar D, Mughal MR, Tae HJ, Kim JW, Carter A, Lustig A, Snir O, Lavie G, Okun E, Mattson MP, Sredni B, Taub DD.

Neuromolecular Med. 2014 Jun;16(2):292-307. doi: 10.1007/s12017-013-8277-3. Epub 2013 Nov 23.

18.

Cyclophosphamide triggers follicle activation and "burnout"; AS101 prevents follicle loss and preserves fertility.

Kalich-Philosoph L, Roness H, Carmely A, Fishel-Bartal M, Ligumsky H, Paglin S, Wolf I, Kanety H, Sredni B, Meirow D.

Sci Transl Med. 2013 May 15;5(185):185ra62. doi: 10.1126/scitranslmed.3005402.

19.

The tellurium redox immunomodulating compound AS101 inhibits IL-1β-activated inflammation in the human retinal pigment epithelium.

Ling D, Liu B, Jawad S, Thompson IA, Nagineni CN, Dailey J, Chien J, Sredni B, Nussenblatt RB.

Br J Ophthalmol. 2013 Jul;97(7):934-8. doi: 10.1136/bjophthalmol-2012-301962. Epub 2013 Apr 27.

PMID:
23624272
20.

Cellular immune function monitoring after allogeneic haematopoietic cell transplantation: evaluation of a new assay.

Israeli M, Klein T, Herscovici C, Ram R, Shpilberg O, Sredni B, Yeshurun M.

Clin Exp Immunol. 2013 Jun;172(3):475-82. doi: 10.1111/cei.12072.

21.

The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.

Halperin-Sheinfeld M, Gertler A, Okun E, Sredni B, Cohen HY.

Aging (Albany NY). 2012 Jun;4(6):436-47.

22.

Multiple signal transduction pathways are involved in G2/M growth arrest and apoptosis induced by the immunomodulator AS101 in multiple myeloma.

Naor Y, Hayun M, Sredni B, Don J.

Leuk Lymphoma. 2013 Jan;54(1):160-6. doi: 10.3109/10428194.2012.704032. Epub 2012 Sep 5.

PMID:
22712839
23.

The immune-modulator AS101 reduces anti-HLA antibodies in sera of sensitized patients: a structural approach.

Israeli M, Sredni B, Mor E, Zakai C, Tadmor B, Klein T.

Int Immunopharmacol. 2012 Aug;13(4):483-9. doi: 10.1016/j.intimp.2012.05.019. Epub 2012 Jun 7.

PMID:
22683182
24.

Bactericidal activity of the organo-tellurium compound AS101 against Enterobacter cloacae.

Daniel-Hoffmann M, Sredni B, Nitzan Y.

J Antimicrob Chemother. 2012 Sep;67(9):2165-72. doi: 10.1093/jac/dks185. Epub 2012 May 24.

PMID:
22628247
25.

In vitro and in vivo activity of AS101 against West Nile virus (WNV).

Indenbaum V, Bin H, Makarovsky D, Weil M, Shulman LM, Albeck M, Sredni B, Mendelson E.

Virus Res. 2012 Jun;166(1-2):68-76. doi: 10.1016/j.virusres.2012.03.004. Epub 2012 Mar 14.

PMID:
22445690
26.

Ribonuclease activity of p53 in cytoplasm in response to various stress signals.

Derech-Haim S, Teiblum G, Kadosh R, Rahav G, Bonda E, Sredni B, Bakhanashvili M.

Cell Cycle. 2012 Apr 1;11(7):1400-13. doi: 10.4161/cc.19812. Epub 2012 Apr 1.

PMID:
22421154
27.

Cancer immunotherapy: are we there yet?

Sredni B, Longo DL.

Semin Cancer Biol. 2012 Feb;22(1):1-2. doi: 10.1016/j.semcancer.2012.01.001. Epub 2012 Jan 8. No abstract available.

PMID:
22240249
28.

Immunomodulating tellurium compounds as anti-cancer agents.

Sredni B.

Semin Cancer Biol. 2012 Feb;22(1):60-9. doi: 10.1016/j.semcancer.2011.12.003. Epub 2011 Dec 21. Review.

PMID:
22202556
29.
30.

Individualized immune monitoring of cardiac transplant recipients by noninvasive longitudinal cellular immunity tests.

Israeli M, Ben-Gal T, Yaari V, Valdman A, Matz I, Medalion B, Battler A, Sredni B, Kristt D, Klein T.

Transplantation. 2010 Apr 27;89(8):968-76. doi: 10.1097/TP.0b013e3181cbabe6.

PMID:
20075792
31.

Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury.

Brodsky M, Hirsh S, Albeck M, Sredni B.

J Hepatol. 2009 Sep;51(3):491-503. doi: 10.1016/j.jhep.2009.04.024. Epub 2009 Jun 6.

PMID:
19595469
32.

A potential antimicrobial treatment against ESBL-producing Klebsiella pneumoniae using the tellurium compound AS101.

Daniel-Hoffmann M, Albeck M, Sredni B, Nitzan Y.

Arch Microbiol. 2009 Aug;191(8):631-8. doi: 10.1007/s00203-009-0490-y. Epub 2009 Jun 16.

PMID:
19529918
33.

REM sleep deprivation in rats results in inflammation and interleukin-17 elevation.

Yehuda S, Sredni B, Carasso RL, Kenigsbuch-Sredni D.

J Interferon Cytokine Res. 2009 Jul;29(7):393-8. doi: 10.1089/jir.2008.0080.

PMID:
19450150
34.

A new genetic isolate of acrodermatitis enteropathica with a novel mutation.

Vardi A, Anikster Y, Eisenkraft A, Shohat M, Abu-Much J, Eisenkraft S, Sredni B, Nir U.

Br J Dermatol. 2009 Jun;160(6):1346-8. doi: 10.1111/j.1365-2133.2009.09128.x. Epub 2009 Apr 16. No abstract available.

PMID:
19416242
35.

Induction therapy in a multiple myeloma mouse model using a combination of AS101 and melphalan, and the activity of AS101 in a tumor microenvironment model.

Hayun M, Saida H, Albeck M, Peled A, Haran-Ghera N, Sredni B.

Exp Hematol. 2009 May;37(5):593-603. doi: 10.1016/j.exphem.2009.01.006.

PMID:
19375650
36.

Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.

Hayun R, Okun E, Berrebi A, Shvidel L, Bassous L, Sredni B, Nir U.

Leuk Lymphoma. 2009 Apr;50(4):625-32. doi: 10.1080/10428190902789181.

PMID:
19373661
37.

The cyclin kinase inhibitor p57kip2 regulates TGF-beta-induced compensatory tubular hypertrophy: effect of the immunomodulator AS101.

Sinuani I, Weissgarten J, Beberashvili I, Rapoport MJ, Sandbank J, Feldman L, Albeck M, Averbukh Z, Sredni B.

Nephrol Dial Transplant. 2009 Aug;24(8):2328-38. doi: 10.1093/ndt/gfn742. Epub 2009 Mar 25.

PMID:
19321762
38.

Protective effect of the immunomodulator AS101 against cyclophosphamide-induced testicular damage in mice.

Carmely A, Meirow D, Peretz A, Albeck M, Bartoov B, Sredni B.

Hum Reprod. 2009 Jun;24(6):1322-9. doi: 10.1093/humrep/den481. Epub 2009 Feb 24.

PMID:
19240057
39.

Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression-An Animal Model Study.

Malkesman O, Asaf T, Shbiro L, Goldstein A, Maayan R, Weizman A, Kinor N, Okun E, Sredni B, Yadid G, Weller A.

Adv Pharmacol Sci. 2009;2009:405107. doi: 10.1155/2009/405107. Epub 2009 Oct 18.

40.

Topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator AS101: assessment of its safety and efficacy.

Friedman M, Bayer I, Letko I, Duvdevani R, Zavaro-Levy O, Ron B, Albeck M, Sredni B.

Br J Dermatol. 2009 Feb;160(2):403-8. doi: 10.1111/j.1365-2133.2008.08853.x. Epub 2008 Sep 19.

PMID:
18808418
41.

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer.

Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP, Rubinek T.

Oncogene. 2008 Nov 27;27(56):7094-105. doi: 10.1038/onc.2008.292. Epub 2008 Sep 1.

PMID:
18762812
42.

ImmuKnow: a new parameter in immune monitoring of pediatric liver transplantation recipients.

Israeli M, Klein T, Sredni B, Avitzur Y, Mor E, Bar-Nathen N, Steinberg R, Dinari G, Shapiro R.

Liver Transpl. 2008 Jun;14(6):893-8. doi: 10.1002/lt.21426.

43.

Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101.

Frei GM, Kremer M, Hanschmann KM, Krause S, Albeck M, Sredni B, Schnierle BS.

Br J Dermatol. 2008 Mar;158(3):578-86. doi: 10.1111/j.1365-2133.2007.08414.x. Epub 2008 Jan 30.

PMID:
18241275
44.
45.

Neutral and positively charged thiols synergize the effect of the immunomodulator AS101 as a growth inhibitor of Jurkat cells, by increasing its uptake.

Frei GM, Lebenthal I, Albeck M, Albeck A, Sredni B.

Biochem Pharmacol. 2007 Sep 1;74(5):712-22. Epub 2007 May 18.

PMID:
17632085
46.

Preceeding the rejection: in search for a comprehensive post-transplant immune monitoring platform.

Israeli M, Yussim A, Mor E, Sredni B, Klein T.

Transpl Immunol. 2007 Jul;18(1):7-12. Epub 2007 Apr 9.

PMID:
17584596
47.

The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme.

Brodsky M, Yosef S, Galit R, Albeck M, Longo DL, Albeck A, Sredni B.

J Interferon Cytokine Res. 2007 Jun;27(6):453-62.

PMID:
17572009
48.

The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice.

Okun E, Arumugam TV, Tang SC, Gleichmann M, Albeck M, Sredni B, Mattson MP.

J Neurochem. 2007 Aug;102(4):1232-41. Epub 2007 Apr 30.

49.

The organotellurium compound ammonium trichloro(dioxoethylene-o,o')tellurate reacts with homocysteine to form homocystine and decreases homocysteine levels in hyperhomocysteinemic mice.

Okun E, Dikshtein Y, Carmely A, Saida H, Frei G, Sela BA, Varshavsky L, Ofir A, Levy E, Albeck M, Sredni B.

FEBS J. 2007 Jun;274(12):3159-70. Epub 2007 May 22.

50.

Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model.

Hayun M, Okun E, Hayun R, Gafter U, Albeck M, Longo DL, Sredni B.

Leukemia. 2007 Jul;21(7):1504-13. Epub 2007 May 17.

PMID:
17508000

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