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Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children's Oncology Group.

Mascarenhas L, Chi YY, Hingorani P, Anderson JR, Lyden ER, Rodeberg DA, Indelicato DJ, Kao SC, Dasgupta R, Spunt SL, Meyer WH, Hawkins DS.

J Clin Oncol. 2019 Sep 12:JCO1900576. doi: 10.1200/JCO.19.00576. [Epub ahead of print]


Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group.

Hibbitts E, Chi YY, Hawkins DS, Barr FG, Bradley JA, Dasgupta R, Meyer WH, Rodeberg DA, Rudzinski ER, Spunt SL, Skapek SX, Wolden SL, Arndt CAS.

Cancer Med. 2019 Oct;8(14):6437-6448. doi: 10.1002/cam4.2504. Epub 2019 Aug 27.


Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy.

Chen EL, Yoo CH, Gutkin PM, Merriott DJ, Avedian RS, Steffner RJ, Spunt SL, Pribnow AK, Million L, Donaldson SS, Hiniker SM.

Pediatr Blood Cancer. 2019 Aug 12:e27967. doi: 10.1002/pbc.27967. [Epub ahead of print]


Successful use of frameless stereotactic radiosurgery for treatment of recurrent brain metastases in an 18-month-old child.

Rahimy E, Chuang C, Spunt SL, Mahaney K, Donaldson SS, Gibbs IC, Soltys SG, Pollom EL, Hiniker SM.

Int J Neurosci. 2019 Dec;129(12):1234-1239. doi: 10.1080/00207454.2019.1655015. Epub 2019 Aug 20.


Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children's Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials.

Spunt SL, Francotte N, De Salvo GL, Chi YY, Zanetti I, Hayes-Jordan A, Kao SC, Orbach D, Brennan B, Weiss AR, van Noesel MM, Million L, Alaggio R, Parham DM, Kelsey A, Randall RL, McCarville MB, Bisogno G, Hawkins DS, Ferrari A.

Eur J Cancer. 2019 May;112:98-106. doi: 10.1016/j.ejca.2019.02.001. Epub 2019 Apr 5.


Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children's Oncology Group study ARST0332.

McCarville MB, Kao SC, Dao TV, Gaffney C, Coffin CM, Parham DM, Hayes-Jordan A, Spunt SL.

Pediatr Radiol. 2019 Jun;49(7):922-932. doi: 10.1007/s00247-019-04389-2. Epub 2019 Mar 30.


Digitally enabled patient-reported outcome measures in cancer care - Authors' reply.

Heathcote LC, Goldberg DS, Eccleston C, Spunt SL, Simons LE, Sharpe L, Earp BD.

Lancet Oncol. 2019 Jan;20(1):e3. doi: 10.1016/S1470-2045(18)30910-0. No abstract available.


The addition of cixutumumab or temozolomide to intensive multiagent chemotherapy is feasible but does not improve outcome for patients with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group.

Malempati S, Weigel BJ, Chi YY, Tian J, Anderson JR, Parham DM, Teot LA, Rodeberg DA, Yock TI, Shulkin BL, Spunt SL, Meyer WH, Hawkins DS.

Cancer. 2019 Jan 15;125(2):290-297. doi: 10.1002/cncr.31770. Epub 2018 Oct 23.


Advancing shared decision making for symptom monitoring in people living beyond cancer.

Heathcote LC, Goldberg DS, Eccleston C, Spunt SL, Simons LE, Sharpe L, Earp BD.

Lancet Oncol. 2018 Oct;19(10):e556-e563. doi: 10.1016/S1470-2045(18)30499-6. Epub 2018 Oct 1. Review.


Genome-Informed Targeted Therapy for Osteosarcoma.

Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, DuBois SG, Hawkins DS, Sweet-Cordero EA.

Cancer Discov. 2019 Jan;9(1):46-63. doi: 10.1158/2159-8290.CD-17-1152. Epub 2018 Sep 28.


Preoperative Intensity Modulated Radiation Therapy Compared to Three-Dimensional Conformal Radiation Therapy for High-Grade Extremity Sarcomas in Children: Analysis of the Children's Oncology Group Study ARST0332.

Rao AD, Chen Q, Million L, Spunt SL, Fitzgerald TJ, Hu C, Rao SS, Laurie F, Kessel S, Morano K, Ladra MM, Terezakis SA.

Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):38-44. doi: 10.1016/j.ijrobp.2018.09.005. Epub 2018 Sep 10.


Association of Tumor [18F]FDG Activity and Diffusion Restriction with Clinical Outcomes of Rhabdomyosarcomas.

Pourmehdi Lahiji A, Jackson T, Nejadnik H, von Eyben R, Rubin D, Spunt SL, Quon A, Daldrup-Link H.

Mol Imaging Biol. 2019 Jun;21(3):591-598. doi: 10.1007/s11307-018-1272-1.


Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.

Hawkins DS, Chi YY, Anderson JR, Tian J, Arndt CAS, Bomgaars L, Donaldson SS, Hayes-Jordan A, Mascarenhas L, McCarville MB, McCune JS, McCowage G, Million L, Morris CD, Parham DM, Rodeberg DA, Rudzinski ER, Shnorhavorian M, Spunt SL, Skapek SX, Teot LA, Wolden S, Yock TI, Meyer WH.

J Clin Oncol. 2018 Sep 20;36(27):2770-2777. doi: 10.1200/JCO.2018.77.9694. Epub 2018 Aug 9.


Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation.

Aghighi M, Theruvath AJ, Pareek A, Pisani LL, Alford R, Muehe AM, Sethi TK, Holdsworth SJ, Hazard FK, Gratzinger D, Luna-Fineman S, Advani R, Spunt SL, Daldrup-Link HE.

Clin Cancer Res. 2018 Sep 1;24(17):4110-4118. doi: 10.1158/1078-0432.CCR-18-0673. Epub 2018 May 15.


Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children's Oncology Group.

Laetsch TW, Roy A, Xu L, Black JO, Coffin CM, Chi YY, Tian J, Spunt SL, Hawkins DS, Bridge JA, Parsons DW, Skapek SX.

Clin Cancer Res. 2018 Aug 15;24(16):3888-3897. doi: 10.1158/1078-0432.CCR-18-0672. Epub 2018 Apr 24.


Whole-body PET/MRI of Pediatric Patients: The Details That Matter.

Pareek A, Muehe AM, Theruvath AJ, Gulaka PK, Spunt SL, Daldrup-Link HE.

J Vis Exp. 2017 Dec 19;(130). doi: 10.3791/57128.


Nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: Results from a prospective study using limited-margin radiotherapy.

Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua CH, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ.

Cancer. 2017 Nov 15;123(22):4419-4429. doi: 10.1002/cncr.30793. Epub 2017 Jul 31.


Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group.

Ferrari A, Chi YY, De Salvo GL, Orbach D, Brennan B, Randall RL, McCarville MB, Black JO, Alaggio R, Hawkins DS, Bisogno G, Spunt SL.

Eur J Cancer. 2017 Jun;78:1-6. doi: 10.1016/j.ejca.2017.03.003. Epub 2017 Apr 7.


Pleomorphic myxoid liposarcoma in an adolescent with Li-Fraumeni syndrome.

Sinclair TJ, Thorson CM, Alvarez E, Tan S, Spunt SL, Chao SD.

Pediatr Surg Int. 2017 May;33(5):631-635. doi: 10.1007/s00383-017-4063-x. Epub 2017 Feb 3.


Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.

Xu L, Wilson RA, Laetsch TW, Oliver D, Spunt SL, Hawkins DS, Skapek SX.

Sci Rep. 2016 Sep 19;6:33429. doi: 10.1038/srep33429.


Opportunities for Improvement in Pathology Reporting of Childhood Nonrhabdomyosarcoma Soft Tissue Sarcomas:  A Report From Children's Oncology Group (COG) Study ARST0332.

Black JO, Coffin CM, Parham DM, Hawkins DS, Speights RA, Spunt SL.

Am J Clin Pathol. 2016 Sep;146(3):328-38. doi: 10.1093/ajcp/aqw114. Epub 2016 Aug 10.


Pulmonary Function after Treatment for Childhood Cancer. A Report from the St. Jude Lifetime Cohort Study (SJLIFE).

Green DM, Zhu L, Wang M, Ness KK, Krasin MJ, Bhakta NH, McCarville MB, Srinivasan S, Stokes DC, Srivastava D, Ojha R, Shelton K, Pui CH, Armstrong GT, Mulrooney DA, Metzger M, Spunt SL, Navid F, Davidoff AM, Rao BN, Robison LL, Hudson MM.

Ann Am Thorac Soc. 2016 Sep;13(9):1575-85. doi: 10.1513/AnnalsATS.201601-022OC.


Limited Margin Radiation Therapy for Children and Young Adults With Ewing Sarcoma Achieves High Rates of Local Tumor Control.

Talleur AC, Navid F, Spunt SL, McCarville MB, Wu J, Mao S, Davidoff AM, Neel MD, Krasin MJ.

Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):119-26. doi: 10.1016/j.ijrobp.2016.04.001. Epub 2016 Apr 12.


Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model.

Tipirneni-Sajja A, Loeffler RB, Oesingmann N, Bissler J, Song R, McCarville B, Jones DP, Hudson M, Spunt SL, Hillenbrand CM.

Physiol Rep. 2016 Apr;4(7). pii: e12755. doi: 10.14814/phy2.12755. Epub 2016 Apr 13.


MRI and CT of Low-Grade Fibromyxoid Sarcoma in Children: A Report From Children's Oncology Group Study ARST0332.

Sargar K, Kao SC, Spunt SL, Hawkins DS, Parham DM, Coffin C, McCarville MB.

AJR Am J Roentgenol. 2015 Aug;205(2):414-20. doi: 10.2214/AJR.14.13972.


Bilateral internal hemipelvectomy for osteosarcoma in a pediatric patient previously treated for rhabdomyosarcoma.

Fernandez-Pineda I, McCarville MB, Brennan RC, Spunt SL, Neel MD, Rao BN.

Orthop Traumatol Surg Res. 2015 May;101(3):395-7. doi: 10.1016/j.otsr.2015.01.012. Epub 2015 Mar 25.


Delayed primary excision with subsequent modification of radiotherapy dose for intermediate-risk rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.

Rodeberg DA, Wharam MD, Lyden ER, Stoner JA, Brown K, Wolden SL, Paidas CN, Donaldson SS, Hawkins DS, Spunt SL, Arndt CA.

Int J Cancer. 2015 Jul 1;137(1):204-11. doi: 10.1002/ijc.29351. Epub 2014 Dec 10.


Imaging features of alveolar soft-part sarcoma: a report from Children's Oncology Group Study ARST0332.

McCarville MB, Muzzafar S, Kao SC, Coffin CM, Parham DM, Anderson JR, Spunt SL.

AJR Am J Roentgenol. 2014 Dec;203(6):1345-52. doi: 10.2214/AJR.14.12462.


Growth plate abnormalities in pediatric cancer patients undergoing phase 1 anti-angiogenic therapy: a report from the Children's Oncology Group Phase I Consortium.

Voss SD, Glade-Bender J, Spunt SL, DuBois SG, Widemann BC, Park JR, Leary SE, Nelson MD, Adamson PC, Blaney SM, Weigel B.

Pediatr Blood Cancer. 2015 Jan;62(1):45-51. doi: 10.1002/pbc.25229. Epub 2014 Sep 24.


Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study.

Green DM, Liu W, Kutteh WH, Ke RW, Shelton KC, Sklar CA, Chemaitilly W, Pui CH, Klosky JL, Spunt SL, Metzger ML, Srivastava D, Ness KK, Robison LL, Hudson MM.

Lancet Oncol. 2014 Oct;15(11):1215-23. doi: 10.1016/S1470-2045(14)70408-5. Epub 2014 Sep 16.


Phase I clinical trial of ifosfamide, oxaliplatin, and etoposide (IOE) in pediatric patients with refractory solid tumors.

Lam CG, Furman WL, Wang C, Spunt SL, Wu J, Ivy P, Santana VM, McGregor LM.

J Pediatr Hematol Oncol. 2015 Jan;37(1):e13-8. doi: 10.1097/MPH.0000000000000186.


Subsequent malignant neoplasms in pediatric patients initially diagnosed with neuroblastoma.

Federico SM, Allewelt HB, Spunt SL, Hudson MM, Wu J, Billups CA, Jenkins J, Santana VM, Furman WL, McGregor LM.

J Pediatr Hematol Oncol. 2015 Jan;37(1):e6-e12. doi: 10.1097/MPH.0000000000000148.


Clinical features and outcomes of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcomas.

Federico SM, Gilpin D, Samant S, Billups CA, Spunt SL.

Head Neck. 2015 Jan;37(1):76-83. doi: 10.1002/hed.23564. Epub 2014 Feb 12.


Histologic and clinical characteristics can guide staging evaluations for children and adolescents with rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.

Weiss AR, Lyden ER, Anderson JR, Hawkins DS, Spunt SL, Walterhouse DO, Wolden SL, Parham DM, Rodeberg DA, Kao SC, Womer RB.

J Clin Oncol. 2013 Sep 10;31(26):3226-32. doi: 10.1200/JCO.2012.44.6476. Epub 2013 Aug 12.


Chemotherapy-related neuropathic symptoms and functional impairment in adult survivors of extracranial solid tumors of childhood: results from the St. Jude Lifetime Cohort Study.

Ness KK, Jones KE, Smith WA, Spunt SL, Wilson CL, Armstrong GT, Srivastava DK, Robison LL, Hudson MM, Gurney JG.

Arch Phys Med Rehabil. 2013 Aug;94(8):1451-7. doi: 10.1016/j.apmr.2013.03.009. Epub 2013 Mar 26.


Lack of specificity of plasma concentrations of inhibin B and follicle-stimulating hormone for identification of azoospermic survivors of childhood cancer: a report from the St Jude lifetime cohort study.

Green DM, Zhu L, Zhang N, Sklar CA, Ke RW, Kutteh WH, Klosky JL, Spunt SL, Metzger ML, Navid F, Srivastava D, Robison LL, Hudson MM.

J Clin Oncol. 2013 Apr 1;31(10):1324-8. doi: 10.1200/JCO.2012.43.7038. Epub 2013 Feb 19.


Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors.

Green DM, Kun LE, Matthay KK, Meadows AT, Meyer WH, Meyers PA, Spunt SL, Robison LL, Hudson MM.

Pediatr Blood Cancer. 2013 Jul;60(7):1083-94. doi: 10.1002/pbc.24487. Epub 2013 Feb 15. Review.


Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: results of a Children's Oncology Group (COG) phase II study.

Skapek SX, Anderson JR, Hill DA, Henry D, Spunt SL, Meyer W, Kao S, Hoffer FA, Grier HE, Hawkins DS, Raney RB.

Pediatr Blood Cancer. 2013 Jul;60(7):1108-12. doi: 10.1002/pbc.24457. Epub 2012 Dec 31.


Children's Oncology Group's 2013 blueprint for research: Soft tissue sarcomas.

Hawkins DS, Spunt SL, Skapek SX; COG Soft Tissue Sarcoma Committee.

Pediatr Blood Cancer. 2013 Jun;60(6):1001-8. doi: 10.1002/pbc.24435. Epub 2012 Dec 19. Review.


Comparison of PET-CT and conventional imaging in staging pediatric rhabdomyosarcoma.

Federico SM, Spunt SL, Krasin MJ, Billup CA, Wu J, Shulkin B, Mandell G, McCarville MB.

Pediatr Blood Cancer. 2013 Jul;60(7):1128-34. doi: 10.1002/pbc.24430. Epub 2012 Dec 19.


Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors.

Navid F, Baker SD, McCarville MB, Stewart CF, Billups CA, Wu J, Davidoff AM, Spunt SL, Furman WL, McGregor LM, Hu S, Panetta JC, Turner D, Fofana D, Reddick WE, Leung W, Santana VM.

Clin Cancer Res. 2013 Jan 1;19(1):236-46. doi: 10.1158/1078-0432.CCR-12-1897. Epub 2012 Nov 8. Erratum in: Clin Cancer Res. 2013 Apr 1;19(7):1914.


Primary intrathoracic dermatofibrosarcoma protuberans.

King L, López-Terrada D, Jakacky J, McCarville MB, Spunt SL, Bridge JA, Bahrami A.

Am J Surg Pathol. 2012 Dec;36(12):1897-902. doi: 10.1097/PAS.0b013e31826b7919.


Overcoming autopsy barriers in pediatric cancer research.

Alabran JL, Hooper JE, Hill M, Smith SE, Spady KK, Davis LE, Peterson LS, Malempati S, Ryan CW, Acosta R, Spunt SL, Keller C.

Pediatr Blood Cancer. 2013 Feb;60(2):204-9. doi: 10.1002/pbc.24320. Epub 2012 Sep 26.


Association of bone mineral density with incidental renal stone in long-term survivors of childhood acute lymphoblastic leukemia.

Gawade PL, Ness KK, Sharma S, Li Z, Srivastava DK, Spunt SL, Nottage K, Krasin MJ, Hudson MM, Kaste SC.

J Cancer Surviv. 2012 Dec;6(4):388-97. doi: 10.1007/s11764-012-0241-y. Epub 2012 Sep 6.


Parent-clinician communication intervention during end-of-life decision making for children with incurable cancer.

Hinds PS, Oakes LL, Hicks J, Powell B, Srivastava DK, Baker JN, Spunt SL, West NK, Furman WL.

J Palliat Med. 2012 Aug;15(8):916-22. doi: 10.1089/jpm.2012.0006. Epub 2012 Jun 26.


Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007.

Pui CH, Pei D, Pappo AS, Howard SC, Cheng C, Sandlund JT, Furman WL, Ribeiro RC, Spunt SL, Rubnitz JE, Jeha S, Hudson MM, Kun LE, Merchant TE, Kocak M, Broniscer A, Metzger ML, Downing JR, Leung W, Evans WE, Gajjar A.

J Clin Oncol. 2012 Jun 1;30(16):2005-12. doi: 10.1200/JCO.2011.40.8617. Epub 2012 Apr 30.


Endometrial cancer in a 15-year-old girl: A complication of Cowden Syndrome.

Elnaggar AC, Spunt SL, Smith W, Depas M, Santoso JT.

Gynecol Oncol Case Rep. 2012 Oct 26;3:18-9. doi: 10.1016/j.gynor.2012.10.006. eCollection 2012.


Vaginal tumors in childhood: the experience of St. Jude Children's Research Hospital.

Fernandez-Pineda I, Spunt SL, Parida L, Krasin MJ, Davidoff AM, Rao BN.

J Pediatr Surg. 2011 Nov;46(11):2071-5. doi: 10.1016/j.jpedsurg.2011.05.003.


Implementation and evaluation of an automated patient death notification policy at a tertiary pediatric oncology referral center.

Baker JN, Harper J, Kane JR, Hicks J, Ward D, Hinds PS, Spunt SL.

J Pain Symptom Manage. 2011 Nov;42(5):652-6. doi: 10.1016/j.jpainsymman.2011.07.002.


Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma.

Geoerger B, Kieran MW, Grupp S, Perek D, Clancy J, Krygowski M, Ananthakrishnan R, Boni JP, Berkenblit A, Spunt SL.

Eur J Cancer. 2012 Jan;48(2):253-62. doi: 10.1016/j.ejca.2011.09.021. Epub 2011 Oct 25.

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