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Mammalian muscle fibers may be simple as well as slow.

Squire JM, Luther PK.

J Gen Physiol. 2019 Nov 8. pii: jgp.201912478. doi: 10.1085/jgp.201912478. [Epub ahead of print] No abstract available.


Myosin Cross-Bridge Behaviour in Contracting Muscle-The T1 Curve of Huxley and Simmons (1971) Revisited.

Knupp C, Squire JM.

Int J Mol Sci. 2019 Oct 2;20(19). pii: E4892. doi: 10.3390/ijms20194892.


Monitoring the myosin crossbridge cycle in contracting muscle: steps towards 'Muscle-the Movie'.

Eakins F, Knupp C, Squire JM.

J Muscle Res Cell Motil. 2019 Jun;40(2):77-91. doi: 10.1007/s10974-019-09543-9. Epub 2019 Jul 20.


Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis.

Sakita JY, Bader M, Santos ES, Garcia SB, Minto SB, Alenina N, Brunaldi MO, Carvalho MC, Vidotto T, Gasparotto B, Martins RB, Silva WA Jr, Brandão ML, Leite CA, Cunha FQ, Karsenty G, Squire JA, Uyemura SA, Kannen V.

J Pathol. 2019 Sep;249(1):102-113. doi: 10.1002/path.5285. Epub 2019 Jun 27.


PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Vidotto T, Saggioro FP, Jamaspishvili T, Chesca DL, Picanço de Albuquerque CG, Reis RB, Graham CH, Berman DM, Siemens DR, Squire JA, Koti M.

Prostate. 2019 Jun;79(9):969-979. doi: 10.1002/pros.23808. Epub 2019 Apr 18.


Supersonic plasma turbulence in the laboratory.

White TG, Oliver MT, Mabey P, Kühn-Kauffeldt M, Bott AFA, Döhl LNK, Bell AR, Bingham R, Clarke R, Foster J, Giacinti G, Graham P, Heathcote R, Koenig M, Kuramitsu Y, Lamb DQ, Meinecke J, Michel T, Miniati F, Notley M, Reville B, Ryu D, Sarkar S, Sakawa Y, Selwood MP, Squire J, Scott RHH, Tzeferacos P, Woolsey N, Schekochihin AA, Gregori G.

Nat Commun. 2019 Apr 15;10(1):1758. doi: 10.1038/s41467-019-09498-y.


Turbulence and jet-driven zonal flows: Secondary circulation in rotating fluids due to asymmetric forcing.

Burin MJ, Caspary KJ, Edlund EM, Ezeta R, Gilson EP, Ji H, McNulty M, Squire J, Tynan GR.

Phys Rev E. 2019 Feb;99(2-1):023108. doi: 10.1103/PhysRevE.99.023108.


Antibiotic Prophylaxis for Dental Treatment in Patients with Immunodeficiency.

Squire JD, Gardner PJ, Moutsopoulos NM, Leiding JW.

J Allergy Clin Immunol Pract. 2019 Mar;7(3):819-823. doi: 10.1016/j.jaip.2019.01.016. Epub 2019 Jan 21. Review.


The Terry Fox Research Institute Canadian Prostate Cancer Biomarker Network: an analysis of a pan-Canadian multi-center cohort for biomarker validation.

Ouellet V, Aprikian A, Bergeron A, Brimo F, Bristow RG, Chevalier S, Drachenberg D, Fazli L, Fleshner NE, Gleave M, Karakiewicz P, Klotz L, Lacombe L, Lattouf JB, van der Kwast T, Squire JA, Latour M, Trudel D, Mes-Masson AM, Saad F.

BMC Urol. 2018 Sep 10;18(1):78. doi: 10.1186/s12894-018-0392-x.


Different Myosin Head Conformations in Bony Fish Muscles Put into Rigor at Different Sarcomere Lengths.

Eakins F, Harford JJ, Knupp C, Roessle M, Squire JM.

Int J Mol Sci. 2018 Jul 18;19(7). pii: E2091. doi: 10.3390/ijms19072091.


Pressure-anisotropy-induced nonlinearities in the kinetic magnetorotational instability.

Squire J, Quataert E, Kunz MW.

J Plasma Phys. 2017 Dec;83(6). pii: 905830613. doi: 10.1017/S0022377817000940. Epub 2017 Dec 18.


Correction to: Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections.

Yoshimoto M, Ludkovski O, Good J, Pereira C, Gooding RJ, McGowan-Jordan J, Boag A, Evans A, Tsao MS, Nuin P, Squire JA.

Lab Invest. 2018 Jun;98(6):839. doi: 10.1038/s41374-018-0037-4.


Clinical implications of PTEN loss in prostate cancer.

Jamaspishvili T, Berman DM, Ross AE, Scher HI, De Marzo AM, Squire JA, Lotan TL.

Nat Rev Urol. 2018 Apr;15(4):222-234. doi: 10.1038/nrurol.2018.9. Epub 2018 Feb 20. Review.


The factors affecting household transmission dynamics and community compliance with Ebola control measures: a mixed-methods study in a rural village in Sierra Leone.

Caleo G, Duncombe J, Jephcott F, Lokuge K, Mills C, Looijen E, Theoharaki F, Kremer R, Kleijer K, Squire J, Lamin M, Stringer B, Weiss HA, Culli D, Di Tanna GL, Greig J.

BMC Public Health. 2018 Feb 13;18(1):248. doi: 10.1186/s12889-018-5158-6.


Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections.

Yoshimoto M, Ludkovski O, Good J, Pereira C, Gooding RJ, McGowan-Jordan J, Boag A, Evans A, Tsao MS, Nuin P, Squire JA.

Lab Invest. 2018 Apr;98(4):403-413. doi: 10.1038/s41374-017-0007-2. Epub 2018 Jan 16. Review. Erratum in: Lab Invest. 2018 Mar 8;:.


Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer.

Vidotto T, Tiezzi DG, Squire JA.

Mol Cytogenet. 2018 Jan 3;11:1. doi: 10.1186/s13039-017-0348-y. eCollection 2018.


Increased STAT1 Expression in High Grade Serous Ovarian Cancer Is Associated With a Better Outcome.

Josahkian JA, Saggioro FP, Vidotto T, Ventura HT, Candido Dos Reis FJ, de Sousa CB, Tiezzi DG, de Andrade JM, Koti M, Squire JA.

Int J Gynecol Cancer. 2018 Mar;28(3):459-465. doi: 10.1097/IGC.0000000000001193.


Publisher's Note: Kinetic Simulations of the Interruption of Large-Amplitude Shear-Alfvén Waves in a High-β Plasma [Phys. Rev. Lett. 119, 155101 (2017)].

Squire J, Kunz MW, Quataert E, Schekochihin AA.

Phys Rev Lett. 2017 Oct 27;119(17):179901. doi: 10.1103/PhysRevLett.119.179901. Epub 2017 Oct 27.


Kinetic Simulations of the Interruption of Large-Amplitude Shear-Alfvén Waves in a High-β Plasma.

Squire J, Kunz MW, Quataert E, Schekochihin AA.

Phys Rev Lett. 2017 Oct 13;119(15):155101. doi: 10.1103/PhysRevLett.119.155101. Epub 2017 Oct 12. Erratum in: Phys Rev Lett. 2017 Oct 27;119(17 ):179901.


Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study.

Pinheiro CA, Soares IC, Penna V, Squire J, Reis RMV, da Silva SRM, de Carvalho I, Camparoto ML, da Silva MFZ, Longatto Filho AL.

Oncol Lett. 2017 Mar;13(3):1835. doi: 10.3892/ol.2017.5633. Epub 2017 Jan 23.


Complex Mosaic Ring Chromosome 11 Associated with Hemizygous Loss of 8.6 Mb of 11q24.2qter in Atypical Jacobsen Syndrome.

Galvão Gomes A, Paiva Grangeiro CH, Silva LR, Oliveira-Gennaro FG, Pereira CS, Joaquim TM, Panepucci RA, Squire JA, Martelli L.

Mol Syndromol. 2017 Jan;8(1):45-49. doi: 10.1159/000452681. Epub 2016 Nov 17.


Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism.

Paul DM, Squire JM, Morris EP.

J Struct Biol. 2017 Mar;197(3):365-371. doi: 10.1016/j.jsb.2017.01.004. Epub 2017 Feb 1.


Myosin and Actin Filaments in Muscle: Structures and Interactions.

Squire JM, Paul DM, Morris EP.

Subcell Biochem. 2017;82:319-371. doi: 10.1007/978-3-319-49674-0_11. Review.


Fibrous Protein Structures: Hierarchy, History and Heroes.

Squire JM, Parry DA.

Subcell Biochem. 2017;82:1-33. doi: 10.1007/978-3-319-49674-0_1. Review.


STAT1-associated intratumoural TH1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancer.

Au KK, Le Page C, Ren R, Meunier L, Clément I, Tyrishkin K, Peterson N, Kendall-Dupont J, Childs T, Francis JA, Graham CH, Craig AW, Squire JA, Mes-Masson AM, Koti M.

J Pathol Clin Res. 2016 Sep 19;2(4):259-270. eCollection 2016 Oct.


X-ray Diffraction Evidence for Low Force Actin-Attached and Rigor-Like Cross-Bridges in the Contractile Cycle.

Eakins F, Pinali C, Gleeson A, Knupp C, Squire JM.

Biology (Basel). 2016 Oct 26;5(4). pii: E41.


Muscle contraction: Sliding filament history, sarcomere dynamics and the two Huxleys.

Squire JM.

Glob Cardiol Sci Pract. 2016 Jun 30;2016(2):e201611. doi: 10.21542/gcsp.2016.11. Review.


Inpatient signs and symptoms and factors associated with death in children aged 5 years and younger admitted to two Ebola management centres in Sierra Leone, 2014: a retrospective cohort study.

Shah T, Greig J, van der Plas LM, Achar J, Caleo G, Squire JS, Turay AS, Joshy G, D'Este C, Banks E, Vogt F, Lokuge K.

Lancet Glob Health. 2016 Jul;4(7):e495-501. doi: 10.1016/S2214-109X(16)30097-3.


Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH.

Lotan TL, Wei W, Ludkovski O, Morais CL, Guedes LB, Jamaspishvili T, Lopez K, Hawley ST, Feng Z, Fazli L, Hurtado-Coll A, McKenney JK, Simko J, Carroll PR, Gleave M, Lin DW, Nelson PS, Thompson IM, True LD, Brooks JD, Lance R, Troyer D, Squire JA.

Mod Pathol. 2016 Aug;29(8):904-14. doi: 10.1038/modpathol.2016.88. Epub 2016 May 13.


Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery.

Nawaz M, Fatima F, Nazarenko I, Ekström K, Murtaza I, Anees M, Sultan A, Neder L, Camussi G, Valadi H, Squire JA, Kislinger T.

Expert Rev Proteomics. 2016;13(4):395-409. doi: 10.1586/14789450.2016.1165613. Review.


Successful Control of Ebola Virus Disease: Analysis of Service Based Data from Rural Sierra Leone.

Lokuge K, Caleo G, Greig J, Duncombe J, McWilliam N, Squire J, Lamin M, Veltus E, Wolz A, Kobinger G, de la Vega MA, Gbabai O, Nabieu S, Lamin M, Kremer R, Danis K, Banks E, Glass K.

PLoS Negl Trop Dis. 2016 Mar 9;10(3):e0004498. doi: 10.1371/journal.pntd.0004498. eCollection 2016 Mar.


In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading.

Picanço-Albuquerque CG, Morais CL, Carvalho FL, Peskoe SB, Hicks JL, Ludkovski O, Vidotto T, Fedor H, Humphreys E, Han M, Platz EA, De Marzo AM, Berman DM, Lotan TL, Squire JA.

Virchows Arch. 2016 May;468(5):607-17. doi: 10.1007/s00428-016-1904-2. Epub 2016 Feb 9.


First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16.

Weberpals JI, Amin MS, Chen BE, Tu D, Spaans JN, Squire JA, Eisenhauer EA, Virk S, Ma D, Duciaume M, Hoskins P, LeBrun DP.

Gynecol Oncol. 2016 Mar;140(3):486-93. doi: 10.1016/j.ygyno.2016.01.015. Epub 2016 Jan 13.


Lacrimal gland anaplastic kinase-positive large B-cell lymphoma (LBCL-ALK+) with an atypical clinical presentation.

Duarte AF, Squire JA, Chahud F, Cruz AA.

Clin Exp Ophthalmol. 2016 Aug;44(6):520-2. doi: 10.1111/ceo.12702. Epub 2016 Feb 11. No abstract available.


Assessment of the MSF triage system, separating patients into different wards pending Ebola virus laboratory confirmation, Kailahun, Sierra Leone, July to September 2014.

Vogt F, Fitzpatrick G, Patten G, van den Bergh R, Stinson K, Pandolfi L, Squire J, Decroo T, Declerck H, Van Herp M.

Euro Surveill. 2015;20(50). doi: 10.2807/1560-7917.ES.2015.20.50.30097.


A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.

Koti M, Siu A, Clément I, Bidarimath M, Turashvili G, Edwards A, Rahimi K, Mes-Masson AM, Squire JA.

Br J Cancer. 2015 Dec 22;113(12):1746. doi: 10.1038/bjc.2015.459. No abstract available.


Electromotive force due to magnetohydrodynamic fluctuations in sheared rotating turbulence.

Squire J, Bhattacharjee A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Nov;92(5):053101. doi: 10.1103/PhysRevE.92.053101. Epub 2015 Nov 2.


Extracellular Vesicles: Evolving Factors in Stem Cell Biology.

Nawaz M, Fatima F, Vallabhaneni KC, Penfornis P, Valadi H, Ekström K, Kholia S, Whitt JD, Fernandes JD, Pochampally R, Squire JA, Camussi G.

Stem Cells Int. 2016;2016:1073140. doi: 10.1155/2016/1073140. Epub 2015 Nov 16. Review.


Current state of biomarkers in ovarian cancer prognosis.

Au KK, Josahkian JA, Francis JA, Squire JA, Koti M.

Future Oncol. 2015;11(23):3187-95. doi: 10.2217/fon.15.251. Epub 2015 Nov 9. Review.


Generation of Large-Scale Magnetic Fields by Small-Scale Dynamo in Shear Flows.

Squire J, Bhattacharjee A.

Phys Rev Lett. 2015 Oct 23;115(17):175003. doi: 10.1103/PhysRevLett.115.175003. Epub 2015 Oct 20.


A phase II study of the HDAC inhibitor SB939 in patients with castration resistant prostate cancer: NCIC clinical trials group study IND195.

Eigl BJ, North S, Winquist E, Finch D, Wood L, Sridhar SS, Powers J, Good J, Sharma M, Squire JA, Bazov J, Jamaspishvili T, Cox ME, Bradbury PA, Eisenhauer EA, Chi KN.

Invest New Drugs. 2015 Aug;33(4):969-76. doi: 10.1007/s10637-015-0252-4. Epub 2015 May 19.


Understanding the emergence of ebola virus disease in sierra leone: stalking the virus in the threatening wake of emergence.

Wauquier N, Bangura J, Moses L, Humarr Khan S, Coomber M, Lungay V, Gbakie M, Sesay MS, Gassama IA, Massally JL, Gbakima A, Squire J, Lamin M, Kanneh L, Yillah M, Kargbo K, Roberts W, Vandi M, Kargbo D, Vincent T, Jambai A, Guttieri M, Fair J, Souris M, Gonzalez JP.

PLoS Curr. 2015 Apr 20;7. pii: ecurrents.outbreaks.9a6530ab7bb9096b34143230ab01cdef. doi: 10.1371/currents.outbreaks.9a6530ab7bb9096b34143230ab01cdef.


A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.

Troyer DA, Jamaspishvili T, Wei W, Feng Z, Good J, Hawley S, Fazli L, McKenney JK, Simko J, Hurtado-Coll A, Carroll PR, Gleave M, Lance R, Lin DW, Nelson PS, Thompson IM, True LD, Brooks JD, Squire JA.

Prostate. 2015 Aug 1;75(11):1206-15. doi: 10.1002/pros.23003. Epub 2015 May 4.


A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.

Koti M, Siu A, Clément I, Bidarimath M, Turashvili G, Edwards A, Rahimi K, Mes-Masson AM, Squire JA.

Br J Cancer. 2015 Mar 31;112(7):1215-22. doi: 10.1038/bjc.2015.81. Erratum in: Br J Cancer. 2015 Dec 22;113(12):1746. Masson, A-M M [corrected to Mes-Masson, A-M].


Statistical simulation of the magnetorotational dynamo.

Squire J, Bhattacharjee A.

Phys Rev Lett. 2015 Feb 27;114(8):085002. Epub 2015 Feb 26.


ERG/AKR1C3/AR Constitutes a Feed-Forward Loop for AR Signaling in Prostate Cancer Cells.

Powell K, Semaan L, Conley-LaComb MK, Asangani I, Wu YM, Ginsburg KB, Williams J, Squire JA, Maddipati KR, Cher ML, Chinni SR.

Clin Cancer Res. 2015 Jun 1;21(11):2569-79. doi: 10.1158/1078-0432.CCR-14-2352. Epub 2015 Mar 9.


Phase II study of PX-866 in recurrent glioblastoma.

Pitz MW, Eisenhauer EA, MacNeil MV, Thiessen B, Easaw JC, Macdonald DR, Eisenstat DD, Kakumanu AS, Salim M, Chalchal H, Squire J, Tsao MS, Kamel-Reid S, Banerji S, Tu D, Powers J, Hausman DF, Mason WP.

Neuro Oncol. 2015 Sep;17(9):1270-4. doi: 10.1093/neuonc/nou365. Epub 2015 Jan 20.


Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.

Meyer M, Reimand J, Lan X, Head R, Zhu X, Kushida M, Bayani J, Pressey JC, Lionel AC, Clarke ID, Cusimano M, Squire JA, Scherer SW, Bernstein M, Woodin MA, Bader GD, Dirks PB.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):851-6. doi: 10.1073/pnas.1320611111. Epub 2015 Jan 5.


TickBot: a novel robotic device for controlling tick populations in the natural environment.

Gaff HD, White A, Leas K, Kelman P, Squire JC, Livingston DL, Sullivan GA, Baker EW, Sonenshine DE.

Ticks Tick Borne Dis. 2015 Mar;6(2):146-51. doi: 10.1016/j.ttbdis.2014.11.004. Epub 2014 Dec 12.


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